Article
Cardiac & Cardiovascular Systems
Giulia Poretti, Stiljan Hoxha, Antonio Segreto, Gardellini Jacopo, Camilla Sandrini, Giuseppe Faggian, Alessandro Varrica, Massimo Chessa, Alessandro Giamberti, Giovanni Battista Luciani
Summary: Cryoablation for supraventricular arrhythmias in ACHD patients is a safe and effective procedure with a low risk of recurrence, and surgical treatment should be considered when further open-heart repair is needed.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Syed Shahyan Bakhtiyar, Sara Sakowitz, Konmal Ali, Nikhil L. Chervu, Arjun Verma, Ming-Sing Si, David D'Alessandro, Peyman Benharash
Summary: The study evaluates the survival rate after heart transplantation in adults with single and biventricular CHD and compares it to that of non-CHD transplant recipients. Single-ventricle physiology is associated with higher short-term mortality, but 10-year conditional survival is similar for biventricular CHD patients and most single-ventricle CHD patients, and notably better for biventricular CHD patients compared to non-CHD heart transplant recipients.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Gabriele Egidy Assenza, Eric Krieger, Helmut Baumgartner, Blanche Cupido, Konstantinos Dimopoulos, Clauden Louis, Adam M. Lubert, Karen K. Stout, Anne Marie Valente, Katja Zeppenfeld, Alexander R. Opotowsky
Summary: The guidelines from the American Heart Association, American College of Cardiology, and European Society of Cardiology for managing adult congenital heart disease show both consensus and differences, requiring further research and discussion for better patient management.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Catherine G. Williamson, Shayan Ebrahimian, Nameer Ascandar, Yas Sanaiha, Sara Sakowitz, Reshma M. Biniwale, Peyman Benharash
Summary: This study assessed the impact of congenital heart disease (CHD) on resource utilization and clinical outcomes in patients undergoing major elective non-cardiac operations. The results showed that patients with CHD had higher rates of in-hospital mortality, longer hospitalization durations, higher costs, and increased risks of complications and readmission.
Review
Cardiac & Cardiovascular Systems
Margarita Brida, Daniel Lovric, Massimo Griselli, Fernando Riesgo Gil, Michael A. Gatzoulis
Summary: Heart failure is the leading cause of morbidity and mortality in adult patients with congenital heart disease. The nature of the underlying congenital heart disease affects the timing and severity of heart failure, and ongoing management is necessary. Drug therapy has some effect on left ventricle failure, but there is currently a lack of data on drug therapy for right ventricle and Fontan circulation failure. Cardiac resynchronization therapy is considered as a treatment option, while mechanical circulatory support and transplantation are last resorts in highly selected patients.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Obstetrics & Gynecology
Shannon L. Son, Lauren L. Hosek, Miranda C. Stein, Amanda A. Allshouse, Anna B. Catino, Arvind K. Hoskoppal, Daniel A. Cox, Kevin J. Whitehead, Ian M. Lindsay, Sean Esplin, Torri D. Metz
Summary: This retrospective longitudinal cohort study found an association between pregnancy and subsequent long-term adverse cardiovascular outcomes in individuals with congenital heart disease. These findings can provide important information for counseling and guidance of individuals with congenital heart disease who are considering pregnancy.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Obstetrics & Gynecology
Luis D. Pacheco, George Saade, Vineet Shrivastava, Raj Shree, Uri Elkayam
Summary: Pregnancy in individuals with a mechanical heart valve is classified as very high risk, requiring special anticoagulation management to prevent complications and mortality. Adjustments to anticoagulation regimens may be made based on valve type, trimester, individual risk tolerance, and timing of delivery.
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
(2022)
Article
Medicine, General & Internal
Mai Baquedano, Samantha E. de Jesus, Filippo Rapetto, Gavin J. Murphy, Gianni Angelini, Umberto Benedetto, Patricia Caldas, Prashant K. Srivastava, Orhan Uzun, Karen Luyt, Cecilia Gonzalez Corcia, Demetris Taliotis, Serban Stoica, Deborah A. Lawlor, Andrew R. Bamber, Alison Perry, Katie L. Skeffington, Ikenna Omeje, John Pappachan, Andrew D. Mumford, Richard J. M. Coward, Damien Kenny, Massimo Caputo
Summary: This study aims to establish a prospective cohort of patients with congenital heart disease (CHD) undergoing cardiac procedures. It will collect clinical data, biological samples, and participant questionnaires to investigate risk factors, predictors, and the effects of surgery on outcomes.
