Article
Cardiac & Cardiovascular Systems
Nadia Bouabdallaoui, Nathan Messas, Nicola Greenlaw, Roberto Ferrari, Ian Ford, Kim M. Fox, Michal Tendera, Datshana P. Naidoo, Christian Hassager, P. Gabriel Steg, Jean-Claude Tardif
Summary: Research shows that compared with never-smokers, current smokers and former smokers have higher risks of all-cause mortality and cardiovascular mortality in patients with stable coronary artery disease. Even after quitting smoking, cardiovascular risk remains elevated compared to never-smokers but lower than current smokers, emphasizing the importance of smoking cessation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2021)
Article
Pharmacology & Pharmacy
Xiao Zou, Liang Wang, Sha-Sha Sun, Yi-Xin Hu, Hong-Wei Liu, Hao Wang, Jian Cao, Hong-Bin Liu, Li Fan
Summary: This study evaluated the impact of discontinuing antiplatelet therapy on clinical outcomes of older patients with stable coronary artery disease. The results showed that cessation of antiplatelet drugs significantly increased the risk of major adverse cardiovascular events, but continuous use of antiplatelet drugs did not increase the risk of minor bleeding.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Leonardo De Luca, Francesca Cappadona, Pier Luigi Temporelli, Lucio Gonzini, Antonietta Ledda, Arturo Raisaro, Francesca Viazzi, Domenico Gabrielli, Furio Colivicchi, Michele Massimo Gulizia, Roberto Pontremoli
Summary: In patients with stable coronary artery disease (CAD), a reduction in estimated glomerular filtration rate (eGFR) is associated with an increased risk of all-cause mortality. Chronic kidney disease may limit treatment optimization.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
David Feldman, Jacqueline Latina, Jana Lovell, Roger S. Blumenthal, Armin Arbab-Zadeh
Summary: The treatment of coronary artery disease focuses on managing symptoms and preventing cardiovascular events. Coronary CTA has emerged as the first line noninvasive imaging modality for evaluating coronary atherosclerosis, improving diagnostic accuracy and patient outcomes.
TRENDS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Elzbieta Paszek, Elzbieta Pociask, Michal Zabczyk, Adam Piorkowski, Saulius Butenas, Jacek Legutko, Anetta Undas
Summary: This study found that active TF and FXIa were associated with clinical outcomes in CAD patients in long-term observation, and FXIa was an independent predictor of the composite endpoint.
Review
Cardiac & Cardiovascular Systems
Danilo Neglia, Natallia Maroz-Vadalazhskaya, Nazario Carrabba, Riccardo Liga
Summary: In recent decades, effective management of cardiovascular risk factors has led to a decrease in coronary artery disease prevalence. However, coronary heart disease remains a leading cause of death globally, and chronic coronary syndromes continue to be targets of cardiac imaging and invasive procedures. Current guidelines recommend non-invasive imaging for CCS patients to identify high-risk individuals for referral to invasive procedures, but recent studies have raised questions about the efficacy of coronary revascularization. The role of imaging in these patients, including those with ischemic cardiomyopathy, remains debated.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Medicine, General & Internal
Yasemin Dogan, Yucel Yilmaz, Saban Kelesoglu, Bekir Calapkorur, Salim Neselioglu, Ozcan Erel, Nihat Kalay
Summary: The aim of this study was to investigate the relationship between thiol, the main component of the antioxidant system, and coronary collateral circulation (CCC). The results showed that patients with stable coronary artery disease (sCAD) who developed poor CCC had lower levels of native thiol, total thiol, and disulfide compared to those with good CCC. Additionally, DM, total thiol, and disulfide were identified as independent predictors of poor CCC.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Kasra Moazzami, Mariana Garcia, Samaah Sullivan, Tene T. Lewis, J. Douglas Bremner, Alexander C. Razavi, Lucy Shallenberger, Yan V. Sun, Paolo Raggi, Amit J. Shah, Arshed A. Quyyumi, Viola Vaccarino
