Article
Biochemistry & Molecular Biology
Jiang-Xue Wu, Qian He, Yan Zhou, Jia-Ying Xu, Zheng Zhang, Cai-Long Chen, Yun-Hsuan Wu, Yun Chen, Li-Qiang Qin, Yun-Hong Li
Summary: This study explored a new way to control weight and improve fatty liver, namely, living in hypoxia environment and supplement with lactoferrin (Lf). Results showed that interventions combining Lf and hypoxia treatments showed better effect against obesity and NAFLD than hypoxia treatment alone. The interventions achieved these effects by restoring gut microbiota composition and bile acid profile.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Cell Biology
Alejo M. Capiglioni, Maria C. Capitani, Julieta Marrone, Raul A. Marinelli
Summary: We have demonstrated that hepatic gene transfer of human aquaporin-8 (hAQP8) improves the detoxification of ammonia to urea in normal mice and mice with impaired hepatocyte ammonia metabolism. Our findings suggest that hAQP8 gene transfer could be a potential therapeutic strategy for disorders with defective hepatic ammonia metabolism.
Article
Medicine, Research & Experimental
Lili Wang, Jiayi Yi, Xinli Guo, Xiangpeng Ren
Summary: Based on a survey of US adults, there is an association between Life's Essential 8 (LE8) and nonalcoholic fatty liver disease (NAFLD), with higher LE8 scores correlating with a lower risk of NAFLD. This association follows a nonlinear dose-response relationship, and is particularly significant among younger individuals, Asians, and those with higher education and income levels.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)
Article
Biotechnology & Applied Microbiology
Alejo M. Capiglioni, Gabriela L. Mueller, Julieta Marrone, Maria L. Alvarez, Raul A. Marinelli
Summary: The study demonstrates that adenoviral gene transfer of human AQP8 to hepatocyte mitochondria enhances ammonia conversion to urea, leading to significantly increased urea synthesis and improved ammonia detoxification in liver cells. This finding indicates the potential therapeutic implications for liver diseases with impaired ammonia detoxification.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Gastroenterology & Hepatology
Shengying Gu, Shanshan Hu, Shuowen Wang, Chendong Qi, Chenyang Shi, Guorong Fan
Summary: This meta-analysis found a positive concurrent and bidirectional relationship between NAFLD and GD, with a higher incidence in females.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Medicine, Research & Experimental
Jian Zhou, Yang Zhao, Ya-Jing Guo, Ya-Shuo Zhao, Han Liu, Jing Ren, Jie-Ru Li, En-Sheng Ji
Summary: This study established a rapid juvenile murine NASH model and found that the combination of CIH and a western-style diet can fully display key pathologic features of NASH.
Article
Physiology
Dong Wang, Dongyu Si, Gang Li, Zhimin Ding, Xiaonan Yang, Chaobing Gao
Summary: Chronic intermittent hypoxia (CIH), a characteristic of obstructive sleep apnea (OSA), is found to be associated with the development of nonalcoholic fatty liver disease (NAFLD). This study reveals a potential link between CIH-induced autophagy and the pathogenesis of OSA-associated NAFLD. The findings suggest that persistent CIH can dysregulate hepatic autophagy, leading to hepatic steatosis, ER stress, and inflammation, providing potential targets for therapeutic intervention against OSA-associated NAFLD.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Materials Science, Multidisciplinary
Lin Xu, Heting Wu, Weiqi Qian, Yang Wang, Chris R. Bowen, Zhong Lin Wang, Ya Yang
Summary: The current treatment for symptomatic gallstones involves surgical methods, but postoperative site infections are a common health risk. This study proposes a new non-invasive method using soft robots for crushing gallstones, providing insights for the advancement of future medical robots.
Article
Materials Science, Multidisciplinary
Lin Xu, Heting Wu, Weiqi Qian, Yang Wang, Chris R. Bowen, Zhong Lin Wang, Ya Yang
Summary: The current treatment for symptomatic gallstones is surgical, but postoperative site infections are a common risk. This study proposes a non-invasive lithotripsy method using ferromagnetic, spiny, flexible, and wireless medical robots to efficiently crush gallstones.
Article
Gastroenterology & Hepatology
Chenhong Lin, Huiqin He, John J. Kim, Xia Zheng, Zhihui Huang, Ning Dai
Summary: Upregulation of AQP8 and AQP3, as well as translocation of AQP8, were observed in colon tissues of patients with functional constipation. The Jun N-terminal kinase and p38 mitogen-activated protein kinase signaling pathways were found to be involved in the regulation of AQP8 in response to changes in osmotic pressure.
