Review
Biology
Xiqi Hu, Yanan Ma, Xuemei Jiang, Wei Tang, Ying Xia, Peipei Song
Summary: With the global aging population increasing rapidly, the prevalence of frailty is also on the rise and has become an emerging public health burden. Frail elderly patients experience a decline in physical status after stress exposure and are at a higher risk of adverse events due to reduced homeostatic reserve capacity. Frailty is closely associated with changes in brain volume and sarcopenia, which in turn leads to reduced physical function and independence. Approximately 10-32% of neurosurgical patients are frail, and the risk of adverse postoperative events is significantly higher in frail individuals. Attention should be given to assessing neurosurgical frailty and muscle function in elderly patients to improve their postoperative prognosis.
Article
Cell Biology
Pasquale Mone, Jessica Gambardella, Antonella Pansini, Antonio de Donato, Giuseppe Martinelli, Eugenio Boccalone, Alessandro Matarese, Salvatore Frullone, Gaetano Santulli
Summary: The study demonstrates the detrimental effects of hypertension and hyperglycemia on endothelial cell function and cognitive decline in older adults. Metformin shows beneficial effects on brain microvascular endothelial cells, improving cell death and reactive oxygen species generation induced by high glucose, and mitigating cognitive impairment.
Article
Environmental Sciences
Chiara Moccia, Costanza Pizzi, Giovenale Moirano, Maja Popovic, Daniela Zugna, Antonio 'Errico, Elena Isaevska, Serena Fossati, Mark J. Nieuwenhuijsen, Piero Fariselli, Tiziana Sanavia, Lorenzo Richiardi, Milena Maule
Summary: This study investigated the impact of socioeconomic position (SEP) on the early-life exposome in Turin children. The results showed that children with lower SEP are less exposed to urbanization factors and more likely to have unhealthy lifestyles and diets compared to those with higher SEP.
ENVIRONMENT INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Giovanna Pel, Sara Tagliaferri, Felice Perrino, Ilaria Righelli, Rossella Montanari, Yari Longobucco, Marco Salvi, Riccardo Calvani, Matteo Cesari, Antonio Cherubini, Roberto Bernabei, Mauro Di Bari, Francesco Landi, Emanuele Marzetti, Fulvio Lauretani, Marcello Maggio
Summary: Older sarcopenic and physically frail patients tend to have left ventricular hypertrophy with a tendency towards concentric geometry. The main determinants of left ventricular mass are clinical systolic blood pressure and body surface area, highlighting the key role that hemodynamic condition plays in determining LVH in this population.
EXPERIMENTAL GERONTOLOGY
(2021)
Article
Geriatrics & Gerontology
Shohei Okamoto, Erika Kobayashi, Hiroshi Murayama, Jersey Liang, Taro Fukaya, Shoji Shinkai
Summary: This empirical study found that differences in cognitive functioning and decline between men and women can be attributed to various individual attributes, such as education and occupation. Men seem to engage in activities that enhance cognitive functioning more than women, supporting the cognitive reserve hypothesis.
Article
Public, Environmental & Occupational Health
Ceciel Pauls, Andrea Dalecka, Wentian Lu, Jaroslav Hubacek, Hynek Pikhart, Martin Bobak
Summary: This study aims to investigate whether the social gradient in all-cause mortality in the Czech Republic changed during the postcommunist transition. The results show that education is significantly associated with reduced risk of death, with a more pronounced gradient in men. The educational gradient did not differ between the two cohorts, suggesting no major increase in educational inequality during the early stage of postcommunist transition.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2022)
Article
Multidisciplinary Sciences
Malini Chari, Vahid Ravaghi, Wael Sabbah, Noha Gomaa, Sonica Singhal, Carlos Quinonez
Summary: This study quantified the magnitude of oral health inequality in Canada, the United States (US), and the United Kingdom (UK), countries with similar socio-political environments but differing oral health care systems. The results showed significant oral health inequality in all three countries. The highest inequality in untreated decay was found in the US, followed by Canada, and the lowest in the UK. The study suggests that the more equitable nature of the oral health care system in the UK might contribute to lower oral health inequality compared to the highly privatized dental care environments in Canada and the US.
