Article
Multidisciplinary Sciences
Kayo Machihara, Shoma Oki, Yuka Maejima, Sou Kageyama, Ayumu Onda, Yurino Koseki, Yasuyuki Imai, Takushi Namba
Summary: Spirulina polysaccharide complex (SPC) restores mitochondrial function and collagen production by scavenging superoxide via upregulation of superoxide dismutase 2 (SOD2) in aging fibroblasts. SPC also stimulates endoplasmic reticulum (ER) protein folding by upregulating ER chaperones expression. Therefore, SPC is proposed as an antiaging material that rejuvenates aging fibroblasts by increasing their antioxidant potential via upregulation of SOD2.
Editorial Material
Biochemistry & Molecular Biology
Anton Kasatkin, Aleksandr Urakov
Summary: Hydrogen peroxide is produced by human cells, and cellular enzymes determine its interaction with cells. Catalase is the main enzyme that decomposes hydrogen peroxide into water and oxygen. The study shows that high doses of hydrogen peroxide can increase the temperature of red blood cells.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Engineering, Environmental
Xiangxiang Li, Shanshan Chu, Zhaosheng Song, Falin He, Zhihan Cui, Rutao Liu
Summary: This study focused on the size-dependent cellular and molecular toxicity of ultrafine carbon black (UFCB), showing that UFCB13 nm induced higher levels of ROS and lipid peroxidation, leading to a significant decrease in cell viability compared to UFCB50 nm and UFCB95 nm.
JOURNAL OF HAZARDOUS MATERIALS
(2022)
Review
Biochemistry & Molecular Biology
Caroline Lelarge-Trouverie, Mathias Cohen, Lug Tremulot, Frank Van Breusegem, Amna Mhamdi, Graham Noctor
Summary: Through the study of the cat2 mutant in Arabidopsis, which lacks the major leaf isoform of catalase, we are able to investigate the potential impact of intracellular H2O2 on plant function. Our analysis focused on the salicylic acid and jasmonic acid pathways reveals metabolic signatures associated with oxidative stress-induced signaling via these defense hormones. We also identify specific enzymes and genes involved in the glucosylation of SA and the production of dihydroxybenzoic acid glycosides.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Article
Environmental Sciences
Yiyuan Ye, Bingyan Liu, Zijian Wang, Ling Liu, Qiu Zhang, Qingzhu Zhang, Wei Jiang
Summary: This study compared the toxic effects of OBS and PFOS on human hepatoma cells. OBS showed higher cytotoxicity than PFOS, inducing oxidative stress and necroptosis by downregulating catalase (CAT) levels. The findings are important for evaluating the safety of OBS as a substitute for PFOS.
SCIENCE OF THE TOTAL ENVIRONMENT
(2024)
Article
Biochemistry & Molecular Biology
Amal F. Dawood, Norah M. Alzamil, Peter W. Hewett, Maha A. Momenah, Mohammad Dallak, Samaa S. Kamar, Dina H. Abdel Kader, Hanaa Yassin, Mohamed A. Haidara, Amro Maarouf, Bahjat Al-Ani
Summary: In this study, it was found that diabetes-induced cardiac injuries in rats were associated with dysregulation of desmin and sarcomeres, as well as the iNOS/mTOR/TIMP-1/collagen axis of fibrosis. Metformin showed beneficial effects on these cardiac injuries.
Article
Oncology
Alvan Amos, Ning Jiang, Dan Zong, Jiajia Gu, Jiawei Zhou, Li Yin, Xia He, Yong Xu, Lirong Wu
Summary: This study aimed to increase the sensitivity of nasopharyngeal carcinoma cells to ionizing radiation by enhancing oxidative stress and ferroptosis through disrupting the mitochondrial anti-oxidant enzyme system. The results showed that SOD2 inhibition induced oxidative stress and ferroptosis, leading to increased sensitivity of nasopharyngeal carcinoma cells to ionizing radiation, and this effect was dependent on the activity of DHODH.
Article
Food Science & Technology
Noriyoshi Ogino, Kenjiro Nagaoka, Kotomi Tomizuka, Yuki Matsuura-Harada, Masamitsu Eitoku, Narufumi Suganuma, Keiki Ogino
Summary: Acatalasemia patients are vulnerable to exogenous oxidative stress, and in an acetaminophen-induced hepatotoxicity model, acatalasemic mice showed a prolonged oxidative stress response compared to wild-type mice.
FOOD AND CHEMICAL TOXICOLOGY
(2021)
Article
Chemistry, Medicinal
Su Ni, Ning Yi, Hang Yuan, Dong Li, Xu Chen, Chao Zhuang
Summary: This study found that angelica sinensis polysaccharide (ASP) improves mitochondrial metabolism in osteoarthritis (OA) chondrocytes by activating PPAR gamma/SOD2/ROS pathways, thereby alleviating the progression of OA.