Summary: Among patients with a history of myocardial infarction, a higher level of psychosocial distress is associated with mental stress-induced myocardial ischemia but not with ischemia induced by a conventional stress test.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Akira Taruya, Yuki Nakajima, Atsushi Tanaka, Manabu Kashiwagi, Takashi Tanimoto, Akio Kuroi, Yasutsugu Shiono, Kunihiro Shimamura, Takashi Kubo, Hiromichi Sougawa, Tomizo Masuno, Yuichi Ozaki, Keisuke Satogami, Shingo Ota, Yosuke Katayama, Yasushi Ino, Hironobu Hoshiya, Takashi Akasaka
Summary: This study found that cancer survivors with coronary artery disease (CAD) have distinct lesion morphologies and poorer outcomes compared to non-cancer controls, likely due to underlying inflammation and presence of high-risk lesions such as thrombi and layered fibrotic plaques. These findings may provide insights for the management of CAD in cancer patients in terms of secondary prevention.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Kiyotaka Hao, Jun Takahashi, Yoku Kikuchi, Akira Suda, Koichi Sato, Jun Sugisawa, Satoshi Tsuchiya, Tomohiko Shindo, Kensuke Nishimiya, Shohei Ikeda, Ryuji Tsuburaya, Takashi Shiroto, Yasuharu Matsumoto, Satoshi Miyata, Yasuhiko Sakata, Satoshi Yasuda, Hiroaki Shimokawa
Summary: The study found that while the incidence of major adverse cardiovascular events was low among patients with vasospastic angina (VSA), those with significant coronary stenosis in the low-FFR group had a poor prognosis. The combination treatment of calcium channel blockers and percutaneous coronary intervention significantly improved the outcomes for VSA patients.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Multidisciplinary Sciences
Yulan Ma, Lulu Zhu, Zhijun Ma, Zhongshan Gao, Yumiao Wei, Youlu Shen, Lin Li, Xingli Liu, Ming Ren
Summary: The study revealed that Tibetan Highlanders suffering from coronary artery disease have higher gut microbiota diversity, which is associated with their unique dietary characteristics.
SCIENTIFIC REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
John W. Eikelboom, Deepak L. Bhatt, Keith A. A. Fox, Jacqueline Bosch, Stuart J. Connolly, Sonia S. Anand, Alvaro Avezum, Scott D. Berkowitz, Kelley R. H. Branch, Gilles R. Dagenais, Camilo Felix, Tomasz J. Guzik, Robert G. Hart, Aldo P. Maggioni, Eva Muehlhofer, Mukul Sharma, Olga Shestakovska, Salim Yusuf
Summary: The combination of rivaroxaban and aspirin reduces overall cardiovascular mortality and specific cause-specific cardiovascular mortality in patients with chronic CAD or PAD. The mortality benefits increase with higher baseline risk factors.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jangho Park, Sangwoo Park, Yong-Giun Kim, Soe Hee Ann, Hyun Woo Park, Jon Suh, Jae-Hyung Roh, Young-Rak Cho, Seungbong Han, Gyung-Min Park
Summary: An analysis of National Health Insurance data in Korea showed that pre-existing depression does not have a significant impact on mortality in patients with established coronary artery disease undergoing PCI. However, younger patients with angina and depression may have a higher risk of all-cause mortality.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Applied
Kasra Moazzami, Mariana Garcia, An Young, Zakaria Almuwaqqat, Bruno B. Lima, Afif Martini, Mhmtjamil Alkhalaf, Amit J. Shah, Felicia C. Goldstein, Ihab Hajjar, Allan Levey, J. Douglas Bremner, Arshed A. Quyyumi, Viola Vaccarino
Summary: This study found that in patients with coronary artery disease (CAD), higher levels of psychological distress are independently associated with worse cognitive performance, indicating that psychological risk factors play a role in the cognitive trajectories of individuals with CAD.
