Article
Medicine, General & Internal
Marine Poulain, Rodine Younes, Paul Pirtea, Julie Trichereau, Dominique de Ziegler, Achraf Benammar, Jean Marc Ayoubi
Summary: The study found that the ratios of Oc/AFC and MII/AFC were associated with live birth rate and could be promising indicators for assessing ovarian response. However, the ratios of Oc/AMH and MII/AMH did not affect the live birth rate or implantation rate after the first or cumulative embryo transfer.
FRONTIERS IN MEDICINE
(2021)
Article
Genetics & Heredity
Philippe Arvis, Catherine Rongieres, Olivier Pirrello, Philippe Lehert
Summary: This study found that AMH and AFC have small variations across different centers but larger variations across patients within each center. The decline in AMH with age is faster than AFC, indicating that their correlation changes with age. The concordance between AMH and AFC is very low, especially in the range of poor responders. AMH seems to have better reproducibility than AFC in successive cycles.
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS
(2022)
Article
Medicine, General & Internal
Khadija Kacem-Berjeb, Marouen Braham, Cyrine Ben Massoud, Hela Hannachi, Manel Hamdoun, Sana Chtourou, Linda Debbabi, Maha Bouyahia, Anis Fadhlaoui, Fethi Zhioua, Anis Feki, Nozha Chakroun, Olfa Bahri
Summary: The aim of this study was to compare follicular liquid levels of IL6 and AMH in women with and without endometriosis and evaluate their impact on ICSI outcomes. The IL-6 levels were higher in the endometriosis group, but there was no statistical difference in AMH levels between the two groups. There was no significant correlation between IL6 and AMH levels in the follicular fluid.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Caitlin R. Sacha, Irene Souter, Paige L. Williams, Jorge E. Chavarro, Jennifer Ford, Shruthi Mahalingaiah, Patricia K. Donahoe, Russ Hauser, David Pepin, Lidia Minguez-Alarcon
Summary: This study found a negative association between urinary concentrations of certain phthalate metabolites and follicular fluid anti-Mullerian hormone concentrations in women undergoing fertility treatment, which may have implications for antral follicle recruitment and fertility treatment outcomes.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Agriculture, Dairy & Animal Science
Laurin Schwarzmann, Arlene Marchand, Barbara Knutti, Rupert Bruckmaier, Heinrich Bollwein, Dragos Scarlet
Summary: This study assessed the effects of postpartum diseases on AFC and AMH concentration in dairy cows, as well as the influence of parity and breed. The results showed no effect of postpartum diseases or breed on AFC or AMH groups. There was a strong interaction between parity and AFC, with primiparous cows having fewer follicles. Pluriparous cows with high AMH concentration had shorter calving to first service and calving to conception intervals, but lower milk yield.
ANIMAL REPRODUCTION SCIENCE
(2023)
Article
Endocrinology & Metabolism
Christopher Arkfeld, Eric Han, Reshef Tal, David B. Seifer
Summary: This study investigated the association between AMH levels and miscarriage rates in ART cycles. The results showed that AMH levels were not associated with increased miscarriage rates overall, but there was a significant difference in non-PCOS patients with AMH < 1 ng/ml. The findings suggest that AMH < 1 ng/mL can be an independent predictor of increased miscarriage rate in non-PCOS infertility patients.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Article
Obstetrics & Gynecology
Piotr S. Gromski, Rajendra Sadashiv Patil, Shruti Mahesh Chougule, Deepali Atul Bhomkar, Padma Rekha Jirge, Scott M. Nelson
Summary: The study found that healthy Indian women have significantly lower levels of anti-Mullerian hormone (AMH) compared to European women, and this difference increases with age. Furthermore, different causes of infertility have varying effects on AMH levels in infertile Indian women compared to healthy controls.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Agriculture, Dairy & Animal Science
Jose F. Torres-Simental, Citlali Pena-Calderon, Leonel Avendano-Reyes, Abelardo Correa-Calderon, Ulises Macias-Cruz, Adriana Rodriguez-Borbon, Jose C. Leyva-Corona, Fernando Rivera-Acuna, Milton G. Thomas, Pablo Luna-Nevarez
Summary: The study evaluated AMH and AFC as predictors of superovulatory and embryo production responses in cattle. Results showed that AMH and AFC were correlated with superovulatory and embryo production variables under different climatic conditions, and demonstrated predictive ability in the absence of heat stress.
