Article
Infectious Diseases
Faduma Nur Adan, Mohamed Osman Omar Jeele, Nasteho Mohamed Sheikh Omar
Summary: This study analyzes the epidemiology of MDR-NFGNB among HAP patients in a tertiary care hospital in Somalia. The prevalence rate of NFGNB in HAP patients was 8%, with higher rates in men and the elderly. Acinetobacter baumannii and Stenotrophomonas maltophilia exhibited the highest antibiotic resistance rate.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Renato Pascale, Silvia Corcione, Linda Bussini, Livia Pancaldi, Daniele Roberto Giacobbe, Simone Ambretti, Tommaso Lupia, Cristina Costa, Anna Marchese, Francesco Giuseppe De Rosa, Matteo Bassetti, Claudio Viscoli, Michele Bartoletti, Maddalena Giannella, Pierluigi Viale
Summary: This study analyzed a cohort of patients with NFGN-BSI in northern Italy and found a high prevalence of DTR, particularly among Acinetobacter baumannii episodes. BSI due to Acinetobacter baumannii was identified as an independent predictor of mortality, highlighting the urgent need for new therapeutic options against this pathogen.
BMC INFECTIOUS DISEASES
(2021)
Article
Infectious Diseases
Guanghui Zheng, Siqi Wang, Hong Lv, Guojun Zhang
Summary: This study included 2940 PNM patients, of whom 207 (17.1%) were infected with NFGNB. The top three NFGNBs were Acinetobacter baumannii (105 cases, 50.7%), Pseudomonas aeruginosa (29 cases, 14.0%), and Acinetobacter lwoffii (20 cases, 9.7%). Hypertension, EVD, and AMV were independent risk factors for mortality.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Environmental Sciences
Zineb Mansouri, Yamina Benmalek, Mounira Korichi-Ouar
Summary: An anthropic pressure on water matrices due to discharge of partially treated or untreated wastewater has led to the presence of micropollutants like heavy metals (HMs). These HMs can result in the co-selection of antibiotic-heavy metal-resistant organisms, causing a significant public health problem. This study aimed to identify and characterize cadmium and carbapenem-resistant non-fermenting Gram-negative bacilli (NFGNB) isolated from urban and hospital wastewater. The study isolated 52 NFGNB strains, with Pseudomonas spp. and Acinetobacter spp. being the most frequently found. The study also revealed the presence of carbapenem-resistant strains and the production of carbapenemases and metal resistance genes.
WATER AIR AND SOIL POLLUTION
(2023)
Article
Immunology
Andrew Bock, Blake M. Hanson, Felicia Ruffin, Joshua B. Parsons, Lawrence P. Park, Batu Sharma-Kuinkel, Michael Mohnasky, Cesar A. Arias, Vance G. Fowler, Joshua T. Thaden
Summary: Recurrent gram-negative bacterial bloodstream infections (GNB-BSI) are mainly caused by relapse, and pulsed-field gel electrophoresis accurately differentiates relapse from reinfection. Having a cardiac device is a risk factor for relapse.
CLINICAL INFECTIOUS DISEASES
(2023)
Article
Medicine, General & Internal
Melise Chaves Silveira, Claudio Marcos Rocha-de-Souza, Ivson Cassiano de Oliveira Santos, Leilane da Silva Pontes, Thamirys Rachel Tavares e Oliveira, Camila Bastos Tavares-Teixeira, Nataly de Almeida Cossatis, Natacha Ferreira Pereira, Orlando Carlos da Conceicao-Neto, Bianca Santos da Costa, Daiana Cristina Silva Rodrigues, Rodolpho Mattos Albano, Fabricio Alves Barbosa da Silva, Elizabeth Andrade Marques, Robson Souza Leao, Ana Paula D'Alincourt Carvalho-Assef
Summary: The study of gram-negative bacilli isolated from bloodstream infections in Brazil using whole-genome sequencing revealed the presence of international high-risk clones and specific gene associations. Additionally, new clones and resistance gene relationships were observed, providing insights for developing approaches to tackle bloodstream infections and nosocomial infections caused by these important pathogens.
