Article
Medicine, Legal
Hyeyoung Choi, Suncheun Kim, Hyejin Jang, Hyung Joo Kim, Sanggil Choe
Summary: A wide variety of new synthetic cannabinoids have emerged globally in recent years, posing challenges in their detection and monitoring. This study presents the first comprehensive analytical characterization of a new cannabimimetic indazole-3-carboxamide derivative named ADB-BRINACA, providing valuable insights for further research.
FORENSIC SCIENCE INTERNATIONAL
(2022)
Article
Chemistry, Analytical
Ricardo Leal Cunha, Celinalva da Silva Lima Oliveira, Aline Lima de Oliveira, Adriano Otavio Maldaner, Pedro Afonso P. Pereira
Summary: Stimulants are commonly abused drugs that act on the central nervous system, with a large number of users worldwide. In northeast Brazil, amphetamine-type stimulants and synthetic cathinones are the main synthetic drugs seized recently. These substances are used in popular festivals and rave parties, but also in cases of drug-facilitated sexual assault and by truck drivers.
MICROCHEMICAL JOURNAL
(2021)
Article
Environmental Sciences
Tsuyoshi Kawakami, Shinobu Sakai, Tomoko Obama, Reiji Kubota, Kaoru Inoue, Yoshiaki Ikarashi
Summary: This study investigates the concentrations of rubber additives and related chemicals in rubber infills used in synthetic turf fields in Japan. The analysis found variations in the types and concentrations of compounds detected between different products and within the same product. Elution tests showed that compound elution rates varied and were affected by coatings, with most compounds having low elution rates.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Chemistry, Analytical
Austin L. Ciesielski, Jarrad R. Wagner, Marissa Alexander-Scott, John Snawder
Summary: The illicit use of powerful opioids like fentanyl is on the rise in the United States, leading to contamination of more locations with potentially lethal substances. A research developed a method for sampling, identifying, and quantitating fentanyls from surfaces, with potential implications for legislation and safety assessments in contaminated areas.
Article
Biochemistry & Molecular Biology
Emmanouil D. Tsochatzis, Joao Alberto Lopes, Margaret V. Holland, Fabiano Reniero, Giovanni Palmieri, Claude Guillou
Summary: The study presents an analytical approach to identify and structurally elucidate a novel synthetic cannabimimetic, also discovering an acid precursor in the same seized material. Various analytical techniques including GC-MS, NMR, HR-MS/MS, and a cheminformatics platform were used for characterization and data interpretation.
Article
Medicine, Legal
Asli Atasoy, Nebile Daglioglu, Ismail Ethem Goren, Alperay Girisbay, Rukiye Aslan, Serap Annette Akgur
Summary: Synthetic cannabinoids pose a significant public health and safety issue as their ever-changing structures complicate drug tests and most cannot be detected by routine screening tests, leading to increased usage. A study found that immunoassay screening tests were insufficient and validated chromatographic methods should be used for clinical and forensic cases to accurately detect synthetic cannabinoids in urine samples.
FORENSIC SCIENCE INTERNATIONAL
(2021)
Article
Medicine, Legal
E. Dale Hart, Nichole D. Bynum, Amy Evans, Kenneth D. Swanson, Thomas A. Blake
Summary: A proficiency testing (PT) scheme was developed for laboratories engaged in bioanalytical testing for synthetic opioid compounds. The scheme involved two PT events each year for two years, with an expansion of participating laboratories in the second year. The PT samples were prepared using compounds from the Opioid Certified Reference Material Kit. The results showed improvements in drug detection between the PT events, highlighting the benefits of PT schemes in identifying and addressing deficiencies in laboratory systems.
FORENSIC SCIENCE INTERNATIONAL
(2023)
Review
Chemistry, Analytical
Carlos A. Valdez
Summary: The misuse of synthetic opioids belonging to the fentanyl class has raised serious safety concerns, prompting efforts worldwide to find effective solutions. Key research areas include controlling production and distribution, developing detection methods, and finding efficient antidotes. The review article summarizes the current literature on the detection and identification of synthetic opioids using GC-MS methods.
CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY
(2022)
Article
Medical Laboratory Technology
Ju-Yu Chen, Guan-Yuan Chen, Hooi-Nee Ong, Mei-Ling Lai, Yi-Ju Ho, Ching-Hua Kuo, Te- Weng
Summary: This study found that blood collection tubes have a significant impact on the recoveries of synthetic cathinones, especially serum separating tubes and gel-containing tubes. However, in real-world scenarios, nonideal collection methods are inevitably employed, so it is important to rigorously interpret forensic toxicological results, especially for susceptible species.
CLINICA CHIMICA ACTA
(2023)
Article
Chemistry, Analytical
Svante Vikingsson, Shannon T. Krauss, Ruth E. Winecker, Ronald R. Flegel, Eugene D. Hayes
Summary: This study found that one adulterant can interfere with urine drug testing, while the other two had no effect. Synthetic urine is difficult to be identified by tools, but authentic urine with specific biomarkers can be clearly distinguished. These findings provide potential targets for future urine testing screening.
JOURNAL OF ANALYTICAL TOXICOLOGY
(2022)
Article
Multidisciplinary Sciences
Carlos A. Valdez, Roald N. Leif, Todd H. Corzett, Mark L. Dreyer
Summary: This study presents a method for the analysis of fentanyl and acetylfentanyl in urine and plasma samples using EI-GC-MS and HR-LC-MS techniques. The method successfully detects the unique products formed from the reaction of these opioids with Troc-Cl at low and high levels in both urine and plasma. The study highlights the importance of using complementary analytical techniques in sample analysis and demonstrates the ability to retrospectively identify unknown fentanyls.
Article
Endocrinology & Metabolism
Chaowen Yu, Lingfang Niu, Luo Li, Ting Li, Limei Duan, Zhenting He, Yan Zhao, Lin Zou, Xiaohou Wu, Chunli Luo
Summary: This study aimed to determine the metabolic features of prostate cancer (PCa) by analyzing plasma and urine metabolites. The results showed altered metabolites related to urea cycle, tricarboxylic acid cycle, fatty acid metabolism, and glycine cleavage system. Plasma Glu/Gln had the highest predictive value in distinguishing PCa patients from healthy controls, and a combination of Glu/Gln and PSA improved diagnostic specificity.
Article
Chemistry, Applied
Ting Zeng, Baohua Fang, Fenglin Huang, Li Dai, Zhi Tang, Jinglin Tian, Guodong Cao, Xuanlin Meng, Yuanchen Liu, Bo Lei, Minghua Lu, Zongwei Cai
Summary: Through metabolomics analysis, it was found that under cadmium stress, most carbohydrates and amino acids were down-regulated as the cadmium concentration increased in rice grains, except for myoinositol which can prevent cadmium toxicity. D-Mannitol and L-cysteine were up-regulated in low-cadmium-accumulating rice with the increase of cadmium concentration. Organic acids, especially 13-(S)-hydroperoxy-9(Z),11(E),15(Z)-octadecatrienoic acid related to alphalinolenic acid metabolism and jasmonic acid production, were activated.
Review
Chemistry, Analytical
Tengfei Yuan
Summary: Analyzing steroids in different biological matrices helps gain insight into the status of steroids.
MICROCHEMICAL JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Mark Newman, Desmond A. Curran
Summary: This study confirms high agreement between liquid and dried urine hormone results, and finds that four dried spot urine samples can be used as a substitute for 24-h urine collection in measuring reproductive hormones. The ease of handling dried urine samples makes them useful for clinical assessment and large epidemiologic studies.