Article
Neurosciences
Alexander Steinke, Bruno Kopp, Florian Lange
Summary: The study reported the split-half reliability estimates for a self-administered computerized variant of the WCST among young volunteers, showing sufficient reliability for the test. This paves the way for advanced digital assessment of executive functions, while also discussing the potential effects of test formats, administration variants, and sample characteristics on reliability.
Article
Anatomy & Morphology
Sara Seoane, Cristian Modrono, Jose Luis Gonzalez-Mora, Niels Janssen
Summary: By analyzing a high spatial resolution 7T rsfMRI dataset, we found the associations between the medial temporal lobe (MTL) and different resting-state networks. Specifically, different sub-regions of the MTL were associated with different resting-state networks such as the default mode, visual, and dorsal attention networks. These findings provide new insights into the role of the MTL in resting-state networks.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Behavioral Sciences
Allison Whitten, Monica L. Jacobs, Dario J. Englot, Baxter P. Rogers, Kaela K. Levine, Hernan F. J. Gonzalez, Victoria L. Morgan
Summary: This study used resting-state functional connectivity measures to assess hippocampal network patterns and their relation to language abilities in patients with right TLE, left TLE, and healthy controls, finding significant impact on hippocampal-temporo-parietal networks relevant to language processing in TLE patients.
EPILEPSY & BEHAVIOR
(2021)
Article
Engineering, Electrical & Electronic
Yi-Hua Huang, Chung-Ming Chen, Yi-Min Wang, Chia-Wei Sun
Summary: This study investigated age-related changes in prefrontal cortex hemodynamics using NIRS, finding a slower activation pattern in oxyhemoglobin concentrations in the elderly group compared to the young group. Quantified results revealed time-varying trends in hemodynamic responses, suggesting that age-related decline in hemodynamic responses may contribute to poorer performance during cognitive tasks.
IEEE JOURNAL OF SELECTED TOPICS IN QUANTUM ELECTRONICS
(2021)
Article
Clinical Neurology
Wei Li, Yuchao Jiang, Yingjie Qin, Xiuli Li, Du Lei, Heng Zhang, Ding Lei, Dezhong Yao, Cheng Luo, Qiyong Gong, Dong Zhou, Dongmei An
Summary: This study explored the resting state networks (RSNs) alterations in patients with unilateral mesial temporal lobe epilepsy (mTLE) before and after surgery. The results showed that before surgery, there was decreased functional connectivity in the visual network and basal ganglia network, while after surgery, the basal ganglia network further decreased but the sensorimotor network and dorsal attention network increased. Successful surgery may lead to RSNs reorganization.
Article
Psychology, Mathematical
Stephanie Miles, Caitlin A. Howlett, Carolyn Berryman, Maja Nedeljkovic, G. Lorimer Moseley, Andrea Phillipou
Summary: This critical review examines the changes in the WCST, differences in existing scoring methods, key terminology and its relation to cognitive flexibility assessment, and issues with the use of WCST in the literature. It particularly focuses on the confusion between 'perseverative responses' and 'perseverative errors' and the inconsistencies in scoring these variables, providing recommendations for future research and clinical practice using the WCST.
BEHAVIOR RESEARCH METHODS
(2021)
Article
Neuroimaging
Xuan Li, Yuchao Jiang, Wei Li, Yingjie Qin, Zhiliang Li, Yan Chen, Xin Tong, Fenglai Xiao, Xiaojun Zuo, Qiyong Gong, Dong Zhou, Dezhong Yao, Dongmei An, Cheng Luo
Summary: The study revealed decreased functional connectivity in white matter networks among unilateral temporal lobe epilepsy patients, especially dysfunction between cerebellar white matter and cerebral cortex, as well as reduced connectivity with ipsilateral hippocampus, suggesting insufficient functional integration in unilateral TLE. Moreover, right TLE showed more severe abnormalities in white matter functional connectivity compared to left TLE.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Behavioral Sciences
Gian Marco Duma, Alberto Danieli, Marcelo G. Mattar, Martina Baggio, Airis Vettorel, Paolo Bonanni, Giovanni Mento
Summary: This study investigated the differences in dynamic network reconfiguration between patients with temporal lobe epilepsy (TLE) and a healthy control group. The findings revealed significant differences in flexibility and integration between the two groups. Patients with TLE showed lower flexibility in brain areas related to cognitive control and attention, as well as excessive inter-network communication. Moreover, the study found correlations between network integration and reduced cognitive performance in visual attention, executive functions, and long-term memory.
