Article
Chemistry, Applied
Suzi Kim, Jaehyun Park, Dirgha Raj Joshi, Na Keum Lee, Hang Le Bich Pham, Linh Khanh Chung, MinJoo Kang, Younggwan Kim, Ikyon Kim, Jeeyeon Lee
Summary: In this study, we report benzofuro[2,3-c]isoquinolines (FiQ) as novel blue AIEgens, in which a -OMe group substituent plays a crucial role in modulating intermolecular interactions, inducing a marked increase in emission of up to 150- and 460-fold in the aggregate and solid states, respectively. Our single-crystal X-ray diffraction analysis revealed that the edge-to-face interactions among phenyl groups generate tight networks that rigidify the assembled structures, resulting in AIE.
Article
Chemistry, Organic
Jasvir Kaur, Harshad A. Mirgane, Sheshanath V. Bhosale, Prabhat K. Singh
Summary: In this study, a simple, real-time, and direct fluorescence detection platform for monitoring ALP levels was developed using aggregation-induced emission. The sensing system showed good sensitivity and applicability with diluted human serum samples.
ORGANIC & BIOMOLECULAR CHEMISTRY
(2022)
Article
Chemistry, Analytical
Xin Zheng, Qiumeng Chen, Zhixiao Zhang, Zhaoli Wang, Zhengjun Gong
Summary: Researchers have designed a fluorescence-enhanced copper nanocluster based on tannic acid templating, which can be used as a new fluorescent probe for tetracycline detection. The modified probe showed good linearity and low detection limit, and demonstrated promising application prospects in actual water samples.
MICROCHEMICAL JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Dongmi Li, Panpan Lv, Xiao-Wen Han, Zhilei Jia, Min Zheng, Hai-Tao Feng
Summary: A simple tetraphenylethene (TPE) derivative with aggregation-induced emission (AIE) characteristics was synthesized and used as a fluorescent sensor for the detection of nitrophenolic explosives with high selectivity. The sensor could identify nitroaromatic compounds in water solution and solid state, and only hydroxyl-containing nitrophenolic explosives caused fluorescence quenching. The sensing mechanism was investigated using fluorescence titration and H-1 NMR spectra. This AIE-active probe has the potential to be applied in the development of portable explosive detection devices.
Article
Materials Science, Biomaterials
Weidong Yin, Jianqing Li, Yucheng Ma, Longjiang Xing, Zeduan Chen, Bo Liu, Yanping Huo, Zujin Zhao, Shaomin Ji
Summary: This study proposed an effective molecular design strategy to improve the reactive oxygen species (ROS) generation efficiency of aggregation-induced emission photosensitizers (AIE PSs). By designing and synthesizing a series of tetraphenylethylene derivatives containing the pyridine ring or pyridinium with different substituents, it was found that these molecules displayed weak emission when molecularly dissolved but showed intense emission upon aggregation, indicating the phenomenon of aggregation-induced emission. One of the molecules was used as a visualization agent to specifically stain mitochondria in living cells, while most of the molecules failed to generate ROS under white light irradiation. In contrast, TPE-Pys-BP containing benzophenone efficiently produced OH and O-1(2) in the presence of light due to its large spin-orbit coupling constant, making it a potential photosensitizer for photodynamic therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Engineering, Environmental
Xirui Chen, Yujie Tu, Song Cheng, Xujing Guo, Tianying Lu, Yuqian Guo, Xiaolin Huang, Yonghua Xiong, Ben Zhong Tang
Summary: In this study, a simple pH-sensitive aggregation-induced emission-active fluorogen was developed for ratiometric monitoring of biogenic amines. The proposed paper chips showed promising potential for real-time monitoring of meat and seafood freshness using bimodal colorimetry and ratiometric fluorescence.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Optics
Rafaela Gomes Martins da Costa, Rafael de Queiroz Garcia, Raquel Mazzoli da R. Fiuza, Luis Maqueira, Alessandra Pazini, Leonardo de Boni, Jones Limberger
Summary: Hybrids containing both chalcone and benzothiadiazole moieties were synthesized and characterized for their photophysical properties. The compounds exhibited absorption maxima ranging from 384 to 408 nm and high extinction coefficient values. Some hybrids showed aggregation-induced enhanced emission properties, with a significant increase in fluorescence intensity and quantum yields observed upon aggregation.
JOURNAL OF LUMINESCENCE
(2021)
Article
Cell Biology
Ya-Nan Chang, Yuelan Liang, Jiayi Wang, Ziteng Chen, Ruyu Yan, Kui Chen, Juan Li, Jiacheng Li, Haojun Liang, Gengmei Xing
Summary: The research team developed a sensitive probe for assessing the resistance of cancer cells to anoikis, which can be used to quantitatively evaluate the ability of different cancer cell lines to resist detachment under the lost nest condition.
