Review
Biology
Fabrizio Ghiselli, Andre Gomes-dos-Santos, Coen M. Adema, Manuel Lopes-Lima, Joel Sharbrough, Jeffrey L. Boore
Summary: The mitochondrial genomes of mollusks exhibit significant variations in size, genome structure, gene duplications and losses. These features present a great potential for studying biological history, processes, and functions, providing valuable insights into evolution and the roles of mitochondria in organismal physiology.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Biotechnology & Applied Microbiology
Yayu Wang, Xiaoyue Zhu, Yang Gu, Zongyu Liu, Yingrui Mao, Xiaojun Liu, Zhiyi Bai, Guiling Wang, Jiale Li
Summary: The heterogeneity of mitochondrial DNA and its unique mode of transmission, called doubly uniparental inheritance (DUI), have received attention in bivalves. The mitochondrial autophagy receptor gene Hcphb2 and its associated autophagy genes may play a role in the degradation of M-type mitochondria in the freshwater mussel. Furthermore, miR-184 negatively regulates Hcphb2 and is involved in this process.
MARINE BIOTECHNOLOGY
(2023)
Article
Biology
Manisha Munasinghe, Benjamin C. Haller, Andrew G. Clark
Summary: In this study, the consequences of sexually antagonistic mitochondrial-nuclear interactions in a subdivided population were investigated using computer simulations. Disrupting these interactions resulted in less-fit males, but the strength of these interactions was not enough to drive population isolation.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2022)
Article
Zoology
Ran Xu, Mariangela Iannello, Justin C. Havird, Liliana Milani, Fabrizio Ghiselli
Summary: This study compared transcription, polymorphism, and synonymous codon usage in the mitochondrial and nuclear OXPHOS genes of the DUI species Ruditapes philippinarum. The results showed different transcription profiles between mitochondrial and nuclear OXPHOS genes, suggesting that the coordination between the two may involve post-transcriptional/translational regulation.
ZOOLOGICAL RESEARCH
(2022)
Article
Genetics & Heredity
Raquel Mejia-Trujillo, Chase H. Smith
Summary: This study presents the complete male-type mitochondrial genome of the freshwater mussel, Potamilus streckersoni, revealing the presence of 14 protein-coding genes, including a male-specific open reading frame. The study found that male-type mtDNA was more abundant than female-type mtDNA in male gonadal tissue. Novel mitogenomes were also discovered within previously described sex-specific monophyletic clades across the subfamily Ambleminae.
MITOCHONDRIAL DNA PART B-RESOURCES
(2022)
Article
Multidisciplinary Sciences
Naoki Urakawa, Satoru Nakamura, Mariko Kishimoto, Yohsuke Moriyama, Shigeyuki Kawano, Tetsuya Higashiyama, Narie Sasaki
Summary: The selective digestion of paternal/uniparental mitochondrial DNA (mtDNA) in isogamy is controlled by a Mg2+-dependent DNase, which is involved in the regulation of mitochondrial uniparental inheritance.
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Emmanouil Zacharioudakis, Bogos Agianian, Vasantha Kumar Mv, Nikolaos Biris, Thomas P. Garner, Inna Rabinovich-Nikitin, Amanda T. Ouchida, Victoria Margulets, Lars Ulrik Nordstrom, Joel S. Riley, Igor Dolgalev, Yun Chen, Andre J. H. Wittig, Ryan Pekson, Chris Mathew, Peter Wei, Aristotelis Tsirigos, Stephen W. G. Tait, Lorrie A. Kirshenbaum, Richard N. Kitsis, Evripidis Gavathiotis
Summary: Mitofusins are proteins that regulate mitochondrial fusion, a process with significant impact on cellular processes. This study identifies small molecules that can activate or inhibit Mitofusins' activity, thereby modulating mitochondrial fusion and functionality. Inhibition of mitochondrial fusion leads to certain physiological changes such as caspase-3/7 activation and DNA damage. The findings highlight the importance of Mitofusins' conformational changes and oligomerization in enabling mitochondrial fusion. The study provides insights into the function and regulation of Mitofusins and offers potential small molecules for pharmacological targeting.
NATURE COMMUNICATIONS
(2022)
Article
Biology
Melanie Tasse, Thierry Choquette, Annie Angers, Donald T. Stewart, Eric Pante, Sophie Breton
Summary: This study discovered a large insertion in the cox2 gene of the male-transmitted mtDNA in a bivalve species, suggesting its significant impact on the functionality of the gene.
Editorial Material
Genetics & Heredity
Alistair T. Pagnamenta, Wei Wei, Shamima Rahman, Patrick F. Chinnery
Summary: Evidence for biparental inheritance of mitochondrial DNA (mtDNA) has been sparse and controversial. Recent studies do not support paternal transmission of mtDNA and suggest that previous observations may be explained by technical artifacts such as the co-amplification of rare, concatenated nuclear mtDNA segments.
NATURE REVIEWS GENETICS
(2021)
Article
Biochemistry & Molecular Biology
Arunas Radzvilavicius
Summary: Selfish gene theories offer valuable insights into genetic evolution, yet can sometimes be misleading. Modern population genetic models provide a more comprehensive explanation, highlighting the impact of genetic variance on selection processes.
