Journal
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
Volume 39, Issue 11, Pages 2283-2292Publisher
WILEY
DOI: 10.1002/hed.24899
Keywords
circulating tumor microemboli; head and neck cancer; isolated circulating tumor cells; poor prognosis; transforming growth factor-beta receptor I (TGF-beta RI)
Categories
Funding
- Sao Paulo Research Foundation (FAPESP) [2013/08125-7]
Ask authors/readers for more resources
Background: Circulating tumor microemboli (CTM) are clusters of circulating tumor cells (CTCs), involved in metastasis, as also transforming growth factor-beta (TGF-beta). The purpose of this study was to verify their role in progression-free survival (PFS). Methods: Blood from patients with locally advanced head and neck squamous cell carcinoma (HNSCC; n = 53) was analyzed in 2 moments. TGF-beta receptor I (TGF-beta RI) expression was evaluated by immunocytochemistry. Results: Comparing CTM1 (baseline) with CTM2 (first follow-up), patients with CTM1-positive disease who became CTM2-negative were classified as favorable (PFS 20 months). Patients with unfavorable evolution (CTM1-negative/CTM2-positive), had PFS of 17.5 months. Patients always CTM-negative showed PFS of 22.4 months, those always positive, 4.7 months (P < .001). The TGF-beta RI expression in the first follow-up correlated with poor PFS (12 x 26 months; P = .007), being an independent prognostic factor (hazard ratio [HR] = 6.088; P = .033). Conclusion: CTM1/2, TGF-beta RI expression, and unfavorable CTM kinetics may represent poor prognosis in locally advanced HNSCC.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available