Article
Immunology
Anthony D. Bai, Carson K. L. Lo, Adam S. Komorowski, Mallika Suresh, Kevin Guo, Akhil Garg, Pranav Tandon, Julien Senecal, Olivier Del Corpo, Isabella Stefanova, Clare Fogarty, Guillaume Butler-Laporte, Emily G. McDonald, Matthew P. Cheng, Andrew M. Morris, Mark Loeb, Todd C. Lee
Summary: In the case of Staphylococcus aureus bacteremia, mortality rates in randomized controlled trials (RCTs) are consistently lower than in observational studies, likely due to the stringent eligibility criteria and exclusion of early deaths in RCTs. Clinicians should consider the potential for lower treatment efficacy when applying RCT results to bedside care.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Immunology
Anita J. Campbell, Laila S. Al Yazidi, Linny K. Phuong, Clare Leung, Emma J. Best, Rachel H. Webb, Lesley Voss, Eugene Athan, Philip N. Britton, Penelope A. Bryant, Coen T. Butters, Jonathan R. Carapetis, Natasha S. Ching, Geoffrey W. Coombs, Denise Daley, Joshua Francis, Te-Yu Hung, Shakeel Mowlaboccus, Clare Nourse, Samar Ojaimi, Alex Tai, Nan Vasilunas, Brendan McMullan, Christopher C. Blyth, Asha C. Bowen
Summary: The ISAIAH study in Australia and New Zealand identified a high incidence of Staphylococcus aureus bacteremia in children hospitalized, with necrotizing pneumonia and multifocal infection being predictors of mortality for the first time in a pediatric setting. Consultation with infectious diseases specialists was found to be protective, highlighting the need to reevaluate pediatric vancomycin trough targets and limit unnecessary empiric vancomycin exposure to reduce poor outcomes and nephrotoxicity.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Infectious Diseases
Rachid Douglas-Louis, Mimi Lou, Brian Lee, Emi Minejima, Juliane Bubeck-Wardenburg, Annie Wong-Beringer
Summary: This study aimed to examine the relationship between early platelet dynamics and the outcome of Staphylococcus aureus bacteremia (SAB). The results showed that early platelet dynamics have prognostic significance for SAB and provide an early window for potential platelet-directed therapeutic interventions to improve outcome.
BMC INFECTIOUS DISEASES
(2023)
Article
Immunology
Yu Wang, Michael Z. Z. Ahmadi, Dustin A. A. Dikeman, Christine Youn, Nathan K. K. Archer
Summary: Staphylococcus aureus is a leading cause of bacteremia, and IL-1R plays a critical role in protecting against this infection, with T cells being the crucial cell type involved.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Edwin Chen, Marla G. Shaffer, Robert E. Bilodeau, Raymond E. West, Patrick J. Oberly, Thomas D. Nolin, Matthew J. Culyba
Summary: This study characterizes five rel mutations that arose during cases of persistent methicillin-resistant Staphylococcus aureus bacteremia. The mutations augment the stringent response (SR) signaling specifically under nutrient-poor conditions, enabling the bacteria to grow and survive more readily. This reveals a strategy used by bacterial pathogens to evade the nutritional immunity imposed by host tissues during infection.
Review
Medicine, General & Internal
Joshua T. Thaden, Sarah Cantrell, Michael Dagher, Yazhong Tao, Felicia Ruffin, Stacey A. Maskarinec, Stacy Goins, Matthew Sinclair, Joshua B. Parsons, Emily Eichenberger, Vance G. Fowler
Summary: In this systematic review and meta-analysis, obtaining FUBCs in patients with GN-BSI was associated with decreased mortality. Positive FUBCs were associated with increased mortality relative to negative blood cultures.
