Article
Biochemistry & Molecular Biology
Jingyuan Cui, Yaru Yang, Peiru Chen, Ruiqiang Hang, Yin Xiao, Xueting Liu, Lixin Zhang, Hui Sun, Long Bai
Summary: Osteocytes play a vital role in bone remodeling during osseointegration, and the surface physicochemical properties can influence their functionality and determine the fate of osseointegration. Nanoscale topography can enhance osteogenesis by promoting osteocyte spreading, proliferation, and mineralization, with the TGF-beta signaling pathway playing a crucial role. Surface designs targeting osteocytes may provide a potential approach to address aseptic loosening and enhance osseointegration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Ze Liu, Qi Liu, Hongbin Guo, Jieyu Liang, Yi Zhang
Summary: Distraction osteogenesis (DO) is a bone regeneration technology that promotes new bone formation through continuous and stable traction force. However, the long consolidation course of DO can lead to complications. Current treatment strategies include gene, growth factor, stem-cell, physical, and pharmacological therapies, with physical and pharmacological therapies being considered safe and effective. Recent research provides evidence for the effectiveness of physical and pharmacological therapies in promoting bone healing during DO.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Arantza Infante, Leire Cabodevilla, Blanca Gener, Clara I. Rodriguez
Summary: Osteogenesis Imperfecta (OI) is a rare genetic disease characterized by bone fragility, and currently there is no cure. Research on therapeutic approaches such as cell therapy with mesenchymal stem cells (MSCs) and inhibition of the TGF-beta pathway for OI patients has shown promising outcomes. Excessive TGF-beta signaling pathway has been found in OI patients and could be modulated by MSCs therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Endocrinology & Metabolism
Jian-Jun Liu, Sylvia Liu, Jiexun Wang, Sharon L. T. Pek, Janus Lee, Resham L. Gurung, Keven Ang, Yi Ming Shao, Subramaniam Tavintharan, Wern Ee Tang, Chee Fang Sum, Su Chi Lim
Summary: This study found that urine LRG1 is associated with the risk of progression to ESKD in individuals with type 2 diabetes. Higher urine LRG1 levels are associated with an increased risk of ESKD and are also related to rapid kidney function decline and progression to macroalbuminuria.
Article
Cell & Tissue Engineering
Junjie Shen, Yi Sun, Xuanzhe Liu, Yu Zhu, Bingbo Bao, Tao Gao, Yimin Chai, Jia Xu, Xianyou Zheng
Summary: EGFL6 was found to stimulate angiogenesis and osteogenic differentiation through the Wnt/beta-catenin signaling pathway in vitro, and promoted CD31(hi)EMCN(hi) type H-positive capillary formation in a rat tibia distraction osteogenesis model. It enhanced the osteogenic differentiation potential of BMSCs and accelerated bone regeneration by stimulating angiogenesis.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Jishizhan Chen, Jia Hu, Wenhui Song
Summary: This study identified three hub genes (IL6, MMP2, and EP300) highly associated with distraction-induced osteogenesis of MSCs, providing a new understanding of optimizing DO through targeted gene therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
John Garcia, Anne M. Delany
Summary: This review highlights the role of miRNAs in regulating bone forming osteoblasts through their effects on the TGF beta and BMP pathways. By targeting ligands, receptors, and SMAD-mediated signaling, miRNAs contribute to the modulation of TGF beta and BMP signaling in the osteoblast lineage, which may have implications for potential therapeutic strategies. Induced during fracture, mechanical unloading, or estrogen deprivation, many of these miRNAs could potentially be used for localized delivery of therapeutics to promote bone formation.
Article
Endocrinology & Metabolism
Megan L. Brophy, John C. Stansfield, Youngwook Ahn, Seng H. Cheng, John E. Murphy, Robert D. Bell
Summary: Classic galactosemia is a rare genetic disorder caused by gene mutations. A study has shown that gene therapy using AAV can restore enzyme activity and prevent cell stress and injury. Furthermore, it was found that AAV-mediated GALT expression can restore cellular homeostasis factors in CG patients and demonstrate proof-of-concept restoration of galactose metabolism in a mouse model.
JOURNAL OF INHERITED METABOLIC DISEASE
(2022)
Article
Multidisciplinary Sciences
Shaoyan Gao, Xiaohe Li, Qiuyan Jiang, Qing Liang, Fangxia Zhang, Shuangling Li, Ruiqin Zhang, Jiaoyan Luan, Jingyan Zhu, Xiaoting Gu, Ting Xiao, Hui Huang, Shanshan Chen, Wen Ning, Guang Yang, Cheng Yang, Honggang Zhou
Summary: Our study demonstrates that PKM2 promotes fibrosis progression by interacting with Smad7 and enhancing TGF-beta 1 signaling. Increased expression of PKM2 in the lungs of mice with pulmonary fibrosis contributes to fibrosis development. The PKM2 tetramer enhances TGF-beta 1 signaling by directly binding with Smad7, making it a key factor in fibrosis progression.
Article
Biotechnology & Applied Microbiology
Shuo Wu, Lijie Zhang, Ruidan Zhang, Kang Yang, Qin Wei, Qiyu Jia, Jian Guo, Chuang Ma
Summary: Injecting bone marrow mesenchymal stem cells and recombinant rat platelet-derived growth factor BB (rrPDGF-BB) into the distraction area can promote the formation and differentiation of new bone tissue, thereby promoting bone regeneration and healing.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Yucheng Peng, Yue Gao, Chao Yang, Rui Guo, Xiangyang Shi, Xueyan Cao
Summary: This study reported the preparation of low-molecular-weight poly(ethylenimine)-poly(ethylene glycol) nanogels loaded with TGF-beta 1 siRNA and Fe3O4 NPs for gene therapy and tumor imaging. The developed hybrid nanogels exhibited good cytocompatibility and enhanced MR imaging performance.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Biochemistry & Molecular Biology
Reginald M. Atkins, Timothy J. Fawcett, Richard Gilbert, Andrew M. Hoff, Richard Connolly, Douglas W. Brown, Mark J. Jaroszeski
Summary: The research in this publication was primarily supported by the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and in part by the National Institute of Biomedical Imaging and Bioengineering. Additional support was provided by various departments at USF, with approximately 80% of the study costs financed with federal money.
BIOELECTROCHEMISTRY
(2021)
Article
Orthopedics
Tao Zhang, Weidong Jiang, Fengchun Liao, Peiqi Zhu, Lina Guo, Zhenchen Zhao, Yan Liu, Xuanping Huang, Nuo Zhou
Summary: This study aimed to investigate whether exosomes derived from distraction osteogenesis (DO) and bone fracture (BF) serum could stimulate osteogenic differentiation and identify the relevant genes involved. The results showed that exosomes accelerated osteogenesis in DO, possibly through co-expression of MSTRG.532277.1 and FBXL14, providing new therapeutic targets for bone regeneration.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2022)
Review
Medicine, General & Internal
Klaus Kallenbach, Anca Remes, Oliver J. Mueller, Rawa Arif, Marcin Zaradzki, Andreas H. Wagner
Summary: The researchers first provided an overview of the historical background and characterization of Marfan syndrome, and found that gene therapy, which is used in genetic diseases, may have a therapeutic effect on this disorder.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Medicine, Research & Experimental
Pengfei Gao, Chanjuan Liu, Hui Dong, Qi Li, Yunfang Chen
Summary: The research shows that TGF-beta can promote the proliferation and osteogenesis of dental pulp stem cells, but it has no significant effect on the number of mineralized nodules.
EUROPEAN JOURNAL OF MEDICAL RESEARCH
(2023)