Article
Materials Science, Multidisciplinary
Huixiang Wu, Shanduo Chen, Yifan Wang, Jiefeng Tan, Yunhui Feng, Liping Hou, Huan Wang
Summary: In this study, two kinds of spiny gold nanoparticles and a triangular gold nanoparticle were synthesized and used for the detection of methyl parathion. The nanoparticles showed high enhancement factors and favorable quantitative analysis capability.
Review
Chemistry, Multidisciplinary
Shanshan Lin, Ziyi Cheng, Qifu Li, Rui Wang, Fabiao Yu
Summary: Molecular imaging technologies, especially SERS imaging, offer significant advantages in clinical diagnostics, enabling accurate detection of biomarkers and cellular microenvironment. The integration of multimodal imaging helps achieve more comprehensive and accurate imaging outcomes, showing strong potential in discriminating pathological tissues and surgical navigation.
Article
Chemistry, Physical
Han-Kyu Choi, Sang-Min Park, Jeeyoon Jeong, Hankyul Lee, Gyu Jin Yeon, Dai-Sik Kim, Zee Hwan Kim
Summary: In this study, a simple photolithographic method was demonstrated to generate highly sensitive SERS hot spot structures at desired positions. The solid-state dewetting of an Ag thin film using a continuous-wave laser resulted in the formation of closely packed assemblies of hemispherical Ag nanoislands with substantial plasmonic-field enhancement. These hot spot structures can be utilized as position-specific chemical-sensing elements in integrated analytical devices.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Myoung Gyu Kim, Miyeon Jue, Kwan Hee Lee, Eun Yeong Lee, Yeonjeong Roh, Minju Lee, Hyo Joo Lee, Sanghwa Lee, Huifang Liu, Bonhan Koo, Yoon Ok Jang, Eui Yeon Kim, Qiao Zhen, Sung-Han Kim, Jun Ki Kim, Yong Shin
Summary: The study introduces a deep learning assisted ZnO-Au-SERS-based direct amplification (ZADA) system for rapid, sensitive molecular diagnostics. The system can amplify target nucleic acids directly on the SERS surface, eliminating the need for post-amplification hybridization and Raman reporters. Clinical validation with COVID-19 samples yielded high sensitivity and specificity. The integration of a deep learning program further enhanced sensitivity and specificity to 100%.
Article
Chemistry, Analytical
Andra-Sorina Tatar, Sanda Boca, Alexandra Falamas, Denisa Cuibus, Cosmin Farcau
Summary: In this study, high-density gold nanostar films were fabricated through self-assembly on polystyrene plates, and their use as solid plasmonic substrates for surface-enhanced optical spectroscopies was explored. The films demonstrated dual-mode surface-enhanced fluorescence and surface-enhanced Raman scattering effects under visible and NIR laser excitation. The experimental results were supported by theoretical modelling, and the potential application of these substrates in the detection of biologically relevant molecules was demonstrated.
Article
Chemistry, Analytical
W. Cheuquepan, S. Hernandez, M. Perez-Estebanez, L. Romay, A. Heras, A. Colina
Summary: Electrochemistry can be used to generate SERS substrates, utilizing the plasmonic properties of nanos-tructures and the chemical mechanism, with time-resolved Raman spectroelectrochemistry providing valuable information. Comparing Au and Ag metals for folic acid detection in drugs, it was found that Ag SERS substrates outperformed Au SERS substrates in complex samples.
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Jingtian Zhao, Ziyun Wang, Jinshen Lan, Imran Khan, Xiaofang Ye, Jing Wan, Yuchen Fei, Shengli Huang, Shuping Li, Junyong Kang
Summary: Phototreatment is a leading edge research area that has been widely used in surface-enhanced Raman spectroscopy for applications in life sciences, environmental protection, and biological analysis, showing unmatched advantages in solving critical challenges and enhancing biomolecular signals at trace levels.
