Article
Medicine, General & Internal
Mireia Obon-Santacana, Anna Diez-Villanueva, Maria Henar Alonso, Gemma Ibanez-Sanz, Elisabet Guino, Ana Lopez, Lorena Rodriguez-Alonso, Alfredo Mata, Ana Garcia-Rodriguez, Andres Garcia Palomo, Antonio J. Molina, Montse Garcia, Gemma Binefa, Vicente Martin, Victor Moreno
Summary: Different risk-based colorectal cancer screening strategies, including the use of polygenic risk scores, have been evaluated to enhance effectiveness. This study assessed the utility of polygenic risk scores in a fecal immunochemical test-based screening program and found that while it plays a role along the CRC tumorigenesis pathway, its ability to stratify the general population or act as a second test after a positive FIT result remains uncertain.
Article
Medicine, General & Internal
D. E. F. W. M. van Toledo, J. E. G. IJspeert, M. C. W. Spaander, I. D. Nagtegaal, M. E. van Leerdam, I. Lansdorp-Vogelaar, E. Dekker
Summary: By analyzing the results of colonoscopy, it was found that the simultaneous presence of high-risk serrated polyps and high-risk adenomas, or the presence of only high-risk serrated polyps, is associated with an increased risk of metachronous colorectal cancer.
Article
Gastroenterology & Hepatology
Maaike Buskermolen, Steffie K. Naber, Esther Toes-Zoutendijk, Miriam P. van der Meulen, Wilhelmina M. U. van Grevenstein, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar
Summary: This study compared the impact of referring patients with complex nonmalignant polyps directly to surgery or to an expert endoscopist for attempted endoscopic removal. The results showed that referring patients to an expert endoscopist first reduced surgery-related deaths and significantly improved the cost-effectiveness of the screening program.
Article
Gastroenterology & Hepatology
Lonne W. T. Meulen, Quirine E. W. van der Zander, Roel M. M. Bogie, Eric T. P. Keulen, Annick B. van Nunen, Bjorn Winkens, Jan Willem A. Straathof, Chantal Hoge, Rogier de Ridder, Leon M. G. Moons, Ad A. M. Masclee
Summary: The study analyzed the quality of endoscopic treatment of large nonpedunculated colorectal polyps (LNPCPs) in the Dutch screening program. It found that technical and clinical success rates decreased with increasing LNPCP size, and the cumulative recurrence rate at 12 months increased with LNPCP size. The study suggested that additional training, quality monitoring, and centralization could benefit endoscopic resection of large polyps in the screening program.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Chemistry, Analytical
Islam Alkabbany, Asem M. Ali, Mostafa Mohamed, Salwa M. Elshazly, Aly Farag
Summary: This study presents an AI-based polyp detection framework for virtual colonoscopy, addressing automatic segmentation and polyp detection. The framework shows promising results in low-dose CT scans, and the Fly-In visualization approach proves effective in assisting gastroenterologists. Synthetic images generated through the fusion of 2D projections with 3D colon representation are used to train a RetinaNet model, achieving high accuracy in polyp detection. The impact of dose variation on polyp visualization is also studied, and a simulation platform is developed for visualization using the Fly-In approach.
Article
Oncology
Oscar Murcia, Alejandro Martinez-Roca, Miriam Juarez, Mar Giner-Calabuig, Miren Alustiza, Cristina Mira, Carolina Mangas-Sanjuan, Eva Serrano, Francisco Antonio Ruiz-Gomez, Sandra Baile-Maxia, Lucia Medina, Cristina Alenda, Artemio Paya, Maria Rodriguez-Soler, Pedro Zapater, Rodrigo Jover
Summary: The study suggests that CIMP may be a useful marker for endoscopic surveillance after polypectomy, improving the accuracy in predicting the risk of metachronous advanced colorectal lesions (MACLs). Patients with CIMP+ polyps show a higher risk and shorter time to MACL development, even after adjustment for other factors. The addition of CIMP analysis enhances the sensitivity, negative predictive value, and overall accuracy in estimating MACL risk.
