Journal
FEBS LETTERS
Volume 591, Issue 8, Pages 1150-1158Publisher
WILEY
DOI: 10.1002/1873-3468.12624
Keywords
S phase; Smurf1; tumorigenesis; Wee1
Funding
- PUMC Youth Fund
- Fundamental Research Funds for the Central Universities [3332016077]
- Basic Research Grant of Central Non-profit Research Institutes, PRC [2016ZX310033]
- National Natural Science Foundation of China [81601375]
- Beijing Natural Science Foundation [5174039]
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Smad ubiquitination regulatory factor 1 (Smurf1) is a HECT-type E3 ubiquitin ligase that regulates several important signaling pathways, including the bone morphogenetic protein pathway and the transforming growth factor-beta (TGF-beta) signaling pathway. However, the function of Smurf1 in cell cycle progression remains unclear. Here, we demonstrate that silencing of Smurf1 results in S phase arrest, confirming that Smurf1 is required for S phase progression. Furthermore, we demonstrate that Smurf1-mediated S phase progression is largely dependent on the ubiquitination-dependent degradation of Wee1. This study defines a novel role for Smurf1 in controlling S phase progression by promoting Wee1 degradation.
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