Article
Biochemical Research Methods
Stefano Fornasaro, Alessandro Esposito, Fiorella Florian, Alberto Pallavicini, Luigina De Leo, Tarcisio Not, Cristina Lagatolla, Marica Mezzarobba, Alessia Di Silvestre, Valter Sergo, Alois Bonifacio
Summary: Significant differences were found in the faecal samples of celiac patients and those on a gluten-free diet using SERS spectroscopy and 16S rRNA sequencing analysis. Although there were no significant differences in bacterial composition, the relative intensity of xanthine and hypoxanthine in the SERS spectra of patients on a gluten-free diet was significantly increased.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2022)
Review
Chemistry, Physical
Marita Wagner, Andreas Seifert, Luis M. Liz-Marzan
Summary: This article reviews SEIRA sensors based on metal plasmonics for the detection of biomolecules such as DNA, proteins, and lipids. It further focuses on chemical SEIRA sensors and their potential applications in quality control, as well as the development of multiresonant SEIRA substrates as sensors for multiple analytes. Finally, the integration of SEIRA sensors with surface-enhanced Raman scattering (SERS) is introduced.
NANOSCALE HORIZONS
(2022)
Review
Chemistry, Multidisciplinary
Hong Zhou, Liangge Xu, Zhihao Ren, Jiaqi Zhu, Chengkuo Lee
Summary: This review introduces the combination of machine learning (ML) and surface-enhanced spectroscopy techniques (SERS/SEIRA) and discusses the benefits of ML algorithms for SERS/SEIRA. It also highlights the applications of ML-combined SEIRA/SERS in molecular diagnostics and screening and provides perspectives on future developments in ML-integrated SEIRA/SERS.
NANOSCALE ADVANCES
(2023)
Article
Chemistry, Physical
Wuwen Yan, Siyu Chen, Pan Li, Ronglu Dong, Hyun-Hang Shin, Liangbao Yang
Summary: In this study, a platform for monitoring label-free molecules at the single-molecule level using surface-enhanced Raman spectroscopy (SERS) was developed based on the photothermal effect of gold nanorods (GNRs). The results showed that single crystal violet (CV) molecules can be observed blinking for up to 4 minutes using dynamic surface-enhanced Raman spectroscopy (D-SERS). The research provides a novel idea for exploring the temporal and spatial dynamic processes of different reactions.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Chemistry, Multidisciplinary
Sheng-Yang Huang, Wei-Ning Gao, Chia-Man Chou, Vincent K. S. Hsiao
Summary: In this study, porous silicon (PSi) modified with Au/TiO2 nanocomposites (NCPs) was investigated for its potential as a substrate for photoinduced enhanced Raman spectroscopy (PIERS). The addition of TiO2 nanoparticles during pulsed laser-induced photolysis (PLIP) led to the formation of spherical Au nanoparticles on the PSi surface. Real-time monitoring of the Raman signals of rhodamine 6G (R6G) under ultraviolet (UV) irradiation showed that PSi substrates decorated with Au/TiO2 NCPs significantly enhanced the Raman signal of R6G.
Article
Chemistry, Inorganic & Nuclear
Shengjie Xiong, Jia Li, Maobin Wei, Donglai Han, Jihui Lang, Huilian Liu, Jinghai Yang, Yang Liu, Ming Gao
Summary: Ag-doped MoS2 (AMS(x)) was prepared as a SERS substrate with excellent reproducibility, stability, and recyclability. It exhibited an enhancement factor of 4.07 x 10(6) and a detection limit of 10(-9) M, proving its potential for applications in SERS sensing.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Physical
Wuwen Yan, Siyu Chen, Pan Li, Ronglu Dong, Hyun-Hang Shin, Liangbao Yang
Summary: In this study, a platform for monitoring single molecules using surface-enhanced Raman spectroscopy (SERS) was developed based on the photothermal effect of gold nanorods (GNRs). By utilizing laser re-irradiation to create nanometer gaps between GNRs, the blinking behavior of single crystal violet (CV) molecules was observed for up to 4 minutes using dynamic surface-enhanced Raman spectroscopy (D-SERS). The confinement of CV molecules in sub-nanometer spaces and the dynamic capture of their orientations provide a new approach for exploring the temporal and spatial dynamic processes of different reactions.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2023)
Article
Nanoscience & Nanotechnology
Matthew E. Berry, Samantha M. McCabe, Sian Sloan-Dennison, Stacey Laing, Neil C. Shand, Duncan Graham, Karen Faulds
Summary: This study investigates the capability of using SESORS imaging to determine the exact location of an object within tissue. Experimental factors related to the optical setup are examined to determine their effect on the three-dimensional positioning capability of SESORS. The study introduces the concept of linear offset-induced image drag and emphasizes the importance of an annular SOBS collection geometry in neutralizing these effects. Additionally, the concept of ratiometric SESORS imaging is introduced for locating buried inclusions in three dimensions.
ACS APPLIED MATERIALS & INTERFACES
(2022)