Article
Chemistry, Applied
Le Huyen Tram, Nguyen Van Thong, Le Thi Thuy, Nguyen Tuan Anh, Nguyen Hoang Minh, Tran Thi Minh, Nguyen Thi Hong Phuong, Tran Thu Ha, Thi Minh Nguyet Nguyen, Duc Dat Le, Nguyen Dinh Hiep, Jong-Tae Park, Truong Thi To Chinh, Tran Thu Huong, Mina Lee
Summary: Valeriana jatamansi is used in Vietnam for various medical purposes, and research has isolated two new compounds along with 16 known ones from this herbal medicine. These compounds showed significant inhibitory effects on the production of TNF-alpha.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Yun Wang, Dao-Qun Shi, Na Jiang, Kai-Rui Rao, Shi-Xian Zhang, Dan Liu, Rong-Tao Li, Hong-Mei Li
Summary: A new acylated iridoid, valejatadoid H (1), and fourteen known compounds were isolated from the roots and rhizomes of Valeriana jatamansi. Compounds 8, 11, and 13 exhibited potent inhibition on NO production, while compound 14 showed significant anti-influenza virus activity.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Antim K. Maurya, Anamika Sharma, Kushal Kumar, Ram Chander, Ashish Kumar, Dharmesh Kumar, Yogendra S. Padwad, Gopi Chand, Vijai K. Agnihotri
Summary: This study investigated the comparative essential oils composition and cytotoxic activity of Valeriana jatamansi Jones from wild growing and cultivated samples at different altitudes. The extracted oils were found to be enriched in specific compounds and showed moderate cytotoxic activity against cancer cells. These findings suggest the potential applications of these essential oils in the fields of flavor, fragrance, and pharmaceuticals.
JOURNAL OF ESSENTIAL OIL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Li-Qiu Quan, Yun Wang, Jian-Xian Tang, Yan Zhou, Cai-Cen Liao, Dan Liu, Xu-Dong Zhao, Rong-Tao Li, Hong-Mei Li
Summary: Eleven new seco-iridoids were isolated from Valeriana jatamansi, with 9-epi-valtral C showing significant inhibition against various bacteria and valeridoid Q exhibiting the most significant inhibition against Salmonella enteritidis.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Biochemistry & Molecular Biology
Trung Huy Ngo, Ajay Uprety, Manju Ojha, Yun-Seo Kil, Hyukjae Choi, Soo Young Kim, Joo -Won Nam
Summary: In this study, seven valeriana-type iridoid glycosides were isolated from the rhizomes of N. jatamansi, four of which were previously unknown. The compounds showed improved biochemical stability in mixture forms compared to purified forms. Moreover, they exhibited a protective effect against hydrogen-peroxide-induced toxicity in human neuroblastoma cells, suggesting their potential therapeutic application.
Article
Biochemistry & Molecular Biology
Huan Liu, Dan Liu, Ming-Yan Jiang, Xu-Dong Zhao, Rong-Tao Li, Hong-Mei Li
Summary: Seven undescribed and 26 known iridoids were isolated from Valeriana jatamansi roots and rhizomes, some of which exhibited stronger inhibition of NO production. Among them, Valeriandoid F and Jatamanvaltrate K showed the most significant inhibitory effects.
Article
Biochemistry & Molecular Biology
Rujing Wang, Sanjun Shi, Yuzhu Tan, Lincai Yao, Lixia Zhu
Summary: A phytochemical study of Valeriana jatamansi Jones identified 45 compounds, including various types of iridoids, sesquiterpenes, steroids, and lignins. This study marks the first report of certain compounds being isolated from Valerianaceae and Valeriana genus, showcasing their potential chemotaxonomic significance.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2021)
Article
Biodiversity Conservation
Shambhu Charmakar, Ripu Mardhan Kunwar, Hari Prasad Sharma, Bhagawat Rimal, Sony Baral, Nabin Joshi, Kalyan Gauli, Ram Prasad Acharya, Bishwa Nath Oli
Summary: The study revealed significant variations in the distribution and production of Valeriana jatamansi in Nepal, with a potential expansion in mountainous areas towards the north and the highest planting potential in western Nepal. It also highlighted the importance of the plant in household economies, despite only being traded and exported after 1995.
