Can small molecule inhibitors of glutaminyl cyclase be used as a therapeutic for Alzheimer's disease?

Synthesis and Evaluation of Diphenyl Conjugated Imidazole Derivatives as Potential Glutaminyl Cyclase Inhibitors for Treatment of Alzheimer’s Disease

(2017) Manman Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Role of inflammatory molecules in the Alzheimer's disease progression and diagnosis

(2017) Eva Bagyinszky et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Role of chemokine CCL2 and its receptor CCR2 in neurodegenerative diseases

(2013) Shambhunath Bose et al.   ARCHIVES OF PHARMACAL RESEARCH

Structure–activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

(2013) Phuong-Thao Tran et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–Activity Relationships of Benzimidazole-Based Glutaminyl Cyclase Inhibitors Featuring a Heteroaryl Scaffold

(2013) Daniel Ramsbeck et al.   JOURNAL OF MEDICINAL CHEMISTRY

Prion-like behaviour and tau-dependent cytotoxicity of pyroglutamylated amyloid-β

(2012) Justin M. Nussbaum et al.   NATURE

CCL2 affects β-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease

(2012) Tomomi Kiyota et al.   NEUROBIOLOGY OF AGING

Inhibition of glutaminyl cyclase attenuates cell migration modulated by monocyte chemoattractant proteins

(2011) Yi-Ling Chen et al.   BIOCHEMICAL JOURNAL

The isoenzyme of glutaminyl cyclase is an important regulator of monocyte infiltration under inflammatory conditions

(2011) Holger Cynis et al.   EMBO Molecular Medicine

Pyroglutamate-Aβ: Role in the natural history of Alzheimer's disease

(2010) Adam P. Gunn et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Pyroglutamate Formation Influences Solubility and Amyloidogenicity of Amyloid Peptides

(2009) Dagmar Schlenzig et al.   BIOCHEMISTRY

Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement

(2009) Mirko Buchholz et al.   JOURNAL OF MEDICINAL CHEMISTRY