PHYTOTHERAPY RESEARCH
(2023)
Article
Cell Biology
Konstantinos Tsesmelis, Gandhari Maity-Kumar, Dana Croner, Jasmin Sprissler, Miltiadis Tsesmelis, Tabea Hein, Bernd Baumann, Thomas Wirth
Summary: Aging of the central nervous system (CNS) leads to motoric and cognitive decline and increases the probability for neurodegenerative disease development. Astrocytes fulfill central homeostatic functions in the CNS including regulation of immune responses and metabolic support of neurons and oligodendrocytes. Our study identifies maintenance of ROS homeostasis in astrocytes as a critical prerequisite for physiological CNS aging.
Article
Cell & Tissue Engineering
Nadia Y. A. Alaidaroos, Amr Alraies, Rachel J. Waddington, Alastair J. Sloan, Ryan Moseley
Summary: There are significant differences in the susceptibilities of DPSC sub-populations to oxidative damage and premature senescence, contributed to by differential SOD2 and GSTZ1 profiles which maintain senescence-resistance/stemness properties in high proliferative DPSCs. Identification of superior antioxidant properties in high proliferative DPSCs enhances our understanding of DPSC biology and senescence, which may be exploited for selective sub-population screening/isolation from dental pulp tissues for regenerative medicine-based applications.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Andrej Poljovka, Milos Musil, David Bednar, Katarina Chovanova, Vladena Bauerova-Hlinkova, Jana Bellova, Lenka Kohutova, Peter Barath, Marcel Zamocky
Summary: The study found that the catalase-peroxidases from thermophilic and mesophilic fungi have similar active center structures and peroxidase activity, while the thermophilic variant CthedisKatG showed enhanced manganese peroxidase activity at higher temperatures. Two constructed mutations completely abolished catalatic activity and altered the peroxidase activity, suggesting the potential biotech applications of bifunctional heme enzymes with variable reactivity.
Article
Oncology
Masakatsu Paku, Naotsugu Haraguchi, Mitsunobu Takeda, Shiki Fujino, Takayuki Ogino, Hidekazu Takahashi, Norikatsu Miyoshi, Mamoru Uemura, Tunekazu Mizushima, Hirofumi Yamamoto, Yuichiro Doki, Hidetoshi Eguchi
Summary: The study revealed the crucial role of SIRT3 in oxidative stress resistance and chemoresistance in CRC cells, regulating SOD2 and PGC-1 alpha. High SIRT3 protein levels were significantly associated with reduced cancer-specific survival in patients with CRC.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Andreas Brodehl, Brenda Gerull
Summary: Restrictive cardiomyopathy is a rare cardiac disease with poor clinical prognosis, and there is still limited understanding of its genetic forms and molecular mechanisms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Cell Biology
Yue Zhang, Xiaozhi Bai, Kuo Shen, Liang Luo, Ming Zhao, Chaolei Xu, Yanhui Jia, Dan Xiao, Yan Li, Xiaowen Gao, Chenyang Tian, Yunchuan Wang, Dahai Hu
Summary: This study found that ADSC-exos could improve diabetic wounds by reducing oxidative stress and inflammation, promoting angiogenesis, and enhancing mitochondrial function. The effects were partly dependent on the regulation of SIRT3/SOD2.
