Article
Immunology
Lindsay T. Fourman, Takara L. Stanley, Mollie W. Ockene, Colin M. McClure, Mabel Toribio, Kathleen E. Corey, Raymond T. Chung, Martin Torriani, David E. Kleiner, Colleen M. Hadigan, Steven K. Grinspoon
Summary: In HIV-associated NAFLD, hepatic fibrosis is characterized by a distinct proteomic signature involving up-regulation of tissue repair and immune response pathways. Understanding these mechanisms and biomarkers is important for the management of NAFLD-related hepatic fibrosis in HIV patients.
JOURNAL OF INFECTIOUS DISEASES
(2023)
Review
Nutrition & Dietetics
Vittoria Schirinzi, Carolina Poli, Chiara Berteotti, Alessandro Leone
Summary: The increasing prevalence of overweight and obesity indicates that current strategies are insufficient to tackle this epidemic. Brown adipose tissue (BAT) is receiving attention as a potential weapon against obesity. Research is focused on developing strategies to increase BAT activity and energy expenditure. This review summarizes knowledge on molecules that promote white-to-brown adipose tissue conversion and assesses the potential role of thermogenic nutraceuticals in combating obesity.
Article
Biochemistry & Molecular Biology
Peter Aldiss, Jo E. Lewis, Irene Lupini, Ian Bloor, Ramyar Chavoshinejad, David J. Boocock, Amanda K. Miles, Francis J. P. Ebling, Helen Budge, Michael E. Symonds
Summary: This study demonstrates that chronic suppression of adaptive thermogenesis leads to weight gain and increased fat mass in rodents. Living in a cool environment (20 degrees C) and treatment with a β3-adrenoreceptor agonist (YM-178) had minimal effects on metabolic health in obese rats raised at thermoneutrality.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
Menghua Zhu, Hongyu Li, Yue Yin, Min Ding, Cyriac Abby Philips, Fernando Gomes Romeiro, Xingshun Qi
Summary: Both excessive deficiency and accumulation of subcutaneous adipose tissues negatively influence the outcomes of cirrhotic patients.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
Pavel Hruska, Jan Kucera, Daniela Kuruczova, Marek Buzga, Matej Pekar, Pavol Holeczy, David Potesil, Zbynek Zdrahal, Julie Bienertova-Vasku
Summary: This study comprehensively characterizes the proteomic landscapes of subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT) in severe obesity patients, and identifies potential serum protein biomarkers. The results suggest a significant role of SAT in the pathogenesis of obesity and related metabolic complications. This study emphasizes the importance of understanding the balance between SAT and VAT in energy homeostasis and protein homeostasis, and the potential role of SAT in the development of metabolic disorders.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2023)
Article
Multidisciplinary Sciences
Xiangyue Meng, Michi Morita, Sayaka Kuba, Hiroko Hayashi, Ryota Otsubo, Megumi Matsumoto, Kosho Yamanouchi, Kazuma Kobayashi, Akihiko Soyama, Masaaki Hidaka, Kengo Kanetaka, Takeshi Nagayasu, Susumu Eguchi
Summary: Loss of E-cadherin expression is associated with adipose tissue invasion and poor prognosis in breast cancer patients. The study found that reduced E-cadherin expression was not only observed in the adipose tissue invasion area but also in the invasive front of the tumor. Decreased E-cadherin expression was correlated with lymph node metastasis and increased risk of recurrence.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Yusuke Igarashi, Muhei Tanaka, Hiroshi Okada, Yoshitaka Hashimoto, Muneaki Kumagai, Miyoko Yamaoka, Hiromi Nishimura, Michiaki Fukui
Summary: This study found that both the quantity and density of visceral adipose tissue (VAT) were associated with the prevalence and incidence of nonalcoholic fatty liver disease (NAFLD). Visceral fat density (VFD) may be more related to the incidence of NAFLD than visceral fat area (VFA) index.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2022)
Review
Endocrinology & Metabolism
Paula Alejandra Sacca, Juan Carlos Calvo
Summary: PPAT plays an important role in PCa, with its metabolic profile potentially related to tumor energy requirements and 5 pathways related to energy balance. Patients at different stages of PPAT have different metabolic profiles, and an in-depth understanding of the key components could have a positive impact on disease treatment.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Alexandra Paul, Belen Chanclon, Cecilia Brannmark, Pernilla Wittung-Stafshede, Charlotta S. Olofsson, Ingrid Wernstedt Asterholm, Sapun H. Parekh
Summary: Brown adipose tissue (BAT) is highly metabolically active and can catabolize nutrients to produce heat. Studies have shown that dietary fatty acids can regulate lipid deposition in BAT, similar to white adipose tissue (WAT). This study aimed to compare the effects of sustained dietary intervention on lipid metabolism and deposition in WAT and interscapular BAT.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Adrian Cordido, Marta Vizoso-Gonzalez, Laura Nunez-Gonzalez, Alberto Molares-Vila, Maria del Pilar Chantada-Vazquez, Susana B. Bravo, Miguel A. Garcia-Gonzalez
Summary: This study used quantitative proteomics based on SWATH-MS technology to compare the hepatic proteomes of wild type and mutant/polycystic livers in a polycystic kidney disease (PKD) mouse model. Several proteins with altered abundance were identified, with a significant association with hepatic cystogenesis. Further analysis revealed a cluster focused on hepatic fibrinogens. Validation of selected targets confirmed their correlation with the quantitative proteomics data, validating the fibrinogen complex.
