Journal
FUTURE MEDICINAL CHEMISTRY
Volume 9, Issue 13, Pages 1539-1555Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0062
Keywords
cancer; cell migration; eIF4E; hybrid drugs; kinase inhibitors; MNK1/2; mTOR; resistance; signaling; translation
Categories
Funding
- School of Life Sciences, University of Sussex
- Biotechnology and Biological Sciences Research Council [BB/L018209/1]
- Biotechnology and Biological Sciences Research Council [BB/L018209/1] Funding Source: researchfish
- BBSRC [BB/L018209/1] Funding Source: UKRI
Ask authors/readers for more resources
Targeting the translational machinery has emerged as a promising therapeutic option for cancer treatment. Cancer cells require elevated protein synthesis and exhibit augmented activity to meet the increased metabolic demand. Eukaryotic translation initiation factor 4E is necessary for mRNA translation, its availability and phosphorylation are regulated by the PI3K/AKT/mTOR and MNK1/2 pathways. The phosphorylated form of eIF4E drives the expression of oncogenic proteins including those involved in metastasis. In this article, we will review the role of eIF4E in cancer, its regulation and discuss the benefit of dual inhibition of upstream pathways. The discernible interplay between the MNK and mTOR signaling pathways provides a novel therapeutic opportunity to target aggressive migratory cancers through the development of hybrid molecules.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available