Article
Pharmacology & Pharmacy
Jiaojiao Wei, Tao Chen, Yamin Liu, Shuai Sun, Zhiqing Yuan, Yixin Zhang, Aizhen Xiong, Linnan Li, Zhengtao Wang, Li Yang
Summary: This study developed and validated a method for simultaneous determination of 42 free and conjugated bile acids (BAs) in human plasma, and explored the metabolomic profile of plasma BAs in healthy volunteers, cholesterol gallbladder polyps (CGP) and cholesterol gallstones (CGS) patients. The results showed that both CGP and CGS were characterized by a significant decrease in plasma BAs pool size, and they shared aberrant BAs metabolic characteristics. Clinical characteristics such as cysteine, ornithine, and body mass index were found to be closely related to metabolisms of certain BA modules.
JOURNAL OF PHARMACEUTICAL ANALYSIS
(2023)
Article
Genetics & Heredity
Jixiang Du, Chao Zhang, Fuchen Liu, Xihan Liu, Dongdong Wang, Dandan Zhao, Guanghou Shui, Yuying Zhao, Chuanzhu Yan
Summary: This study aimed to elucidate the characteristic metabolic alterations and associated homeostatic regulation caused by TYMP deficiency. The results showed distinct metabolic profiles in patients with TYMP deficiency compared to those with the m.3243A > G mutation. TYMP deficiency leads to a global disruption of nucleoside metabolism and inhibits cholesterol and fatty acid metabolism. The findings suggest potential metabolite biomarkers that could be valuable clinical tools to improve the diagnosis of MNGIE. Overall, this study is important for expanding our knowledge of the biochemical outcome of TYMP deficiency in mitochondrial disorders.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Pharmacology & Pharmacy
Ting Hu, Yuan Sun, Zhuoling An
Summary: This study investigated the dose- and time-dependent manner of liver injury induced by moxifloxacin using a targeted metabolomics method. The results showed that moxifloxacin caused transient hepatotoxicity, with the most severe liver injury occurring after 7 days of continuous administration. Serum concentrations of fatty acyl carnitines, fatty acids, and dehydroepiandrosterone changed dynamically with the severity of moxifloxacin-related liver injury, suggesting their potential as biomarkers for predicting hepatotoxicity.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Emma J. Robinson, Matthew C. Taddeo, Xin Chu, Weixing Shi, Craig Wood, Christopher Still, Virginia G. Rovnyak, David Rovnyak
Summary: Determining biomarkers and characterizing the biochemical progression of NAFLD in morbidly obese females remains a clinical challenge. A targeted H-1-NMR study combined with clinical variables successfully detected and localized biomarkers to different stages of NAFLD. Early features of NAFLD include inhibition of fatty acid oxidation and disruption of the hepatic urea cycle, while markers in fibrosis support inflammation, hepatocyte damage, and decreased liver function.
Article
Cell Biology
Yingjie Ai, Xiaoquan Huang, Wei Chen, Ling Wu, Siyu Jiang, Ying Chen, Shiyao Chen
Summary: This study characterized unique metabolites in the serum of patients with cirrhotic esophagogastric variceal bleeding (EVB) and identified potential noninvasive biomarkers for detecting and assessing the risk of variceal bleeding and cirrhosis progression. The findings suggest that the use of metabolomics-based approaches could provide a feasible avenue for early detection of EVB.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Agriculture, Multidisciplinary
Jing Sun, Haoan Zhao, Fanhua Wu, Min Zhu, Ying Zhang, Ni Cheng, Xiaofeng Xue, Liming Wu, Wei Cao
Summary: This study analyzed the different metabolites of honey samples at different stages using a metabolomics approach, revealing a distinct metabolic profile in mature honey compared to immature honey. Specific fatty acids, such as decenedioic acid, were identified as potential markers for discriminating between immature and mature honey. Additionally, mature honey showed higher concentrations of fatty acids, particularly three fatty acids that were significantly richer in mature honey compared to immature honey.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Environmental Sciences
Guozhu Ye, Xu Zhang, Xinyu Liu, Xu Liao, Han Zhang, Changzhou Yan, Yi Lin, Qiansheng Huang
Summary: The study found that exposure to polystyrene microplastics significantly altered the metabolism of marine medaka livers, leading to changes in various metabolic pathways and levels of specific metabolites. The effects of different sizes of microplastics (10-mu m and 200-mu m) on hepatic metabolism were observed, with differences in the impact on carbohydrate, amino acid, and lipid metabolism. Overall, the results provide new insights into the ecotoxicology of microplastics in aquatic organisms.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Agriculture, Multidisciplinary
Bing Wang, Yuejun Wang, Shuxian Zuo, Sijia Peng, Zhanjun Wang, Yingjun Zhang, Hailing Luo
Summary: This study investigated the meat metabolome of Tan lamb and rumen bacterial community under different feeding regimes, revealing that artificial pasture grazing led to changes in amino acid and fatty acid composition in the muscle, resulting in healthier lamb meat products.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Biochemical Research Methods
Sicheng Tian, Chuan Wang, Yongyu Li, Xiaoming Bao, Yunwen Zhang, Tian Tang
Summary: SlyA is an important transcriptional regulator in Salmonella typhimurium, affecting the virulence and cell metabolism of the bacterium. Deletion of slyA impairs cell growth and alters several glycolytic and lipid metabolism pathways in S. typhimurium. Transcriptional analysis showed downregulation of genes associated with glycolysis and lipid turnover in the absence of slyA.