DIGESTIVE AND LIVER DISEASE
(2023)
Article
Multidisciplinary Sciences
Yuan-jie Liu, Jie-pin Li, Hui-ru Li, Shu-hong Zeng, Yu-gen Chen, Mei Han, Qian-wen Ye, Jin-yong Zhou, Shen-lin Liu, Xi Zou
Summary: This study identifies the role of TBC1D8 gene in colorectal cancer, potentially involving molecular mechanisms such as hypoxia and immune cell infiltration.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Christina Krueger, Anne Joerns, Jonas Kaynert, Markus Waldeck-Weiermair, Thomas Michel, Matthias Elsner, Sigurd Lenzen
Summary: Aquaporin-8 (AQP8) is a peroxiporin protein expressed in the mitochondrial and plasma membranes of pancreatic beta-cells. AQP8 knockdown cells exhibit increased sensitivity to proinflammatory cytokines, leading to enhanced oxidative stress and decreased cell viability due to decreased nitric oxide (NO center dot) generation.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Endocrinology & Metabolism
C. Mele, A. Crino, D. Fintini, S. Mai, A. Convertino, S. Bocchini, P. Di Paolo, G. Grugni, G. Aimaretti, M. Scacchi, P. Marzullo
Summary: PWS children showed lower FFM values but healthier insulin profiles and PMI values compared to matched controls. ANGPTL8 levels are directly associated with the presence and severity of NAFLD in patients with PWS.
JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
(2021)
Correction
Clinical Neurology
Su-Hyun Kim, Hyunmin Jang, Na Young Park, Yeseul Kim, So-Yeon Kim, Min Young Lee, Jae-Won Hyun, Ho Jin Kim
Summary: A study retrospectively reviewed 17 NMOSD patients who discontinued IST after a sustained remission period, finding that 82% relapsed after stopping the therapy, with 18% experiencing severe attacks. Caution is advised when discontinuing IST, especially in patients with a history of severe attacks.
NEUROLOGY-NEUROIMMUNOLOGY & NEUROINFLAMMATION
(2021)
Article
Cell Biology
Satya Srirama Karthik Divvela, Eric Bekoe Offei, Florian Suerland, David Revuelta Garcia, Julia Kwiatkowski, Ajeesh Balakrishnan-Renuka, Pauline Bohne, Marion Boing, Gabriela Morosan-Puopolo, Melanie D. Mark, Beate Brand-Saberi
Summary: This study demonstrates the significance of Atoh8 in both myogenesis and the maintenance of skeletal muscle. The results show that Atoh8 regulates myoblast proliferation and muscle fiber type through signaling pathways, playing a crucial role in muscle development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Environmental Sciences
Kentaro Tajima, Tomofumi Ishikawa, Fumiko Matsuzaki, Aoi Noda, Kei Morishita, Ryusuke Inoue, Noriyuki Iwama, Hidekazu Nishigori, Junichi Sugawara, Masatoshi Saito, Taku Obara, Nariyasu Mano
Summary: This study developed and validated claims-based algorithms to identify live birth, fetal death, and cesarean section using administrative data from a university hospital in Japan. The algorithms were able to accurately evaluate the end date of pregnancy. The findings suggest that these algorithms are useful for future studies in evaluating these outcomes.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Hideto Kawaratani, Yasuteru Kondo, Ryoji Tatsumi, Naoto Kawabe, Norikazu Tanabe, Akira Sakamaki, Kazuo Okumoto, Yoshihito Uchida, Kei Endo, Takumi Kawaguchi, Tsunekazu Oikawa, Yoji Ishizu, Shuhei Hige, Taro Takami, Shuji Terai, Yoshiyuki Ueno, Satoshi Mochida, Yasuhiro Takikawa, Takuji Torimura, Tomokazu Matsuura, Masatoshi Ishigami, Kazuhiko Koike, Hitoshi Yoshiji
Summary: This study found that long-term treatment with rifaximin is effective and safe for patients with hepatic encephalopathy. Ammonia levels significantly improved after 3 months of treatment and remained improved until 12 months. There were no serious adverse events reported, and the incidence of overt hepatic encephalopathy was low.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Eiji Hishinuma, Yoko Narita, Evelyn Marie Gutierrez Rico, Akiko Ueda, Kai Obuchi, Yoshikazu Tanaka, Sakae Saito, Shu Tadaka, Kengo Kinoshita, Masamitsu Maekawa, Nariyasu Mano, Tomoki Nakayoshi, Akifumi Oda, Noriyasu Hirasawa, Masahiro Hiratsuka
Summary: This study investigates the effects of genetic polymorphisms within the DPYS gene on the enzymatic activity of DHPase, which contributes to the degradation of 5-fluorouracil, and suggests that these polymorphisms could be used as pharmacogenomic markers for predicting severe 5-FU-related toxicity in the Japanese population.