Article
Radiology, Nuclear Medicine & Medical Imaging
Ju Gang Nam, Whal Lee, Baren Jeong, Eun-Ah Park, Ji Yeon Lim, Yujin Kwak, Hong-Gook Lim
Summary: Inexperienced cardiothoracic surgeons improved their performance in terms of surgical proficiency and operation time during the experience of three simulation surgeries using a 3D-printed TOF model using Tango 27 composite.
KOREAN JOURNAL OF RADIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Parag N. Jain, Katherine B. Salciccioli, Danielle Guffey, Jinyoung Byun, Timothy B. Cotts, Peter Ermis, Michael Gaies, Nancy Ghanayem, Francis Kim, Javier J. Lasa, Andrew Smith, Stephanie Fuller
Summary: This study analyzed the postoperative care of adults with congenital heart disease in pediatric cardiac intensive care units, finding that high complexity operations, previous sternotomies, preoperative arrhythmias, renal dysfunction, and respiratory failure are independent risk factors for prolonged length of stay and/or major complications.
ANNALS OF THORACIC SURGERY
(2022)
Article
Cardiac & Cardiovascular Systems
Richard D. Mainwaring, Lou Capecci, R. Thomas Collins, Frank L. Hanley
Summary: This study assessed the midterm fate of unifocalized major aortopulmonary collateral arteries (MAPCAs) in patients with retroesophageal MAPCAs. The majority of unifocalized MAPCAs remained widely patent, but a quarter developed stenoses or occlusion. Close vigilance is necessary for the management of these patients.
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
(2022)
Article
Pediatrics
Alba Perez-Perez, Sara Vigil-Vazquez, Ana Gutierrez-Velez, Gonzalo Solis-Garcia, Maria Lopez-Blazquez, Jose Luis Zunzunegui Martinez, Constancio Medrano Lopez, Juan Miguel Gil-Jaurena, Juan Carlos de Agustin-Asensio, Manuel Sanchez-Luna
Summary: The aim of this study was to analyze the occurrence and risk factors of chylothorax in neonatal patients after congenital heart disease surgery. A retrospective and observational study was conducted on neonates who underwent surgery between January 2014 and December 2019. The results showed a high incidence of chylothorax after surgery, leading to longer hospital stays and increased morbidity and mortality.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Cardiac & Cardiovascular Systems
Patryk Leczycki, Maciej Banach, Marek Maciejewski, Agata Bielecka-Dabrowa
Summary: In recent decades, there has been a significant increase in the number of adults with congenital heart diseases (ACHD), necessitating thorough evaluation of their current condition. There is currently a lack of universal parameters or scales to easily assess the deterioration of ACHD patients' condition, emphasizing the need to identify widely available, cost-effective, and user-friendly factors. Studies have shown potential prognostic factors including echocardiography and magnetic resonance imaging, cardiopulmonary exercise testing, and biomarkers. However, further research is needed to create a specific assessment panel for patients with specific congenital heart diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Surgery
Amanda R. Jensen, Raghavendra Rao, Jeremy L. Herrmann, Troy A. Markel, Brian W. Gray
Summary: This study compared outcomes of gastrostomy tube placement between patients undergoing cardiac surgery and those who did not. It found that patients undergoing cardiac surgery had a higher incidence of feeding intolerance and took longer to attain full feeds, but technical complications were similar between the two groups. Additionally, a significant portion of cardiac surgery patients were able to wean off supplemental enteral feeding assistance within a year after gastrostomy tube placement.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Peng Gao, Xu Wang, Peiyao Zhang, Yu Jin, Liting Bai, Wenting Wang, Yixuan Li, Jinping Liu
Summary: This study found that absolute iron deficiency was associated with preoperative anemia and cyanotic heart disease in infants undergoing cardiac surgery, and it was an independent risk factor for postoperative blood transfusion.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Sarah Ghonim, Michael A. Gatzoulis, Sabine Ernst, Wei Li, James C. Moon, Gillian C. Smith, Ee Ling Heng, Jennifer Keegan, Siew Yen Ho, Karen P. McCarthy, Darryl F. Shore, Anselm Uebing, Aleksander Kempny, Francisco Alpendurada, Gerhard P. Diller, Konstantinos Dimopoulos, Dudley J. Pennell, Sonya V. Babu-Narayan
Summary: This study aimed to identify high-risk patients with repaired tetralogy of Fallot (rTOF) who are at risk of death and malignant ventricular arrhythmia (VA). Late gadolinium enhancement cardiovascular magnetic resonance (CMR) was used to define ventricular fibrosis in addition to proven risk markers. The study identified several independent predictors of mortality and developed risk scores to differentiate high-risk patients. The study also found that right ventricular late gadolinium enhancement (RVLGE) had a strong prognostic value in both risk scores.