FRONTIERS IN MEDICINE
(2021)
Article
Multidisciplinary Sciences
Maria Dolores Alcantar-Curiel, Manuel Huerta-Cedeno, Ma Dolores Jarillo-Quijada, Catalina Gayosso-Vazquez, Jose Luis Fernandez-Vazquez, Maria Luisa Hernandez-Medela, Manuelita Zavala-Pineda, Miguel Angel Morales-Gil, Veronica Alejandra Hernandez-Guzman, Manuel Ismael Bolanos-Hernandez, Silvia Giono-Cerezo, Jose Ignacio Santos-Preciado
Summary: This study describes the incidence of bacteremia caused by Gram-negative ESKAPE bacilli during the COVID-19 pandemic and characterizes the clinical and microbiological findings, including antimicrobial resistance. The results show that these bacteria, especially Acinetobacter baumannii, are highly multidrug-resistant and associated with a high mortality rate in patients with COVID-19. The study highlights the important role of multidrug-resistant Gram-negative ESKAPE bacteria in causing bloodstream infections in healthcare settings and suggests that the COVID-19 pandemic has not had a significant impact on antimicrobial resistance rates in the short term.
Article
Microbiology
Alicia Macias-Valcayo, John-Jairo Aguilera-Correa, Antonio Broncano, Raul Parron, Alvaro Aunon, Joaquin Garcia-Canete, Antonio Blanco, Jaime Esteban
Summary: This study analyzed a large number of isolates of Gram-negative bacilli that cause prosthetic joint infection. The study includes biofilm development and antimicrobial susceptibility testing of both planktonic and sessile bacteria. The results obtained support the clinical knowledge about the treatment of these bacteria when biofilms are involved.
MICROBIOLOGY SPECTRUM
(2022)
Review
Infectious Diseases
Jessica Waters, Andrew F. F. Shorr
Summary: Newer antibiotics have been developed and proven effective in treating various types of multidrug-resistant infections, but there is limited information on their efficacy specifically for bloodstream infections.
Article
Medicine, General & Internal
Jorge Calderon Parra, Daniel De Castro-Campos, Patricia Munoz Garcia, Maria Olmedo Samperio, Mercedes Marin Arriaza, Aristides De Alarcon, Encarnacion Gutierrez-Carretero, Maria Carmen Farinas Alvarez, Jose Maria Miro Meda, Miguel Angel Goneaga Sanchez, Raquel Rodriguez Garcia, Guillermo Ojeda Burgos, Zeltia Valcarce-Gonzalez, Antonio Ramos-Martinez
Summary: IE caused by non-HACEK Gram-Negative Bacilli is a rare infection affecting elderly patients with high comorbidity, nosocomial acquisition, and unfavorable outcome. Factors associated with mortality include age, prosthetic valve, and failure to undergo indicated surgery. Patients treated with quinolone combination therapy had lower mortality rates.
EUROPEAN JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Infectious Diseases
Linli Lu, Cong Xu, Yishu Tang, Liwen Wang, Qian Cheng, Xin Chen, Jian Zhang, Ying Li, Han Xiao, Xin Li
Summary: Carbapenem resistance has dramatically increased in hematologic malignancy patients with Gram-negative bacteria bloodstream infection in recent years and is associated with a worse prognosis, especially for non-fermenting bacteria. Early screening of respiratory tract specimens in high-risk patients may help detect colonization of non-fermenting bacteria and protect patients from breakthrough bloodstream infections.
INFECTION AND DRUG RESISTANCE
(2022)
Article
Infectious Diseases
Joshua T. Thaden, Pranita D. Tamma, Yohei Doi, Nick Daneman
Summary: There is extensive heterogeneity in oral step-down practices for Gram-negative bloodstream infections (GN-BSIs), with US providers more likely to practice oral step-down than non-US providers. Most providers expressed interest in enrolling patients in a trial of full IV versus early oral step-down for GN-BSIs, indicating a need for further investigation into the optimal role of oral step-down in managing GN-BSIs.
INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
(2021)
Article
Infectious Diseases
Ayan Ali Ragueh, Mohamed Houmed Aboubaker, Sitani Idriss Mohamed, Jean-Marc Rolain, Seydina M. Diene
Summary: This study investigated the resistance rate to carbapenems among multidrug-resistant Gram-negative bacteria (MDR-GNB) in Djibouti and characterized their resistance mechanisms. The results showed that out of 256 isolates, 20 were resistant to carbapenems. Carbapenemase genes such as bla(OXA-48) and bla(NDM-5) were identified in the isolates.
Review
Infectious Diseases
Rafael San-Juan, Maria Ruiz-Ruigomez, Jose Maria Aguado
Summary: The incidence of GNB-CRBSI has been increasing in recent years, posing a challenge due to high rates of multidrug resistance. There are no specific guidelines for its management and optimal treatment duration has not been clearly defined. Recent studies show that complications risk differs from that of Staphylococcus aureus. Therefore, a short course of antibiotics after CVC removal may be effective, while monitoring complications through blood cultures or echocardiography seems less helpful.
