Article
Chemistry, Applied
Rafael Valdelvira, Guadalupe Garcia-Medina, Jesus F. Crespo, Beatriz Cabanillas
Summary: Recently introduced alimentary pasta made of chickpeas retains an important allergenic content, which is transferred to the cooking water during boiling.
Review
Gastroenterology & Hepatology
Maureen M. Leonard, Benjamin Lebwohl, Alberto Rubio-Tapia, Federico Biagi
Summary: This study provides consensus statements on the diagnosis and management of patients with suspected celiac disease but negative results from serologic tests. Recommendations include reviewing histologic findings, conducting serologic tests, analyzing patient diets, collecting medication histories, and genetic testing to aid in accurate diagnosis and management.
Article
Allergy
Christopher Warren, Dawn Lei, Scott Sicherer, Robert Schleimer, Ruchi Gupta
Summary: The prevalence of self-reported peanut allergy among US adults is 2.9%, with over 17% of cases being adult-onset. Adults with childhood-onset PA are more likely to have received a physician diagnosis, have an epinephrine prescription, and use an epinephrine autoinjector compared to those with adult-onset PA.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2021)
Review
Food Science & Technology
Ru-Xin Foong, Alexandra F. Santos
Summary: Oral tolerance is the absence of response to food allergens, and efforts have been made to induce oral tolerance for the prevention and treatment of food allergy. Early introduction of allergenic foods and allergen-specific immunotherapy have shown promising results in promoting oral tolerance.
Article
Nutrition & Dietetics
Elizabeth Yakaboski, Lacey B. Robinson, Anna Arroyo, Janice A. Espinola, Ruth J. Geller, Ashley F. Sullivan, Susan A. Rudders, Carlos A. Camargo
Summary: This study suggests that early introduction of egg and peanut is associated with decreased risk of developing food allergy. It also indicates that early introduction of peanut was uncommon before 2015.
Article
Gastroenterology & Hepatology
Mukaddes Tozlu, Brooks Cash, Mamoun Younes, Atilla Ertan
Summary: The overlap of clinical symptoms between IBD and IBS complicates the diagnosis and management of post-IBD IBS-D patients. The prevalent theories regarding the pathophysiology of this condition include alterations in mucosal inflammation, the microbiota, mucosal permeability, and gut-brain interactions. Investigation into eosinophilic colopathy and therapy focused on food-derived immune response in patients with post-IBD IBS-D is warranted.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Allergy
Connor Prosty, Marina Delli Colli, Sofianne Gabrielli, Ann E. Clarke, Judy Morris, Jocelyn Gravel, Rodrick Lim, Edmond S. Chan, Ran D. Goldman, Andrew O'Keefe, Jennifer Gerdts, Derek K. Chu, Julia Upton, Elana Hochstadter, Adam Bretholz, Christine McCusker, Xun Zhang, Jennifer L. P. Protudjer, Moshe Ben-Shoshan
Summary: This study investigates the setting, management, and severity of pediatric food-induced anaphylaxis (FIA) in Canada. Home is the most common location for FIA, while prehospital epinephrine autoinjector (EAI) use is higher in school/daycare settings. The setting is not associated with reaction severity or hospitalization.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2022)
Article
Allergy
Riccardo Asero, Renato Ariano, Arianna Aruanno, Claudio Barzaghi, Paolo Borrelli, Moira Busa, Giorgio Celi, Massimo Cinquini, Gabriele Cortellini, Francesca D'Auria, Marco De Carli, Camilla Di Paolo, Giulia Garzi, Fabio Lodi Rizzini, Monica Magnani, Giuseppina Manzotti, Alessandro Marra, Stefano Miceli Sopo, Francesco Murzilli, Eleonora Nucera, Elena Pinter, Valerio Pravettoni, Federica Rivolta, Angela Rizzi, Nicoletta Saporiti, Enrico Scala, Danilo Villalta, Mona-Rita Yacoub, Giuliana Zisa
Summary: The study found that systemic reactions induced by PR-10 and profilin are facilitated by PPI, ingestion of large amounts of unprocessed foods, and fasting. Soybean beverages represent a risk for PR-10 hypersensitive patients.
