CBL family E3 ubiquitin ligases control JAK2 ubiquitination and stability in hematopoietic stem cells and myeloid malignancies

A Multi-Institution Phase I Trial of Ruxolitinib in Patients with Chronic Myelomonocytic Leukemia (CMML)

(2016) E. Padron et al.   CLINICAL CANCER RESEARCH

Mutation allele burden remains unchanged in chronic myelomonocytic leukaemia responding to hypomethylating agents

(2016) Jane Merlevede et al.   Nature Communications

A novel CBL-Bflox/flox mouse model allows tissue-selective fully conditional CBL/CBL-B double-knockout: CD4-Cre mediated CBL/CBL-B deletion occurs in both T-cells and hematopoietic stem cells

(2016) Benjamin Goetz et al.   Oncotarget

Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions

(2015) Eric M. Pietras et al.   Cell Stem Cell

Itch WW Domains Inhibit Its E3 Ubiquitin Ligase Activity by Blocking E2-E3 Ligase Trans-thiolation

(2015) Christopher Riling et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The genomic landscape of juvenile myelomonocytic leukemia

(2015) Elliot Stieglitz et al.   NATURE GENETICS

Dasatinib Targets B-Lineage Cells but Does Not Provide an Effective Therapy for Myeloproliferative Disease in c-Cbl RING Finger Mutant Mice

(2014) Johanna M. Duyvestyn et al.   PLoS One

GM-CSF-dependent pSTAT5 sensitivity is a feature with therapeutic potential in chronic myelomonocytic leukemia

(2013) E. Padron et al.   BLOOD

Making sense of the myelodysplastic/myeloproliferative neoplasms overlap syndromes

(2013) Ramon V. Tiu et al.   CURRENT OPINION IN HEMATOLOGY

Comparison of placebo and best available therapy for the treatment of myelofibrosis in the phase 3 COMFORT studies

(2013) R. A. Mesa et al.   HAEMATOLOGICA

CBL Linker Region and RING Finger Mutations Lead to Enhanced Granulocyte-Macrophage Colony-stimulating Factor (GM-CSF) Signaling via Elevated Levels of JAK2 and LYN

(2013) Mojib Javadi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SOCS3 binds specific receptor–JAK complexes to control cytokine signaling by direct kinase inhibition

(2013) Nadia J Kershaw et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Lnk deficiency partially mitigates hematopoietic stem cell aging

(2012) Alexey Bersenev et al.   AGING CELL

Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases

(2012) Bhopal Mohapatra et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Flt3 inhibitor AC220 is a potent therapy in a mouse model of myeloproliferative disease driven by enhanced wild-type Flt3 signaling

(2012) S. J. Taylor et al.   BLOOD

Suppression of Cytokine Signaling by SOCS3: Characterization of the Mode of Inhibition and the Basis of Its Specificity

(2012) Jeffrey J. Babon et al.   IMMUNITY

14-3-3 regulates the LNK/JAK2 pathway in mouse hematopoietic stem and progenitor cells

(2012) Jing Jiang et al.   JOURNAL OF CLINICAL INVESTIGATION

Fluorescence-Based Sensors to Monitor Localization and Functions of Linear and K63-Linked Ubiquitin Chains in Cells

(2012) Sjoerd J.L. van Wijk et al.   MOLECULAR CELL

Polyubiquitin-sensor proteins reveal localization and linkage-type dependence of cellular ubiquitin signaling

(2012) Joshua J Sims et al.   NATURE METHODS

Chronic Myelomonocytic Leukemia and Atypical Chronic Myeloid Leukemia: Novel Pathogenetic Lesions

(2012) Hideki Muramatsu et al.   SEMINARS IN ONCOLOGY

Loss of JAK2 regulation via a heterodimeric VHL-SOCS1 E3 ubiquitin ligase underlies Chuvash polycythemia

(2011) Ryan C Russell et al.   NATURE MEDICINE

Clinical Effect of Point Mutations in Myelodysplastic Syndromes

(2011) Rafael Bejar et al.   NEW ENGLAND JOURNAL OF MEDICINE

DNA Damage Stress and Inhibition of Jak2-V617F Cause Its Degradation and Synergistically Induce Apoptosis through Activation of GSK3β

(2011) Toshikage Nagao et al.   PLoS One

Novel mutations in the inhibitory adaptor protein LNK drive JAK-STAT signaling in patients with myeloproliferative neoplasms

(2010) S. T. Oh et al.   BLOOD

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling

(2010) Chozhavendan Rathinam et al.   CANCER CELL

Notch-induced Asb2 expression promotes protein ubiquitination by forming non-canonical E3 ligase complexes

(2010) Lei Nie et al.   CELL RESEARCH

A CSF-1 Receptor Phosphotyrosine 559 Signaling Pathway Regulates Receptor Ubiquitination and Tyrosine Phosphorylation

(2010) Ying Xiong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lnk constrains myeloproliferative diseases in mice

(2010) Alexey Bersenev et al.   JOURNAL OF CLINICAL INVESTIGATION

Germline CBL mutations cause developmental abnormalities and predispose to juvenile myelomonocytic leukemia

(2010) Charlotte M Niemeyer et al.   NATURE GENETICS

Rapidly fatal myeloproliferative disorders in mice with deletion of Casitas B-cell lymphoma (Cbl) and Cbl-b in hematopoietic stem cells

(2010) M. Naramura et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ubiquitination and degradation of the thrombopoietin receptor c-Mpl

(2009) S. J. Saur et al.   BLOOD

Mutations in CBL occur frequently in juvenile myelomonocytic leukemia

(2009) M. L. Loh et al.   BLOOD

Efficient protection and isolation of ubiquitylated proteins using tandem ubiquitin-binding entities

(2009) Roland Hjerpe et al.   EMBO REPORTS

Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies

(2009) Hideki Makishima et al.   JOURNAL OF CLINICAL ONCOLOGY

Linkage-Specific Avidity Defines the Lysine 63-Linked Polyubiquitin-Binding Preference of Rap80

(2009) Joshua J. Sims et al.   MOLECULAR CELL

Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms

(2009) Masashi Sanada et al.   NATURE

Single-Cell Profiling Identifies Aberrant STAT5 Activation in Myeloid Malignancies with Specific Clinical and Biologic Correlates

(2008) Nikesh Kotecha et al.   CANCER CELL

The E3 ubiquitin ligase c-Cbl restricts development and functions of hematopoietic stem cells

(2008) C. Rathinam et al.   GENES & DEVELOPMENT

Lnk controls mouse hematopoietic stem cell self-renewal and quiescence through direct interactions with JAK2

(2008) Alexey Bersenev et al.   JOURNAL OF CLINICAL INVESTIGATION

c-Cbl-Dependent Monoubiquitination and Lysosomal Degradation of gp130

(2008) Y. Tanaka et al.   MOLECULAR AND CELLULAR BIOLOGY