CURRENT OPINION IN INFECTIOUS DISEASES
(2022)
Article
Immunology
Mariana Albano, Wim Alexander Fleischmann, Kerryl E. Greenwood-Quaintance, Robin Patel
Summary: Arbekacin showed inhibitory activity against drug-resistant Gram-negative bacilli, with similar MIC50 values to amikacin and gentamicin, lower than tobramycin, and higher than plazomicin.
JOURNAL OF MICROBIOLOGY IMMUNOLOGY AND INFECTION
(2021)
Article
Environmental Sciences
Anna Rozanska, Jerzy Rosinski, Andrzej Jarynowski, Katarzyna Baranowska-Tateno, Malgorzata Siewierska, Jadwiga Wojkowska-Mach, Marta Walaszek, Joanna Domanska, Joanna Liberda, Agnieszka Misiewska-Kaczur, Marzena Lech, Malgorzata Rozwadowska, Marlena Karwacka
Summary: This study analyzed the incidence of surgical site infections (SSIs) in Poland, finding that the highest rates occurred in June and August after surgeries, while the lowest rate was in October. The study also showed that bacterial infections were significantly higher in the period from November to January and from June to August, which may be attributed to increased absences associated with holidays and furloughs. Efforts are needed to establish a comprehensive surveillance network for hospital-acquired infections, including SSIs, at the national level.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Environmental Sciences
Mateusz Gajda, Emilia Zalugowicz, Monika Pomorska-Wesolowska, Tomasz Bochenek, Barbara Gryglewska, Dorota Romaniszyn, Agnieszka Chmielarczyk, Jadwiga Wojkowska-Mach
Summary: This study investigated the virulence and drug resistance of Staphylococcus aureus strains in infected chronic venous ulcers (VUs). The results showed that multi-drug resistant SA was more common in hospitalized patients, while MLSB resistance was more prevalent in non-hospitalized patients.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Medicine, General & Internal
Barbara Zoltowska, Ilona Baranska, Katarzyna Szczerbinska, Anna Rozanska, Krzysztof Mydel, Wojciech Sydor, Piotr B. Heczko, Estera Jachowicz, Jadwiga Wojkowska-Mach
Summary: The study revealed inadequate IPC practices among healthcare workers, especially in terms of training programs. There is an urgent need to include theory and practice of IPC in the curricula of health professions training to equip students with necessary knowledge and skills for both future pandemic situations and everyday work.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Estera Jachowicz, Magdalena Gebicka, Daria Plakhtyr, Myroslav Shynkarenko, Juri Urbanowicz, Maciej Mach, Jacek Czepiel, Jakub Marchewka, Jadwiga Wojkowska-Mach
Summary: The study compared the annual incidence of vaccine-preventable childhood diseases in EU and EFTA countries over the past 5 years, showing variations in vaccine schedules and disease epidemiology. The increasing incidence of diseases like measles, potentially influenced by anti-vaccine movements and misinformation, highlights the need for standardization of vaccine schedules and documentation in EU countries.
Article
Environmental Sciences
Barbara Zoltowska, Ilona Baranska, Estera Jachowicz, Wojciech Sydor, Barbara Maziarz, Krzysztof Mydel, Anna Rozanska, Barbara Wizner, Jerzy Rosinski, Magdalena Kossowska, Kaja Glomb, Jadwiga Wojkowska-Mach
Summary: The aim of this study was to assess the seroprevalence of SARS-CoV-2 in relation to demographic, social, and organizational factors at a university hospital. The results showed that the use of personal protective equipment did not significantly affect the testing results for anti-SARS-CoV-2 antibodies, while caring for COVID-19 patients significantly increased the risk of developing the disease. Not being aware of the COVID-19 status of healthcare workers posed a threat to other staff members, patients, and their family members and friends. Therefore, caution should be exercised when using respirators with exhalation valves during the pandemic.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Estera Jachowicz, Agnieszka Pac, Anna Rozanska, Barbara Gryglewska, Jadwiga Wojkowska-Mach
Summary: This observational study aimed to analyze the incidence of Clostridioides difficile infection (CDI) after discharge in patients undergoing hip or knee arthroplasty, and identified postoperative antibiotic prescription as the main risk factor for CDI. The study highlights the importance of improving infection control programs for CDI prevention.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Elzbieta Rafa, Malgorzata Kolpa, Marta Zofia Walaszek, Adam Domanski, Michal Jan Walaszek, Anna Rozanska, Jadwiga Wojkowska-Mach
