Article
Biochemistry & Molecular Biology
Paula Aldaz, Amaya Fernandez-Celis, Natalia Lopez-Andres, Imanol Arozarena
Summary: Dexamethasone (DEXA) is commonly used in glioblastoma (GBM) patients to reduce brain inflammation, activating the glucocorticoid receptor (GR) which can influence the mineralocorticoid receptor (MR) signaling. MR signaling in GBM has been shown to have anti-proliferative effects and inhibit the self-renewal of GSCs, while spironolactone (SPI) may not have significant anti-neoplastic potential in GBM.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Behavioral Sciences
Claire L. Pince, Kimberly E. Whiting, Tammy Wang, Andras H. Leko, Lisa A. Farinelli, Diane Cooper, Mehdi Farokhnia, Leandro F. Vendruscolo, Lorenzo Leggio
Summary: This scoping review summarizes the role of aldosterone and mineralocorticoid receptor (MR) in addiction and the potential effects of pharmacological manipulations of MR on addiction-related outcomes. The findings suggest that dysregulations of aldosterone and MR occur in both peripheral and central systems and are influenced by drug exposure patterns and genetic factors. Antagonism of MR holds promise as a potential target for the treatment of addiction, but further research is needed.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Endocrinology & Metabolism
Rachel M. B. Bell, Elisa Villalobos, Mark Nixon, Allende Miguelez-Crespo, Lee Murphy, Angie Fawkes, Audrey Coutts, Matthew G. F. Sharp, Martha Koerner, Emma Allan, Onno C. Meijer, Rene Houtman, Alex Odermatt, Katharina R. Beck, Scott G. Denham, Patricia Lee, Natalie Z. M. Homer, Brian R. Walker, Ruth A. Morgan
Summary: Carbonyl reductase 1 regulates glucocorticoid and mineralocorticoid receptor activation in adipose tissue, influencing glucose homeostasis in lean mice.
MOLECULAR METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Manuel Morales, Pablo Martin-Vasallo, Julio Avila
Summary: Enzalutamide treatment may increase the risk of cardiovascular-related hospitalization in patients, potentially due to MR gene polymorphism, suggesting the importance of evaluating MR rs5522 polymorphism before starting AR inhibitor therapy.
Article
Biochemistry & Molecular Biology
Chiara Sabbadin, Carlo Saccardi, Alessandra Andrisani, Amerigo Vitagliano, Loris Marin, Eugenio Ragazzi, Luciana Bordin, Guido Ambrosini, Decio Armanini
Summary: Endometriosis is a chronic inflammatory disease that is associated with pelvic pain, infertility, and increased cardiovascular risk. This study aimed to evaluate the levels of aldosterone and cortisol, as well as blood pressure values, in women with endometriosis. The results showed that there was increased biological aldosterone activity and dysregulation of the hypothalamic-pituitary-adrenal axis in early stages of endometriosis. These findings suggest new therapeutic targets for aldosterone receptor blockers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Peripheral Vascular Disease
Lara Matilla, Eva Jover, Mattie Garaikoetxea, Ernesto Martin-Nunez, Vanessa Arrieta, Amaia Garcia-Pena, Adela Navarro, Amaya Fernandez-Celis, Alicia Gainza, Virginia Alvarez, Diego Alvarez de la Rosa, Rafael Sadaba, Frederic Jaisser, Natalia Lopez-Andres
Summary: There are sex differences in the pathophysiology of aortic valve (AV) calcification in patients with aortic stenosis. Aldosterone (Aldo) promotes proteoglycan synthesis in valve interstitial cells (VICs) via the mineralocorticoid receptor (MR). The MR/Aldo pathway plays a role in fibrosis in women and in early AV calcification in men.
Article
Endocrinology & Metabolism
Lisa L. Koorneef, Merel van der Meulen, Sander Kooijman, Elena Sanchez-Lopez, Jari F. Scheerstra, Maaike C. Voorhoeve, Ajith N. Nadamuni Ramesh, Patrick C. N. Rensen, Martin Giera, Jan Kroon, Onno C. Meijer
Summary: Add-on treatment with corticosterone can partially attenuate the metabolic effects of synthetic glucocorticoid dexamethasone, while exacerbating other effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Bin Zhang, Mengshi Yang, Qiongyu Yan, Xiaojian Xu, Fei Niu, Jinqian Dong, Yuan Zhuang, Shenghua Lu, Qianqian Ge, Baiyun Liu
Summary: The study found that different doses of corticosterone have dual effects on hippocampal cell survival and spatial memory in rats, with low doses improving cell survival and memory, while high doses may have the opposite effect. This suggests that endogenous glucocorticoids have neuroprotective and neurotoxic effects depending on the threshold level, and caution should be exercised with higher doses after traumatic brain injury.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Anna Gromotowicz-Poplawska, Piotr Szoka, Agnieszka Zakrzeska, Patrycjusz Kolodziejczyk, Natalia Marcinczyk, Janusz Szemraj, Piotr Tutka, Ewa Chabielska
Summary: The study found that aldosterone can enhance arterial thrombosis in rats, especially under diabetic and hyperglycemic conditions. Aldosterone shortens bleeding time, increases levels of tissue factor and plasminogen activator inhibitor in plasma, decreases levels of nitric oxide metabolites, and increases oxidative stress. Aldosterone induces a prothrombotic phenotype in endothelial cells, particularly under hyperglycemic conditions, by impacting primary hemostasis, the TF-dependent coagulation cascade, fibrinolysis, NO bioavailability, and oxidative stress balance.
