Journal
FITOTERAPIA
Volume 121, Issue -, Pages 159-163Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.07.012
Keywords
Dysoxylum hainanense; Meliaceae; Triterpenoids; Anti-inflammatory; Radical scavenging activities
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Funding
- Guangdong Province Medical Research Foundation [A2016292]
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A phytochemical investigation on the 70% EtOH extract of the bark of Dysoxylwn hainanense resulted in the isolation of four new triterpenoids, dysoxyhaines A-D (1-4). Structural elucidation of all the compounds were performed by spectral methods such as 1D and 2D (H-1-H-1 COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated components were evaluated in vitro for anti-inflammatory activities for Cox-1 and Cox-2, and radical scavenging potential using ABTS(+) and DPPH test. As a result, nor seco-olean type triterpenoid 1 exhibited significant anti-inflammatory potential, while tirucallane triterpenoids 3 and 4 showed radical scavenging activities.
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