Journal
GREEN CHEMISTRY
Volume 19, Issue 13, Pages 2952-2956Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c7gc01341h
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Funding
- Research Grant Council of Hong Kong [ECS 605912, GRF 605113, GRF 16305314]
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An environmentally friendly and efficient protocol (KX/oxone) for oxidative halocyclization of tryptamine/tryptophol derivatives was developed and demonstrated with 28 examples and concise total synthesis of cyclotryptamine alkaloid protubonines A and B. The distinct advantage of this protocol over all previous methods is that no organic byproduct is generated from a halogenating agent or oxidant, thus greatly reducing the environmental impact of halocyclization and facilitating the post-reaction purification.
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