Article
Biochemistry & Molecular Biology
Meile Mo, Bihu Liu, Yihuan Luo, Jennifer Hui Juan Tan, Xi Zeng, Xiaoyun Zeng, Dongping Huang, Changhua Li, Shun Liu, Xiaoqiang Qiu
Summary: This study identified three pivotal HCC-related circRNAs and provided novel insights into the underlying mechanisms of the circRNA-miRNA-mRNA regulatory network in HCC.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2022)
Article
Biotechnology & Applied Microbiology
Yong-Fa Zhang, Yi-Xiu Wang, Ning- Zhang, Zhen-Hai Lin, Long-Rong Wang, Yun Feng, Qi Pan, Lu Wang
Summary: RBM25 is overexpressed in HCC patients and associated with poor prognosis, especially in male patients and those in the N0 stage. RBM25 may interact with CDCA5 and INCENP to regulate HCC.
Article
Biochemical Research Methods
Yi-Jie Zhang, De-Hui Yi
Summary: This study analyzed multiomics data to construct a regulatory network involving kinases, transcription factors, and immune genes in hepatocellular carcinoma (HCC) prognosis. The study identified key immune genes and their relationships, and validated the effects of the CDK1-SRC-HSP90AB1 network on HCC progression and antitumor immunity. The findings highlight the importance of this network in HCC prognosis and immune regulation.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Oncology
Hua-Yu Wu, Li-Feng Luo, Fang Wei, Hong-Mian Jiang
Summary: This study confirmed the upregulation of FOXM1 in HCC and identified it as an independent risk factor. It also enriched our understanding of the complex transcriptional mechanisms underlying HCC pathogenesis, with FOXM1 potentially promoting HCC progression by activating other transcription factors within the cell cycle pathway.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Plant Sciences
Syed Sarfaraz Hussain, Manzar Abbas, Sammar Abbas, Mingke Wei, Ahmed H. El-Sappah, Yuhan Sun, Yun Li, Arthur J. Ragauskas, Quanzi Li
Summary: Alternative splicing in plants regulates gene expression through differential transcriptional modifications, allowing adaptation to environmental stresses and different growth stages. It causes the retention of introns in messenger RNA, leading to the translation of differentially expressed proteins. Additionally, alternative splicing remodels transcription factors at the post-transcriptional level, activating or repressing transcription.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Microbiology
Liu Tian, Tong Liu, Kang-Jian Hua, Xiao-Pan Hu, Bin-Guang Ma
Summary: The transcriptional regulatory network (TRN) is crucial for prokaryotic organisms to receive and respond to environmental information. This study explores the spatial organization characteristics of bacterial TRNs using chromatin interaction data, revealing various stable spatial organization features related to biological functions.
Article
Biochemistry & Molecular Biology
Biao Zhang, Hai-Yang Wang, De-Xi Zhao, Dong-Xing Wang, Quan Zeng, Jia-Fei Xi, Xue Nan, Li-Juan He, Jun-Nian Zhou, Xue-Tao Pei, Wen Yue
Summary: The study found that hnRNPU is overexpressed in hepatocellular carcinoma (HCC) tissues and is correlated with poor prognosis in HCC patients. Mechanistically, a regulatory loop between hnRNPU and c-Myc synergistically promotes HCC proliferation and self-renewal, suggesting hnRNPU as a potential therapeutic target for c-Myc-driven HCC.
Article
Genetics & Heredity
Yi Shen, Yi Shao, Chen Niu, Xiaoli Ruan, Zhaoping Zang, Rena Nakyeyune, Xiuhua Guo, Fen Liu
Summary: This study identified 33 differentially expressed circRNAs in the blood of ESCC patients, and constructed an ESCC-associated circRNA-miRNA-mRNA network. Enrichment analyses showed the association of DEGs with various biological processes and cancer-related pathways.
FRONTIERS IN GENETICS
(2021)
Article
Oncology
Yuan Fang, Yang Yang, XiaoLi Zhang, Na Li, Bo Yuan, Li Jin, Sheng Bao, MengGe Li, Dan Zhao, LingRui Li, Zhong Zeng, HanFei Huang
Summary: This study identified key gene modules and central genes associated with relapsed HCC, constructing lncRNA-mRNA networks related to it. These genes have potential prognostic value and could serve as novel biomarkers or diagnostic targets for relapsed HCC.
FRONTIERS IN ONCOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yakun Li, Lihong Ding, Mei Zhou, Zhixiang Chen, Yanfei Ding, Cheng Zhu
Summary: Cadmium, a highly toxic non-essential heavy metal, can be sensed, transported, and detoxified by plants through specialized mechanisms. Recent studies have identified numerous transporters involved in Cd uptake, transport, and detoxification. However, the intricate transcriptional regulatory networks associated with Cd response are still not fully understood.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Genetics & Heredity
Bo Hu, Xiaolu Ma, Peiyao Fu, Qiman Sun, Weiguo Tang, Haixiang Sun, Zhangfu Yang, Mincheng Yu, Jian Zhou, Jia Fan, Yang Xu
Summary: This study identified novel prognostic mRNA and miRNA biomarkers for HCC using systems biology methods. Through Cox survival analysis, a mRNA co-expression network and mRNA-miRNA regulatory network were constructed, leading to the identification of mRNAs and miRNAs associated with HCC patient prognosis. Functional annotation of specific miRNAs indicated their associations with cancer-related pathways, providing a bioinformatics method for biomarker screening.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Biochemical Research Methods
Qiuyan Huo, Yuying Ma, Yu Yin, Guimin Qin
Summary: This study investigated the pathogenesis of LIHC and CHOL based on gene regulatory networks, identifying common and distinct regulatory properties between the two liver cancers. Predicted biomarkers for LIHC and CHOL were determined, with the Collagen gene family potentially playing a significant role in cancer development.
CURRENT BIOINFORMATICS
(2021)
Article
Genetics & Heredity
Bin Jiang, Maolin Tian, Gang Li, Abuduhaibaier Sadula, Dianrong Xiu, Chunhui Yuan, Yuntao Bing
Summary: This study explores the function and molecular mechanism of circular RNAs (circRNAs) in hepatocellular carcinoma (HCC) progression. The findings reveal that circEPS15 plays a novel role in repressing HCC through the ceRNA network and encodes a functional protein. These discoveries enhance our understanding of HCC and provide new directions for further research and treatment.
FRONTIERS IN GENETICS
(2022)
Article
Medicine, Research & Experimental
Jiacheng Wu, Shan Qiao, Yien Xiang, Menying Cui, Xiaoxiao Yao, Ruixin Lin, Xuewen Zhang
Summary: Endoplasmic reticulum (ER) stress plays a critical role in the occurrence and progression of hepatocellular carcinoma (HCC), driving tumorigenesis and progression of tumors. Targeting the ER stress signaling pathway and related molecules may have a key role in anti-HCC strategies.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Chemistry, Multidisciplinary
Bin Zhang, Zhi-yi Liu, Rui Wu, Cheng-ming Zhang, Kuan Cao, Wen-gang Shan, Zhen Liu, Ming Ji, Zi-lu Tian, Gautam Sethi, Heng-liang Shi, Ren-hao Wang
Summary: CTR9, a scaffold protein of the PAF1 complex, plays essential roles in hepatocellular carcinoma by promoting cell proliferation, invasion, and migration. CTR9 also promotes HCC development by enhancing the transcription of the oncogene PEG10. Targeting CTR9 may provide a novel therapeutic strategy for HCC.
ACTA PHARMACOLOGICA SINICA
(2022)