Article
Oncology
Katharine McKinley Esselen, Annika Gompers, Michele R. Hacker, Sara Bouberhan, Meghan Shea, Sarah S. Summerlin, Lindsay R. Rucker, Warner K. Huh, Maria Pisu, Margaret Liang
Summary: The study evaluated the economic burden and cost-coping strategies of gynecologic oncology patients at different levels of financial toxicity. Factors such as younger age, non-white race, lower education, unemployment, lower income, use of systemic therapy, and shorter time since diagnosis were associated with worse financial toxicity. Patients with moderate or severe financial toxicity were more likely to use economic cost-coping strategies such as changing spending habits and borrowing money, and those with severe financial toxicity had a higher risk of behavioral cost-coping through medication non-compliance.
INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
(2021)
Review
Medicine, General & Internal
Maria Eugenia Espinoza Moya, Jason Robert Guertin, Michel Dorval, Julie Lapointe, Karine Bouchard, Hermann Nabi, Maude Laberge
Summary: This scoping review aims to systematically analyze collaborative models used for adult patients with inherited cancers and evaluate their implementation, effectiveness, and economic impact. By filling the knowledge gap, this study seeks to strengthen the understanding of these interventions and provide guidance for defining and classifying collaborative models in oncogenetics, and identify areas that require further research.
Article
Oncology
Emily M. Ko, Justin E. Bekelman, Katherine Hicks-Courant, Colleen M. Brensinger, Genevieve P. Kanter
Summary: This study examined the impact of gynecologic oncology (GYO) versus medical oncology (MEDONC) care on survival, healthcare utilization, and spending outcomes in women with advanced gynecologic cancers. The findings showed that GYO care was associated with improved overall survival and similar spending in ovarian cancer patients. Uterine and cervical cancer patients had similar survival and lower or equal spending when treated by GYO compared to MEDONC.
GYNECOLOGIC ONCOLOGY
(2022)
Article
Oncology
Stephanie Blank, Warner K. Huh, Maria Bell, Sarah Dilley, Melissa Hardesty, Ebony R. Hoskins, Jason Lachance, Fernanda Musa, Emily Prendergast, B. J. Rimel, Mark Shahin, Fidel Valea
Summary: The original vision of gynecologic oncology was to establish a multidisciplinary approach to the management of patients with gynecologic cancers. Scientific advances have greatly changed the overall practice of gynecologic oncology, but the profession still struggles to define its value - financial and otherwise.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Oncology
Daniel Margul, Camilla Yu, Mariam M. AlHilli
Summary: Gynecologic cancers have a complex tumor immune microenvironment that affects treatment response. Recent advancements in immunotherapy have shown promise in certain gynecologic malignancies, but challenges remain. This article reviews the current understanding of the tumor immune microenvironment in ovarian, endometrial, cervical, vulvar, and vaginal cancer, and discusses the potential for targeted therapeutics.
Review
Oncology
Adeola Akapo, Kseniya Anishchenko, Carolyn Lefkowits, Ashley L. Greenwood
Summary: Brain metastases are rare in gynecologic cancers and have a poor prognosis. The management requires an interdisciplinary approach and includes targeted therapies, management of neurologic side effects, and improved imaging techniques. Screening for brain metastases in gynecologic oncology patients is recommended for those with new neurologic symptoms.
CURRENT TREATMENT OPTIONS IN ONCOLOGY
(2022)
Review
Oncology
Kaylee A. Underkofler, Kari L. L. Ring
Summary: Lynch syndrome is an autosomal dominant hereditary cancer syndrome caused by pathogenic variants in DNA mismatch repair genes or the EPCAM gene. It is estimated to affect 1 in 300 individuals and confers a lifetime risk of cancer. Identification and diagnosis of individuals with Lynch syndrome, as well as evidence-based screening and risk reduction recommendations, are crucial for gynecologists and gynecologic oncologists.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
G. Contos, Y. Baca, J. Xiu, J. Brown, R. Holloway, W. M. Korn, T. J. Herzog, N. Jones, I Winer
Summary: Analysis of biomarkers in gynecologic cancers shows that HPV-driven genital tract cancers have higher frequencies of PD-L1 expression, MSI-H, and TMB-H. Endometrial cancers are characterized by MSI-H and TMB, whereas ovarian cancers have a low frequency of MSI-H and modest PD-L1 or TMB-H. The incidence of 'triple positive cases' was less than 2%.
GYNECOLOGIC ONCOLOGY
(2021)
Article
Oncology
Logan Corey, Julie Ruterbusch, Ron Shore, Martins Ayoola-Adeola, Michael Baracy, Alex Vezina, Ira Winer
Summary: The study evaluated the risk of developing a second primary cancer and associated survival times in women diagnosed with cancer in the United States between 1992 and 2017. It found that women with gynecologic cancer may develop non-gynecologic primary cancer, and women with non-gynecologic cancer may also develop gynecologic cancer. The risk and survival time of the second primary cancer depend on the order and site of the index and subsequent cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
G. Nelson, C. Fotopoulou, J. Taylor, G. Glaser, J. Bakkum-Gamez, L. A. Meyer, R. Stone, G. Mena, K. M. Elias, A. D. Altman, S. P. Bisch, P. T. Ramirez, S. C. Dowdy
Summary: This article presents the updated evidence and recommendations for implementing Enhanced Recovery After Surgery (ERAS) in gynecologic oncology surgery. It focuses on addressing implementation challenges and provides evidence-based guidelines.