Article
Cell Biology
Say Viengchareun, Eric Pussard, Mireille Castanet, Laurent M. Sachs, Thi An Vu, Pascal Boileau, Marc Lombes, Laetitia Martinerie
Summary: At birth, mammals transition from aquatic to terrestrial life, leading to significant changes in sodium and water homeostasis. The mineralocorticoid signaling pathway plays a crucial role during this critical developmental period, with aldosterone likely being one of the main hormones regulating this transition.
MOLECULAR AND CELLULAR ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Zachary M. Howard, Chetan K. Gomatam, Arden B. Piepho, Jill A. Rafael-Fortney
Summary: Duchenne muscular dystrophy (DMD) is a muscle degenerative disease caused by the loss of dystrophin protein. Current standard-of-care treatment for DMD has limited efficacy and serious side effects. Mineralocorticoid receptor antagonists (MRAs) have shown promise as a therapeutic target for DMD, as they can improve muscle function and reduce inflammation and fibrosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Endocrinology & Metabolism
Gianluigi Savarese, Felix Lindberg, Gerasimos Filippatos, Javed Butler, Stefan D. Anker
Summary: The overactivation of mineralocorticoid receptors affects multiple physiological systems, and the use of classical MR antagonists has shown improvements in heart failure. However, concerns about side effects and limited tolerability have hindered their implementation in other settings. Non-steroidal MR antagonists have shown potential benefits and better safety profiles. This review provides an overview of the impact of MR overactivation and discusses the potential of non-steroidal MR antagonists.
Review
Endocrinology & Metabolism
Morag J. Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos
Summary: Mineralocorticoid receptor (MR) antagonists, also known as aldosterone blockers, have shown clinical benefits in treating patients with heart failure, including those with reduced ejection fraction and preserved ejection fraction with reduced left ventricular filling. The MR has various physiological and pathophysiological roles in the heart, vasculature, and other tissues, which underpin the use of MR antagonists in cardiovascular disease, particularly heart failure. The development of MR antagonists has progressed from potassium-sparing diuretics to more receptor-selective options, demonstrating the evolution of treatment options for cardiovascular diseases.
Review
Endocrinology & Metabolism
Morag J. Young, Monica Kanki, Nikshay Karthigan, Penny Konstandopoulos
Summary: Mineralocorticoid receptor antagonists, also known as aldosterone blockers, have been widely recognized for their clinical benefits in treating heart failure, improving outcomes for both HFrEF and HFpEF patients. As research continues to evolve, new nonsteroidal receptor antagonists like esaxerenone and finerenone have emerged, showcasing the constantly evolving landscape of cardiovascular disease treatment.
Review
Biochemistry & Molecular Biology
Michael Crompton, Laura J. Skinner, Simon C. Satchell, Matthew J. Butler
Summary: The renin angiotensin aldosterone system plays a crucial role in blood pressure regulation. Excessive stimulation of mineralocorticoid receptors by aldosterone can lead to various pathological effects in the heart, kidney, and endothelial cells. In this article, we discussed the association between hyperaldosteronism and fibrosis, cardiac dysfunction, maladaptive hypertrophy, proteinuria, and fibrosis. We also reviewed how aldosterone exposure damages the endothelial glycocalyx and suggested that preventing glycocalyx remodeling may offer a novel strategy for limiting endothelial damage.