Article
Environmental Sciences
Rui Wang, Xuanzhao Li, Jiwei Qi
Summary: The presence of doubly uniparental inheritance (DUI) in three species of Macridiscus in Veneroida has been reported, along with the complete M-type mitogenomes. The M-type and F-type mitogenomes have similar features except for gene order. This finding supports the theory that Veneroida and Mytiloida have a more similar DUI pattern.
FRONTIERS IN MARINE SCIENCE
(2022)
Article
Biology
Cyril Degletagne, Doris Abele, Gernot Gloeckner, Benjamin Alric, Heike Gruber, Christoph Held
Summary: In the bivalve species A. islandica, a unique genetic phenomenon involving the exclusive presence of male-type mitochondria in both male and female individuals in somatic tissues has been observed. This leads to a significant decrease in respiratory capacity at the cellular and potentially whole animal levels.
COMMUNICATIONS BIOLOGY
(2021)
Article
Fisheries
Vojtech Kaspar, Martin Hubalek, Martin Psenicka, Katsutoshi Arai, John B. Taggart, Roman Franek
Summary: Methods of induction of uniparental inheritance have been developed for model organisms as well as for species of commercial interest, with cold-shock androgenesis showing promise in successfully inducing haploid progeny in common carp. Compared to other techniques, cold-shock androgenesis was found to be effective in common carp, providing a new possibility for isogenic line production.
Article
Biochemistry & Molecular Biology
Chase H. Smith, Raquel Mejia-Trujillo, Sophie Breton, Brendan J. Pinto, Mark Kirkpatrick, Justin C. Havird
Summary: Mitochondrial and nuclear genes play important roles in sex determination in DUI bivalves. The study found that M mtDNA releases sncRNA that targets a pathway related to female development and mitophagy, and is directly involved in gene silencing. Additionally, genome-wide patterns of genetic differentiation and heterozygosity do not support the presence of a nuclear sex-determining region.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Multidisciplinary Sciences
Wonyul Jang, Dmytro Puchkov, Paula Samso, YongTian Liang, Michal Nadler-Holly, Stephan J. Sigrist, Ulrich Kintscher, Fan Liu, Kamel Mamchaoui, Vincent Mouly, Volker Haucke
Summary: Cells respond to fluctuating nutrient supply by changing organelle dynamics and metabolism. This study reveals that lipid signaling on the endoplasmic reticulum can control mitochondrial morphology and function, enabling cells to adapt to changing nutrient environments.
Article
Zoology
Donald T. Stewart, Marion Sinclair-Waters, Alexandra Rice, Ryan A. Bunker, Brent M. Robicheau, Sophie Breton
CANADIAN JOURNAL OF ZOOLOGY
(2018)
Article
Evolutionary Biology
Charlotte Capt, Sebastien Renaut, Fabrizio Ghiselli, Liliana Milani, Nathan A. Johnson, Bernard E. Sietman, Donald T. Stewart, Sophie Breton
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Evolutionary Biology
Sebastien Renaut, Davide Guerra, Walter R. Hoeh, Donald T. Stewart, Arthur E. Bogan, Fabrizio Ghiselli, Liliana Milani, Marco Passamonti, Sophie Breton
GENOME BIOLOGY AND EVOLUTION
(2018)
Article
Biochemistry & Molecular Biology
Davide Guerra, Karim Bouvet, Sophie Breton
MOLECULAR PHYLOGENETICS AND EVOLUTION
(2018)
Editorial Material
Biology
Fabrizio Ghiselli, Sophie Breton, Liliana Milani
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2018)
Article
Multidisciplinary Sciences
Brent M. Robicheau, Emily E. Chase, Walter R. Hoeh, John L. Harris, Donald T. Stewart, Sophie Breton
Review
Medicine, Research & Experimental
Annie Angers, Philip Ouimet, Assia Tsyvian-Dzyabko, Tanya Nock, Sophie Breton
M S-MEDECINE SCIENCES
(2019)
Article
Veterinary Sciences
Jenna Marie Priest, Donald T. Stewart, Michael Boudreau, Jason Power, Dave Shutler
Article
Genetics & Heredity
E. E. Chase, B. M. Robicheau, W. R. Hoeh, J. L. Harris, D. T. Stewart, S. Breton
MITOCHONDRIAL DNA PART B-RESOURCES
(2019)
Article
Biology
Stefano Bettinazzi, Enrique Rodriguez, Liliana Milani, Pierre U. Blier, Sophie Breton
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2019)
Article
Genetics & Heredity
Donald T. Stewart, Brent M. Robicheau, Noor Youssef, Manuel A. Garrido-Ramos, Emily E. Chase, Sophie Breton
Summary: Studies have found additional putative sperm transmission element (STE) signatures in the large unassigned regions of various marine clams and freshwater mussels with doubly uniparental inheritance (DUI), indicating potential implications for understanding the origin of DUI in ancestral bivalve mollusks and suggesting future in vitro and in silico studies to further refine our understanding of this unusual mtDNA inheritance system.
Article
Genetics & Heredity
Andre Gomes-dos-Santos, Elsa Froufe, Rafaela Amaro, Paz Ondina, Sophie Breton, Davide Guerra, David C. Aldridge, Ivan N. Bolotov, Ilya V. Vikhrev, Han Ming Gan, Duarte Goncalves, Arthur E. Bogan, Ronaldo Sousa, Donald Stewart, Amilcar Teixeira, Simone Varandas, David Zanatta, Manuel Lopes-Lima
MITOCHONDRIAL DNA PART B-RESOURCES
(2019)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.