Article
Endocrinology & Metabolism
Ruiyi Zhu, Shuchun Chen
Summary: This study investigated the effect of semaglutide on lipid metabolism in obese mice. The results showed that semaglutide can effectively reduce visceral fat and blood lipids and improve glucose metabolism in obese mice.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Spectroscopy
Erica Gianazza, Maura Brioschi, Sonia Eligini, Cristina Banfi
Summary: Adipose tissue is not only the primary site of lipid storage but also an endocrine organ that plays a crucial role in cardiovascular health. Mass spectrometry-based studies have allowed us to characterize the size and components of the human secretome, providing insights into the molecular mechanisms controlling the crosstalk between adipose tissue and the cardiovascular system.
MASS SPECTROMETRY REVIEWS
(2022)
Article
Endocrinology & Metabolism
Daniel G. Sadler, Lillie Treas, James D. Sikes, Craig Porter
Summary: Transitioning mice from 24 to 30 degrees Celsius reduces energy expenditure and UCP1 protein content in brown adipose tissue. Protein expression in adipose tissue is also influenced by housing temperature, and there are sex-specific differences in protein expression at higher temperature.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2022)
Article
Biochemistry & Molecular Biology
Nikolaus Berndt, Christian A. Hudert, Johannes Eckstein, Christoph Loddenkemper, Stephan Henning, Philip Bufler, David Meierhofer, Ingolf Sack, Susanna Wiegand, Iwona Wallach, Hermann-Georg Holzhutter
Summary: This study used a mathematical model to analyze liver metabolism in children with NAFLD, showing significant alterations in carbohydrate, lipid, and ammonia metabolism that increase with obesity and NAFLD severity. NASH and IR have opposite associations with carbohydrate and lipid metabolism, while simultaneously decreasing urea synthesis and increasing glutamine release.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Yuki Kitamura, Shinji Oikawa, Jie Chang, Yurie Mori, Gaku Ichihara, Sahoko Ichihara
Summary: This study used 2D-Oxyblot and 2D-DIGE techniques to analyze carbonylated proteins induced by oxidative stress in a metabolic syndrome animal model, as well as changes in protein expression levels in adipose tissue at different stages of the syndrome. The results showed that up-regulated proteins at the pre-symptomatic stage were mainly involved in ATP production and redox reactions, while down-regulated proteins at the symptomatic stage were associated with antioxidant activity and the TCA cycle. Increased levels of carbonylated proteins, including gelsolin, may contribute to the oxidative stress state and progression of metabolic syndrome.
Article
Biochemistry & Molecular Biology
Francesco Visioli, Avery Ingram, Joseph S. Beckman, Kathy R. Magnusson, Tory M. Hagen
Summary: Mitochondria play vital roles in cellular function beyond energy production, and their decay is believed to be a key factor in aging and age-related diseases. While a variety of nutritional strategies are being explored to promote mitochondrial function, research using animal models and human clinical trials has yielded mixed results, highlighting the need for further investigation into optimal dosages and intervention timing before recommending potential mitochondrial rejuvenating compounds for human use.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Review
Cell Biology
Hatim Boughanem, Yvonne Bottcher, Joao Tome-Carneiro, Maria-Carmen Lopez de Las Hazas, Alberto Davalos, Akin Cayir, Manuel Macias-Gonzalez
Summary: Mitochondrial epitranscriptomics refers to modifications occurring in various types of RNA within mitochondria. These modifications play a critical role in accurate protein synthesis and have implications in mitochondrial-related diseases. Research has focused on mutations in mitochondrial and nuclear DNA genes encoding enzymes involved in these modifications. This article reviews current evidence on mitochondrial RNA modifications and their role in metabolic disorders, and explores the potential of using them as targets for prevention and early detection.
WILEY INTERDISCIPLINARY REVIEWS-RNA
(2023)
Article
Pharmacology & Pharmacy
Andrea del Saz-Lara, Hatim Boughanem, Maria-Carmen Lopez de las Hazas, Carmen Crespo, Alicia Saz-Lara, Francesco Visioli, Manuel Macias-Gonzalez, Alberto Davalos
Summary: The Mediterranean diet is associated with lower incidence of cardio-vascular and cerebrovascular diseases as well as cancer. Extra virgin olive oil, with its phenolic components such as hydroxytyrosol, has been attributed with many healthful effects. Recent studies show that extra virgin olive oil and hydroxytyrosol modulate epigenetic mechanisms, specifically DNA methylation, in human tissues. In this study, colorectal cancer cells treated with hydroxytyrosol demonstrated an increase in global DNA methylation, suggesting a potential gene target for this compound.