Article
Polymer Science
Hong Xue, De-Shan Li, Hua-Wen Cai, Xiao-Li Sun, Wen-Ming Wan
Summary: Nontraditional intrinsic luminescent (NTIL) polymers are a new class of luminescent polymer materials. In this study, a series of aggregation-induced emission (AIE) type NTIL polymers were successfully synthesized through reversible addition-fragmentation chain transfer (RAFT) polymerization-induced emission (PIE). The triphenylmethyl azide moiety was found to be a novel PIE luminogen for the molecular design of NTIL polymers. These NTIL polymers showed potential applications in explosive detection and luminescence energy transfer.
Article
Chemistry, Analytical
Wei Wang, Min Ji, Junqing Chen, Peng Wang
Summary: In this study, a turn-on type aggregation-induced emission (AIE) fluorescent probe BQM-NBD was developed for selective detection of Cys and Hcy in organisms, showing good selectivity. Additionally, BQM-NBD exhibited low cytotoxicity when used for imaging Cys in living cells.
Article
Engineering, Biomedical
Xiaoxue Ge, Meng Gao, Bairong He, Nannan Cao, Kerun Li, Yong Liu, Sanmei Tang, Kai Liu, Jing Zhang, Fang Hu, Lei Zheng, Bo Situ
Summary: Increasing resistance among fungi to antimicrobials poses global health threats. A new antifungal susceptibility testing (AFST) method using a luminogen with aggregation-induced emission characteristics (AIEgen) called DMASP can assess fungal susceptibility to various antimicrobials within 12 hours, rapidly detect possible drug-resistant fungal strains, and guide the precise use of antimicrobials.
Article
Chemistry, Applied
Jingyu Deng, Ranran Kong, Zhiping Liu, Yuchen Weng, Li-Juan Fan
Summary: This study introduces tetraphenylethylene (TPE), which has aggregation-induced emission (AIE) effect, into UV-curable adhesive and optimizes the concentration of TPE-modified methacrylate (TPE-MA) to achieve blue fluorescence under UV light for visualizing the adhesive's location. By comparing the cured products, it is found that the one with TPE-MA forming covalent bonds has higher fluorescence intensity and better stability. The addition of a small amount of TPE-MA has no significant effect on the adhesive's performance.
Article
Chemistry, Analytical
Ruihong Yao, Zhijian Li, Gang Liu, Congbin Fan, Shouzhi Pu
Summary: A ratiometric fluorometric method based on luminol-Europium complex was developed for the detection of tetracycline, showing quenching of fluorescence at 453 nm due to inner filter effect in the presence of TC and observation of Eu3+ emission peak at 626 nm thanks to antenna effect. This strategy is fast, sensitive, and visual for TC detection, allowing for detection from 0.5 to 80 mu M with a detection limit of 39 nM, and demonstrating color change from blue to red in real samples using luminol-Eu-based test paper under 365 nm ultraviolet light.
Article
Chemistry, Analytical
Chenrui Jiang, Geyuan Li, Yue Chen, Liping Xi, Meiru Liu, Jun Peng, Pierre Dramou, Hua He
Summary: A fast, simple, sensitive and stable turn-on fluorescent probe method was developed using the self-assembly of aggregation-induced emission luminogen 1,1,2,2-tetra(biphenyl-4-yl)ethene and cucurbit[7]uril for the selective determination of metformin. The host-guest complex improves the water solubility of traditional aggregation-induced emission material. The method shows good sensitivity and accuracy for metformin detection with a linear correlation between relative fluorescence intensity and metformin concentration in the range of 5 to 100 μM.
MICROCHEMICAL JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Fengyan Song, Xinwen Ou, Tsu Yu Chou, Junkai Liu, Hui Gao, Ruoyao Zhang, Xiaolin Huang, Zujin Zhao, Jianwei Sun, Sijie Chen, Jacky W. Y. Lam, Ben Zhong Tang
Summary: Microviscosity is a crucial parameter in the biophysics of life science, and the development of real-time quantitative monitoring of microviscosity inside cells is significant. This study introduces loose packing nanoaggregates with aggregation-induced delayed fluorescence as probes for viscosity mapping via time-resolved luminescence imaging. The feasibility of using these nanoparticles for microviscosity mapping was demonstrated, showing potential for understanding the physiologically dynamic microenvironment and advancing diagnostic and therapeutic methods for related diseases.