Review
Food Science & Technology
Xiaowen Pi, Yili Yang, Yuxue Sun, Xibo Wang, Yin Wan, Guiming Fu, Xin Li, Jianjun Cheng
Summary: The increasing incidence of food allergy is a global public health problem. Producing hypoallergenic foods using food irradiation is a competitive alternative, offering high nutritional value and long shelf-life.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Medicine, General & Internal
Jesus Gilberto Aramburo-Galvez, Oscar Gerardo Figueroa-Salcido, Giovanni Isai Ramirez-Torres, Eli Teran-Cabanillas, Martina Hilda Gracia-Valenzuela, Aldo Alejandro Arvizu-Flores, Cesar Antonio Sanchez-Cardenas, Jose Antonio Mora-Melgem, Luisamaria Valdez-Zavala, Feliznando Isidro Cardenas-Torres, Noe Ontiveros
Summary: This study aimed to estimate the prevalence of food allergies in a Mexican preschool population and found that a significant number of cases required emergency room visits. Proper management of food allergies and prevention of cross-contamination should be prioritized.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Nutrition & Dietetics
Fumiko Okazaki, Hiroyuki Wakiguchi, Yuno Korenaga, Kazumasa Takahashi, Hiroki Yasudo, Ken Fukuda, Mototsugu Shimokawa, Shunji Hasegawa
Summary: Little is known about the clinical features of food protein-induced enterocolitis syndrome (FPIES) in patients with Down syndrome (DS). This study found that FPIES in DS patients is associated with greater severity and earlier onset of symptoms. Cow's milk formula and wheat were the main causative foods. The surgical history of colostomy and postoperative nutrition may contribute to the onset of FPIES. Therefore, the use of amino acid-based formula should be considered for DS children undergoing gastrointestinal surgeries, and FPIES should be considered when acute gastrointestinal disease is suspected in DS children.
Article
Allergy
Christopher M. Warren, Anita Roach, Rajeshree Das, Thomas B. Casale, Brian P. Vickery, Richard L. Wasserman, Ruchi S. Gupta
Summary: The study shows that awareness of OIT is low among a nationally representative sample of FA patients and pediatric caregivers, with over 95% lacking personal experience with OIT. Furthermore, the data suggest that current OIT awareness is disproportionately elevated among wealthier, more highly educated respondents.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Article
Chemistry, Applied
Stefan Kabasser, Kunal Pratap, Sandip Kamath, Aya C. Taki, Thanh Dang, Jennifer Koplin, Kirsten Perrett, Karin Hummel, Christian Radauer, Heimo Breiteneder, Andreas L. Lopata, Merima Bublin
Summary: Macadamia nut is a popular choice for a healthy diet, but it is also a potent allergen. Research has identified four IgE-binding proteins in sera from individuals allergic to macadamia nut, with three of them successfully purified and characterized. These newly discovered allergens have the potential to improve molecular diagnostics for macadamia nut allergy.
Review
Food Science & Technology
Xiaowen Pi, Yili Yang, Yuxue Sun, Qiang Cui, Yin Wan, Guiming Fu, Hongbing Chen, Jianjun Cheng
Summary: The increasing prevalence of food allergies poses a significant challenge to global food health and safety. Fermentation has unique advantages in reducing allergenicity and may represent a new trend in preventing food-induced allergies. It is an efficient approach for reducing or eliminating food allergenicity, while improving the nutritional value and physicochemical properties of food materials. Combination of mixed strain fermentation with additional processing methods can efficiently reduce allergenicity of various foods and preserve their taste and nutritional components, which is significant for patients with allergies.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2022)
Review
Food Science & Technology
Xiaoli Zhao, Astrid Hogenkamp, Xin Li, Hongbing Chen, Johan Garssen, Leon M. J. Knippels
Summary: Food allergy is a pathological immune reaction that can be managed by strict avoidance of the offending food. Selenium supplementation may be a promising new approach to improve immune homeostasis and the quality of life for food allergic patients.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Gastroenterology & Hepatology
Pasquale Mansueto, Gabriele Spagnuolo, Silvia Calderone, Carmela Cinzia D'Agate, Salvatore Cosenza, Giuseppe Leonardi, Salvatore Camilleri, Mirco Pistone, Giovanna Seminara, Carlo Alaimo, Maurizio Soresi, Antonio Carroccio, Serena Garufi
Summary: This study retrospectively evaluated the data of 369 patients with CD from the Sicilian Network and found that non-classical CD presentation was more common, there was a diagnostic delay of approximately 9 years, most patients did not undergo multiple duodenal biopsies, and 59.9% of the patients received unrecommended CD serology assays.
