Engineering of microscale three-dimensional pancreatic islet modelsin vitroand their biomedical applications

Dimensionality and Size Scaling of Coordinated Ca2+ Dynamics in MIN6 β-cell Clusters

(2014) Thomas H. Hraha et al.   BIOPHYSICAL JOURNAL

Decreasing Cx36 Gap Junction Coupling Compensates for Overactive KATPChannels to Restore Insulin Secretion and Prevent Hyperglycemia in a Mouse Model of Neonatal Diabetes

(2014) Linda M. Nguyen et al.   DIABETES

Geometric effect of the hydrogel grid structure on in vitro formation of homogeneous MIN6 cell clusters

(2014) Chae Yun Bae et al.   LAB ON A CHIP

Scaffold Architecture Controls Insulinoma Clustering, Viability, and Insulin Production

(2014) Britani N. Blackstone et al.   TISSUE ENGINEERING PART A

Multiparameter analyses of three-dimensionally cultured tumor spheroids based on respiratory activity and comprehensive gene expression profiles

(2013) Yuanshu Zhou et al.   ANALYTICAL BIOCHEMISTRY

A multicellular 3D heterospheroid model of liver tumor and stromal cells in collagen gel for anti-cancer drug testing

(2013) Derek Yip et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The generation of pancreatic β-cell spheroids in a simulated microgravity culture system

(2013) Hiroyasu Tanaka et al.   BIOMATERIALS

3D co-culturing model of primary pancreatic islets and hepatocytes in hybrid spheroid to overcome pancreatic cell shortage

(2013) Yesl Jun et al.   BIOMATERIALS

Combination of microwell structures and direct oxygenation enables efficient and size-regulated aggregate formation of an insulin-secreting pancreatic β-cell line

(2013) Marie Shinohara et al.   BIOTECHNOLOGY PROGRESS

Molecular basis for the regulation of islet beta cell mass in mice: the role of E-cadherin

(2013) N. Wakae-Takada et al.   DIABETOLOGIA

Hanging drop: An in vitro air toxic exposure model using human lung cells in 2D and 3D structures

(2013) Faye F. Liu et al.   JOURNAL OF HAZARDOUS MATERIALS

Signaling in Insulin-Secreting MIN6 Pseudoislets and Monolayer Cells

(2013) Azazul Chowdhury et al.   JOURNAL OF PROTEOME RESEARCH

The fractal spatial distribution of pancreatic islets in three dimensions: a self-avoiding growth model

(2013) Junghyo Jo et al.   PHYSICAL BIOLOGY

Development of In Vitro 3D TissueFlex® Islet Model for Diabetic Drug Efficacy Testing

(2013) Zhaohui Li et al.   PLoS One

Enhanced Survival and Function of Islet-Like Clusters Differentiated from Adipose Stem Cells on a Three-Dimensional Natural Polymeric Scaffold: An In Vitro Study

(2013) Neena Aloysious et al.   TISSUE ENGINEERING PART A

Long-Term Functions of Encapsulated Islets Grafted in Nonhuman Primates Without Immunosuppression

(2013) Mitnala Sasikala et al.   TRANSPLANTATION

Optimal Formation of Genetically Modified and Functional Pancreatic Islet Spheroids by Using Hanging-Drop Strategy

(2013) H.J. Kim et al.   TRANSPLANTATION PROCEEDINGS

Pseudoislet of Hybrid Cellular Spheroids From Commercial Cell Lines

(2013) Y.H. Jo et al.   TRANSPLANTATION PROCEEDINGS

Self-assembling glucagon-like peptide 1-mimetic peptide amphiphiles for enhanced activity and proliferation of insulin-secreting cells

(2012) Saahir Khan et al.   Acta Biomaterialia

Isolation of Langerhans islets by dielectrophoresis

(2012) Sarah Burgarella et al.   ELECTROPHORESIS

Distinctions Between the Islets of Mice and Men: Implications for New Therapies for Type 1 and 2 Diabetes

(2012) Claresa Levetan et al.   Endocrine Practice

Perfluorinated alginate for cellular encapsulation

(2012) Kerim M. Gattás-Asfura et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Configuration of electrofusion-derived human insulin-secreting cell line as pseudoislets enhances functionality and therapeutic utility

(2012) Hong Guo-Parke et al.   JOURNAL OF ENDOCRINOLOGY

Engineering Complex Tissues

(2012) A. Atala et al.   Science Translational Medicine

Paracrine and autocrine interactions in the human islet: More than meets the eye

(2012) Alejandro Caicedo   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

A Microwell Cell Culture Platform for the Aggregation of Pancreatic β-Cells

(2012) Abigail B. Bernard et al.   TISSUE ENGINEERING PART C-METHODS

Type 1 Diabetes: Current Concepts in Epidemiology, Pathophysiology, Clinical Care, and Research

(2012) Mary Joyce Gan et al.   Current Problems in Pediatric and Adolescent Health Care

In situ formation and collagen-alginate composite encapsulation of pancreatic islet spheroids

(2011) Bo Ram Lee et al.   BIOMATERIALS

Embryonic stem cell bioprinting for uniform and controlled size embryoid body formation

(2011) Feng Xu et al.   Biomicrofluidics

Cadherin Engagement Protects Human β-Cells from Apoptosis

(2011) Géraldine Parnaud et al.   ENDOCRINOLOGY

Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters

(2011) Dennis Van Hoof et al.   Stem Cell Research

High-throughput 3D spheroid culture and drug testing using a 384 hanging drop array

(2010) Yi-Chung Tung et al.   ANALYST

Unique Arrangement of  - and  -Cells in Human Islets of Langerhans

(2010) D. Bosco et al.   DIABETES

The role of glucagon- and somatostatin-secreting cells in the regulation of insulin release and beta-cell function in heterotypic pseudoislets

(2010) Catriona Kelly et al.   DIABETES-METABOLISM RESEARCH AND REVIEWS

Rat islet cell aggregates are superior to islets for transplantation in microcapsules

(2010) E. S. O’Sullivan et al.   DIABETOLOGIA

Patterning of Mono- and Multilayered Pancreatic β-Cell Clusters

(2010) Adam D. Mendelsohn et al.   LANGMUIR

Agonist of growth hormone-releasing hormone as a potential effector for survival and proliferation of pancreatic islets

(2010) Barbara Ludwig et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudoislets as primary islet replacements for research

(2010) Shanta J. Persaud et al.   Islets

Regulated laminin-332 expression in human islets of Langerhans

(2009) Mathieu Armanet et al.   FASEB JOURNAL

Collagen fibrillogenesis: fibronectin, integrins, and minor collagens as organizers and nucleators

(2008) Karl E Kadler et al.   CURRENT OPINION IN CELL BIOLOGY

Unique basement membrane structure of human pancreatic islets: implications for β-cell growth and differentiation

(2008) T. Otonkoski et al.   DIABETES OBESITY & METABOLISM

Dielectrophoretic assembly of insulinoma cells and fluorescent nanosensors into three-dimensional pseudo-islet constructs

(2008) R. Pethig et al.   IET Nanobiotechnology

Cell–Matrix Interactions Improve β-Cell Survival and Insulin Secretion in Three-Dimensional Culture

(2008) Laney M. Weber et al.   TISSUE ENGINEERING PART A