Phosphodiesterase 4 inhibitor and phosphodiesterase 5 inhibitor combination therapy has antifibrotic and anti-inflammatory effects in mdx mice with Duchenne muscular dystrophy

Resveratrol attenuates hyperoxia-induced oxidative stress, inflammation and fibrosis and suppresses Wnt/β-catenin signalling in lungs of neonatal rats

(2015) Wei Xu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Effect of genetic background on the dystrophic phenotype inmdxmice

(2015) William D. Coley et al.   HUMAN MOLECULAR GENETICS

Cyclic Nucleotide Signalling in Kidney Fibrosis

(2015) Elisabeth Schinner et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic effects of losartan on the muscles and the serologic profiles of mdx mice

(2015) Eun-Mi Lee et al.   LIFE SCIENCES

A new therapeutic effect of simvastatin revealed by functional improvement in muscular dystrophy

(2015) Nicholas P. Whitehead et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Histochemical Detection of Collagen Fibers by Sirius Red/Fast Green Is More Sensitive than van Gieson or Sirius Red Alone in Normal and Inflamed Rat Colon

(2015) Cristina Segnani et al.   PLoS One

Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1α axis

(2014) Vladimir Ljubicic et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Resveratrol improves muscle function but not oxidative capacity in young mdx mice

(2014) Bradley S. Gordon et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

PDE5 inhibition alleviates functional muscle ischemia in boys with Duchenne muscular dystrophy

(2014) M. D. Nelson et al.   NEUROLOGY

Dysfunctional Muscle and Liver Glycogen Metabolism in mdx Dystrophic Mice

(2014) David I. Stapleton et al.   PLoS One

A Wnt-TGF 2 axis induces a fibrogenic program in muscle stem cells from dystrophic mice

(2014) S. Biressi et al.   Science Translational Medicine

Finding a Target for Resveratrol

(2012) Ruth I. Tennen et al.   CELL

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

SIRT1 Is Required for AMPK Activation and the Beneficial Effects of Resveratrol on Mitochondrial Function

(2012) Nathan L. Price et al.   Cell Metabolism

Resveratrol decreases inflammation and increases utrophin gene expression in the mdx mouse model of duchenne muscular dystrophy

(2012) Bradley S. Gordon et al.   CLINICAL NUTRITION

Pharmacological therapies for muscular dystrophies

(2012) Hoda Abdel-Hamid et al.   CURRENT OPINION IN NEUROLOGY

Monocyte chemoattractant protein-1 (MCP-1) deficiency enhances alternatively activated M2 macrophages and ameliorates insulin resistance and fatty liver in lipoatrophic diabetic A-ZIP transgenic mice

(2012) Y. Nio et al.   DIABETOLOGIA

Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor

(2012) Thérèse Keravis et al.   PLoS One

Rescue of Dystrophic Skeletal Muscle by PGC-1α Involves a Fast to Slow Fiber Type Shift in the mdx Mouse

(2012) Joshua T. Selsby et al.   PLoS One

Tadalafil Alleviates Muscle Ischemia in Patients with Becker Muscular Dystrophy

(2012) E. A. Martin et al.   Science Translational Medicine

The nuclear receptor PPAR /  programs muscle glucose metabolism in cooperation with AMPK and MEF2

(2011) Z. Gan et al.   GENES & DEVELOPMENT

Simultaneous LC–MS/MS analysis of the biomarkers cAMP and cGMP in plasma, CSF and brain tissue

(2011) Patrick Oeckl et al.   JOURNAL OF NEUROSCIENCE METHODS

Resveratrol Ameliorates Muscular Pathology in the Dystrophic mdx Mouse, a Model for Duchenne Muscular Dystrophy

(2011) Y. S. Hori et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Quantitative Proteomic Analysis of Dystrophic Dog Muscle

(2011) Laetitia Guevel et al.   JOURNAL OF PROTEOME RESEARCH

cGMP Inhibits TGF-β Signaling by Sequestering Smad3 with Cytosolic β2-Tubulin in Pulmonary Artery Smooth Muscle Cells

(2011) Kaizheng Gong et al.   MOLECULAR ENDOCRINOLOGY

Drug screening in a zebrafish model of Duchenne muscular dystrophy

(2011) G. Kawahara et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic Background Affects Properties of Satellite Cells and mdx Phenotypes

(2010) So-ichiro Fukada et al.   AMERICAN JOURNAL OF PATHOLOGY

Stress-induced opening of the permeability transition pore in the dystrophin-deficient heart is attenuated by acute treatment with sildenafil

(2010) Alexis Ascah et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Targeting Fibrosis in Duchenne Muscular Dystrophy

(2010) Lan Zhou et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dystrophins carrying spectrin-like repeats 16 and 17 anchor nNOS to the sarcolemma and enhance exercise performance in a mouse model of muscular dystrophy

(2009) Yi Lai et al.   JOURNAL OF CLINICAL INVESTIGATION

Endomysial Fibrosis in Duchenne Muscular Dystrophy: A Marker of Poor Outcome Associated With Macrophage Alternative Activation

(2009) Isabelle Desguerre et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Diagnosis and management of Duchenne muscular dystrophy, part 1: diagnosis, and pharmacological and psychosocial management

(2009) Katharine Bushby et al.   LANCET NEUROLOGY

Expression and Activity of Phosphodiesterase Isoforms during Epithelial Mesenchymal Transition: The Role of Phosphodiesterase 4

(2009) Ewa Kolosionek et al.   MOLECULAR BIOLOGY OF THE CELL

SIRT1 Regulates Hepatocyte Lipid Metabolism through Activating AMP-activated Protein Kinase

(2008) Xiuyun Hou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sildenafil citrate as a phosphodiesterase inhibitor has an antioxidant effect in the blood of men

(2008) H. Perk et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Prevention of muscle fibrosis and improvement in muscle performance in the mdx mouse by halofuginone

(2008) Tidhar Turgeman et al.   NEUROMUSCULAR DISORDERS

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

(2008) B. Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA