Article
Oncology
Yue Wang, Bao Xuan Li, Xiang Li
Summary: This study identified angiogenesis-related genes (ARGs) and constructed a new prognostic signature for ovarian cancer. The signature showed good predictive ability for overall survival and correlated with immune infiltration and gene defects.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Moran Yang, Jiaqi Lu, Guodong Zhang, Yiying Wang, Mengdi He, Qing Xu, Congjian Xu, Haiou Liu
Summary: This study reveals the critical role of CXCL13 in shaping the antitumor microenvironment by facilitating the maintenance of CXCR5(+)CD8(+) T cells in TLSs, and supports a clinical investigation for a combination of CXCL13 and PD-1 blockade therapy in HGSC.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Review
Health Care Sciences & Services
Hina Amer, Apriliana E. R. Kartikasari, Magdalena Plebanski
Summary: The study revealed that IL6 levels in the blood were significantly higher in ovarian cancer patients than in healthy controls, but not significantly higher than those with benign ovarian growths. The levels of IL6 in ascites were also significantly elevated in both late-stage and early-stage OC. Ascitic IL6 showed higher sensitivity in early detection of OC.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Oncology
Esther Schoutrop, Lidia Moyano-Galceran, Stephanie Lheureux, Jonas Mattsson, Kaisa Lehti, Hanna Dahlstrand, Isabelle Magalhaes
Summary: This article summarizes the current knowledge on the development and metastatic progression of ovarian cancer, with a specific focus on the characteristics and functions of the immunosuppressive tumor microenvironment. Additionally, current and future treatment modalities are discussed, and an overview of different experimental models used for developing novel therapies is provided.
SEMINARS IN CANCER BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Diana Luisa Almeida-Nunes, Ana Mendes-Frias, Ricardo Silvestre, Ricardo Jorge Dinis-Oliveira, Sara Ricardo
Summary: Ovarian cancer spreads via transcoelomic metastasis, with malignant ascites playing a crucial role in tumor cell dissemination. The microenvironment of malignant ascites affects tumor behavior, including proliferation, progression, chemoresistance, and immune evasion. Tumor cells induce immune suppression, leading to disease progression and treatment failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Wendi Kang, Xiang Qiu, Yingen Luo, Jianwei Luo, Yang Liu, Junqing Xi, Xiao Li, Zhengqiang Yang
Summary: The advent of immunotherapy has brought attention to the tumor microenvironment (TME) as a critical area of research. Radiomics and pathomics provide comprehensive assessment of the TME, and integrating them with genomics and transcriptomics can offer insights into tumor heterogeneity and predict cancer prognosis.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Oncology
Iva Truxova, David Cibula, Radek Spisek, Jitka Fucikova
Summary: Epithelial ovarian cancer (EOC) ranks among the top causes of cancer-related death in women due to early dissemination of malignant cells to the peritoneum. Despite improvements in medical therapies, EOC remains insensitive to immune checkpoint inhibitors, mainly due to a tumor microenvironment characterized by poor immune cell infiltration and immune suppression by tumor-associated macrophages (TAMs). TAMs have emerged as potential therapeutic targets to reverse immunosuppression and enhance the effectiveness of immunotherapy. This review focuses on the biological features of TAMs and their relevance as targets for treating EOC, including therapies that modulate TAM recruitment, polarization, survival, and function in the EOC tumor microenvironment for better combinatorial regimens with immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Immunology
Songwei Feng, Yi Xu, Zhu Dai, Han Yin, Ke Zhang, Yang Shen
Summary: This study identified prognostic genes associated with cancer-associated fibroblasts (CAFs) in ovarian cancer patients. The researchers used bioinformatics analysis to identify CAF-associated hub genes and constructed a prognostic signature. The analysis indicated that high-risk patients have worse prognosis, weaker immune response, and lower tumor mutational burden (TMB) status but may be more sensitive to routine chemotherapeutic agents. The study suggests that the CAF-related signature may serve as a pretreatment guide for anti-CAFs and prognostic markers in CAFs could be potential therapeutic targets to inhibit ovarian cancer progression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Jenny Sprooten, Ann Vankerckhoven, Isaure Vanmeerbeek, Daniel M. Borras, Yani Berckmans, Roxanne Wouters, Raquel S. Laureano, Thais Baert, Louis Boon, Chiara Landolfo, Antonia Carla Testa, Daniela Fischerova, Caroline Van Holsbeke, Tom Bourne, Valentina Chiappa, Wouter Froyman, Dominique Schols, Patrizia Agostinis, Dirk Timmerman, Sabine Tejpar, Ignace Vergote, An Coosemans, Abhishek D. Garg
Summary: The study established a novel biomarker resource for serum screening in patients with ovarian cancer to evaluate peripheral immunodynamics, patient survival trends, malignancy risk, and preclinical chemo-immunotherapy strategies. The in silico data-driven framework predicted that analysis of myeloid NF kappa B signaling and interferon-stimulated genes' responses could capture patients' peripheral immunodynamics effectively. Multiparametric serum profiling of patients with ovarian cancer showed that the sFIS assay can decode peripheral immunology, estimate survival trends, and co-estimate malignancy risk.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Medicine, General & Internal
Xiazi Nie, Lina Song, Xiaohua Li, Yirong Wang, Bo Qu
Summary: This study identified prognostic signature of ovarian cancer using tumor microenvironment related genes, with risk score being an independent prognostic factor. Nomogram model reliably predicted patient survival, and certain immune cell types were found to be associated with the risk score differences.
Review
Medicine, Research & Experimental
Nathalie D. Mckenzie, Sarfraz Ahmad, Ahmad Awada, Theresa M. Kuhn, Fernando O. Recio, Robert W. Holloway
Summary: The prognosis of high-grade serous ovarian cancer is influenced by the immune profile of the tumor microenvironment. Altering the gut microbiome and TME metabolism through dietary interventions may provide opportunities for immunomodulation.
Article
Immunology
Xiaoyu Xu, Songcheng Yin, Yun Wang, Qingqing Zhu, Guoxing Zheng, Yingsi Lu, Tian Li, Chengming Zhu
Summary: In this study, the expression of LILRB1 was found in both tumor cells and immune cells in ovarian cancer patients. High expression of LILRB1 in immune cells was associated with advanced disease stage, shorter survival outcomes, and worse response to chemotherapy. LILRB1 expression was also linked to immunosuppressive characteristics, such as increased infiltration of M2 macrophages and dysfunction of CD8+ T cells. Tumor-infiltrating LILRB1+ immune cells can be used as an independent prognostic factor and predictive biomarker for therapy responsiveness in ovarian cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Immunology
Jinhui Liu, Can Chen, Yichun Wang, Cheng Qian, Junting Wei, Yan Xing, Jianling Bai
Summary: Recent research has focused on the relationship between N1-methyladenosine (m1A) methylation modifications and tumor progression and prognosis. The study revealed three different m1A modification patterns in ovarian cancer patients, corresponding to three tumor immune phenotypes, and showed that individual tumor m1A modification patterns can predict patient survival, stage, and grade. High m1Ascore in patients was associated with better survival and lower mutational load, as well as therapeutic benefits in chemotherapy and immunotherapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Xiaosi Yu, Juan Guo, Qian Zhou, Wenjie Huang, Chen Xu, Xinghua Long
Summary: By analyzing immune-related genes in breast cancer, a prognostic risk assessment model was successfully constructed, showing accurate prognostic value. Prognostic transcription factors were also identified, and multiple signaling pathways that inhibit tumor progression were enriched in the low-risk group.
Article
Reproductive Biology
Li Liu, Qing Wang, Jia-Yun Zhou, Bei Zhang
Summary: This study aimed to identify LncRNA signatures associated with Cuproptosis in ovarian cancer as prognostic indicators. Using RNA sequencing and statistical analysis, 129 Cuproptosis-related LncRNAs were selected and a prognostic model was constructed. The results showed that these LncRNA signatures could serve as independent prognostic factors for ovarian cancer patients.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Oncology
Kelly L. Singel, Kassondra S. Grzankowski, A. N. M. Nazmul H. Khan, Melissa J. Grimm, Anthony C. D'Auria, Kayla Morrell, Kevin H. Eng, Bonnie Hylander, Paul C. Mayor, Tiffany R. Emmons, Nikolett Lenart, Rebeka Fekete, Zsuzsanna Kornyei, Uma Muthukrishnan, Jonathan D. Gilthorpe, Constantin F. Urban, Kiyoshi Itagaki, Carl J. Hauser, Cynthia Leifer, Kirsten B. Moysich, Kunle Odunsi, Adam Denes, Brahm H. Segal
BRITISH JOURNAL OF CANCER
(2019)
Article
Oncology
Devalingam Mahalingam, Grey A. Wilkinson, Kevin H. Eng, Paul Fields, Patrick Raber, Jennifer L. Moseley, Karol Cheetham, Matt Coffey, Gerard Nuovo, Pawel Kalinski, Bin Zhang, Sukeshi Patel Arora, Christos Fountzilas
CLINICAL CANCER RESEARCH
(2020)
Article
Biochemistry & Molecular Biology
Swati Venkat, Arwen A. Tisdale, Johann R. Schwarz, Abdulrahman Alahmari, H. Carlo Maurer, Kenneth Olive, Kevin H. Eng, Michael E. Feigin
Article
Oncology
Anm Nazmul H. Khan, Tiffany R. Emmons, Jerry T. Wong, Emad Alqassim, Kelly L. Singel, Jaron Mark, Brandon E. Smith, Joseph D. Tario, Kevin H. Eng, Kirsten B. Moysich, Kunle Odunsi, Scott I. Abrams, Brahm H. Segal
CANCER IMMUNOLOGY RESEARCH
(2020)
Meeting Abstract
Oncology
S. Lynam, F. O. Recio, M. Roy, S. Belliotti, S. N. Akers, P. J. Frederick, S. B. Lele, E. Zsiros, K. H. Eng, K. Odunsi
GYNECOLOGIC ONCOLOGY
(2020)
Article
Oncology
Ashley Mussell, He Shen, Yanmin Chen, Michalis Mastri, Kevin H. Eng, Wiam Bshara, Costa Frangou, Jianmin Zhang
Article
Biology
Justin Zonneville, Moyi Wang, Mohammed M. Alruwaili, Brandon Smith, Megan Melnick, Kevin H. Eng, Thomas Melendy, Ben Ho Park, Renuka Iyer, Christos Fountzilas, Andrei Bakin
Summary: Zonneville et al. demonstrate that p53 mutant cancers with high replication activity and BER pathway expression can be targeted using a combination of fluorinated deoxyuridine analogues and PARP inhibitors, resulting in DNA damage induction and tumor growth suppression in mice. This study highlights a novel selective combination therapy strategy for p53 mutant cancers that shows a greater anti-neoplastic efficacy compared to monotherapy.