JOURNAL OF PROTEOME RESEARCH
(2021)
Article
Nutrition & Dietetics
Antonio Augusto Ferreira Carioca, Josiane Steluti, Aline Martins de Carvalho, Alexsandro Macedo Silva, Ismael Dale Cotrim Guerreiro da Silva, Regina Mara Fisberg, Dirce Maria Marchioni
Summary: Plasma metabolomic profiles were found to be associated with MetS, especially the amino acid serine and some acyl-alkyl phosphatidylcholines.
Article
Nutrition & Dietetics
Maria Juarez-Fernandez, Sara Roman-Saguillo, David Porras, Maria Victoria Garcia-Mediavilla, Pedro Linares, Maria Dolores Ballesteros-Pomar, Ana Urioste-Fondo, Begona Alvarez-Cuenllas, Javier Gonzalez-Gallego, Sonia Sanchez-Campos, Francisco Jorquera, Esther Nistal
Summary: Bariatric surgery can improve the health status of obese patients, significantly impact gut microbiota composition, and be associated with specific metabolome profiles. The study suggests that bariatric surgery has long-term positive effects on the remission of obesity.
Review
Pharmacology & Pharmacy
Shubhangi Saxena, Neha Dagar, Vishwadeep Shelke, Maciej Lech, Pragyanshu Khare, Anil Bhanudas Gaikwad
Summary: The kidney undergoes metabolic reprogramming in various disease states, and understanding the involved bioenergetic pathways and developing targeted interventions are crucial for addressing the high number of kidney disease cases worldwide. Reprogramming of metabolic pathways has been observed in kidney disease, and therapies targeting these pathways have shown promising results in retarding disease progression. This review focuses on potential pharmacological interventions targeting metabolic reprogramming that have advanced through clinical trials and preclinical studies, with the aim of managing kidney disease effectively in the future.
DRUG DISCOVERY TODAY
(2023)
Article
Agriculture, Dairy & Animal Science
Qiuya He, Jun Luo, Jiao Wu, Zhuang Li, Weiwei Yao, Saige Zang, Huimin Niu
Summary: The role of ELOVL6 gene in the synthesis of long-chain saturated and monounsaturated fatty acids is important. Studies have shown that SREBP1 regulates the transcription of ELOVL6 through the SRE elements in the ELOVL6 promoter.
JOURNAL OF DAIRY SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Lu Liu, Xingyu Zhu, Huike Ye, Yingying Wen, Biswarup Sen, Guangyi Wang
Summary: This study investigates the effects of dissolved oxygen (DO) supply on the fermentation process and accumulation of intracellular metabolites in Aurantiochytrium PKU#Mn16 strain. The results show that a constant supply of 10% DO can yield higher biomass and DHA content, and downregulate the expression of genes involved in central carbon, amino acid, and fatty acid metabolism. These findings are important for improving DHA production.
MICROBIAL CELL FACTORIES
(2023)
Review
Surgery
Jane Ha, Yeongkeun Kwon, Sungsoo Park
Summary: Metabolomics has played a significant role in identifying biomarkers related to metabolic effects in patients undergoing bariatric surgery. This research provides new directions for the future selection of candidates and treatment strategies.