Article
Obstetrics & Gynecology
Mohammed M. Laqqan, Maged M. Yassin
Summary: This study aims to investigate the best predictor factors for diminished ovarian reserve (DOR) in women under 40 years old. Through a study on 500 women suffering from idiopathic infertility problems, it is found that AMH and AFC levels are the best biomarkers, followed by age.
REPRODUCTIVE SCIENCES
(2023)
Article
Endocrinology & Metabolism
Lu Li, Bo Sun, Fang Wang, Yile Zhang, Yingpu Sun
Summary: AMH is associated with oocyte collection rate and TE rate in women with diminished ovarian reserve. An AMH level of 0.355 ng/ml is a cutoff value for predicting TE. For patients undergoing embryo transfer, AMH is not associated with clinical pregnancy while female age is an independent risk factor.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Cell Biology
Q. E. Xie, M. Y. Wang, Z. P. Cao, X. Du, D. M. Ji, D. Liang, Y. X. Cao, Y. J. Liu
Summary: The study showed that melatonin rescued impairment of mitochondrial and ovarian reserve function, as well as production of mitochondrial ROS and cell cycle arrest induced by excessive autophagy through down-regulated ERK pathway, suggesting a potential therapeutic drug target for POI.
Article
Medicine, Research & Experimental
Wei Yong, Haiying Ma, Man Na, Teng Gao, Ye Zhang, Liying Hao, Hang Yu, Huazhe Yang, Xin Deng
Summary: Melatonin is a multifunctional hormone regulated by the circadian rhythm, with roles in sleep-wake cycle rhythms, ageing retardation, antioxidant and anti-inflammatory functions, as well as significant impact on reproductive functions.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Review
Medicine, General & Internal
Honghao Sun, Jiao Jiao, Feng Tian, Qing Liu, Jiansu Bian, Rongmin Xu, Da Li, Xiuxia Wang, Hong Shu
Summary: This study found that inflammatory bowel disease (IBD) may reduce ovarian reserve in reproductive age women, and in vitro fertilization (IVF) treatment may improve pregnancy outcomes in IBD patients with impaired fertility.
Article
Biochemistry & Molecular Biology
Dan Li, Jun-Hua Pan, Xiao-Fang Huang, Yu-Qing Liao, Yong-Jin Ling, Jing-Ying Luo
Summary: This study performed a systematic review and meta-analysis to evaluate the antioxidant effect of melatonin in animal models of fibrosis. The results showed that melatonin supplementation significantly reduced oxidative indicators such as malondialdehyde, lipid peroxidation, and nitric oxide levels, and increased antioxidant indicators such as glutathione, glutathione peroxidase, and superoxide dismutase levels, in fibrotic diseases, suggesting a beneficial role of melatonin in correcting oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Francisca Felix, Catarina C. V. Oliveira, Elsa Cabrita
Summary: The study focuses on the effects of novel antioxidants in protecting fish cells, highlighting the importance of antioxidants in fish reproduction and their potential in improving gamete quality. The review discusses various types of antioxidants and their mechanisms of action, with a particular emphasis on the protective role of melatonin in preventing oxidative stress damage on fish spermatozoa.
Article
Obstetrics & Gynecology
Chen-Ming Xu, Si-Jia Lu, Song-Chang Chen, Jing-Lan Zhang, Cong-Jian Xu, Yuan Gao, Yi-Ping Shen, Yun-Xia Cao, Ling-Qian Wu, Fan Jin, Ge Lin, Ping Liu, Yi-Min Zhu, Yan-Ting Wu, Dan Zhang, Bill Yee, Vitaly A. Kushnir, Zhi-Hong Yang, Jia-Yin Liu, Zi-Jiang Chen, Alan Thornhill, Angie N. Beltsos, Johan Smitz, John Frattarelli, Alan Handyside, Jie Qiao, He-Feng Huang
Summary: The International Society of Reproductive Genetics (ISRG) formed a workgroup comprised of clinicians, clinical laboratory directors, and scientists to develop guidelines for preimplantation genetic testing (PGT). These guidelines incorporate the latest information and clinical insights to provide optimal PGT practice. Recommendations are given to embryologists, medical geneticists, clinical laboratorians, and other healthcare providers to enhance the well-being of patients seeking assisted reproductive treatment and their offspring.