DIGESTIVE AND LIVER DISEASE
(2022)
Review
Medicine, General & Internal
Fausto Fama', Alessandro Sindoni, Hui Sun, Hoon Yub Kim, Girolamo Geraci, Michele Rosario Colonna, Carmelo Mazzeo, Gabriela Brenta, Mariarosaria Galeano, Salvatore Benvenga, Gianlorenzo Dionigi
Summary: This study aimed to evaluate the occurrence of histologically verified thyroid pathologies in breast cancer survivors. The results showed that some women experienced pathological changes in the thyroid after breast cancer treatment, including both benign and malignant conditions. Therefore, breast cancer survivors should be aware of the risk of thyroid pathologies and undergo regular screening.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Surgery
Gaspare Cucinella, Giuseppe Di Buono, Girolamo Geraci, Federica Ricupati, Giuseppe Gullo, Elisa Maienza, Giorgio Romano, Giulia Bonventre, Giuseppe Amato, Salvatore Buscemi, Antonino Agrusa
Summary: Klippel-Trenaunay syndrome is a rare vascular malformation with a wide range of symptoms, including rare involvement of the uterus which can cause severe menorrhagia. Diagnosis is based on physical signs and symptoms, and CT and MRI are the preferred methods for evaluating the extent of the lesion and tissue infiltration. Treatment is generally conservative, but surgery may be considered.
FRONTIERS IN SURGERY
(2022)
Review
Nutrition & Dietetics
Pasquale Mansueto, Aurelio Seidita, Marta Chiavetta, Dario Genovese, Alessandra Giuliano, Walter Priano, Antonio Carroccio, Alessandra Casuccio, Emanuele Amodio
Summary: This narrative review analyzed the correlation between diet and clinical outcomes of familial Mediterranean fever (FMF). Conflicting results were found regarding the association between high-fat and high-salt food intake and FMF attack recurrence. Wheat was suggested to potentially play a role in FMF. A diet rich in antioxidants and anti-inflammatory supplements may partly reduce symptoms and improve the well-being of FMF patients. However, further studies are needed to clarify the impact of diet on FMF symptom triggering.
Article
Medicine, General & Internal
Aurelio Seidita, Pasquale Mansueto, Alessandra Giuliano, Marta Chiavetta, Francesca Mandreucci, Maurizio Soresi, Mattia Pistone, Stella Compagnoni, Daniele Castellucci, Gianluca Bisso, Francesco Faraci, Salvatore Maestri, Rosaria Disclafani, Anna Sapone, Alessio Fasano, Antonio Carroccio
Summary: This observational study found that Non-celiac Wheat Sensitivity (NCWS) patients who consume ancient grains may have a delayed diagnosis due to the clinical benefit (tolerability) obtained with these grains. Even after diagnosis, some patients continue to consume ancient grains and have mild or no symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Surgery
Giuseppe Di Buono, Matilde Micheli, Gaia Russo, Roberta Vella, Giuseppe Amato, Girolamo Geraci, Antonino Agrusa
Summary: Endometriosis is a common disease affecting women of fertile age, with deep infiltrating endometriosis of the rectosigmoid colon presenting symptoms mimicking intestinal obstruction or neoplasm. This case report presents a 39-year-old female patient with pelvic pain and anemia during the menstrual cycle, who was found to have ectopic endometrial tissue in the rectum and underwent a surgical procedure.