Article
Cardiac & Cardiovascular Systems
Dominique Hansen, Ana Abreu, Marco Ambrosetti, Veronique Cornelissen, Andreas Gevaert, Hareld Kemps, Jari A. Laukkanen, Roberto Pedretti, Maria Simonenko, Matthias Wilhelm, Constantinos H. Davos, Wolfram Doehner, Marie-Christine Iliou, Nicolle Krankel, Heinz Voller, Massimo Piepoli
Summary: The proper determination of exercise intensity is crucial for the rehabilitation of patients with cardiovascular disease, as it affects the effectiveness and safety of exercise training. Various organizations have published position statements on aerobic exercise intensity assessment and prescription in cardiovascular rehabilitation. Subsequent research has highlighted controversies and refinements in commonly applied concepts related to exercise intensity determination in cardiovascular rehabilitation.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Stamatiki Katraki-Pavlou, Pinelopi Kastana, Dimitris Bousis, Despoina Ntenekou, Aimilia Varela, Constantinos H. Davos, Sophia Nikou, Eleni Papadaki, Grigorios Tsigkas, Emmanouil Athanasiadis, Gonzalo Herradon, Constantinos M. Mikelis, Dimitris Beis, Evangelia Papadimitriou
Summary: Protein tyrosine phosphatase receptor-zeta 1 (PTPRZ1) is expressed in fetal but not adult heart and seems to affect heart development. In both mouse and zebrafish animal models, loss of PTPRZ1 results in dilated left ventricle cavity, decreased ejection fraction, and fraction shortening, with no signs of cardiac hypertrophy. PTPRZ1 also seems to be involved in atrioventricular canal specification, outflow tract morphogenesis, and heart angiogenesis. These results suggest that PTPRZ1 plays a role in heart development and support the hypothesis that it may be involved in congenital cardiac pathologies.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Eleni Dede, Dimitrios Liapis, Constantinos Davos, Michalis Katsimpoulas, Aimilia Varela, Ioannis Mpotis, Nikolaos Kostomitsopoulos, Nikolaos P. E. Kadoglou
Summary: The study revealed that systemic exercise training can beneficially alter ECM proteins and cardiac function in mice with diabetic cardiomyopathy. ET reduced cardiac collagen and MMP-9 levels, increased TIMP-1 levels, and improved left ventricle function, indicating a therapeutic effect on diabetic cardiomyopathy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Review
Cardiac & Cardiovascular Systems
Iain T. Parsons, Edward D. Nicol, David Holdsworth, Norbert Guettler, Rienk Rienks, Constantinos H. Davos, Martin Halle, Gianfranco Parati
Summary: Occupational cardiology aims to combine traditional cardiology with prevention and risk management for specific employment settings, focusing on high-risk occupations. Currently, there is a lack of consensus and contemporary evidence in this field, requiring further research.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fani Vlachou, Aimilia Varela, Konstantina Stathopoulou, Konstantinos Ntatsoulis, Evgenia Synolaki, Harris Pratsinis, Dimitris Kletsas, Paschalis Sideras, Constantinos H. Davos, Yassemi Capetanaki, Stelios Psarras
Summary: Galectin-3 plays a role in promoting cardiac adverse remodeling, inflammation, and failure by affecting functions of cardiac fibroblasts and macrophages. This study suggests that Galectin-3 is a valid intervention target for treating heart failure and associated comorbidities.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Rienk Rienks, David Holdsworth, Constantinos H. Davos, Martin Halle, Alexander Bennett, Gianfranco Parati, Norbert Guettler, Edward D. Nicol
Summary: This article provides an overview of the recommendations from the Aviation and Occupational Cardiology Task Force on returning individuals to high-hazard occupations after COVID-19 infection. The recommendations include screening and investigative processes to identify individuals with underlying cardiopulmonary disease and provide a pragmatic approach to assess employee health prior to a return to work.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Frank L. J. Visseren, Francois Mach, Yvo M. Smulders, David Carballo, Konstantinos C. Koskinas, Maria Back, Athanase Benetos, Alessandro Biffi, Jose Manuel Boavida, Davide Capodanno, Bernard Cosyns, Carolyn Crawford, Constantinos H. Davos, Ileana Desormais, Emanuele Di Angelantonio, Oscar H. Franco, Sigrun Halvorsen, F. D. Richard Hobbs, Monika Hollander, Ewa A. Jankowska, Matthias Michal, Simona Sacco, Naveed Sattar, Lale Tokgozoglu, Serena Tonstad, Konstantinos P. Tsioufis, Ineke van Dis, Isabelle C. van Gelder, Christoph Wanner, Bryan Williams
REVISTA ESPANOLA DE CARDIOLOGIA
(2022)
Article
Medicine, General & Internal
Varsamo Antoniou, Andrew Xanthopoulos, Gregory Giamouzis, Constantinos Davos, Ladislav Batalik, Vasileios Stavrou, Konstantinos Gourgoulianis, Eleni Kapreli, John Skoularigis, Garyfallia Pepera
Summary: This study aims to investigate the efficacy, efficiency, safety, and cost-effectiveness of a telerehabilitation program based on objective exercise telemonitoring and evaluation of cardiorespiratory fitness. A supervised, parallel-group, single-blind randomized controlled trial will be conducted with 124 patients with coronary disease. The primary outcomes are cardiorespiratory fitness, and secondary outcomes include physical activity, safety, quality of life, training adherence, etc.