Article
Endocrinology & Metabolism
Jinyoung Choi, Ken-ichi T. Suzuki, Tetsushi Sakuma, Leena Shewade, Takashi Yamamoto, Daniel R. Buchholz
Article
Neurosciences
Noah T. Ashley, David W. Sams, Audrey C. Brown, Jennifer E. Dumaine
NEUROSCIENCE LETTERS
(2016)
Article
Endocrinology & Metabolism
Katelin A. Schneider, Leena H. Shewade, Nicolas Buisine, Laurent M. Sachs, Daniel R. Buchholz
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2018)
Article
Microbiology
Maureen A. Carey, Vincent Covelli, Audrey Brown, Gregory L. Medlock, Mareike Haaren, Jessica G. Cooper, Jason A. Papin, Jennifer L. Guler
Article
Endocrinology & Metabolism
Zachary R. Sterner, Leena H. Shewade, Kala M. Mertz, Savannah M. Sturgeon, Daniel R. Buchholz
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2020)
Article
Multidisciplinary Sciences
Audrey C. Brown, Christopher C. Moore, Jennifer L. Guler
SCIENTIFIC REPORTS
(2020)
Article
Genetics & Heredity
Shiwei Liu, Adam C. Huckaby, Audrey C. Brown, Christopher C. Moore, Ian Burbulis, Michael J. McConnell, Jennifer L. Guler
Summary: This study presents a single-cell sequencing pipeline for the intracellular parasite Plasmodium falciparum and provides a framework for optimizing single-cell amplification and variant analysis in challenging genomes. The work enables detection of parasite heterogeneity contributing to P. falciparum adaptation.
Article
Biochemical Research Methods
XuHai Huang, Karina Torres-Castro, Walter Varhue, Armita Salahi, Ahmed Rasin, Carlos Honrado, Audrey Brown, Jennifer Guler, Nathan S. Swami
Summary: This study introduces a novel method for cell separation using dielectrophoresis, which achieves efficient and precise separation by designing specific device geometries. Experimental validation on healthy and fixed red blood cells demonstrates the effectiveness of this method, highlighting its potential for further applications.
Article
Endocrinology & Metabolism
Leena H. Shewade, Jamee A. Schoephoerster, Matthew D. Patmann, Saurabh S. Kulkarni, Daniel R. Buchholz
Review
Parasitology
Audrey C. Brown, Jennifer L. Guler
TRENDS IN PARASITOLOGY
(2020)
Meeting Abstract
Oncology
Claire E. Repellin, Puja Patel, Yihui Shi, Helena Gong, Leena Shewade, Thomas Webb, Lidia Sambucetti, Subarna Sinha
MOLECULAR CANCER THERAPEUTICS
(2019)
Meeting Abstract
Zoology
K. A. Schneider, L. H. Shewade, D. R. Buchholz, K. Schneider
INTEGRATIVE AND COMPARATIVE BIOLOGY
(2017)
Article
Endocrinology & Metabolism
Xiaomeng Li, Charles Brighton Ndandala, Qi Zhou, Chunyan Huang, Guangli Li, Huapu Chen
Summary: This study investigated the role of estrogen receptors (ERs) in vitellogenesis (Vtgs) regulation in pompano fish. The findings suggest that E2 may regulate the expression of different subtypes of vtg through ERs, displaying a compensatory expression effect on the regulation of ers and vtgs. This provides a theoretical basis for further research on reproductive endocrinology in pompano fish.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Norio Kansaku, Takeshi Ohkubo
Summary: Endocrine changes during bird reproduction, particularly the relationship between prolactin and incubation behavior, were investigated. The study monitored the physiological status and incubation behavior of Silkie hens over 1-2 years. The results showed that most mature hens exhibited incubation behavior multiple times, and there was a noticeable increase in nest occupancy 7-10 days before incubation onset. Protein analysis revealed that secreted prolactin during the reproductive cycle contains various isoforms, suggesting post-translational modifications like glycosylation and phosphorylation.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Minghui Li, Lina Sun, Linyan Zhou, Deshou Wang
Summary: This article summarizes the importance of the Nile tilapia as an excellent animal model for studying reproductive endocrinology in fish, with a focus on the crucial role of estrogen in female development.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)
Article
Endocrinology & Metabolism
Breanna N. Harris, Carolyn M. Bauer, James A. Carr, Caitlin R. Gabor, Jennifer L. Grindstaff, Caleigh Guoynes, Jennifer J. Heppner, Cris C. Ledon-Rettig, Patricia C. Lopes, Sharon E. Lynn, Carla B. Madelaire, Lorin A. Neuman-Lee, Maria G. Palacios, Paul Soto, Jennifer Terry
Summary: The COVID-19 pandemic had a significant impact on academics, particularly on those with minoritized identities or who were early career, caregivers, or had intersecting identities. The pandemic altered the impact factors of academia, including scholarly products, and affected the way individuals could respond. It is predicted that the pandemic will have long-term impacts on the population dynamics, composition, and landscape of the academic ecosystem. The number of journal submissions decreased, especially among women authors, and the pandemic heavily impacted women authors from Asia and the Middle East.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2024)