Initiation of mtDNA transcription is followed by pausing, and diverges across human cell types and during evolution

Ancient Out-of-Africa Mitochondrial DNA Variants Associate with Distinct Mitochondrial Gene Expression Patterns

(2016) Tal Cohen et al.   PLoS Genetics

POLRMT regulates the switch between replication primer formation and gene expression of mammalian mtDNA

(2016) I. Ku hl et al.   Science Advances

Integrative analysis of 111 reference human epigenomes

(2015) Anshul Kundaje et al.   NATURE

Identification of active transcriptional regulatory elements from GRO-seq data

(2015) Charles G Danko et al.   NATURE METHODS

Replication-transcription switch in human mitochondria

(2015) K. Agaronyan et al.   SCIENCE

Disrupting Mitochondrial–Nuclear Coevolution Affects OXPHOS Complex I Integrity and Impacts Human Health

(2014) Moran Gershoni et al.   Genome Biology and Evolution

Transcription Factors Bind Negatively Selected Sites within Human mtDNA Genes

(2014) Amit Blumberg et al.   Genome Biology and Evolution

Analysis of nascent RNA identifies a unified architecture of initiation regions at mammalian promoters and enhancers

(2014) Leighton J Core et al.   NATURE GENETICS

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

(2014) M. H. Larson et al.   SCIENCE

Interactions between RNA polymerase and the "core recognition element" counteract pausing

(2014) I. O. Vvedenskaya et al.   SCIENCE

RNA-DNA Differences Are Generated in Human Cells within Seconds after RNA Exits Polymerase II

(2014) Isabel X. Wang et al.   Cell Reports

Control of Transcriptional Elongation

(2013) Hojoong Kwak et al.   Annual Review of Genetics

Evolutionary perspectives on the links between mitochondrial genotype and disease phenotype

(2013) Damian K. Dowling   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: Implications for population susceptibility to diseases

(2013) M. Cristina Kenney et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Organelle transcriptomes: products of a deconstructed genome

(2013) Ian D Small et al.   CURRENT OPINION IN MICROBIOLOGY

Functional Recurrent Mutations in the Human Mitochondrial Phylogeny: Dual Roles in Evolution and Disease

(2013) Liron Levin et al.   Genome Biology and Evolution

RNA–DNA differences in human mitochondria restore ancestral form of 16S ribosomal RNA

(2013) Dan Bar-Yaacov et al.   GENOME RESEARCH

Precise Maps of RNA Polymerase Reveal How Promoters Direct Initiation and Pausing

(2013) H. Kwak et al.   SCIENCE

An integrated encyclopedia of DNA elements in the human genome

(2012)   NATURE

Transcription from the second heavy-strand promoter of human mtDNA is repressed by transcription factor A in vitro

(2012) M. F. Lodeiro et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcriptional requirements of the distal heavy-strand promoter of mtDNA

(2012) O. Zollo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A mitochondrial etiology of Alzheimer and Parkinson disease

(2011) Pinar Coskun et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

TEFM (c17orf42) is necessary for transcription of human mtDNA

(2011) Michal Minczuk et al.   NUCLEIC ACIDS RESEARCH

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

A compendium of human mitochondrial gene expression machinery with links to disease

(2010) Timothy E. Shutt et al.   ENVIRONMENTAL AND MOLECULAR MUTAGENESIS

Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups

(2010) Aurora Gómez-Durán et al.   HUMAN MOLECULAR GENETICS

HaploGrep: a fast and reliable algorithm for automatic classification of mitochondrial DNA haplogroups

(2010) Anita Kloss-Brandstätter et al.   HUMAN MUTATION

Human Mitochondrial Transcription Revisited

(2010) Dmitry Litonin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Core human mitochondrial transcription apparatus is a regulated two-component system in vitro

(2010) T. E. Shutt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

Fast and accurate short read alignment with Burrows-Wheeler transform

(2009) H. Li et al.   BIOINFORMATICS

Expression profiling of Drosophila mitochondrial genes via deep mRNA sequencing

(2009) Tatiana Teixeira Torres et al.   NUCLEIC ACIDS RESEARCH

Nascent RNA Sequencing Reveals Widespread Pausing and Divergent Initiation at Human Promoters

(2008) Leighton J. Core et al.   SCIENCE