COMMUNICATIONS BIOLOGY
(2021)
Article
Oncology
James Ellegate, Michalis Mastri, Emily Isenhart, John J. Krolewski, Gurkamal Chatta, Eric Kauffman, Melissa Moffitt, Kevin H. Eng
Summary: The MAGEC3 gene is found to be lost in ovarian cancers, and its loss is associated with better survival rate. The MAGEC3 protein is also correlated with immune-related features and DNA repair pathway expression. Therefore, MAGEC3 is considered a prognostic biomarker in ovarian cancer.
Article
Oncology
Chetan C. Oturkar, Nishant Gandhi, Pramod Rao, Kevin H. Eng, Austin Miller, Prashant K. Singh, Emese Zsiros, Kunle O. Odunsi, Gokul M. Das
Summary: High grade serous ovarian cancer (HGSOC) is a common and deadly subtype of ovarian cancer with a high prevalence of mutant p53. This study investigated the interaction between estrogen receptor-beta (ER beta) and mutant p53 in HGSOC. The researchers found that ER beta 2 and mutant p53 co-dependently regulated the transcription of the FOXM1 gene, leading to increased cell proliferation and resistance to treatment. High levels of ER beta 2 and FOXM1 were correlated with worse patient survival. This suggests that targeting the ER beta 2-mutant p53-FOXM1 axis could be a novel therapeutic strategy for HGSOC.
Article
Oncology
Emmanuel B. Omole, Iqbal Aijaz, James Ellegate, Emily Isenhart, Mohamed M. Desouki, Michalis Mastri, Kristen Humphrey, Emily M. Dougherty, Spencer R. Rosario, Kent L. Nastiuk, Joyce E. Ohm, Kevin H. Eng
Summary: The study revealed a weak inverse correlation between the expression of MAGEC3 and BRCA2 in epithelial ovarian cancer, suggesting that the combined expression of MAGEC3 and BRCA2 may serve as a better predictor of prognosis than each marker alone.
Meeting Abstract
Immunology
Sora Suzuki, Thejaswini Giridharan, A. N. M. Nazmul Khan, Tiffany R. Emmons, Michael B. Yaffe, Kipp Weiskopf, Madhumita Das, Kevin H. Eng, Emese Zsiros, Brahm H. Segal
JOURNAL OF IMMUNOLOGY
(2022)
Meeting Abstract
Oncology
Justin Zonneville, Moyi Wang, Mohammed Alruwaili, Kevin Eng, Thomas Melendy, Ben Ho Park, Renuka Iyer, Christos Fountzilas, Andrei V. Bakin
Meeting Abstract
Oncology
Yuhao Shi, Melissa Dolan, Michalis Mastri, James W. Hill, Kevin Eng, John M. Ebos
Article
Medicine, Research & Experimental
Chunliu Pan, Neha Jaiswal Agrawal, Yanni Zulia, Shalini Singh, Kai Sha, James L. Mohler, Kevin H. Eng, Joe Chakkalakal, John J. Krolewski, Kent L. Nastiuk
Meeting Abstract
Oncology
H. Takahashi, W. He, L. Spokauskaite, K. H. Eng, A. Witkiewicz, F. Ito
ANNALS OF SURGICAL ONCOLOGY
(2019)
Article
Oncology
Dimitrios Nasioudis, Stefan Gysler, Nawar Latif, Lory Cory, Robert L. Giuntoli II, Sarah H. Kim, Fiona Simpkins, Lainie Martin, Emily M. Ko
Summary: The prevalence of ERBB2 gene amplification was investigated among patients with gynecologic malignancies. The study found that ERBB2 amplification is frequently encountered in uterine serous carcinoma and mucinous ovarian carcinoma, but less common in endometrioid endometrial carcinoma.
GYNECOLOGIC ONCOLOGY
(2024)