JACC-CARDIOVASCULAR IMAGING
(2022)
Article
Cardiac & Cardiovascular Systems
Amara Majeed, Tal Geva, Lynn A. Sleeper, Julia A. Graf, Minmin Lu, Sonya Babu-Narayan, Rachel M. Wald, Barbara J. M. Mulder, Anne Marie Valente
Summary: The aim of this study was to identify cardiac magnetic resonance (CMR) markers of a good clinical course in adults with repaired tetralogy of Fallot (rTOF). The results showed that adults with rTOF and mild or no significant right ventricular dysfunction combined with no significant right ventricular hypertrophy are likely to be free from serious adverse clinical events into their sixth decade of life and may require less frequent cardiac testing.
AMERICAN HEART JOURNAL
(2022)
Letter
Cardiac & Cardiovascular Systems
Sarah Ghonim, Sonya V. Babu-Narayan
JACC-CARDIOVASCULAR IMAGING
(2022)
Review
Cardiac & Cardiovascular Systems
Richard J. Jabbour, Bushra Rana, Nilesh Sutaria, Angela Frame, Henry Seligman, Deepa Gopalan, Ben Ariff, Saeed Mirsadraee, Edward Barden, Neil Ruparelia, Iqbal S. Malik
Summary: Percutaneous closure of paravalvar leaks has become the treatment of choice and is now being used off label in non-surgical cases involving complex native mitral valve regurgitation. This review evaluates the literature on percutaneous treatment and discusses challenging cases where percutaneous devices were used to treat severe leaks due to previous infective endocarditis.
CARDIOVASCULAR REVASCULARIZATION MEDICINE
(2022)
Review
Cardiac & Cardiovascular Systems
Richard J. Jabbour, Nick Curzen
Summary: Cardiologists in the UK primarily rely on NICE and European Society of Cardiology guidelines for decision-making. This article evaluates the current NICE recommendations on myocardial revascularization and compares them with other major international guidelines. Although there are similarities, subtle differences exist due to variations in evidence base, healthcare systems, and cost-effectiveness models. The clinical implications of these disparities will be analyzed.
Editorial Material
Medicine, General & Internal
Richard J. Jabbour, Helen Routledge, Nick Curzen
Summary: Stroke is a leading cause of death in the UK, and mechanical thrombectomy is the most effective treatment for large vessel ischaemic strokes. Unfortunately, the use of mechanical thrombectomy is low among UK patients. In this editorial, the main barriers to its use and strategies to improve its uptake are explored.
BRITISH JOURNAL OF HOSPITAL MEDICINE
(2023)
Editorial Material
Cardiac & Cardiovascular Systems
Bernard De Bruyne, Marta Belmonte, Richard J. Jabbour, Nick Curzen
Article
Cardiac & Cardiovascular Systems
Kaushiga Krishnathasan, Konstantinos Dimopoulos, Neill Duncan, Piera Ricci, Alexander Kempny, Isma Rafiq, Michael A. Gatzoulis, Ee Ling Heng, Sarah Blakey, Claudia Montanaro, Sonya Babu-Narayan, Darrel P. Francis, Wei Li, Andrew Constantine
Summary: Renal dysfunction in adults with congenital heart disease (CHD) and heart failure is associated with disease progression, increased diuretic doses, and longer hospital stays. Chronic kidney disease (CKD) is common and triples the risk of death, transplantation, or ventricular assist device. Intensified monitoring, optimization of medical therapy, and collaborative management with renal physicians are necessary in these patients.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Konstantinos Kalogeras, Richard J. Jabbour, Radoslaw Pracon, Tito Kabir, Joanne Shannon, Alison Duncan, Cesare Quarto, Ee-Ling Heng, Hazim Rahbi, Evangelos Oikonomou, Efstratios Katsianos, Niket Patel, Navin Chandra, Michael-Andrew Vavuranakis, Suzane Cadiz, Maria Bougiakli, Robert D. Smith, Gerasimos Siasos, Manolis Vavuranakis, Simon Davies, Miles Dalby, Vasileios Panoulas
Summary: This study compared the effectiveness of balloon-expandable and self-expanding transcatheter heart valves in patients with small aortic annulus. The results showed similar survival rates up to 3 years for both types of valves. The self-expanding valves had lower peak and mean gradients at discharge, while the balloon-expandable valves had lower rates of paravalvular regurgitation. In patients with small transcatheter heart valves, there was a trend for improved survival with the self-expanding valves.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Review
Cardiac & Cardiovascular Systems
Balen Abdulrahman, Richard J. Jabbour, Nick Curzen
Summary: The prevalence of AF is high in patients with coronary artery disease. Guidelines recommend combination single antiplatelet and anticoagulation therapy for 12 months after percutaneous coronary intervention, followed by anticoagulation alone. However, the evidence for anticoagulation alone in reducing stent thrombosis risk is limited, while combined therapy increases the risk of bleeding.