Article
Immunology
Antonio Fernando Boing, Alexandra Crispim Boing, Lorena Barberia, Marcelo Eduardo Borges, S. V. Subramanian
Summary: Vaccination is crucial for reducing severe COVID-19 cases, but vaccine access disparities within countries may lead to inequalities in coverage. This study investigated potential inequalities in vaccine coverage among Brazilian adults based on demographic, geographic, and socioeconomic characteristics. The study found higher vaccination coverage among the elderly and women, as well as socioeconomic and demographic disparities in coverage.
Article
Dentistry, Oral Surgery & Medicine
Leandro Machado Oliveira, Thayna Regina Pelissari, Carlos Heitor Cunha Moreira, Thiago Machado Ardenghi, Flavio Fernando Demarco, Fabricio Batistin Zanatta
Summary: This study investigated whether the association between alcohol consumption and tooth loss is influenced by socioeconomic positions in Brazilian older adults. The results showed that heavy drinkers with low socioeconomic status and low educational attainment had a higher prevalence of tooth loss compared to their counterparts. This association was confirmed in sensitivity analyses.
Article
Public, Environmental & Occupational Health
Vilde Hatlevoll Stensrud, Lise Tuset Gustad, Jan Kristian Damas, Erik Solligard, Steinar Krokstad, Tom Ivar Lund Nilsen
Summary: This study finds that socioeconomic status is inversely associated with sepsis risk and mortality. Approximately 80% of the effect of education on sepsis risk can be explained by modifiable lifestyle and health-related factors, such as smoking, alcohol consumption, and risk factors of cardiovascular disease and chronic diseases.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2023)
Article
Psychology, Multidisciplinary
Marijke Veenstra, Goril Kvamme Loset, Svein Olav Daatland
Summary: This study investigates the impact of socioeconomic inequalities on elderly mortality, revealing that lower levels of wealth and perceived control independently predict increased mortality among older adults over an 11-year period.
FRONTIERS IN PSYCHOLOGY
(2021)
Article
Clinical Neurology
Laiss Bertola, Isabela M. Bensenor, Sandhi Maria Barreto, Luana Giatti, Arlinda B. Moreno, Maria Carmen Viana, Paulo A. Lotufo, Claudia K. Suemoto
Summary: The study explored the impact of early life socioeconomic status on cognitive performance in the Brazilian Longitudinal Study of Adult Health. Results showed that early life SES can impact cognition through indirect paths involving education and late life SES, with slightly different effects observed in middle-aged and older adults.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Article
Environmental Sciences
Rebecca S. Geary, Daniel Thompson, Amy Mizen, Ashley Akbari, Joanne K. Garrett, Francis M. Rowney, Alan Watkins, Ronan A. Lyons, Gareth Stratton, Rebecca Lovell, Mark Nieuwenhuijsen, Sarah C. Parker, Jiao Song, Dialechti Tsimpida, James White, Mathew P. White, Susan Williams, Benedict W. Wheeler, Richard Fry, Sarah E. Rodgers
Summary: Living in or moving to areas with more green space or better access to green and blue spaces (GBS) is associated with better mental health. Increased ambient greenness and access to GBS are related to decreased odds of mental health disorders, while a greater distance to the nearest GBS is associated with increased odds of mental health disorders.
LANCET PLANETARY HEALTH
(2023)
Article
Multidisciplinary Sciences
Xiaoyong Hu, Tiantian Wang, Duan Huang, Yanli Wang, Qiong Li
Summary: Studies have shown a relationship between social class and health, with health self-management playing a mediating role. Lower social class individuals have poorer health self-management abilities, leading to lower physical and mental health compared to higher social class individuals.
Review
Cell Biology
Emma Wagg, Fiona M. Blyth, Robert G. Cumming, Saman Khalatbari-Soltani
Summary: This systematic review found a positive association between educational level and income/wealth with healthy ageing, while evidence regarding occupational position was inconclusive. The study highlights the importance of addressing inequalities through integrated health and social policies and strategies.
