BRCA1alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA-like breast cancers treated with neoadjuvant chemotherapy

Targeted sequencing ofBRCA1andBRCA2across a large unselected breast cancer cohort suggests that one-third of mutations are somatic

(2016) C. Winter et al.   ANNALS OF ONCOLOGY

Replication fork stability confers chemoresistance in BRCA-deficient cells

(2016) Arnab Ray Chaudhuri et al.   NATURE

Screening of Pleural Mesotheliomas for DNA-damage Repair Players by Digital Gene Expression Analysis Can Enhance Clinical Management of Patients Receiving Platin-Based Chemotherapy

(2016) Robert Fred Henry Walter et al.   Journal of Cancer

Cyclin E1 is a strong prognostic marker for death from lymph node negative breast cancer. A population-based case-control study

(2015) Claudia Lundgren et al.   ACTA ONCOLOGICA

The Fanconi Anemia Pathway Maintains Genome Stability by Coordinating Replication and Transcription

(2015) Rebekka A. Schwab et al.   MOLECULAR CELL

Exploiting the Fanconi Anemia Pathway for Targeted Anti-Cancer Therapy

(2015) Ukhyun Jo et al.   MOLECULES AND CELLS

Whole–genome characterization of chemoresistant ovarian cancer

(2015) Ann-Marie Patch et al.   NATURE

Homologous Recombination and Human Health: The Roles of BRCA1, BRCA2, and Associated Proteins

(2015) Rohit Prakash et al.   Cold Spring Harbor Perspectives in Biology

c-Myc Suppression of DNA Double-strand Break Repair

(2015) Zhaozhong Li et al.   NEOPLASIA

Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy

(2013) Mamoru Takada et al.   BMC CANCER

Mechanisms of resistance to therapies targeting BRCA-mutant cancers

(2013) Christopher J Lord et al.   NATURE MEDICINE

Synthetic lethality between CCNE1 amplification and loss of BRCA1

(2013) D. Etemadmoghadam et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response and cancer therapy

(2012) Christopher J. Lord et al.   NATURE

BRCA1-methylated sporadic breast cancers are BRCA-like in showing a basal phenotype and absence of ER expression

(2012) Amanjit Bal et al.   VIRCHOWS ARCHIV

Integrated genomic analyses of ovarian carcinoma

(2011) D. Bell et al.   NATURE

An aCGH classifier derived from BRCA1-mutated breast cancer and benefit of high-dose platinum-based chemotherapy in HER2-negative breast cancer patients

(2010) M. A. Vollebergh et al.   ANNALS OF ONCOLOGY

MRG15 binds directly to PALB2 and stimulates homology-directed repair of chromosomal breaks

(2010) T. Hayakawa et al.   JOURNAL OF CELL SCIENCE

Genome-Wide Loss of Heterozygosity and Uniparental Disomy in BRCA1/2-Associated Ovarian Carcinomas

(2008) C. S. Walsh et al.   CLINICAL CANCER RESEARCH

The methylation status ofRASSF1Apromoter predicts responsiveness to chemotherapy and eventual cure in hepatoblastoma patients

(2008) Shohei Honda et al.   INTERNATIONAL JOURNAL OF CANCER

Gene silencing in cancer by histone H3 lysine 27 trimethylation independent of promoter DNA methylation

(2008) Yutaka Kondo et al.   NATURE GENETICS