A conduit to metastasis: circulating tumor cell biology

Tumor cell dormancy

(2017) Roger R. Gomis et al.   Molecular Oncology

Cancer metastasis through the prism of epithelial-to-mesenchymal transition in circulating tumor cells

(2017) Douglas S. Micalizzi et al.   Molecular Oncology

Genome-wide in vivo screen identifies novel host regulators of metastatic colonization

(2017) Louise van der Weyden et al.   NATURE

Upholding a role for EMT in breast cancer metastasis

(2017) Xin Ye et al.   NATURE

Whole-body imaging of lymphovascular niches identifies pre-metastatic roles of midkine

(2017) David Olmeda et al.   NATURE

Upholding a role for EMT in pancreatic cancer metastasis

(2017) Nicole M. Aiello et al.   NATURE

Analysis of DNA methylation in single circulating tumor cells

(2017) C F Pixberg et al.   ONCOGENE

An RNA-based signature enables high specificity detection of circulating tumor cells in hepatocellular carcinoma

(2017) Mark Kalinich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Origins of lymphatic and distant metastases in human colorectal cancer

(2017) Kamila Naxerova et al.   SCIENCE

Mechanisms governing metastatic dormancy in breast cancer

(2017) Jürgen Dittmer   SEMINARS IN CANCER BIOLOGY

Expression of β-globin by cancer cells promotes cell survival during blood-borne dissemination

(2017) Yu Zheng et al.   Nature Communications

Profiling protein expression in circulating tumour cells using microfluidic western blotting

(2017) Elly Sinkala et al.   Nature Communications

Microfluidic Isolation of Circulating Tumor Cell Clusters by Size and Asymmetry

(2017) Sam H. Au et al.   Scientific Reports

Recent Advances in the Analysis of Single Cells

(2016) Lucas Armbrecht et al.   ANALYTICAL CHEMISTRY

Mass Cytometry: Single Cells, Many Features

(2016) Matthew H. Spitzer et al.   CELL

EMT: 2016

(2016) M. Angela Nieto et al.   CELL

Epithelial-Mesenchymal Transition Is Associated with a Distinct Tumor Microenvironment Including Elevation of Inflammatory Signals and Multiple Immune Checkpoints in Lung Adenocarcinoma

(2016) Y. Lou et al.   CLINICAL CANCER RESEARCH

Circulating tumor cell counts/change for outcome prediction in patients with extensive-stage small-cell lung cancer

(2016) Ying Cheng et al.   Future Oncology

Distinctive properties of metastasis-initiating cells

(2016) Toni Celià-Terrassa et al.   GENES & DEVELOPMENT

HER2 expression identifies dynamic functional states within circulating breast cancer cells

(2016) Nicole Vincent Jordan et al.   NATURE

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

Polyclonal breast cancer metastases arise from collective dissemination of keratin 14-expressing tumor cell clusters

(2016) Kevin J. Cheung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A collective route to metastasis: Seeding by tumor cell clusters

(2016) K. J. Cheung et al.   SCIENCE

Mutational analysis of single circulating tumor cells by next generation sequencing in metastatic breast cancer

(2016) Francesca De Luca et al.   Oncotarget

Genomic Instability Is Induced by Persistent Proliferation of Cells Undergoing Epithelial-to-Mesenchymal Transition

(2016) Valentine Comaills et al.   Cell Reports

Circulating Tumor Cell Count Correlates with Colorectal Neoplasm Progression and Is a Prognostic Marker for Distant Metastasis in Non-Metastatic Patients

(2016) Wen-Sy Tsai et al.   Scientific Reports

Single-Cell Codetection of Metabolic Activity, Intracellular Functional Proteins, and Genetic Mutations from Rare Circulating Tumor Cells

(2015) Yu Zhang et al.   ANALYTICAL CHEMISTRY

Surfactant functionalization induces robust, differential adhesion of tumor cells and blood cells to charged nanotube-coated biomaterials under flow

(2015) Michael J. Mitchell et al.   BIOMATERIALS

Platelets at the interface of thrombosis, inflammation, and cancer

(2015) A. T. Franco et al.   BLOOD

Tracking and Functional Characterization of Epithelial-Mesenchymal Transition and Mesenchymal Tumor Cells during Prostate Cancer Metastasis

(2015) M. Ruscetti et al.   CANCER RESEARCH

Detection of BRAF-V600E and V600K in melanoma circulating tumour cells by droplet digital PCR