DRUG METABOLISM AND DISPOSITION
(2023)
Review
Medicine, General & Internal
Yu Sasaki, Yasuhiko Abe, Naoko Mizumoto, Eiki Nomura, Yoshiyuki Ueno
Summary: Eosinophilic gastroenteritis (EoGE) is a rare digestive disorder characterized by eosinophilic infiltration in the stomach and intestines. The endoscopic findings of EoGE in the small intestine are not well understood, but this literature review identified common findings such as redness, villous atrophy, erosion, ulceration, edema, and stenosis. These findings contribute to the development of EoGE practice.
Article
Pharmacology & Pharmacy
Junji Furuse, Namiki Izumi, Kenta Motomura, Yoshitaka Inaba, Yoshio Katamura, Yasuteru Kondo, Kazuhisa Yabushita, Katsuaki Motoyoshi, Masatoshi Kudo
Summary: This study aimed to evaluate the real-world safety and effectiveness of Lenvatinib for unresectable hepatocellular carcinoma (uHCC) in clinical practice in Japan. Data of 703 uHCC patients were analyzed, and it was found that the treatment response rate and median overall survival of Lenvatinib were similar to or better than the results of the global Phase III REFLECT trial.
DRUGS-REAL WORLD OUTCOMES
(2023)
Article
Oncology
Masami Tsuchiya, Taku Obara, Masafumi Kikuchi, Nariyasu Mano
Summary: This study investigates the current status of end-of-life chemotherapy and targeted therapy in Japan using a large database. It found that 11.6% of deaths were prescribed anticancer drugs in their last 30 days of life. These findings will contribute to future research and strategies to improve the quality of life for advanced cancer patients.
CANCER CHEMOTHERAPY AND PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Shinpei Sugahara, Hiroaki Haga, Chisaki Ikeda, Naohiko Makino, Akiko Matsuda, Yasuharu Kakizaki, Kyoko Hoshikawa, Tomohiro Katsumi, Tetsuya Ishizawa, Toshikazu Kobayashi, Keita Maki, Fumiya Suzuki, Ryoko Murakami, Hidenori Sato, Yoshiyuki Ueno
Summary: Despite extensive study on liver regeneration, the impact of bile-derived extracellular vesicles (bile EVs) on hepatocytes remains unclear. Using a rat model of partial hepatectomy (PH), this study found that bile EVs released 12 hours after PH significantly promoted hepatocyte proliferation. Transcriptome analysis revealed an upregulation of genes promoting cell cycle progression in hepatocytes treated with PH24-EVs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Guan Chen, Zhenhua Li, Kenji Iemura, Kozo Tanaka
Summary: Chromosomal instability (CIN), characterized by chromosome missegregation and micronucleation, emerges in fibroblasts from aged mice, along with an increased rate of aneuploid cells. This CIN is associated with oxidative stress, as indicated by increased reactive oxygen species and mitochondrial functional decline. Antioxidant treatments reduce CIN by alleviating replication stress and potentially stabilizing microtubules.
JOURNAL OF CELL SCIENCE
(2023)
Article
Medicine, Research & Experimental
Shinji Ono, Jiro Ogura, Hiroki Sugiura, Minami Yamauchi, Atsushi Tanaka, Toshihiro Sato, Masamitsu Maekawa, Hiroaki Yamaguchi, Nariyasu Mano
Summary: Protein disulfide isomerase (PDI) is involved in oxidative protein folding and S-nitrosylated PDI is considered a main cause of Alzheimer's disease. The mechanisms of PDI S-nitrosylation are not yet understood. GSH depletion is a pathological feature of Alzheimer's disease, so this study investigated the effect of GSH depletion on PDI S-nitrosylation.
