Journal
GLYCOCONJUGATE JOURNAL
Volume 34, Issue 6, Pages 817-823Publisher
SPRINGER
DOI: 10.1007/s10719-017-9801-8
Keywords
Podocalyxin; Embryonic stem cells; Keratan sulfate; Glycosaminoglycans; Induced pluripotent stem cells
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Funding
- R-GIRO (Ritsumeikan Global Innovation Research Organization) Program
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Podocalyxin (PC) was first identified as a heavily sialylated transmembrane protein of glomerular podocytes. Recent studies suggest that PC is a remarkable glycoconjugate that acts as a universal glyco-carrier. The glycoforms of PC are responsible for multiple functions in normal tissue, human cancer cells, human embryonic stem cells (hESCs), and human induced pluripotent stem cells (hiPSCs). PC is employed as a major pluripotent marker of hESCs and hiPSCs. Among the general antibodies for human PC, TRA-1-60 and TRA-1-81 recognize the keratan sulfate (KS)-related structures. Therefore, It is worthwhile to summarize the outstanding chemical characteristic of PC, including the KS-related structures. Here, we review the glycoforms of PC and discuss the potential of PC as a novel KS proteoglycan in undifferentiated hESCs and hiPSCs.
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