Suppression of protein tyrosine phosphatase N23 predisposes to breast tumorigenesis via activation of FYN kinase

PTP1B Deficiency Enables the Ability of a High-Fat Diet to Drive the Invasive Character of PTEN-Deficient Prostate Cancers

(2016) D. P. Labbe et al.   CANCER RESEARCH

The protein-tyrosine phosphatase DEP-1 promotes migration and phagocytic activity of microglial cells in part through negative regulation of fyn tyrosine kinase

(2016) Nadine Schneble et al.   GLIA

Haploinsufficiency of the ESCRT Component HD-PTP Predisposes to Cancer

(2016) Sanaz Manteghi et al.   Cell Reports

High-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities

(2015) Traver Hart et al.   CELL

A Novel Phosphatidic Acid-Protein-tyrosine Phosphatase D2 Axis Is Essential for ERBB2 Signaling in Mammary Epithelial Cells

(2015) Mathangi Ramesh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Striatal-enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway

(2015) Jian Xu et al.   JOURNAL OF NEUROCHEMISTRY

Gene essentiality and synthetic lethality in haploid human cells

(2015) V. A. Blomen et al.   SCIENCE

Identification and characterization of essential genes in the human genome

(2015) T. Wang et al.   SCIENCE

Interplay of Endosomal pH and Ligand Occupancy in Integrin α5β1 Ubiquitination, Endocytic Sorting, and Cell Migration

(2015) Dmitri Kharitidi et al.   Cell Reports

Human UTY(KDM6C) Is a Male-specificNϵ-Methyl Lysyl Demethylase

(2014) Louise J. Walport et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The protein tyrosine phosphatase PRL-2 interacts with the magnesium transporter CNNM3 to promote oncogenesis

(2014) S Hardy et al.   ONCOGENE

Genetic alterations of protein tyrosine phosphatases in human cancers

(2014) S Zhao et al.   ONCOGENE

Recruitment of UBPY and ESCRT Exchange Drive HD-PTP-Dependent Sorting of EGFR to the MVB

(2013) Nazim Ali et al.   CURRENT BIOLOGY

Tumor-suppressive Function of Protein-tyrosine Phosphatase Non-receptor Type 23 in Testicular Germ Cell Tumors Is Lost upon Overexpression of miR142–3p microRNA

(2013) Kiyoko Tanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification and use of biomarkers in treatment strategies for triple-negative breast cancer subtypes

(2013) Brian D Lehmann et al.   JOURNAL OF PATHOLOGY

Ptpn11 deletion in a novel progenitor causes metachondromatosis by inducing hedgehog signalling

(2013) Wentian Yang et al.   NATURE

PTPN12 promotes resistance to oxidative stress and supports tumorigenesis by regulating FOXO signaling

(2013) I S Harris et al.   ONCOGENE

Drosophila PRL-1 Is a Growth Inhibitor That Counteracts the Function of the Src Oncogene

(2013) Krystle T. Pagarigan et al.   PLoS One

Antibody Therapeutics in Cancer

(2013) M. X. Sliwkowski et al.   SCIENCE

ALIX and the multivesicular endosome: ALIX in Wonderland

(2013) Christin Bissig et al.   TRENDS IN CELL BIOLOGY

System-Wide Analysis Reveals a Complex Network of Tumor-Fibroblast Interactions Involved in Tumorigenicity

(2013) Megha Rajaram et al.   PLoS Genetics

PTP1B Is an Androgen Receptor-Regulated Phosphatase That Promotes the Progression of Prostate Cancer

(2012) L. Lessard et al.   CANCER RESEARCH

Regulation of the Src Family Kinases by Csk

(2012) Masato Okada   International Journal of Biological Sciences

Expression Profiling during Mammary Epithelial Cell Three-Dimensional Morphogenesis Identifies PTPRO as a Novel Regulator of Morphogenesis and ErbB2-Mediated Transformation

(2012) M. Yu et al.   MOLECULAR AND CELLULAR BIOLOGY

The genomic and transcriptomic architecture of 2,000 breast tumours reveals novel subgroups

