Journal
FUTURE MEDICINAL CHEMISTRY
Volume 9, Issue 13, Pages 1483-1493Publisher
FUTURE SCI LTD
DOI: 10.4155/fmc-2017-0054
Keywords
lipid-metabolizing enzymes; lipid profile; radiation; thymoquinone analogs
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Aim: Thymoquinone (TQ), has been reported to possess strong antihyperlipidemic properties. However, a variety of serious side effects has been reported for TQ. The present study aimed to evaluate the potential antihyperlipidemic activity of newly synthesized TQ analogs. Methods & results: first, novel TQ derivatives were studied against radiation-induced dyslipidemia in male rats. Second, the most promising sulfur derivatives (4-7), were further tested to elucidate their possible mechanism(s) of actions. Results showed that they possess Hydroxymethyl Glutaryl-Co A reductase inhibitory activity, as well as stimulatory effects on the activities of each of plasma Lecithin-Cholesterol Acyltransferase and lipoprotein lipase enzymes. Conclusion: TQ derivatives (4-7), could be considered as promising agents in pathologies implicating impaired lipid metabolism, preclinical evaluation is warranted. [GRAPHICS] .
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