Article
Gastroenterology & Hepatology
Dianne Bosch, Laura W. Leicher, Nina C. A. Vermeer, Koen C.M.J. Peeters, Wouter H. de Vos Tot Nederveen Cappel, Henderik L. van Westreenen
Summary: The implementation of the Dutch national bowel screening programme in 2014 led to an increased rate of detection of polyps. Since then, there has been a doubling in the number of referrals for surgical resection of colorectal polyps, with a significant shift towards organ-preserving techniques. The overall complication rate of organ-preserving surgery was found to be lower than for segmental resections.
COLORECTAL DISEASE
(2021)
Article
Multidisciplinary Sciences
Selda Tekiner, Gulsen Ceyhun Peker, Mine Ceylan Dogan
Summary: This study evaluated the health beliefs of relatively young individuals in Turkey regarding colorectal cancer screening before the screening age, finding that attitudes towards preventive health measures are mainly associated with age, gender, education level, and marital status.
Article
Microbiology
Limin Zhang, Ziying Feng, Yinghua Li, Cuiting Lv, Chunchun Li, Yue Hu, Mingsheng Fu, Liang Song
Summary: This study investigated the differences in fecal and salivary microbiota between patients with colorectal polyps and healthy controls, and identified potential microbiota-based biomarkers for the detection of colorectal polyps.
FRONTIERS IN MICROBIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Dan Li, Amanda R. Doherty, Menaka Raju, Liyan Liu, Nan Ye Lei, Laura B. Amsden, Jeffrey K. Lee, Theodore R. Levin, Douglas A. Corley, Lisa J. Herrinton
Summary: This community-based, case-control study found a close association between serrated polyps (SPs) and the risk of colorectal cancer (CRC), especially large proximal serrated lesions or those with dysplasia. Close endoscopic surveillance of serrated polyps can help reduce the risk of CRC. Proximal unspecified SPs are also associated with an increased risk of CRC and should be managed as serrated lesions.
Article
Biochemical Research Methods
Meifang Tang, Liuhong Zeng, Zhaolei Zeng, Jie Liu, Jie Yuan, Dongjie Wu, Ying Lu, Jin Zi, Mingzhi Ye
Summary: Colorectal cancer (CRC) is a malignant tumor with high morbidity and mortality worldwide. Proteins are generally considered key molecular biomarkers of cancer. This study identifies TFR1, SAHH, and HV307 as potential biomarkers for CRC screening through a quantitative proteomics analysis.
JOURNAL OF PROTEOMICS
(2021)
Article
Gastroenterology & Hepatology
David E. F. W. M. van Toledo, Emilie C. H. Breekveldt, Joep E. G. IJspeert, Anneke J. van Vuuren, Folkert J. van Kemenade, Christian Ramakers, Iris D. Nagtegaal, Monique E. van Leerdam, Manon C. W. Spaander, Iris Lansdorp-Vogelaar, Esther Toes-Zoutendijk, Evelien Dekker
Summary: This study assessed the detection rate and positive predictive value (PPV) of advanced serrated polyps (ASPs) in a FIT-based screening program. The results showed that 5.9% of FIT-positive screenees had ASPs, and including ASPs slightly increased the yield of the screening.
Editorial Material
Medicine, General & Internal
John M. M. Carethers
Summary: A 56-year-old man with no significant medical history declined screening colonoscopy in the past but now wants a less invasive test due to his father's death from colorectal cancer. What is the next course of action?
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Review
Oncology
Enea Ferlizza, Rossella Solmi, Michela Sgarzi, Luigi Ricciardiello, Mattia Lauriola
Summary: Colorectal cancer (CRC) ranks as the third most common cancer worldwide, emphasizing the significance of early detection. Screening through fecal occult blood tests has shown to reduce CRC incidence and mortality, however, low participation rates and false positives are key challenges. Recent research has focused on new fecal tests, biomarkers, and liquid biopsy methods to enhance accuracy and participation in CRC screening.
Article
Gastroenterology & Hepatology
Sara Nafisi, Kristin R. Randel, Nathalie C. Stoer, Marit B. Veierod, Geir Hoff, Oyvind Holme, Anna L. Schult, Edoardo Botteri
Summary: The study found that long-term use of aspirin may have a protective effect against adenomas and colorectal cancer, but not advanced serrated lesions.
DIGESTIVE AND LIVER DISEASE
(2023)