Review
Immunology
Daniel J. Minter, Ayesha Appa, Henry F. Chambers, Sarah B. Doernberg
Summary: This review aims to provide a comprehensive overview of the evaluation and management of Staphylococcus aureus bacteremia, with a special focus on areas where the highest level of evidence is lacking to inform best practices.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Felicia Ruffin, Michael Dagher, Lawrence P. Park, Lisa Wanda, Jonathan Hill-Rorie, Michael Mohnasky, Julia Marshall, Maria Souli, Paul Lantos, Batu K. Sharma-Kuinkel, Stacey A. Maskarinec, Emily M. Eichenberger, Charles Muiruri, Brittney Broadnax, Vance G. Fowler
Summary: The study found that Black and White patients with Staphylococcus aureus bacteremia had similar outcomes, despite differences in age, diabetes, and hemodialysis dependence. The results highlight the need for further research on the reasons behind the disparities.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Immunology
Si-Ho Kim, Minji Jeon, Sukbin Jang, Seok Jun Mun
Summary: This study evaluated the effects of treatment response and bacteremia duration on mortality in patients with persistent Staphylococcus aureus bacteremia. The results showed that Pitt bacteremia score at treatment day 4 was strongly associated with 30-day in-hospital mortality, while defervescence and bacteremia duration were not independent factors.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2023)
Article
Medicine, General & Internal
Petros Ioannou, Maria Zacharioudaki, Despoina Spentzouri, Antonia Koutoulakou, Konstantinos Kitsos-Kalyvianakis, Christoforos Chontos, Stamatis Karakonstantis, Sofia Maraki, George Samonis, Diamantis P. Kofteridis
Summary: This study retrospectively evaluated a cohort of SAB patients hospitalized in Heraklion, Greece, and identified factors independently associated with mortality. The study found that female gender, older age, severe sepsis, and MRSA infection were positively associated with in-hospital mortality. The study also emphasized the urgency of improving antimicrobial stewardship, involving infectious diseases physicians, providing education and training, and creating and implementing local guidelines.
Review
Infectious Diseases
Anthony D. Bai, Carson Kl Lo, Adam S. Komorowski, Mallika Suresh, Kevin Guo, Akhil Garg, Pranav Tandon, Julien Senecal, Olivier Del Corpo, Isabella Stefanova, Clare Fogarty, Guillaume Butler-Laporte, Emily G. McDonald, Matthew P. Cheng, Andrew M. Morris, Mark Loeb, Todd C. Lee
Summary: This study compared the mortality rates of Staphylococcus aureus bacteremia in low- and middle-income countries versus high-income countries, finding that middle-income countries had significantly higher in-hospital mortality rates than high-income countries. It is important to note the low representation of low-income countries in related research, highlighting the need for further studies in these countries to better understand the differences in mortality rates.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2022)
Article
Microbiology
Joya-Rita Hindy, Juan A. Quintero-Martinez, Brian D. Lahr, Daniel C. DeSimone, Larry M. Baddour
Summary: This retrospective study evaluated the incidence and six-month mortality rates of polymicrobial Staphylococcus aureus bacteremia (p-SAB) in the United States (US) and found a lower incidence rate compared to previous reports, with almost half of the cases caused by Gram-positive bacteria. Additionally, p-SAB patients had poor survival compared to monomicrobial SAB (m-SAB) cases.
Article
Infectious Diseases
Ilse J. E. Kouijzer, L. T. D. Speijker, E. H. J. G. Aarntzen, W. H. C. Rijnen, M. P. Somford, I Maat, M. P. A. van Meer, J. Ten Oever, E. H. Gisolf
Summary: This study investigated the likelihood of occult infection in patients with clinically unsuspected orthopedic implants during Staphylococcus aureus bacteremia. Results showed that only 5 out of 136 unsuspected implants showed increased uptake on [F-18]FDG-PET/CT, and there were no clinical symptoms of infection or relapse of bacteremia during follow-up, suggesting that additional investigations or prolonged antibiotic treatment were unnecessary.
Article
Immunology
Thomas W. van der Vaart, Jan M. Prins, Robin Soetekouw, Gitte van Twillert, Jan Veenstra, Bjorn L. Herpers, Wouter Rozemeijer, Rogier R. Jansen, Marc J. M. Bonten, Jan T. M. van der Meer
Summary: Staphylococcus aureus bacteremia is a heterogeneous disease with changing epidemiology. This study found a high proportion of infection-related mortality, with the majority of deaths occurring within 30 days post-infection.
OPEN FORUM INFECTIOUS DISEASES
(2022)
Article
Immunology
Nesrin Ghanem-Zoubi, Olga Kagna, Jawad Abu-Elhija, Mona Mustafa-Hellou, Majd Qasum, Zohar Keidar, Mical Paul
Summary: The study found that performing FDG-PET/CT in patients with Staphylococcus aureus bacteremia (SAB) seemed to improve survival rates through guiding treatment duration and interventions.
CLINICAL INFECTIOUS DISEASES
(2021)