Article
Cell Biology
Xi Li, Yinan Zhang, Lingya Xu, Aoxue Wang, Yejun Zou, Ting Li, Li Huang, Weicai Chen, Shuning Liu, Kun Jiang, Xiuze Zhang, Dongmei Wang, Lijuan Zhang, Zhuo Zhang, Zeyi Zhang, Xianjun Chen, Wei Jia, Aihua Zhao, Xinfeng Yan, Haimeng Zhou, Linyong Zhu, Xinran Ma, Zhenyu Ju, Weiping Jia, Congrong Wang, Joseph Loscalzo, Yi Yang, Yuzheng Zhao
Summary: In this study, a highly sensitive lactate sensor called FiLa was developed, which allows for monitoring subtle lactate fluctuations in living cells and animals. It was found that lactate is highly enriched in mammalian mitochondria and functions as a key hub sensing various metabolic activities. The FiLa sensors also enable direct imaging of elevated lactate levels in diabetic mice and provide a simple, rapid, and sensitive lactate assay for clinical screening. Overall, the FiLa sensors are powerful and broadly applicable tools for studying lactate metabolism in health and disease.
Article
Oncology
Zongmei Zheng, Xinxin Hou, Zhaoxiang Bian, Wei Jia, Ling Zhao
Summary: This review explores the crucial role of gut microbiota in the metastasis of colorectal cancer (CRC) and elucidates the molecular mechanisms through which gut microbiota contribute to the formation of a tumor-permissive microenvironment, as well as facilitate malignant transformation and dissemination of tumor cells, thus mediating CRC metastasis.
Article
Biotechnology & Applied Microbiology
Jiaxin Li, Yuqi Chen, Rui Li, Xianglong Zhang, Tao Chen, Fengyi Mei, Ruofan Liu, Meiling Chen, Yue Ge, Hongbin Hu, Rongjuan Wei, Zhenfeng Chen, Hongying Fan, Zhenhua Zeng, Yongqiang Deng, Haihua Luo, Shuiwang Hu, Shumin Cai, Feng Wu, Nengxian Shi, Zhang Wang, Yunong Zeng, Ming Xie, Yong Jiang, Zhongqing Chen, Wei Jia, Peng Chen
Summary: Sepsis, a global public health challenge, lacks effective treatment or intervention. This study reveals that hyodeoxycholic acid (HDCA) has excellent anti-inflammatory properties in sepsis. HDCA administration significantly decreases systemic inflammatory responses and improves the survival of septic mice. The mechanism involves the competitive blockade of lipopolysaccharide binding to TLR4 and MD-2 receptor complex by HDCA. These findings highlight the potential value of HDCA as a therapeutic molecule for sepsis.
Review
Pharmacology & Pharmacy
Kenneth Chat Pan Cheung, Ma Jiao, Xingxuan Chen, Jia Wei
Summary: This article discusses the potential of extracellular vesicles in the treatment of osteoporosis, and introduces their characteristics and application prospects.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Lijuan Yu, Chunhua Huang, Wei Yang, Zhenxing Ren, Lifeng Li, Huiyuan Cheng, Chengyuan Lin, Lixiang Zhai, Ziwan Ning, Hoileong Xavier Wong, Quanbin Han, Wei Jia, Zhaoxiang Bian, Ling Zhao
Summary: This study evaluated the effect of cinnamon extract on bowel symptoms in rat models of irritable bowel syndrome with diarrhea (IBS-D). It found that cinnamon extract reduced defecation frequency and visceral hyperalgesia in the rat models, and the efficacy was comparable to a positive drug. Furthermore, cinnamon extract directly inhibited the expression of Tph1 and controlled serotonin synthesis, providing a scientific viewpoint for the traditional use of cinnamon in treating IBS.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Oncology
Cheng Li, Xiaojing Ma, Jingyi Lu, Rui Tao, Xia Yu, Yifei Mo, Wei Lu, Yuqian Bao, Jian Zhou, Weiping Jia
Summary: Continuous glucose monitoring (CGM) can assess diabetic statuses continuously, and the complexity of glucose time series index (CGI) derived from CGM data is significantly associated with various glucose metabolism-related parameters, making it a novel marker for evaluating glucose homeostasis.
FRONTIERS OF MEDICINE
(2023)
Article
Microbiology
Yu Pi, Yujun Wu, Xiangyu Zhang, Dongdong Lu, Dandan Han, Jiangchao Zhao, Xiaojiao Zheng, Shiyi Zhang, Hao Ye, Shuai Lian, Yu Bai, Zhenyu Wang, Shiyu Tao, Dongjiao Ni, Xinhua Zou, Wei Jia, Guolong Zhang, Defa Li, Junjun Wang
Summary: In this study, the difference in fecal microbiome and bile acid (BA) profiles between low birth weight (LBW) and normal birth weight (NBW) piglets were investigated. Fecal microbiota transplantation confirmed the link between microbial BA metabolism and intestinal inflammation. The therapeutic potential of ursodeoxycholic acid (UDCA) was evaluated and it was found to alleviate intestinal inflammation through M2 macrophage polarization and suppression of inflammatory cytokines.