(2012) Christina Curtis et al.   NATURE

Ptpn11/Shp2 Acts as a Tumor Suppressor in Hepatocellular Carcinogenesis

(2011) Emilie A. Bard-Chapeau et al.   CANCER CELL

Activation of Multiple Proto-oncogenic Tyrosine Kinases in Breast Cancer via Loss of the PTPN12 Phosphatase

(2011) Tingting Sun et al.   CELL

Identification of PTPN23 as a novel regulator of cell invasion in mammary epithelial cells from a loss-of-function screen of the 'PTP-ome'

(2011) G. Lin et al.   GENES & DEVELOPMENT

Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies

(2011) Brian D. Lehmann et al.   JOURNAL OF CLINICAL INVESTIGATION

A Raf-induced allosteric transition of KSR stimulates phosphorylation of MEK

(2011) Damian F. Brennan et al.   NATURE

The pseudokinase domain of JAK2 is a dual-specificity protein kinase that negatively regulates cytokine signaling

(2011) Daniela Ungureanu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Potential role of mesenchymal stem cells (MSCs) in the breast tumour microenvironment: stimulation of epithelial to mesenchymal transition (EMT)

(2010) F. T. Martin et al.   BREAST CANCER RESEARCH AND TREATMENT

Fyn

(2010) Yoshihito D. Saito et al.   CANCER

Tyrosine Phosphorylation Profiling Reveals the Signaling Network Characteristics of Basal Breast Cancer Cells

(2010) F. Hochgrafe et al.   CANCER RESEARCH

Advances in Targeting Src in the Treatment of Breast Cancer and Other Solid Malignancies

(2010) E. L. Mayer et al.   CLINICAL CANCER RESEARCH

Protein-tyrosine Phosphatase PTPN9 Negatively Regulates ErbB2 and Epidermal Growth Factor Receptor Signaling in Breast Cancer Cells

(2010) Taichang Yuan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ErbB3/HER3 intracellular domain is competent to bind ATP and catalyze autophosphorylation

(2010) Fumin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leukemogenic Ptpn11 causes fatal myeloproliferative disorder via cell-autonomous effects on multiple stages of hematopoiesis

(2009) G. Chan et al.   BLOOD

Association of genetic variation in mitotic kinases with breast cancer risk

(2009) Xianshu Wang et al.   BREAST CANCER RESEARCH AND TREATMENT

Fyn and Src Are Effectors of Oncogenic Epidermal Growth Factor Receptor Signaling in Glioblastoma Patients

(2009) K. V. Lu et al.   CANCER RESEARCH

Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome

(2009) Alastair J. Barr et al.   CELL

Tyrosine phosphorylation: thirty years and counting

(2009) Tony Hunter   CURRENT OPINION IN CELL BIOLOGY

Expression analysis and essential role of the putative tyrosine phosphatase His-domain-containing protein tyrosine phosphatase (HD-PTP)

(2009) Marie-Claude Gingras et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

Src kinases as therapeutic targets for cancer

(2009) Lori C. Kim et al.   Nature Reviews Clinical Oncology

HD-PTP Is a Catalytically Inactive Tyrosine Phosphatase Due to a Conserved Divergence in Its Phosphatase Domain

(2009) Marie-Claude Gingras et al.   PLoS One

Differential Matrix Rigidity Response in Breast Cancer Cell Lines Correlates with the Tissue Tropism

(2009) Ana Kostic et al.   PLoS One

FYNis overexpressed in human prostate cancer

(2008) Edwin M. Posadas et al.   BJU INTERNATIONAL

CASK Functions as a Mg2+-Independent Neurexin Kinase

(2008) Konark Mukherjee et al.   CELL

A signature predictive of disease outcome in breast carcinomas, identified by quantitative immunocytochemical assays

(2008) Colette Charpin et al.   INTERNATIONAL JOURNAL OF CANCER

Basal-Like Breast Cancer: A Critical Review

(2008) Emad A. Rakha et al.   JOURNAL OF CLINICAL ONCOLOGY

The Metastasis-Associated Gene Prl-3 Is a p53 Target Involved in Cell-Cycle Regulation

(2008) Shashwati Basak et al.   MOLECULAR CELL