AGEING RESEARCH REVIEWS
(2021)
Article
Gerontology
Anouk M. van Loon, Marja F. I. A. Depla, Cees M. P. M. Hertogh, Martijn Huisman, Almar A. L. Kok
Summary: This study examines the subjective well-being (SWB) of older adults with substantial functional decline. It suggests that, despite the decline, most older adults are able to maintain their SWB. The study finds that negative affect and life satisfaction are more affected by functional decline, while positive affect is less affected. Perceived control emerges as a consistent factor associated with maintaining higher levels of SWB.
JOURNAL OF AGING AND HEALTH
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gerben J. C. Zwezerijnen, Jakoba J. Eertink, Maria C. Ferrandez, Sanne E. Wiegers, Coreline N. Burggraaff, Pieternella J. Lugtenburg, Martijn W. Heymans, Henrica C. W. de Vet, Josee M. Zijlstra, Ronald Boellaard
Summary: This study evaluates the variation in liver standardised uptake value (SUV) measurements in lymphoma [18F]FDG PET/CT studies using different uptake metrics. The results show that SUVmean(liver) is the most reproducible metric for liver uptake.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Geriatrics & Gerontology
Menelaos M. Dimitriadis, Hans W. Jeuring, Radboud M. Marijnissen, Thomas H. Wieringa, Emiel O. Hoogendijk, Richard C. Oude Voshaar
Summary: Using the health-deficit accumulation method, it was found that adverse childhood experiences (ACE) are positively associated with frailty. ACE accelerates the accumulation of health deficits, leading to the onset of frailty.
Article
Medicine, General & Internal
Xingqi Cao, Zhenqing Yang, Xueqin Li, Chen Chen, Emiel O. Hoogendijk, Jingyun Zhang, Nengliang Aaron Yao, Lina Ma, Yawei Zhang, Yong Zhu, Xuehong Zhang, Yuxian Du, Xiaofeng Wang, Xifeng Wu, Thomas M. Gill, Zuyun Liu
Summary: Using two widely used frailty indicators, this study found that frailty, even in the very early stage, was positively associated with the incidence risk of cardiovascular disease and type 2 diabetes mellitus among long-term cancer survivors.
Article
Medicine, General & Internal
C. S. van Dam, M. J. L. Peters, E. O. Hoogendijk, P. W. B. Nanayakkara, M. Muller, M. C. Trappenburg
Summary: This study compares the characteristics and outcomes of older adults at the Emergency Department (ED) with nonspecific complaints (NSC) versus specific complaints (SC) patients. The results show that NSC patients were older, more frail, and had a higher risk of functional decline and institutionalization, but not mortality. Therefore, emergency physicians should pay attention to NSC and provide appropriate observation and evaluation.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Psychiatry
Tjalling J. Holwerda, Eva Jaarsma, Elisabeth M. van Zutphen, Aartjan T. F. Beekman, Kuan-Yu Pan, Majoge van Vliet, Najada Stringa, Judith H. van den Besselaar, Janet L. MacNeil-Vroomen, Emiel O. Hoogendijk, Almar A. L. Kok
Summary: This study aims to assess protective and buffering factors against adverse mental health changes related to COVID-19 in older adults. The findings suggest that exposure to COVID-19 adversity has a cumulative negative impact on mental health, and factors such as internet use, mastery, social network, and religious beliefs can provide protection. COVID-19 vaccination also has a positive effect on mental health.
SOCIAL PSYCHIATRY AND PSYCHIATRIC EPIDEMIOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Irina Motoc, Emiel O. Hoogendijk, Erik J. Timmermans, Dorly Deeg, Brenda W. J. H. Penninx, Martijn Huisman
Summary: Neighbourhood characteristics are associated with anxiety but not with depression incidence in older adults. Factors such as urban density, proportion of immigrants, proximity to retail facilities, housing quality, safety, air pollution, and green space are related to the incidence of anxiety.