Article
Chemistry, Inorganic & Nuclear
Jianbing Shi, Ling Wang, Si Pei, Han Wang
Summary: Through a mixed-ligand approach, a new Cu(II)-based coordination polymer was synthesized, displaying a unique 3D framework structure with interpenetrated networks. The compound showed promising potential in reducing thrombus formation and decreasing inflammatory responses in vascular endothelial cells. Molecular docking simulation suggested potential interactions with C-reactive protein.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Wenbo Dai, Yahui Zhang, Xinghui Wu, Shuai Guo, Jieran Ma, Jianbing Shi, Bin Tong, Zhengxu Cai, Haiyan Xie, Yuping Dong
Summary: This study reports the development of new red-emissive organic room-temperature phosphorescence (RTP) materials through the integration of the ring-fusing effect and host-guest interaction. These materials exhibit long lifetimes and high luminescence efficiency, making them promising for applications in fluorescence imaging.
Article
Chemistry, Multidisciplinary
Wenbo Dai, Xiaowei Niu, Xinghui Wu, Yue Ren, Yongfeng Zhang, Gengchen Li, Han Su, Yunxiang Lei, Jiawen Xiao, Jianbing Shi, Bin Tong, Zhengxu Cai, Yuping Dong
Summary: By introducing intermolecular halogen bonding, the system's intersystem crossing was promoted and the triplet excitons were stabilized, resulting in strong phosphorescence emission. Additionally, this method enabled colorimetric multi-stimuli responsive behaviors, greatly enriching the luminescence functionality of the materials.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Physics, Applied
Changlin Ding, Yibao Dong, Yuanbo Wang, Jianbing Shi, Shilong Zhai, Xiaopeng Zhao
Summary: Acoustic metamaterials and acoustic metasurfaces are artificially structured materials with unique properties. They can achieve negative modulus and negative mass density using different meta-atoms or meta-molecules, and can be used to fabricate materials with topologically protected edge state propagation and anomalous manipulation for acoustic waves.
JOURNAL OF PHYSICS D-APPLIED PHYSICS
(2022)
Article
Chemistry, Multidisciplinary
Yue Ren, Wenbo Dai, Shuai Guo, Lichao Dong, Siqi Huang, Jianbing Shi, Bin Tong, Nairong Hao, Lianwei Li, Zhengxu Cai, Yuping Dong
Summary: PDHPs synthesized via one-pot method exhibit tunable triplet energy levels, with the formation of large clusters extending phosphorescence wavelength. Structural information on host-guest systems can be analyzed through static and dynamic laser light scattering, and fluorescence and phosphorescence emission can be easily tuned by varying excitation wavelength, concentration, and molecular weight.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2022)
Article
Engineering, Biomedical
Pai Liu, Fei Ren, Subin Son, Myung Sun Ji, Peng Li, Zhengxu Cai, Jianbing Shi, Yi Liu, Yuping Dong, Jong Seung Kim
Summary: This study reports two novel intersystem crossing photosensitizers and draws attention to mitochondria-related DAMP-TFAM produced by cancer cells under forceful oxidative stress. The combination of photodynamic therapy and immunogenic experiments shows promising treatment outcomes and offers a new target for immunotherapy.
Article
Chemistry, Applied
Na Lin, Xinghui Wu, Zhengxu Cai, Jianbing Shi, Bin Tong, Yuping Dong
Summary: Three types of 4'-methoxychalcone derivatives were synthesized and studied, and it was found that the presence of a hydroxyl group at the 2-position of the A ring and strong electron-donating groups at the 4-position of the B ring were favorable for the fluorescence properties of the compounds. Different chalcone fluorophores with varying fluorescence properties could be obtained by modulating substituents at the 2-position of the A ring.
Article
Chemistry, Multidisciplinary
Ziting Li, Shisheng Cui, Jiayu Yu, Jiamin Qu, Jianbing Shi, Bin Tong, Zhengxu Cai, Yuping Dong
Summary: Real-time monitoring of cell membrane biological dynamics is important for understanding the physiological state of cells. A type of amphiphilic near infrared (NIR) aggregation-induced emission (AIE) molecules, such as MAP22, has been found to have a large emission wavelength and Stokes shift in the aggregation state, and can generate reactive oxygen species. These AIE MAPs show potential as theranostic nanoagents for targeting cell membranes and ablating cancer cells.