Article
Clinical Neurology
Junpeng Zhang, Jingwen Feng, Yifan Zhang, Site Mo, Jingjing Dong, Haitao Zhu, Ling Zhang, Ting Wu, Yuan Cui, Duo Chen
Summary: This study evaluated the relationship between network metrics of 68 brain regions and the duration of temporal lobe epilepsy (TLE) in 53 patients. Different metrics showed significant positive or negative correlations with TLE duration in different frequency bands and brain regions. Changes in network metrics for specific brain regions occurred as the duration of TLE increased, suggesting the importance of further research in studying the pathogenesis and clinical treatment of long-term TLE.
Article
Neurosciences
Lucas E. Sainburg, Aubrey A. Little, Graham W. Johnson, Andrew P. Janson, Kaela K. Levine, Hernan F. J. Gonzalez, Baxter P. Rogers, Catie Chang, Dario J. Englot, Victoria L. Morgan
Summary: This study investigates the fMRI signal alterations in patients with mesial temporal lobe epilepsy (mTLE) and provides insights into the relationship between these alterations and the severity of the disease. It also reveals the potential spread of epileptic fMRI activity across networks and the distinct properties of fMRI activity in the default mode network of mTLE patients.
Article
Multidisciplinary Sciences
Katrin M. Beckmann, Adriano Wang-Leandro, Henning Richter, Rima N. Bektas, Frank Steffen, Matthias Dennler, Ines Carrera, Sven Haller
Summary: By comparing the large-scale resting state networks of epileptic dogs and healthy control dogs, the study found significantly increased functional connectivity in the anterior default mode network of dogs with idiopathic epilepsy. These group-level differences could serve as a foundation for more advanced resting state network analysis in epileptic dogs.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Alireza Mansouri, Jurgen Germann, Alexandre Boutet, Gavin J. B. Elias, Brij Karmur, Clemens Neudorfer, Aaron Loh, Mary Pat McAndrews, George M. Ibrahim, Andres M. Lozano, Taufik A. Valiante
Summary: This study revealed a significant correlation between disease duration and global cortical thinning in patients with mesial temporal lobe epilepsy, with a greater rate of cortical volume loss in subjects with a right seizure focus. Sclerosis in the posterior hippocampus was associated with greater seizure severity, while the right hippocampus demonstrated greater brain-wide connectivity compared to the left side.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Bruno Kopp, Bilal Al-Hafez, Alexander Steinke
Summary: Wisconsin card-sorting tasks provide unique opportunities for studying cognitive flexibility and its limitations. We explored error-suppression effects (ESE) across three studies, and found that ESE are not only a highly replicable phenomenon, but also provide an opportunity to study cognitive mechanisms of goal-directed instrumental control.
Review
Behavioral Sciences
Victoria Ives-Deliperi, James T. Butler
Summary: Temporal lobe epilepsy is the most common form of focal epilepsy, with cognitive dysfunction impacting significantly on quality of life. Studies on aberrant resting-state functional connectivity show associations with memory performance, with increased and decreased connectivity in different brain regions compensating for memory deficits in left and right TLE respectively. Working memory dysfunction, executive dysfunction, and language dysfunction are also related to specific patterns of reduced RSFC in different brain networks. Further research with large patient samples is needed to confirm these findings and control for various confounding factors.
EPILEPSY & BEHAVIOR
(2021)
Article
Clinical Neurology
Marinho A. Lopes, Dominik Krzeminski, Khalid Hamandi, Krish D. Singh, Naoki Masuda, John R. Terry, Jiaxiang Zhang
Summary: The study investigated the applicability of the BNI framework to resting-state MEG in patients with JME, finding that patients with JME had a higher propensity to generate seizures compared to healthy controls. The BNI framework was effective in differentiating between epilepsy patients and healthy controls.
CLINICAL NEUROPHYSIOLOGY
(2021)