GLOBAL ECOLOGY AND CONSERVATION
(2021)
Article
Virology
Bifan Chu, Rex Frimpong Anane, Shangyun Li, Like Gao, Shaomei Zi, Kai Yan, Kaifei Ji, Zeli Chen, Mingfu Zhao
Summary: A new positive-sense, single-stranded RNA virus called Valeriana jatamansi tymovirus 1 (VaJV1, OQ730267) was isolated from Valeriana jatamansi Jones with vein-clearing symptoms in Yunnan Province, China. The genome of VaJV1 has 6,215 nucleotides and contains three open reading frames (ORFs). VaJV1 shares the highest sequence similarity (65.5% nucleotides and 50.5% amino acid sequence identity) with an isolate of the tymovirus okra mosaic virus (NC_009532). Phylogenetic analysis confirms that VaJV1 belongs to the genus Tymovirus as a new species.
ARCHIVES OF VIROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Li-Qiu Quan, Yan Zhou, Dan Liu, Chin-Ho Chen, Hong-Mei Li, Rong-Tao Li
Summary: Twenty-one new iridoids, including two new compounds, were isolated from the roots and rhizomes of Valeriana jatamansi. Some of these compounds showed potent antiinfluenza virus activities.
BIOORGANIC CHEMISTRY
(2022)
Article
Plant Sciences
Yu-Lei Ma, Zi-Mei Wu, Xiao Liu, Jiang-Er Lan, Wen-Jing Zai, Xin Jin, Hui Xie, Qing Mu, Hong-Rui Liu
Summary: This study found that two extracts of Valeriana jatamansi Jones and Qiuxieling mixture exerted protective effects on castor oil-induced diarrhea in mice through various mechanisms, including antioxidant stress, restoration of tight junctions between intestinal mucosal cells, and regulation of the GSDMD-mediated pyroptosis pathway.
JOURNAL OF ETHNOPHARMACOLOGY
(2022)
Article
Plant Sciences
Mingkang Feng, Chen Chen, Junzhang Qu-Bie, Axiang Qu-Bie, Xiaoming Bao, Qi Cui, Xinjia Yan, Ying Li, Yuan Liu, Shaoshan Zhang
Summary: In this study, the accumulation and biosynthesis of sesquiterpenoids in different tissues of Nardostachys jatamansi were analyzed using SMRT and RNA-seq techniques. The results showed that sesquiterpenoids were mainly enriched in roots and rhizomes, with aromatic compounds detected exclusively in flowers. The study identified candidate genes associated with sesquiterpenoid biosynthesis and revealed a positive correlation between gene expression and sesquiterpenoid accumulation levels.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Chemistry, Applied
Antim K. K. Maurya, Vijai K. K. Agnihotri
Summary: One new iridoid compound, rupesin F (1), and four known compounds (2-5) were isolated from the roots of Valeriana jatamansi Jones. The structures were determined by spectroscopic methods and comparison with literature data. Compounds 1 and 3 showed strong alpha-glucosidase inhibition activity with IC50 values of 10.13 +/- 0.11 and 9.13 +/- 0.03 μg/mL, respectively. This study enriches the chemical diversity of metabolites and contributes to the development of antidiabetic agents.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Antim K. Maurya, Ashish Kumar, Vijai K. Agnihotri
Summary: Two new iridoids, valerialloside A and valerianoside A, along with five known compounds, were isolated from the roots of Valeriana jatamansi Jones. The structures of the new compounds were determined using NMR techniques.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Applied
Li-Qiu Quan, Qian Zhao, Rong-Tao Li, Hong-Mei Li
Summary: A new norsesquiterpene and a new lignan were isolated from Valeriana jatamansi, along with known compounds. The structures of the new compounds were determined using NMR and HR-ESI-MS spectra. Some compounds were also evaluated for their anti-influenza A virus effects.