(2015) Anna L. Reid et al.   CLINICAL BIOCHEMISTRY

Detection of T790M, the Acquired Resistance EGFR Mutation, by Tumor Biopsy versus Noninvasive Blood-Based Analyses

(2015) T. K. Sundaresan et al.   CLINICAL CANCER RESEARCH

VEGF suppresses T-lymphocyte infiltration in the tumor microenvironment through inhibition of NF-κB-induced endothelial activation

(2015) Hua Huang et al.   FASEB JOURNAL

Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer

(2015) Xiaofeng Zheng et al.   NATURE

Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance

(2015) Kari R. Fischer et al.   NATURE

Oxidative stress inhibits distant metastasis by human melanoma cells

(2015) Elena Piskounova et al.   NATURE

A microfluidic device for label-free, physical capture of circulating tumor cell clusters

(2015) A Fatih Sarioglu et al.   NATURE METHODS

Improved Overall Survival in Melanoma with Combined Dabrafenib and Trametinib

(2015) Caroline Robert et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rociletinib in EGFR-Mutated Non–Small-Cell Lung Cancer

(2015) Lecia V. Sequist et al.   NEW ENGLAND JOURNAL OF MEDICINE

AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer

(2015) Pasi A. Jänne et al.   NEW ENGLAND JOURNAL OF MEDICINE

Nivolumab versus Docetaxel in Advanced Squamous-Cell Non–Small-Cell Lung Cancer

(2015) Julie Brahmer et al.   NEW ENGLAND JOURNAL OF MEDICINE

RNA-Seq of single prostate CTCs implicates noncanonical Wnt signaling in antiandrogen resistance

(2015) D. T. Miyamoto et al.   SCIENCE

Improved method increases sensitivity for circulating hepatocellular carcinoma cells

(2015) Hui-Ying Liu   WORLD JOURNAL OF GASTROENTEROLOGY

Real-Time Imaging Reveals Local, Transient Vascular Permeability, and Tumor Cell Intravasation Stimulated by TIE2hi Macrophage-Derived VEGFA

(2015) A. S. Harney et al.   Cancer Discovery

Deformability of Tumor Cells versus Blood Cells

(2015) Josephine Shaw Bagnall et al.   Scientific Reports

Gene expression profiling of circulating tumor cells and peripheral blood mononuclear cells from breast cancer patients

(2015) Michal Hensler et al.   OncoImmunology

Implications of the Hybrid Epithelial/Mesenchymal Phenotype in Metastasis

(2015) Mohit Kumar Jolly   Frontiers in Oncology

Classification of Circulating Tumor Cells by Epithelial-Mesenchymal Transition Markers

(2015) Shiyang Wu et al.   PLoS One

Circulating Tumor Cell Clusters Are Oligoclonal Precursors of Breast Cancer Metastasis

(2014) Nicola Aceto et al.   CELL

Epithelial-Mesenchymal Transitioned Circulating Tumor Cells Capture for Detecting Tumor Progression

(2014) A. Satelli et al.   CLINICAL CANCER RESEARCH

TLR activation of tumor-associated macrophages from ovarian cancer patients triggers cytolytic activity of NK cells

(2014) Francesca Bellora et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Comparative analysis of innate immune system function in metastatic breast, colorectal, and prostate cancer patients with circulating tumor cells

(2014) Mark F. Santos et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Heterogeneity of PIK3CA mutational status at the single cell level in circulating tumor cells from metastatic breast cancer patients

(2014) Marta Pestrin et al.   Molecular Oncology

The E3 ligase Cbl-b and TAM receptors regulate cancer metastasis via natural killer cells

(2014) Magdalena Paolino et al.   NATURE

Convergent loss of PTEN leads to clinical resistance to a PI(3)Kα inhibitor

(2014) Dejan Juric et al.   NATURE

Tumor endothelium FasL establishes a selective immune barrier promoting tolerance in tumors

(2014) Gregory T Motz et al.   NATURE MEDICINE

Microfluidic, marker-free isolation of circulating tumor cells from blood samples

(2014) Nezihi Murat Karabacak et al.   Nature Protocols

AR-V7 and Resistance to Enzalutamide and Abiraterone in Prostate Cancer

(2014) Emmanuel S. Antonarakis et al.   NEW ENGLAND JOURNAL OF MEDICINE

Rapid Phenotypic and Genomic Change in Response to Therapeutic Pressure in Prostate Cancer Inferred by High Content Analysis of Single Circulating Tumor Cells

(2014) Angel E. Dago et al.   PLoS One

“Sentinel” Circulating Tumor Cells Allow Early Diagnosis of Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease

(2014) Marius Ilie et al.   PLoS One

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

(2014) M. Yu et al.   SCIENCE

Isolation and Molecular Characterization of Circulating Melanoma Cells

(2014) Xi Luo et al.   Cell Reports

Single-Cell RNA Sequencing Identifies Extracellular Matrix Gene Expression by Pancreatic Circulating Tumor Cells

(2014) David T. Ting et al.   Cell Reports

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

Size-Based Isolation of Circulating Tumor Cells in Lung Cancer Patients Using a Microcavity Array System

(2013) Masahito Hosokawa et al.   PLoS One

Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition

(2013) M. Yu et al.   SCIENCE

Isolation and retrieval of circulating tumor cells using centrifugal forces

(2013) Han Wei Hou et al.   Scientific Reports

Relationship Between Lymphocytopenia and Circulating Tumor Cells as Prognostic Factors for Overall Survival in Metastatic Breast Cancer

(2012) Ugo De Giorgi et al.   Clinical Breast Cancer

N-WASP-mediated invadopodium formation is involved in intravasation and lung metastasis of mammary tumors

(2012) B. Gligorijevic et al.   JOURNAL OF CELL SCIENCE

RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis

(2012) Min Yu et al.   NATURE

Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing

(2012) Marco Gerlinger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Androgen Receptor Signaling in Circulating Tumor Cells as a Marker of Hormonally Responsive Prostate Cancer

(2012) David T. Miyamoto et al.   Cancer Discovery

Direct Signaling between Platelets and Cancer Cells Induces an Epithelial-Mesenchymal-Like Transition and Promotes Metastasis

(2011) Myriam Labelle et al.   CANCER CELL

Adoptive Transfer of Autologous Natural Killer Cells Leads to High Levels of Circulating Natural Killer Cells but Does Not Mediate Tumor Regression

(2011) M. R. Parkhurst et al.   CLINICAL CANCER RESEARCH

DNA Methylation of Tumor Suppressor and Metastasis Suppressor Genes in Circulating Tumor Cells

(2011) M. Chimonidou et al.   CLINICAL CHEMISTRY

Evaluation and Prognostic Significance of Circulating Tumor Cells in Patients With Non–Small-Cell Lung Cancer

(2011) Matthew G. Krebs et al.   JOURNAL OF CLINICAL ONCOLOGY

TGF-β Signaling in Breast Cancer Cell Invasion and Bone Metastasis

(2011) Yvette Drabsch et al.   JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation

(2011) Sachie Hiratsuka et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Framework models of tumor dormancy from patient-derived observations

(2010) Christoph A Klein   CURRENT OPINION IN GENETICS & DEVELOPMENT

Selectins promote tumor metastasis

(2010) Heinz Läubli et al.   SEMINARS IN CANCER BIOLOGY

Epithelial to Mesenchymal Transition Contributes to Drug Resistance in Pancreatic Cancer

(2009) T. Arumugam et al.   CANCER RESEARCH

Heterozygous Deficiency of PHD2 Restores Tumor Oxygenation and Inhibits Metastasis via Endothelial Normalization

(2009) Massimiliano Mazzone et al.   CELL

Genes that mediate breast cancer metastasis to the brain

(2009) Paula D. Bos et al.   NATURE

Localized and reversible TGFβ signalling switches breast cancer cells from cohesive to single cell motility

(2009) Silvia Giampieri et al.   NATURE CELL BIOLOGY

Real-time imaging reveals the single steps of brain metastasis formation

(2009) Yvonne Kienast et al.   NATURE MEDICINE

Collective cell migration in morphogenesis, regeneration and cancer

(2009) Peter Friedl et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Epithelial-Mesenchymal Transition Generates Cells with Properties of Stem Cells

(2008) Sendurai A. Mani et al.   CELL

Circulating Tumor Cells Predict Survival Benefit from Treatment in Metastatic Castration-Resistant Prostate Cancer

(2008) J. S. de Bono et al.   CLINICAL CANCER RESEARCH

Relationship of Circulating Tumor Cells to Tumor Response, Progression-Free Survival, and Overall Survival in Patients With Metastatic Colorectal Cancer

(2008) Steven J. Cohen et al.   JOURNAL OF CLINICAL ONCOLOGY

Detection of Mutations inEGFRin Circulating Lung-Cancer Cells

(2008) Shyamala Maheswaran et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelin B receptor mediates the endothelial barrier to T cell homing to tumors and disables immune therapy

(2007) Ronald J Buckanovich et al.   NATURE MEDICINE