FRONTIERS IN SURGERY
(2022)
Article
Biochemistry & Molecular Biology
Lydia Giannitrapani, Luigi Mirarchi, Simona Amodeo, Anna Licata, Maurizio Soresi, Francesco Cavaleri, Salvatore Casalicchio, Gregorio Ciulla, Maria Elena Ciuppa, Melchiorre Cervello, Mario Barbagallo, Nicola Veronese
Summary: The immune response to COVID-19 is important, but some patients experience persistent symptoms that lead to a global health and economic burden. This study investigates the potential role of IL-6 levels as a marker for long COVID. The analysis of 184 patients admitted to a hospital in Italy revealed that higher IL-6 levels were associated with a doubled risk of long COVID, mobility decline, and PTSD, indicating the significance of IL-6 in disease severity, unfavorable outcomes, and long COVID development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Aurelio Seidita, Pasquale Mansueto, Alessandra Giuliano, Marta Chiavetta, Maurizio Soresi, Antonio Carroccio
Summary: Inflammatory/allergic conditions should be considered in self-reported milk intolerance patients who test negative and/or are asymptomatic at Lactose Hydrogen Breath Test. Fecal calprotectin values were analyzed in these patients and suggest the existence of an allergic/inflammatory pathogenetic mechanism in a subset of self-reported milk intolerance subjects. Fecal calprotectin results are in keeping with this hypothesis, but cannot differentiate lactose tolerant from intolerant patients.
Article
Surgery
Giuseppe Di Buono, Gaia Russo, Giuseppe Amato, Matilde Micheli, Girolamo Geraci, Antonino Agrusa
Summary: This case report describes the successful extraction of a giant gastric phytobezoar through a combined laparoscopic and endoscopic surgery. The laparoscopic approach appears to have better postoperative outcomes, but is criticized for the risk of abdominal spillage and longer operative times. In this case, a laparoscopic and endoscopic cooperative surgery was performed to overcome the limitations of a single technique.
INTERNATIONAL JOURNAL OF SURGERY CASE REPORTS
(2023)
Article
Geriatrics & Gerontology
Francesco Saverio Ragusa, Luisa Solimando, Caterina Mandala, Roberta Masnata, Gregorio Ciulla, Stefano Ciriminna, Francesco La Blasca, Pasquale Mansueto, Nicola Veronese, Mario Barbagallo
Summary: The study found a positive association between higher multidimensional prognostic index (MPI) values, indicating frailty, and the prevalence of infectious diseases, including multidrug-resistant pathogens, resulting in increased antibiotic costs.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Medicine, General & Internal
Girolamo Geraci, Gerlando Cocchiara, Manuela Palazzolo, Aurelio Cajozzo
Summary: Ultrasound-guided FNA is a useful and minimally invasive method for diagnosing anatomopathological characteristics with low risk and high accuracy. It can be used for the diagnosis of intrathoracic lesions and can be performed in one day surgery.
ACTA MEDICA MEDITERRANEA
(2022)
Article
Medicine, General & Internal
Girolamo Geraci, Gerlando Cocchiara, Manuela Palazzolo, Aurelio Cajozzo
Summary: This retrospective study evaluated the utility of US-guided percutaneous puncture (PP) in the diagnosis and therapy of malignant pleural effusion (PE). The results showed that the US-guided PP fluid examination had high diagnostic accuracy and sensitivity for malignant PE, with minimal complications.
ACTA MEDICA MEDITERRANEA
(2022)
Meeting Abstract
Gastroenterology & Hepatology
M. Pistone, A. Seidita, P. Mansueto, M. Soresi, F. La Blasca, L. Giannitrapani, A. Carroccio
DIGESTIVE AND LIVER DISEASE
(2022)
Meeting Abstract
Gastroenterology & Hepatology
A. Seidita, P. Mansueto, M. Soresi, G. Chiarello, F. La Blasca, L. Giannitrapani, A. Carroccio
DIGESTIVE AND LIVER DISEASE
(2022)