PHARMACOLOGICAL RESEARCH
(2023)
Review
Peripheral Vascular Disease
Joao Tome-Carneiro, Francesco Visioli
Summary: Accumulating data suggest that plant-based diets are linked to reduced blood pressure. Recent studies show that plant-based diets result in lower blood pressure readings when compared to diets based on animal products. The mechanisms of action, involving various macro- and micronutrients in plants and dishes prepared with them, are actively being investigated.
CURRENT HYPERTENSION REPORTS
(2023)
Review
Biochemistry & Molecular Biology
Andrea Poli, Carlo Agostoni, Francesco Visioli
Summary: Among polyunsaturated fatty acids, the n-3 series (ALA, EPA, and DHA) have been extensively studied for their cardiovascular health benefits, while recent research is focusing on n-6 PUFAs, especially linoleic acid (LA). Although n-6 PUFAs are criticized for being pro-inflammatory, growing evidence suggests their positive effects on cardiovascular health. This review discusses the role of n-6 PUFAs in inflammation, human health, and prognosis, concluding that adequate intakes of n-6 fatty acids are associated with better cardiovascular health and child development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Analytical
Guillermo Aragoneses-Cazorla, Maria Vallet-Regi, Ma. Milagros Gomez-Gomez, Blanca Gonzalez, Jose L. Luque-Garcia
Summary: A combination of transcriptomics and metabolomics was used to study the mechanisms behind the antitumor action of a nanosystem called Ag@MSNs-Tf. Transcriptomics analysis was done using gene microarrays and RT-qPCR, while metabolomics analysis was done using high-resolution mass spectrometry. This multiomics approach revealed the impact of the nanosystem on various molecular pathways, including glycolysis, the pentose phosphate pathway, oxidative phosphorylation, and fatty acid synthesis.
Letter
Rheumatology
G. Pela, F. Visioli, M. Aiello, E. Solinas, C. Ferrari, A. Chetta
SCANDINAVIAN JOURNAL OF RHEUMATOLOGY
(2023)
Editorial Material
Biology
Jose L. Luque-Garcia, Rafael Prados-Rosales
Article
Mathematical & Computational Biology
Sergio Romero-Tapiador, Blanca Lacruz-Pleguezuelos, Ruben Tolosana, Gala Freixer, Roberto Daza, Cristina M. Fernandez-Diaz, Elena Aguilar-Aguilar, Jorge Fernandez-Cabezas, Silvia Cruz-Gil, Susana Molina, Maria Carmen Crespo, Teresa Laguna, Laura Judith Marcos-Zambrano, Ruben Vera-Rodriguez, Julian Fierrez, Ana Ramirez de Molina, Javier Ortega-Garcia, Isabel Espinosa-Salinas, Aythami Morales, Enrique Carrillo de Santa Pau
Summary: The increasing prevalence of diet-related diseases has led to a demand for improved nutritional advice. Personalized nutrition aims to meet this demand by tailoring dietary and lifestyle guidelines to each individual. The AI4Food database (AI4FoodDB) is introduced as a valuable resource for research in precision health, as it centralizes data from a nutritional weight loss intervention, including food images, wearable sensors, questionnaires, and biological samples.
DATABASE-THE JOURNAL OF BIOLOGICAL DATABASES AND CURATION
(2023)
Article
Psychiatry
Nicola Meda, Susanna Pardini, Paolo Rigobello, Francesco Visioli, Caterina Novara
Summary: University students' mental health is a major concern, with worse mental health status than peers in other occupations. Economic worries are associated with depression, and predicting students' mental health outcomes is more challenging than predicting symptom worsening.
EPIDEMIOLOGY AND PSYCHIATRIC SCIENCES
(2023)
Article
Food Science & Technology
Maria V. Calvo, Viviana Loria Kohen, Carmen Diaz-Mardomingo, Sara Garcia-Herranz, Shishir Baliyan, Joao Tome-Carneiro, Gonzalo Colmenarejo, Francesco Visioli, Cesar Venero, Javier Fontecha
Summary: Cognitive decline is a significant consequence of aging, and pharmacological therapies have not been effective. The use of a milk drink fortified with MFGM as a dietary supplement may improve cognitive function, particularly in women.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Food Science & Technology
Maria-Carmen Lopez de las Hazas, Andrea del Saz-Lara, Lidia Cedo, Maria Carmen Crespo, Joao Tome-Carneiro, Luis A. Chapado, Alba Macia, Francesco Visioli, Joan C. Escola-Gil, Alberto Davalos
Summary: HT supplementation in humanized mice resulted in systemic dyslipidemia, impaired glucose metabolism, increased body weight, and accumulation of triacylglycerols in different tissues. The expression of genes related to lipid metabolism, such as Pltp or Lpl, was also modulated by HT. Further studies are needed to fully understand the potential effects of HT consumption.
MOLECULAR NUTRITION & FOOD RESEARCH
(2023)