NATURAL PRODUCT RESEARCH
(2022)
Article
Chemistry, Medicinal
Saeed Reza Simaei, Vahid Reza Askari, Mahboobeh Rostami, Mohammad Kamalinejad, Mohammad Hosein Farzaei, Mohammadreza Morovati, Fatemeh Heydarpour, Zahra Jafari, Vafa Baradaran Rahimi
Summary: This study demonstrates that lavender and metformin have similar effects in treating PCOS patients, as both significantly increase progesterone levels and regulate menstrual cycles.
Article
Chemistry, Medicinal
Peng-Ran Cao, Xiao Ren, Jie Lin, Yun-Long Mu, Yue-Qi Shan, Jing-Tong Zhu, Rong-Yi Xu, Xue-Xia Zhang, Wei-Guo Hu, Xin-Hua Lu
Summary: Four previously unknown angucyclinones umezawaones A-D (1-4) were isolated from the liquid cultures of Umezawaea beigongshangensis. Their structures were determined using spectroscopic analysis, single crystal X-ray diffraction, quantum chemical 13C NMR, and electronic circular dichroism calculations. All compounds exhibited potent inhibitory activities against indoleamine 2,3-dioxygenase and tryptophan-2,3-dioxygenase in enzymatic assays, with compound 2 showing the highest activity.
Article
Chemistry, Medicinal
Marwa Mersni, Bingqing Zhou, Guillaume Reversat, Mohamed Larbi Khouja, Alexandre Guy, Camille Oger, Jean-Marie Galano, Thierry Durand, Chokri Messaoud, Claire Vigor
Summary: The relevance of oxylipins as biomarkers of oxidative stress has been established in recent years. This study evaluated the lipidomic profiling of different aerial parts of Acacia cyanophylla Lindl. using LC-MS/MS technology for the first time. The analysis revealed the existence of six PhytoPs and three PhytoFs, with stems having the highest amount of these metabolites. This study provides a foundation for exploring Acacia cyanophylla Lindl. as a potential source of plant oxylipins for therapeutic or pharmaceutical uses.
Review
Chemistry, Medicinal
Lorenzo Buzzelli, Andrea Segreti, Daniela Di Gioia, Erika Lemme, Maria Rosaria Squeo, Antonio Nenna, Giuseppe Di Gioia
Summary: This review provides a comprehensive assessment of red yeast rice, including its biochemical composition, historical studies, cardiovascular disease prevention, and other clinical effects. Red yeast rice preparations have been proven safe and effective in improving lipid profiles, with a potential role in reducing cardiovascular risk.
Article
Chemistry, Medicinal
Xiuwen Zheng, Yuxin Zhang, Yinfeng Tan, Yonghui Li, Qianrong Xue, Hailong Li, Xuguang Zhang, Yipeng Pan, Jian Xu, Junqing Zhang
Summary: Alpinia officinarum Hance (AOH) may protect against diabetic gastroparesis (DGP) through multiple mechanisms, including lowering blood glucose levels, increasing gastrointestinal propulsion rate, improving gastric histological morphology, and regulating gut microbiota.
Article
Chemistry, Medicinal
Na Chen, Rui Xie, Jia-pei Chen, Ying-li Zhong, Xian-wen Zhang, Qing-wen Gui, Chun Guo, Hua Yang
Summary: The study clones the SinSyn gene from Sinomenium acutum and analyzes its catalytic activity, confirming the biosynthetic pathway of sinoacutine and discussing its classification and pharmacological action.
Article
Chemistry, Medicinal
Noura Bentarhlia, Badr Eddine Kartah, Mouhcine Fadil, Said El Harkaoui, Bertrand Matthaeus, Oualid Abboussi, Hanaa Abdelmoumen, Omar Bouhnik, Hanae El Monfalouti
Summary: The lipidic extract of Dittrichia viscosa exhibits significant wound healing activity and antimicrobial effects. It is rich in fatty acids such as linolenic acid, oleic acid, and linoleic acid, as well as compounds like gamma-tocopherols and sterols.
Article
Chemistry, Medicinal
Hawraa Zbeeb, Hala Khalifeh, Giulio Lupidi, Francesca Baldini, Lama Zeaiter, Mohamad Khalil, Annalisa Salis, Gianluca Damonte, Laura Vergani
Summary: This study assessed the biological properties of S. spinosum fruits and found that the ethanolic extract exhibited significant anti-steatotic and antioxidant activities.