Optimization of lentiviral vector production for scale-up in fixed-bed bioreactor

Challenges of up-scaling lentivirus production and processing

(2016) Alexandra McCarron et al.   JOURNAL OF BIOTECHNOLOGY

Development and Optimization of AAV hFIX Particles by Transient Transfection in an iCELLis®Fixed-Bed Bioreactor

(2016) Alicia D. Powers et al.   Human Gene Therapy Methods

Process Development of Adenoviral Vector Production in Fixed Bed Bioreactor: From Bench to Commercial Scale

(2015) Hanna P. Lesch et al.   HUMAN GENE THERAPY

B-cell reconstitution after lentiviral vector–mediated gene therapy in patients with Wiskott-Aldrich syndrome

(2015) Maria Carmina Castiello et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Insect cell entrapment, growth and recovering using a single-use fixed-bed bioreactor. Scaling up and recombinant protein production

(2015) D. Ventini-Monteiro et al.   JOURNAL OF BIOTECHNOLOGY

Large-scale Clinical-grade Retroviral Vector Production in a Fixed-Bed Bioreactor

(2015) Xiuyan Wang et al.   JOURNAL OF IMMUNOTHERAPY

Optimization of lentiviral vector production using polyethylenimine-mediated transfection

(2014) YONG TANG et al.   Oncology Letters

Assessment of packed bed bioreactor systems in the production of viral vaccines

(2014) Ramya Rajendran et al.   AMB Express

Influence of Mildly Acidic pH Conditions on the Production of Lentiviral and Retroviral Vectors

(2014) Nathalie Holic et al.   Human Gene Therapy Clinical Development

Gene therapy clinical trials worldwide to 2012 - an update

(2013) Samantha L. Ginn et al.   JOURNAL OF GENE MEDICINE

Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome

(2013) A. Aiuti et al.   SCIENCE

Lentiviral vector common integration sites in preclinical models and a clinical trial reflect a benign integration bias and not oncogenic selection

(2011) A. Biffi et al.   BLOOD

Retroviral vector production under serum deprivation: The role of lipids

(2009) A.F. Rodrigues et al.   BIOTECHNOLOGY AND BIOENGINEERING

Development of a scalable process for high-yield lentiviral vector production by transient transfection of HEK293 suspension cultures

(2009) Sven Ansorge et al.   JOURNAL OF GENE MEDICINE

Simplified lentivirus vector production in protein-free media using polyethylenimine-mediated transfection

(2009) Hitoshi Kuroda et al.   JOURNAL OF VIROLOGICAL METHODS

Insertional oncogenesis in 4 patients after retrovirus-mediated gene therapy of SCID-X1

(2008) Salima Hacein-Bey-Abina et al.   JOURNAL OF CLINICAL INVESTIGATION