GYNECOLOGIC ONCOLOGY
(2023)
Review
Oncology
Allen Yen, Chenyang Shen, Kevin Albuquerque
Summary: Online adaptive radiation is a new treatment modality for gynecologic cancers that utilizes improved imaging, technology, and artificial intelligence to tailor radiation delivery. This has the potential to improve tumor coverage and spare normal tissue. Clinical trials are ongoing to investigate the benefits of online adaptive radiotherapy, but implementation requires significant clinical resources and optimization of timing and workflow.
Article
Oncology
Yuya Nogami, Hiroaki Komatsu, Takeshi Makabe, Yuri Hasegawa, Yoshihito Yokoyama, Kei Kawana, Aikou Okamoto, Mikio Mikami, Hidetaka Katabuchi
Summary: This study conducted a nationwide survey to assess the impact of the COVID-19 pandemic on gynecologic oncology treatment in Japan. The results showed a decrease in outpatient visits due to patient reluctance, but no significant decrease in surgeries. There was also no increase in the rate of advanced stage cancers, but a significant proportion of participants perceived an impact on management and prognosis.
JOURNAL OF GYNECOLOGIC ONCOLOGY
(2022)
Article
Obstetrics & Gynecology
Connor C. Wang, Dandi S. Huang, Anisa M. Carlson, Zhanhai Li, Ahmed Al-Niaimi, Makeba Williams
Summary: Younger age at surgery is associated with receiving surgical menopause counseling, gynecologic cancer patients experienced significant menopause-related disturbances, improving understanding of patient and provider preferences and greater emphasis on surgical menopause and survivorship will improve care for gynecologic oncology patients.
MENOPAUSE-THE JOURNAL OF THE NORTH AMERICAN MENOPAUSE SOCIETY
(2022)
Review
Oncology
Mingjing Deng, Qi Wang
Summary: Oncolytic viruses have become a major strategy in cancer biotherapy, selectively killing tumor cells without harming normal tissues. In the treatment of gynecologic cancers, oncolytic virus therapy has shown promising clinical effects, either alone or in combination with other therapies.
CURRENT CANCER DRUG TARGETS
(2023)
Article
Obstetrics & Gynecology
Rebecca Stone, Erin Carey, Amanda N. Fader, Jocelyn Fitzgerald, Lee Hammons, Alysha Nensi, Amy J. Park, Stephanie Ricci, Rick Rosenfield, Stacey Scheib, Erica Weston
Summary: This guideline is specifically designed for women undergoing minimally invasive gynecologic surgery to standardize and optimize perioperative care. It provides more comprehensive recommendations for minimally invasive endoscopic and vaginal surgery, including specific advice on managing conditions such as anemia, hyperglycemia, and obstructive sleep apnea.
JOURNAL OF MINIMALLY INVASIVE GYNECOLOGY
(2021)
Editorial Material
Oncology
Kevin Lin, Heather R. MacDonald, Merry L. Tetef, Colleen L. Coleman
ADVANCES IN RADIATION ONCOLOGY
(2023)
Article
Oncology
Rebecca S. Kristeleit, Yvette Drew, Amit M. Oza, Susan M. Domchek, Susana Banerjee, Rosalind M. Glasspool, Judith Balmana, Lee-may Chen, Manish R. Patel, Howard A. Burris, Tamar Safra, Jennifer Borrow, Kevin K. Lin, Sandra Goble, Lara Maloney, Ronnie Shapira-Frommer
Summary: This study evaluated the efficacy and safety of oral rucaparib monotherapy in heavily pretreated patients with ovarian cancer. The results showed that rucaparib had robust antitumour activity and a good safety profile in patients who had received multiple prior chemotherapies.
BRITISH JOURNAL OF CANCER
(2023)
Article
Oncology
Eve Rodler, Priyanka Sharma, William E. Barlow, Julie R. Gralow, Shannon L. Puhalla, Carey K. Anders, Lori Goldstein, Debu Tripathy, Ursa A. Brown-Glaberman, Thu-Tam Huynh, Christopher S. Szyarto, Andrew K. Godwin, Harsh B. Pathak, Elizabeth M. Swisher, Marc R. Radke, Kirsten M. Timms, Danika L. Lew, Jieling Miao, Lajos Pusztai, Daniel F. Hayes, Gabriel N. Hortobagyi
Summary: PARP inhibitors are effective in germline BRCA1/2-mutated metastatic breast cancer. This study demonstrates that adding veliparib to cisplatin improves progression-free survival in patients with BRCA-like metastatic triple-negative breast cancer.