Article
Chemistry, Multidisciplinary
Yi Zhang, Yangyang Zhu, Jinghui Wang, Li Jin, Mingwei Guo, Liwei Chen, Lina Zhang, Yangyang Li, Baocheng Wan, Rong Zhang, Weiping Jia, Cheng Hu
Summary: Nrg4 is an adipose tissue-enriched factor that regulates glucose and lipid metabolism and is closely associated with obesity. It acts on ErbB4 in the hypothalamus, excites PVN neurons, and influences energy balance. Its effects on reducing obesity are mediated through ErbB4-mediated excitation of Oxt release from Oxt neurons.
Article
Endocrinology & Metabolism
Yanping Yuan, Xianghai Zhou, Weiping Jia, Jian Zhou, Fan Zhang, Jianling Du, Linong Ji
Summary: The study aimed to develop an HbA1c prediction model with both fasting and postprandial capillary blood glucose to estimate HbA1c in type 2 diabetes. The new HbA1c prediction model using ridge regression showed better prediction ability and good agreement.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Multidisciplinary Sciences
Alessio Butera, Massimiliano Agostini, Matteo Cassandri, Francesca De Nicola, Maurizio Fanciulli, Lorenzo D'Ambrosio, Laura Falasca, Roberta Nardacci, Lu Wang, Mauro Piacentini, Richard A. Knight, Wei Jia, Qiang Sun, Yufang Shi, Ying Wang, Eleonora Candi, Gerry Melino
Summary: An essential function of the epidermis is to provide a physical barrier that prevents water loss. Alteration of ceramides, cholesterol, and very long chain fatty acids, mediators of this barrier function, causes human pathologies. A study shows that genetic deletion of ZFP750 in mice leads to the loss of epidermal barrier function due to a reduction in ceramides. ZFP750 directly and/or indirectly regulates the expression of enzymes involved in ceramide biosynthesis, contributing to our understanding of skin disease pathogenesis.
Article
Psychology, Multidisciplinary
Ruoting Liu, Xueying Zheng, Ziyu Wang, Mingjie Zhou, Jianping Weng, Yan-mei Li, Xuefeng Chen
Summary: This study investigates the social motives underlying compliance among individuals with infectious diseases. The results show that individuals with COVID-19 symptoms have lower levels of compliance, which is attributed to a decrease in disease avoidance and familial motives. The study also suggests that exclusion concern weakens the effects of COVID-19 symptoms on compliance. Therefore, enhancing disease avoidance and familial motives may serve as effective intervention strategies to promote compliance among potentially infected individuals.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Siu Leung Chau, Aihua Zhao, Wei Jia, Lu Wang
Summary: This study presents a method for rapidly detecting pesticide residues and mycotoxins in Pu-erh tea. The results showed no pesticide residues and mycotoxins detected in the collected samples, all of which were below the legal limits.
Article
Nutrition & Dietetics
Hung N. Luu, Chi Thi-Du Tran, Renwei Wang, Mai Vu-Tuyet Nguyen, Mo Thi Tran, Thuy Thi-Van Tuong, Quang Hong Tran, Linh Cu Le, Huong Thi-Thu Pham, Hien Huy Vu, Nam Chi Bui, Hien Thi-Thu Ha, Dung Tuan Trinh, Claire E. Thomas, Jennifer Adams-Haduch, Liudmilla Velikokhatnaya, Robert E. Schoen, Guoxiang Xie, Wei Jia, Paolo Boffetta, Jose C. Clemente, Jian-Min Yuan
Summary: The study found that colorectal advanced adenoma is associated with alterations in ileal juice bile acids. The concentrations of hyodeoxycholic acid (HCA) species in ileal juice were significantly higher in advanced adenoma patients compared to controls. The relative abundance of ursodeoxycholic acid (UDCA) in total bile acids was significantly reduced in cases than controls.
Article
Biochemical Research Methods
Kun Ge, Dan Zheng, Jieyi Wang, Wei Jia, Aihua Zhao
Summary: A simple and rapid method for quantifying ceramides and dihydroceramides in animal tissues has been developed. The results indicate significant differences in ceramide and dihydroceramide levels between liver and small intestine tissues, which may be related to the compositional features of ceramides.
ANALYTICAL BIOCHEMISTRY
(2023)