REPRODUCTIVE AND DEVELOPMENTAL MEDICINE
(2023)
Article
Environmental Sciences
Lihong Pang, Wenhao Yu, Jiale Lv, Yunde Dou, Han Zhao, Shanshan Li, Yuming Guo, Gongbo Chen, Linlin Cui, Jingmei Hu, Yueran Zhao, Qi Zhao, Zi-Jiang Chen
Summary: This study investigates the association between exposure to different air pollutants and ovarian reserve in Shandong Province, China. The findings show a negative association between air pollution and ovarian reserve, particularly during the primary to secondary follicle stage. This association varies among different population sub-groups.
ENVIRONMENTAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Qi Jiang, Ruolan Miao, Yuhuan Wang, Wenqi Wang, Dingying Zhao, Yue Niu, Qiaoqiao Ding, Yan Li, Peter C. K. Leung, Daimin Wei, Zi-Jiang Chen
Summary: Polycystic ovary syndrome (PCOS) is a common and heterogeneous endocrine disorder, which is the main cause of ovulatory obstacle associated with abnormal folliculogenesis. Dysfunction of ovarian granulosa cells (GCs) is recognized as a major factor that underlies abnormal follicle maturation. The expression of angiopoietin-like 4 (ANGPTL4) in GCs differs between patients with and without PCOS. In this study, ANGPTL4 was found to be upregulated in patients with PCOS and its overexpression inhibited the proliferation of GCs through the EGFR/JAK1/STAT3-mediated induction of p21, providing a novel epigenetic mechanism for the pathogenesis of PCOS.
Article
Obstetrics & Gynecology
Zheng Liu, Yukun Zheng, Bingyu Wang, Jialin Li, Lang Qin, Xiao Li, Xin Liu, Yuehong Bian, Zijiang Chen, Han Zhao, Shigang Zhao
Summary: This study examined the association between sleep quality before embryo transfer and pregnancy outcomes. The results showed that good sleep quality was associated with higher clinical pregnancy and live birth rates. Treating sleep disorders and providing sleep behavior guidance may improve pregnancy outcomes in IVF-ET.
FERTILITY AND STERILITY
(2023)
Article
Biochemistry & Molecular Biology
Simin Zhao, Chengzi Huang, Yajuan Yang, Weiwei Xu, Yongze Yu, Canxin Wen, Lili Cao, Fei Gao, Yingying Qin, Zi-Jiang Chen, Ting Guo, Shidou Zhao
Summary: When DNA interstrand crosslink lesions occur, a core complex of Fanconi anemia proteins promotes the ubiquitination of FANCD2 and FANCI, which recruit downstream factors to repair the lesion. FANCD2 maintains genome stability through both its ubiquitination-dependent and ubiquitination-independent functions. This study analyzed germ cell development in Fancd2 KO and ubiquitination-deficient mutant mice, and found that the ubiquitination-dependent and ubiquitination-independent functions of FANCD2 were required for different aspects of germ cell development.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Review
Endocrinology & Metabolism
Yiyuan Zhang, Peihao Liu, Wei Zhou, Jingmei Hu, Linlin Cui, Zi-Jiang Chen
Summary: The aim of this study was to clarify the relationships between large for gestational age (LGA) and cardiometabolic risk factors. A meta-analysis of 42 studies involving 841,325 individuals showed that individuals born LGA had higher odds of overweight and obesity, type 1 diabetes, hypertension, and metabolic syndrome compared to those born appropriate for gestational age. No significant difference was found in hypertriglyceridemia and hypercholesterolemia.
Review
Endocrinology & Metabolism
Yiting Zhang, Xiao Fu, Shuli Gao, Shuzhe Gao, Shanshan Gao, Jinlong Ma, Zi-Jiang Chen
Summary: In the past decade, the use of frozen-thawed embryo transfer treatment has significantly increased. Hormone replacement therapy and the natural cycle are two popular methods for preparing the endometrium. While hormone replacement therapy offers convenience for timing coordination, there are potential risks associated with achieving pregnancy without a corpus luteum. Therefore, there is growing interest in expanding the use of natural cycle FET in ovulatory women to address these concerns and improve outcomes.
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY
(2023)
Letter
Biology
Xiaolei Chen, Huangcong Shi, Cheng Li, Wanxia Zhong, Linlin Cui, Wenjun Zhang, Ling Geng, Kuona Hu, Mei Fang, Daimin Wei, Junhao Yan, Yun Sun, Keliang Wu, Han Zhao, Zi-Jiang Chen
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Dan Liang, Aleksei Mikhalchenko, Hong Ma, Nuria Marti Gutierrez, Tailai Chen, Yeonmi Lee, Sang-Wook Park, Rebecca Tippner-Hedges, Amy Koski, Hayley Darby, Ying Li, Crystal Van Dyken, Han Zhao, Keliang Wu, Jingye Zhang, Zhenzhen Hou, Seongjun So, Jongsuk Han, Jumi Park, Chong-Jai Kim, Kai Zong, Jianhui Gong, Yilin Yuan, Ying Gu, Yue Shen, Susan B. Olson, Hui Yang, David Battaglia, Thomas O'Leary, Sacha A. Krieg, David M. Lee, Diana H. Wu, P. Barton Duell, Sanjiv Kaul, Jin-Soo Kim, Stephen B. Heitner, Eunju Kang, Zi-Jiang Chen, Paula Amato, Shoukhrat Mitalipov
Summary: The range of DNA repair in response to double-strand breaks induced in human preimplantation embryos is uncertain due to the complexity of analyzing single- or few-cell samples. Whole genome amplification, which is necessary for sequencing such minute DNA input, can introduce artifacts that restrict genotyping accuracy. This study shows that allelic dropouts occur in over 25% of pre-existing heterozygous loci in control single blastomere samples after whole genome amplification. To overcome these limitations, the authors validate gene editing seen in human embryos by studying embryonic stem cells.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Yanling Wan, Shuang Yang, Tongtong Li, Yuling Cai, Xinyue Wu, Mingyu Zhang, Tahir Muhammad, Tao Huang, Yue Lv, Wai-Yee Chan, Gang Lu, Jingxin Li, Qian-Qian Sha, Zi-Jiang Chen, Hongbin Liu
Summary: LSM14B knockout disrupts the assembly of MARDO, leading to improper mRNA storage and clearance, ultimately resulting in female infertility.
NUCLEIC ACIDS RESEARCH
(2023)
Correction
Cell Biology
Xiaoyu Merlin Zhang, Keliang Wu, Yuxuan Zheng, Han Zhao, Junpeng Gao, Zhenzhen Hou, Meiling Zhang, Jiaoyang Liao, Jingye Zhang, Yuan Gao, Yuanyuan Li, Lin Li, Fuchou Tang, Zi-Jiang Chen, Jinsong Li
Letter
Cell Biology
Yuan Gao, Lizhi Yi, Jianhong Zhan, Lijuan Wang, Xuelong Yao, Junhao Yan, Sijing Jian, Lei Gao, Mamadboqirova Farangez, Ming Gao, Yang Zou, Xuan Gao, Keliang Wu, Jiang Liu, Zi-Jiang Chen
Article
Medicine, Research & Experimental
Chengzi Huang, Simin Zhao, Yajuan Yang, Ting Guo, Hanni Ke, Din Mi, Yingying Qin, Zi-Jiang Chen, Shidou Zhao
Summary: Mutations in TP63 gene impair the TID of TAp63 alpha protein, leading to constitutive activation and oocyte apoptosis, resulting in POI. These findings provide insight into the genetic diagnosis of POI and potential therapeutic targets for preserving female fertility.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Obstetrics & Gynecology
Daimin Wei, Yaxin Su, Peter C. K. Leung, Yan Li, Zi-Jiang Chen
Summary: This review summarizes the current knowledge on the pathophysiological roles of BMPs and their underlying molecular mechanisms in regulating human endometrial proliferation and decidualization, aiming to promote the development of innovative strategies for diagnosing, treating, and preventing infertility and adverse pregnancy complications associated with dysregulated human endometrial remodeling.
HUMAN REPRODUCTION UPDATE
(2023)
Article
Obstetrics & Gynecology
Na Chen, Jingyu Li, Yexing Li, Yiyuan Zhang, Jiarong Li, Jie Gao, Jingmei Hu, Linlin Cui, Zi-Jiang Chen
Summary: This study explores the risk factors for monozygotic twinning in offspring conceived by assisted reproductive technology (ART). The factors influencing MZ twinning include parental ages, the transfer of fresh versus frozen embryos, and the grade of blastocysts.
HUMAN REPRODUCTION OPEN
(2023)