Article
Multidisciplinary Sciences
Shane T. Killarney, Rachel Washart, Ryan S. Soderquist, Jacob P. Hoj, Jamie Lebhar, Kevin H. Lin, Kris C. Wood
Summary: During apoptosis, the release of mitochondrial RNA into the cytosol can be prevented by casp3/7, which inhibits inflammatory signaling. Inhibition of casp3/7 promotes a cytosolic mtRNA-driven Type I interferon response, increasing the immunogenicity of chemotherapy-induced apoptosis.
NATURE COMMUNICATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
Ramtin Sadid-Zadeh, Kevin Lin, Rui Li, Katalin Nagy
Summary: This study evaluated the fracture strength of zirconia crowns connected to zirconia and titanium implants after simulating 5 years of clinical use. The results showed that the zirconia crowns connected to titanium-zirconia and titanium implants had significantly higher fracture strength than those connected to pure zirconia or lubricant zirconia implants. Therefore, zirconia crowns can withstand the common occlusal forces in the anterior and premolar regions.
JOURNAL OF PROSTHODONTICS-IMPLANT ESTHETIC AND RECONSTRUCTIVE DENTISTRY
(2023)
Article
Cell Biology
Colette B. Rogers, Rachel E. Kram, Kevin Lin, Chad L. Myers, Alexandra Sobeck, Eric A. Hendrickson, Anja-Katrin Bielinsky
Summary: Activation of the Fanconi anemia (FA) pathway is crucial for preventing chromosome translocations referred to as "radials" after treatment with mitomycin C (MMC). Radials induced by MMC are dependent on DNA polymerase theta (POLq)-mediated alternative end joining (A-EJ) in FA-deficient cells, specifically involving POL theta and DNA ligase III. Blocking POLq in FA-deficient cells eliminates radials and leads to the accumulation of breaks at common fragile sites. These findings provide mechanistic insights into the formation of radials and offer potential therapeutic strategies for FA pathway-deficient cancers using POLq inhibitors.
Article
Medicine, General & Internal
Olivier Colomban, Elizabeth M. Swisher, Rebecca Kristeleit, Iain McNeish, Ronnie Shapira-Frommer, Sandra Goble, Kevin K. Lin, Lara Maloney, Gilles Freyer, Benoit You
Summary: Mathematical modeling of early CA-125 kinetics can be used as an indicator of rucaparib efficacy in recurrent ovarian carcinoma patients. The KELIM-PARP score is associated with treatment response and progression-free survival. This study suggests the potential use of this strategy in selecting patients for PARPi-based treatment regimens.
Article
Biotechnology & Applied Microbiology
Shuxiao Chen, Bokai Zhu, Sijia Huang, John W. Hickey, Kevin Z. Lin, Michael Snyder, William J. Greenleaf, Garry P. Nolan, Nancy R. Zhang, Zongming Ma
Summary: This article introduces a cross-modal data integration method called MaxFuse, which utilizes iterative coembedding, data smoothing, and cell matching to achieve high-quality integration even with weakly linked features. The method is modality-agnostic and demonstrates high robustness and accuracy in the weak linkage scenario, achieving a relative improvement of 20% to 70% over existing methods on benchmarking datasets.
NATURE BIOTECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Kevin Z. Lin, Nancy R. Zhang
Summary: Multimodal single-cell technologies enable the analysis of multiple modalities for each cell simultaneously, providing a more comprehensive characterization of cell populations. Our developed method, Tilted Canonical Correlation Analysis (Tilted-CCA), effectively separates and quantifies shared information among cells and modality-specific information, allowing meaningful visualization and quantification of cross-modal information.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Meeting Abstract
Oncology
Ethan S. Sokol, Russell W. Madison, Dexter X. Jin, Kuei Ting Chen, Zoe Fleischmann, Justin Newberg, Alexa Shrock, David Fabrizio, Jie He, Neeru Bhardwaj, Kevin K. Lin, Iain A. McNeish, Elizabeth M. Swisher
Meeting Abstract
Oncology
Elizabeth M. Swisher, Linda R. Duska, Erika P. Hamilton, Amit M. Oza, Gini Fleming, Oladapo O. Yeku, Alexander I. Spira, Debra L. Richardson, Robin Guo, Jackie Walling, Kerry Inokuchi, Dmitriy Zamarin
Meeting Abstract
Oncology
Bojana Stefanovska, Kevin Lin, Benjamin Troness, Chad Myers, Reuben Harris
Meeting Abstract
Clinical Neurology
David Glickenstein, Avinash Karamchandani, Camille Korbut, Michelle Bang, Alexa Aucoin, Leah Callovini, Kevin Lin, Patricia Haynes
Meeting Abstract
Oncology
Katherine Kramme, Emily Welker, Oana Andreea Raicu, Melvin Silverstein, Sadia Khan, Peter Chen, Kevin Lin, Brian Kim, Shane Lloyd
ANNALS OF SURGICAL ONCOLOGY
(2023)
Meeting Abstract
Oncology
Emily Welker, Peter Chen, Sadia Khan, Brian Kim, Katherine Kramme, Kevin Lin, Shane Lloyd, Oana Andreea Raicu, Melvin Silverstein
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)