Summary: This study conducted in neurosurgery units in Poland investigated the epidemiology and microbiology of healthcare-associated infections (HAI). The results suggest that the surveillance system in hospital B could lead to better detection of infections and lower risk of certain types of HAI compared to hospital A. Further research is needed in this area.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Medicine, General & Internal
Marta Klos, Estera Jachowicz, Monika Pomorska-Wesolowska, Dorota Romaniszyn, Grzegorz Kandzierski, Jadwiga Wojkowska-Mach
Summary: This study highlights the antimicrobial resistance among Enterobacteriaceae isolated from bloodstream infections in hospitals in southern Poland. The predominant pathogen identified was Escherichia coli in internal medicine and surgery units, while Klebsiella pneumoniae was more frequently isolated in intensive care units. Enterobacteriaceae demonstrated high resistance to most antimicrobial agents.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Izabella Owsianka, Agnieszka Pac, Estera Jachowicz, Karolina Gutkowska, Wiktor Szczucinski, Barbara Maziarz, Elzbieta Sochacka-Tatara, Piotr Heczko, Wojciech Sydor, Barbara Zoltowska, Jadwiga Wojkowska-Mach
Summary: The purpose of this study was to determine the level of antibodies against SARS-CoV-2 in healthcare workers before and after vaccination with mRNA preparations. The results showed that vaccinated healthcare workers had almost 100 times higher antibody levels than the unvaccinated workers. Participants under 30 years of age had significantly higher antibody levels compared to older workers.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Microbiology
Iwona Pawlowska, Grzegorz Ziolkowski, Estera Jachowicz-Matczak, Michal Stasiowski, Mateusz Gajda, Jadwiga Wojkowska-Mach
Summary: The study aimed to analyze the incidence of carbapenem-resistant Enterobacteriaceae (CRE) at a provincial hospital from 2019-2021. Multiplex PCR was used to detect carbapenemase genes. A total of 399 cases of CRE were detected, including 104 healthcare-associated infections. The most frequently present genes among the identified CRE strains were the ones mediating oxacillinase OXA-48 (71%) and KPC (26%), while New Delhi NDM metallo-beta-lactamase genes were less common (2.5%). Two isolates produced both OXA-48 and KPC carbapenemases. The study highlights the need for continuous monitoring and prevention measures to control the spread of CRE strains in hospitals.
Article
Microbiology
Iwona Gregorczyk-Maga, Michal Kania, Beata Sulik-Tyszka, Magdalena Namysl, Anna Sepiolo, Dorota Romaniszyn, Estera Jachowicz-Matczak, Jadwiga Wojkowska-Mach
Summary: This study aimed to investigate the risk of invasive candidiasis in critically ill COVID-19 patients on mechanical ventilation in the ICU. The study found that nearly half of the patients had non-albicans Candida species in their oral samples, indicating impaired oral health. The incidence of yeast infections, including invasive cases, was high in these patients, possibly due to the severity of COVID-19 and specific interventions in the ICU.
Article
Microbiology
Magdalena Skora, Mateusz Gajda, Magdalena Namysl, Jerzy Wordliczek, Joanna Zorska, Piotr Piekielko, Barbara Zoltowska, Pawel Krzysciak, Piotr B. Heczko, Jadwiga Wojkowska-Mach
Summary: This study aimed to assess the morbidity of CAPA among ICU patients in Poland and analyze the diagnostic and therapeutic procedures. The study found an incidence rate of 1% and a fatality rate of 76.5% for CAPA. It highlights the importance of increased awareness among medical staff regarding fungal co-infections in ICU patients with COVID-19 and the need for more effective use of available diagnostic and therapeutic tools.
Article
Health Care Sciences & Services
Mateusz Gajda, Agnieszka Pac, Barbara Gryglewska, Paulina Gajda, Anna Rozanska, Jadwiga Wojkowska-Mach
Summary: Arthroplasty procedures, particularly hip and knee replacements, are increasingly common in Poland. This study analyzed national datasets from 2017, showing a majority of primary surgeries with patients mostly hospitalized due to arthrosis. Comorbidities were prevalent, highlighting the need for better pre-surgery preparation as patients age.
Meeting Abstract
Peripheral Vascular Disease
Anna Kantoch, Barbara Gryglewska, Jadwiga Wojkowska-Mach, Barbara Wizner, Piotr Heczko, Tomasz Grodzicki
JOURNAL OF HYPERTENSION
(2021)
Article
Medicine, General & Internal
Anna Kantoch, Agnieszka Pac, Barbara Wizner, Jadwiga Wojkowska-Mach, Piotr Heczko, Tomasz Grodzicki, Barbara Gryglewska
Summary: Residents of long-term care facilities with treated hypertension had a higher one-year survival rate compared to those without. Appropriate antihypertensive therapy may serve as a protective factor against mortality in frail nursing home residents.
POLISH ARCHIVES OF INTERNAL MEDICINE-POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ
(2021)