Article
Cardiac & Cardiovascular Systems
Ziwei Xi, Jianan Li, Hong Qiu, Tingting Guo, Yong Wang, Yang Li, Jianfeng Zheng, Kefei Dou, Bo Xu, Yongjian Wu, Shubin Qiao, Weixian Yang, Yuejin Yang, Runlin Gao
Summary: This study demonstrates that in patients with SCAD undergoing complex PCI, ticagrelor can significantly reduce the risk of adverse cardiovascular events compared to clopidogrel, without an increased risk of major bleeding.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Rehabilitation
Elizabeth Stratton, Nick Glozier, Alix Woolard, Vicki Gibbs, Eleni A. Demetriou, Kelsie A. Boulton, Ian Hickie, Elizabeth Pellicano, Adam J. Guastella
Summary: The employment rates for autistic individuals are low, and mental health symptoms and disabilities are associated with vocational functioning. The association between anxiety and stress with vocational outcomes is attenuated in a multivariable model. Depression and disabilities are independent factors associated with vocational outcomes.
DISABILITY AND REHABILITATION
(2023)
Article
Psychiatry
Kevin Thien Anh Hoang, Richard W. Morris, Diana Nicole Naehrig, Nick Glozier
Summary: Occupational surveys consistently show that doctors have higher rates of depression and anxiety compared to the general population. However, a study in Australia found that doctors had better mental health and life satisfaction levels compared to other professions prior to the COVID-19 pandemic, and their mental health did not decline disproportionately compared to other occupations during the pandemic.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Nick Glozier, Richard Morris, Stefanie Schurer
Summary: Contrary to predictions made during the early stages of the COVID-19 pandemic, the suicide rates have not increased but rather declined in the majority of countries and regions with available data by the end of 2021. The study provides four reasons why the predictions of suicide models were exaggerated, including government intervention, the actual impact of the pandemic and lockdowns on mental health, weak evidence for the link between economic downturns and suicide, and the difficulty of predicting suicide.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Editorial Material
Clinical Neurology
Nick Glozier, Parisa Vidafar
Correction
Health Care Sciences & Services
Samineh Sanatkar, Isabelle Counson, Andrew Mackinnon, Alexandra Bartholomew, Nick Glozier, Samuel Harvey
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Editorial Material
Medicine, General & Internal
Nicholas Glozier
MEDICAL JOURNAL OF AUSTRALIA
(2023)
Article
Biochemistry & Molecular Biology
Chang-Won Kang, Anneke C. Blackburn, Amos Hong Pheng Loh, Kuick Chick Hong, Jian Yuan Goh, Nadine Hein, Denis Drygin, Chris R. Parish, Ross D. Hannan, Katherine M. Hannan, Lucy A. Coupland
Summary: The survival rate of patients with osteosarcoma has not improved in the past 30 years. Mutations in TP53, RB1, and c-Myc genes enhance the activity of RNA Polymerase I (Pol I), leading to uncontrolled cancer cell proliferation. Pol I inhibition may be an effective therapeutic strategy for osteosarcoma.
Article
Health Care Sciences & Services
Isabella Choi, Gemma Mestroni, Caroline Hunt, Nick Glozier
Summary: This study developed a web application to support help seeking among Chinese international students. The app provided personalized feedback and tailored psychoeducation and resources. The study found promising levels of demand, uptake, and engagement with the web application.
JMIR FORMATIVE RESEARCH
(2023)
Letter
Psychiatry
Nick Glozier, Richard Morris
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Anthony Rodgers, Dilara Bahceci, Christopher G. Davey, Mary Lou Chatterton, Nick Glozier, Malcolm Hopwood, Colleen Loo
Summary: This paper explores the challenges of repurposing established medicines using the example of ketamine as a new treatment for severe depression. The evaluation of generic ketamine was delayed due to insufficient incentives for commercial entities and lack of support for non-commercial entities. Meanwhile, commercial investment enabled the widespread registration of Spravato, a patented ketamine formulation, but at a significantly higher cost. This has left the treatment largely inaccessible for many patients, despite emerging evidence suggesting the effectiveness of generic ketamine as an alternative. The paper emphasizes the need for systemic reforms to ensure affordable and effective options become accessible, including commercial incentives, public and public-private funding schemes, reduced regulatory barriers, and coordinated international public funding schemes to support translational research.
AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY
(2023)
Article
Psychiatry
Christiane Klinner, Nick Glozier, Margaret Yeung, Katrina Conn, Alyssa Milton
Summary: Rural and regional communities in Australia face geographic isolation and frequent natural disasters, which have a significant impact on the mental health of their inhabitants. This study aims to explore the facilitators of mental health and help-seeking behaviors among adolescents in these areas. The findings suggest that a well-coordinated community approach, with locally available and engaging mental health education and support services, is crucial for meeting the needs of young people. Integrating existing mental health supporters and resources, such as teachers and school counseling services, is also highlighted.
Article
Psychiatry
Colleen Loo, Nick Glozier, David Barton, Bernhard T. Baune, Natalie T. Mills, Paul Fitzgerald, Paul Glue, Shanthi Sarma, Veronica Galvez-Ortiz, Dusan Hadzi-Pavlovic, Angelo Alonzo, Vanessa Dong, Donel Martin, Stevan Nikolin, Philip B. Mitchell, Michael Berk, Gregory Carter, Maree Hackett, John Leyden, Sean Hood, Andrew A. Somogyi, Kyle Lapidus, Elizabeth Stratton, Kirsten Gainsford, Deepak Garg, Nicollette L. R. Thornton, Celia Fourrier, Karyn Richardson, Demi Rozakis, Anish Scaria, Cathrine Mihalopoulos, Mary Lou Chatterton, William M. Mcdonald, Philip Boyce, Paul E. Holtzheimer, F. Andrew Kozel, Patricio Riva-Posse, Anthony Rodgers
Summary: This study is a phase 3 trial on the efficacy and safety of subcutaneous racemic ketamine in the treatment of treatment-resistant depression (TRD). The results showed that subcutaneous racemic ketamine was effective and safe over a 4-week treatment period. The dosing and route of administration were considered practical and feasible.
BRITISH JOURNAL OF PSYCHIATRY
(2023)
Article
Health Care Sciences & Services
Mark Deady, Daniel A. J. Collins, Isobel Lavender, Andrew Mackinnon, Nicholas Glozier, Richard Bryant, Helen Christensen, Samuel B. Harvey
Summary: This study aimed to evaluate the effectiveness of a smartphone-based intervention in preventing depression in workers with moderate stress levels. The results showed that the intervention group had significant reductions in depressive and anxiety symptoms, as well as improved work performance. However, the intervention did not show effectiveness in preventing clinically diagnosed depression in the intention-to-treat analysis.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2023)
Article
Psychology, Biological
Stefanie Schurer, Kadir Atalay, Nick Glozier, Esperanza Vera-Toscano, Mark Wooden
Summary: Melbourne's 111-day lockdown had statistically significant but small impacts on various aspects of human life. Women experienced lower mental health and working hours but exercised more and received more government transfers. Men felt less part of their community and reduced working hours. Families with children were the main drivers of negative outcomes.
NATURE HUMAN BEHAVIOUR
(2023)
Article
Public, Environmental & Occupational Health
Jane Brandt Sorensen, K. S. Kylie Lee, Andrew Dawson, Angela Dawson, Lalith Senarathna, P. H. G. Janaka Pushpakumara, Thilini Rajapakse, Flemming Konradsen, Nick Glozier, Katherine M. Conigrave, Prabash Siriwardhana, David Hansen, Alexandra Buhl, Chamill Priyadhasana, Kamal Senawirathna, Malith Herath, Sudesh Mantillake, Priyantha Fonseka, Melissa Pearson
Summary: Risky alcohol use is a major global and Sri Lankan public health concern. This study introduces a complex community-based intervention utilizing arts-based research to reduce alcohol consumption and evaluates its scalability. The intervention design incorporates behavior change theories and targets individuals and communities through multifaceted arts-based interventions. Modifications were made to the study due to COVID-19 and the financial crisis, with ethical approval obtained. Findings will be disseminated through various channels.
GLOBAL HEALTH ACTION
(2023)