INTERVENTIONAL CARDIOLOGY-REVIEWS RESEARCH RESOURCES
(2023)
Article
Cardiac & Cardiovascular Systems
Matthew O'Connor, Umberto Barbero, Daniel B. Kramer, Angela Lee, Alina Hua, Tevfik Ismail, Karen P. Mccarthy, Steven Niederer, Christopher A. Rinaldi, Vias Markides, John-Ross D. Clarke, Sonya Babu-Narayan, Siew Yen Ho, Tom Wong
Summary: This study evaluated the anatomy of the right atrium and the adjacent structures to identify the optimal and safest location for implanting an atrial leadless pacemaker. Three potential locations were identified: the base of the right atrial appendage, the anteromedial recess of the right atrial appendage apex, and the right atrial lateral wall. Based on anatomical review and 3D modeling, the base of the right atrial appendage appears to be the best compromise for implantation.
Article
Cardiac & Cardiovascular Systems
Ana Barradas-Pires, Pablo Meras, Andrew Constantine, Giulia Costola, Teresa Segura de la Cal, Isma Rafiq, Aleksander Kempny, Wei Li, Sonya V. Babu-Narayan, J. Andreas Hoschtitzky, Michael A. Gatzoulis, Antonio Martinez Rubio, Konstantinos Dimopoulos
Summary: This study investigates the indications and outcomes of aortic valve replacement (AVR) in young adults with severe aortic regurgitation, as well as the relationship between presurgical echocardiographic parameters and postoperative left ventricular size and function. The results show that a higher presurgical left ventricular end-systolic diameter is associated with a lack of left ventricular normalization after AVR. Pre- and postoperative left ventricular dimensions and postoperative left ventricular ejection fraction predict clinical events during follow-up.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2023)
Article
Cardiac & Cardiovascular Systems
Sian Chivers, Aoife Cleary, Rachel Knowles, Sonya Babu-Narayan, John M. Simpson, Heba Nashat, Konstantinos Dimopoulos, Michael A. Gatzoulis, Dirk Wilson, Milos Prica, James Anthony, Paul F. Clift, Victoria Jowett, Petra Jenkins, Bernadette Khodaghalian, Caroline B. Jones, Antonia Hardiman, Catherine Head, Owen Miller, Natali A. Y. Chung, Umar Mahmood, Frances A. Bu'Lock, Tristan K. W. Ramcharan, Ashish Chikermane, Jennifer Shortland, Andrew Tometzki, David S. Crossland, Zdenka Reinhardt, Clive Lewis, Leila Rittey, Dominic Hares, Olga Panagiotopoulou, Benjamin Smith, Muhammad L. Najih, Tara Bharucha, Piers E. F. Daubeney
Summary: This study examines the impact of COVID-19 on patients with congenital heart disease (CHD) and identifies risk factors for adverse outcomes. The study finds that children with CHD have a lower risk of death and hospitalization due to COVID-19, but younger children have higher hospital admission rates. In adults, the likelihood of death increases with age and pulmonary arterial hypertension, while the likelihood of hospitalization increases with age, comorbidities, and genetic disease.
Meeting Abstract
Cardiac & Cardiovascular Systems
Miriam Conway, Sonia Nielles Vallespin, Pedro Ferreira, Andrew Scott, Malte Roehl, Karen McCarthy, Gillian C. Smith, Siew Yen Ho, Wei Li, Dudley J. Pennell, Sonya Babu-Narayan
Article
Medical Informatics
Johan H. Thygesen, Christopher Tomlinson, Sam Hollings, Mehrdad A. Mizani, Alex Handy, Ashley Akbari, Amitava Banerjee, Jennifer Cooper, Alvina G. Lai, Kezhi Li, Bilal A. Mateen, Naveed Sattar, Reecha Sofat, Ana Torralbo, Honghan Wu, Angela Wood, Jonathan A. C. Sterne, Christina Pagel, William N. Whiteley, Cathie Sudlow, Harry Hemingway, Spiros Denaxas
Summary: This study used nationwide linked electronic health records to define and validate ten COVID-19 phenotypes, providing insights into the different stages and transitions of the disease. The results showed infection rates, hospitalization rates, intensive care unit usage, and mortality rates of COVID-19. Longer patient trajectories were observed in the second wave compared to the first wave.
LANCET DIGITAL HEALTH
(2022)