Editorial Material
Cardiac & Cardiovascular Systems
Benjamin D. Levine, Edward D. Nicol, Constantinos H. Davos
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Review
Medicine, General & Internal
Varsamo Antoniou, Constantinos H. Davos, Eleni Kapreli, Ladislav Batalik, Demosthenes B. Panagiotakos, Garyfallia Pepera
Summary: Wearable sensors-assisted home-based cardiac rehabilitation (HBCR) shows significant improvement in cardiorespiratory health of cardiovascular disease (CVD) patients compared to center-based cardiac rehabilitation (CBCR), but the effect is not significant compared to usual care (UC). There are no significant differences in physical activity, quality of life, depression levels, modification of cardiovascular risk factors/laboratory parameters, and adherence.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Oliver O'Sullivan, Rienk Rienks, David Holdsworth, Constantinos H. Davos, Martin Halle, Alexander Bennett, Gianfranco Parati, Norbert Guettler, Edward Nicol
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Roberto F. E. Pedretti, Dominique Hansen, Marco Ambrosetti, Maria Back, Thomas Berger, Mariana Cordeiro Ferreira, Veronique Cornelissen, Constantinos H. Davos, Wolfram Doehner, Carmen de Pablo Y. Zarzosa, Ines Frederix, Andrea Greco, Donata Kurpas, Matthias Michal, Elena Osto, Susanne Pedersen, Rita Esmeralda Salvador, Maria Simonenko, Patrizia Steca, David R. Thompson, Matthias Wilhelm, Ana Abreu
Summary: Optimal patient adherence to treatment is crucial for successful secondary prevention of cardiovascular disease (CVD). However, unsatisfactory adherence rates have been consistently observed for CVD risk factors and treatment. This consensus document provides a modern reappraisal of adherence to optimal treatment and offers simple, practical, and feasible suggestions to achieve this goal in the clinical setting, focusing on evidence-based concepts.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Andreas B. Gevaert, Nathanael Wood, Jente R. A. Boen, Constantinos H. Davos, Dominique Hansen, Henner Hanssen, Guido Krenning, Trine Moholdt, Elena Osto, Francesco Paneni, Roberto F. E. Pedretti, Torsten Plosch, Maria Simonenko, T. Scott Bowen
Summary: This article discusses the link between changes in epigenetic systems and cardiovascular disease, as well as the acute and chronic effects of physical activity and dietary changes on epigenetics. It proposes exercise and nutrition as potential triggers for epigenetic signals that can reshape the transcriptional programs affecting CVD phenotypes.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2022)
Article
Pediatrics
Styliani A. Geronikolou, Vasilis Vasdekis, Aimilia Mantzou, Constantinos Davos, Dennis V. Cokkinos, George P. Chrousos
Summary: This study aims to evaluate the dynamics of the autonomic nervous system (ANS), the hypothalamic-pituitary-adrenal (HPA) axis, and their interplay with low-level inflammation in healthy schoolchildren during consecutive extrinsic stimuli. The results show that low-level inflammation and baseline morning cortisol levels have no effect on ANS dynamics but influence the HPA axis response.
Article
Medicine, General & Internal
D. A. Holdsworth, R. M. Barker-Davies, R. R. Chamley, O. O'Sullivan, P. Ladlow, S. May, A. D. Houston, J. Mulae, C. Xie, M. Cranley, E. Sellon, J. Naylor, M. Halle, G. Parati, C. Davos, O. J. Rider, A. B. Bennett, E. D. Nicol
Summary: Objective Post-COVID-19 syndrome presents a health and economic challenge affecting approximately 10% of patients recovering from COVID-19. This study found that cardiopulmonary exercise testing and functional capacity testing can be used to exclude clinically significant disease in this population, while reported symptoms and spirometry cannot discriminate significant disease.
BMJ MILITARY HEALTH
(2022)
Correction
Biochemistry & Molecular Biology
Siew Chin Chan, Chih-Wei Tung, Chia-Wei Lin, Yun-Shiuan Tung, Po-Min Wu, Pei-Hsun Cheng, Chuan-Mu Chen, Shang-Hsun Yang
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Suyuan Liu, Meiling Tan, Jiangxue Cai, Chenxuan Li, Miaoxin Yang, Xiaoxiao Sun, Bin He
Summary: This study reveals that the antibiotic doxycycline effectively inhibits NLRP3 inflammasome activation by targeting mitochondrial translation and mtDNA synthesis, offering potential for the treatment of NLRP3-related diseases.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)
Article
Biochemistry & Molecular Biology
Hao Liu, Nana Li, Ge Kuang, Xia Gong, Ting Wang, Jun Hu, Hui Du, Minxuan Zhong, Jiashi Guo, Yao Xie, Yang Xiang, Shengwang Wu, Yiling Yuan, Xinru Yin, Jingyuan Wan, Ke Li
Summary: Protectin D1 (PTD1) improves hepatic steatosis, inflammation and fibrosis in a NASH mouse model by inhibiting the activation of TLR4 downstream signaling pathway, possibly through upregulation of IRAK-M expression, suggesting a potential new treatment for NASH.
FREE RADICAL BIOLOGY AND MEDICINE
(2024)