SOCIAL SCIENCE & MEDICINE
(2023)
Article
Public, Environmental & Occupational Health
Xingqi Cao, Xueqin Li, Jingyun Zhang, Xiaoyi Sun, Gan Yang, Yining Zhao, Shujuan Li, Emiel Hoogendijk, Xiaofeng Wang, Yimin Zhu, Heather Allore, Thomas M. Gill, Zuyun Liu
Summary: Frailty is significantly associated with higher risks of multiple adverse outcomes in middle-aged adults with prediabetes, including type 2 diabetes, diabetes-related diseases, and all-cause mortality. It is suggested that assessment of frailty should be incorporated into routine care for adults with prediabetes to improve resource allocation and reduce diabetes-related burden.
JMIR PUBLIC HEALTH AND SURVEILLANCE
(2023)
Article
Geriatrics & Gerontology
Najada Stringa, Natasja M. van Schoor, Emiel O. Hoogendijk, Yuri Milaneschi, Martijn Huisman
Summary: The phenotypic associations between grip strength, frailty, physical performance, and functional limitations were replicated over follow-up periods up to 23 years. However, these associations were not explained by shared genetics, potentially indicating a more relevant involvement of non-genetic factors.
Editorial Material
Geriatrics & Gerontology
Emiel O. Hoogendijk, Elsa Dent, Kaisa Koivunen
Summary: The concept of intrinsic capacity (IC) was introduced by WHO as a new approach to healthy aging, but there is insufficient evidence to support its effectiveness in improving care for older adults. The operationalization of IC also leads to confusion and redundant research, highlighting the need for clarification and validation.
Article
Geriatrics & Gerontology
Erwin Stolz, Hannes Mayerl, Judith Godin, Emiel O. Hoogendijk, Olga Theou, Wolfgang Freidl, Kenneth Rockwood
Summary: This study examined the reliability of the Frailty Index (FI) and found that it demonstrated good internal consistency and reliability in differentiating frailty levels among community-dwelling older adults. However, measurement error was large, suggesting that small changes in FI may not reliably detect individual health deteriorations or improvements.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Hematology
Julia Driessen, Gerben J. C. Zwezerijnen, Heiko Schoeder, Marie Jose Kersten, Alison J. Moskowitz, Craig H. Moskowitz, Jakoba J. Eertink, Martijn W. Heymans, Ronald Boellaard, Josee M. Zijlstra
Summary: We developed a prognostic model for progression-free survival (PFS) in patients with relapsed or primary refractory classical Hodgkin lymphoma (R/R cHL) using baseline quantitative F-18-fluorodeoxyglucose positron emission tomography (PET) radiomics features and clinical characteristics. The model can help predict PFS outcomes and guide risk-stratified treatment strategies for R/R cHL patients.
Article
Medicine, General & Internal
Min-gu Kang, Oh Seok Kim, Emiel O. Hoogendijk, Hee -Won Jung
Summary: This study aimed to evaluate the nationwide trend of frailty prevalence in older adults in Korea from 2008 to 2020. The study found a significant decrease in the prevalence of frailty during this period, which may be attributed to improvements in healthcare access and preventive measures.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)
Article
Public, Environmental & Occupational Health
Sophie C. C. Renckens, H. Roeline Pasman, Martijn Huisman, Emiel O. O. Hoogendijk, Bregje D. D. Onwuteaka-Philipsen
Summary: This study aimed to investigate self-reported changes in personal development and meaning in life among older adults in the Netherlands during the COVID-19 pandemic, as well as the characteristics of the groups reporting these changes. The results showed that a substantial number of older adults paid more attention to things they enjoy doing in their spare time, reflected more on important things in life, and made fewer future plans during the pandemic. The reported changes varied among different subgroups, and were associated with personal adverse experiences and health issues.
HEALTH & SOCIAL CARE IN THE COMMUNITY
(2023)
Article
Geriatrics & Gerontology
Kaisa Koivunen, Emiel O. Hoogendijk, Laura A. Schaap, Martijn Huisman, Martijn W. Heymans, Natasja M. van Schoor
Summary: This study developed a comprehensive Intrinsic Capacity (IC) score that measures a person's performance in five domains of capacity, and found that it is associated with subsequent functional decline and mortality.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