Article
Chemistry, Multidisciplinary
Wenbo Dai, Gengchen Li, Yongfeng Zhang, Yue Ren, Yunxiang Lei, Jianbing Shi, Bin Tong, Zhengxu Cai, Yuping Dong
Summary: This article develops an effective strategy for preparing RTP materials with controllably regulated properties by constructing dynamic metal-ligand coordination. The coordination interaction promotes the phosphorescence emission of the materials and allows the modulation of their photophysical properties. By utilizing the reversible metal-ligand coordination, the activation and deactivation of RTP can be dynamically manipulated, providing possibilities for anti-counterfeiting applications in inkjet printing of high-resolution patterns.
ADVANCED FUNCTIONAL MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Yueyue Si, Yeyun Zhao, Wenbo Dai, Shisheng Cui, Peng Sun, Jianbing Shi, Bin Tong, Zhengxu Cai, Yuping Dong
Summary: A fused-ring structure is proposed in this study to decrease the triplet energy level and extend the emission wavelength of phosphorescence. The fused-ring structure exhibits a high molar extinction coefficient and high luminescence efficiency. Crystalline hosts (IDB) are developed to stabilize the triplet excitons generated from the fused-ring molecules. Water-disperse nanoparticles are successfully prepared for in vivo time-resolved bioimaging, eliminating fluorescence interference from biological tissues.
CHINESE JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Applied
Xin Zhao, Chen Zhang, Xinghui Wu, Kai Zhang, Jianbing Shi, Zhengxu Cai, Bin Tong, Cong Chao, Yuping Dong
Summary: Six asymmetric tetraphenyl-1,3-butadiene derivatives with aggregation-induced emission (AIE) characteristics were synthesized. The single crystal structure of one derivative showed that a distorted structure and strong intermolecular interactions enhance the fluorescence emission. Two other derivatives exhibited mechanofluorochromic (MFC) properties, with MFC attributed to a transition from crystalline to amorphous state. One derivative selectively responded to two compounds in real-time with low detection limits. This work has significance in AIE molecule design and applications.
Review
Chemistry, Multidisciplinary
Yahui Zhang, Hairong Li, Mengdie Yang, Wenbo Dai, Jianbing Shi, Bin Tong, Zhengxu Cai, Zhouyu Wang, Yuping Dong, Xiaoqi Yu
Summary: This article provides an overview of the research on organic room-temperature phosphorescence (RTP) materials in the field of bioimaging. Compared to conventional imaging modalities based on organic fluorescent dyes, RTP materials with long lifetime enable time-resolved imaging to improve imaging resolution by avoiding autofluorescence. The strategies for achieving high performance RTP materials for bioimaging, as well as the optimization of nanonization processes, and the emerging methods for preparing RTP materials for bioimaging, are summarized in this review.
CHEMICAL COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Cong Chao, Lingling Kang, Wenbo Dai, Changsheng Zhao, Jianbing Shi, Bin Tong, Zhengxu Cai, Yuping Dong
Summary: Modulation of triplet exciton decay using microfluidic technology can generate highly reactive oxygen species (ROS) in organic room-temperature phosphorescence (RTP) materials, making it a promising strategy for efficient photodynamic therapy.
JOURNAL OF MATERIALS CHEMISTRY B
(2023)
Article
Chemistry, Multidisciplinary
Yongfeng Zhang, Chenchen Xiong, Wenbo Wang, Wenbo Dai, Yue Ren, Junming Xia, Gengchen Li, Jianbing Shi, Bin Tong, Xiaoyan Zheng, Xiangfeng Shao, Zhengxu Cai, Yuping Dong
Summary: The non-uniform electrostatic potential distributions of polycyclic aromatic materials in Buckybowl structures exhibit unique photoelectric performance. By selecting five host molecules with different functional units, the triplet exciton transition processes of OTC were dynamically modulated, resulting in regulated delayed emissions from 536 to 624 nm. Experimental data and theoretical calculations revealed that the varied triplet transition behaviors were attributed to the competition between the intersystem crossing process of OTC-monomer and the reverse intersystem crossing process of OTC-aggregates. This study demonstrates the superior structure of buckybowl-based luminophore in controlling triplet exciton transition processes and provides a new perspective for persistent afterglow luminophore design.
Article
Chemistry, Multidisciplinary
Jiamin Qu, Yahui Zhang, Zhengxu Cai, Bin Tong, Haiyan Xie, Yuping Dong, Jianbing Shi
Summary: Developing efficient photosensitizers that can generate type I reactive oxygen species under illumination is crucial for improving photodynamic therapy outcomes in tumor environments. A new multiarylpyrrole derivative photosensitizer with an acceptor-shielding strategy was synthesized to efficiently produce type I ROS in aggregated states. This strategy not only enhanced ROS generation but also showed synergistic immunotherapy effects by transforming protumoral M2 macrophages into antitumoral M1 macrophages in in vivo experiments.