Article
Oncology
Takayuki Tokunaga, Masakuni Tateyama, Yasuteru Kondo, Satoshi Miuma, Shiho Miyase, Kentaro Tanaka, Satoshi Narahara, Hiroki Inada, Sotaro Kurano, Yoko Yoshimaru, Katsuya Nagaoka, Takehisa Watanabe, Hiroko Setoyama, Kotaro Fukubayashi, Motohiko Tanaka, Yasuhito Tanaka
Summary: This study aimed to evaluate the impact of therapeutic modifications of atezolizumab plus bevacizumab therapy in patients with unresectable hepatocellular carcinoma (uHCC). Patients with therapeutic modifications other than discontinuation of both drugs had favorable overall survival and time to progression, while those with discontinuation of both drugs had unfavorable outcomes. Modified liver function and immune-related adverse events increased the risk of discontinuation without other therapeutic modifications. Avoiding discontinuation without other therapeutic modifications may be the optimal management for uHCC.
Article
Multidisciplinary Sciences
Tensei Hirasawa, Masafumi Kikuchi, Shinya Takasaki, Masaki Kumondai, Yu Sato, Toshihiro Sato, Eishi Imoto, Yoshihiro Hayakawa, Masamitsu Maekawa, Nariyasu Mano
Summary: A simultaneous quantitative method for 20 oral molecular-targeted anticancer drugs and the active metabolite of sunitinib was developed, incorporating four ion abundance adjustment techniques. The method demonstrated reproducibility and usefulness in clinical practice. It is expected to contribute to the promotion of personalized medicine.
Article
Oncology
Masatoshi Kudo, Kazuomi Ueshima, Issei Saeki, Toru Ishikawa, Yoshitaka Inaba, Naoki Morimoto, Hiroshi Aikata, Nobukazu Tanabe, Yoshiyuki Wada, Yasuteru Kondo, Masahiro Tsuda, Kazuhiko Nakao, Takanori Ito, Tetsuya Hosaka, Yusuke Kawamura, Teiji Kuzuya, Shunsuke Nojiri, Chikara Ogawa, Hironori Koga, Keisuke Hino, Masafumi Ikeda, Michihisa Moriguchi, Takashi Hisai, Kenichi Yoshimura, Junji Furuse, Yasuaki Arai
Summary: The TACTICS-L trial investigated the efficacy and safety of TACE plus lenvatinib in patients with unresectable intermediate-stage HCC. The results showed that LEN-TACE has significant anti-tumor activity and an acceptable safety profile.
Article
Medicine, General & Internal
Masaki Kumondai, Masafumi Kikuchi, Atsushi Mizuguchi, Nagomi Hayashi, Masahiro Ui, Takashi Hirama, Yoshinori Okada, Yu Sato, Toshihiro Sato, Masamitsu Maekawa, Nariyasu Mano
Summary: Patients with lymphangioleiomyomatosis (LAM) and lung transplantations require multiple drugs for long-term immunosuppression and infection prevention. However, managing polypharmacy is critical due to drug-drug interactions caused by factors like drug-metabolizing enzymes. This case study highlights the importance of therapeutic drug monitoring (TDM) and personalized medicine approaches in managing drug concentrations and minimizing adverse events.
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Masaki Kumondai, Masamitsu Maekawa, Eiji Hishinuma, Yu Sato, Toshihiro Sato, Masafumi Kikuchi, Masahiro Hiratsuka, Nariyasu Mano
Summary: A LC-MS/MS method was developed and validated to measure levels of predictive biomarkers related to CYP3A4 activity. This method can be used to predict individual CYP3A4 activity.
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2023)
Article
Biochemistry & Molecular Biology
Keitaro Miyoshi, Eiji Hishinuma, Naomi Matsukawa, Yoshitaka Shirasago, Masahiro Watanabe, Toshihiro Sato, Yu Sato, Masaki Kumondai, Masafumi Kikuchi, Seizo Koshiba, Masayoshi Fukasawa, Masamitsu Maekawa, Nariyasu Mano
Summary: This study aimed to investigate proteomic alterations in Niemann-Pick disease type C (NPC) by performing a global proteomic analysis on NPC model cells. The results showed more than 300 differentially expressed proteins in the NPC model cells, with 35 proteins shared between the two models. Bioinformatics analysis revealed the involvement of pathways such as ferroptosis and mitophagy in NPC.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)