Article
Oncology
Chao Liu, Wenhui Gao, Yijun Shi, Lu Lv, Weifeng Tang
Summary: This study investigated the relationship between miRNA rs2910164, rs11614913, and rs3746444 polymorphisms and the susceptibility to esophageal squamous cell cancer (ESCC) in the Chinese Han nationality. The results suggest that the rs3746444 GG genotype is associated with an increased risk of ESCC, while rs11614913 and rs2910164 polymorphisms are not associated with ESCC.
Article
Endocrinology & Metabolism
Wei-Wei Chang, Li-Ying Wen, Liu Zhang, Xin Tong, Yue-Long Jin, Gui-Mei Chen
Summary: This study investigated the relationship between the miR-146a rs2910164 polymorphism and the genetic susceptibility of T2DM in the Chinese Han population and conducted a meta-analysis. The results showed that the miR-146a rs2910164 polymorphism was associated with the risk of T2DM in certain age and BMI subgroups, but no significant association was found in the overall meta-analysis.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiakai Jiang, Sheng Zhang, Weifeng Tang, Zhiyuan Qiu
Summary: The miR-146a rs2910164 C/G polymorphism is not associated with the susceptibility of CRC, and further research is needed to confirm these results.
BIOSCIENCE REPORTS
(2021)
Review
Allergy
Young Ho Lee, Gwan Gyu Song
Summary: This study aimed to determine if miR-146a and miR-499 polymorphisms are associated with susceptibility to SLE. The results showed that the miR-146a rs2431697 C allele is associated with SLE and has a protective effect. However, the miR-146a rs2910164 is not associated with susceptibility to SLE.
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
(2023)
Article
Genetics & Heredity
Yingying Yuan, Yachun Wang, Xiaodong Niu, Yungang Han, Wenbo Li, Meijin Cheng, Zheng Li, Jiao Tan, Yue Zhao, Wei Wang
Summary: This study provides a more precise estimation of the relationship between lncRNA H19 polymorphisms and cancer risk based on a meta-analysis of 53 studies. The results suggest that the rs2839698 polymorphism in H19 is associated with increased cancer risk in all participants. Stratification analysis reveals that certain mutations are linked to specific cancer types.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Silvia Jimenez-Morales, Juan Carlos Nunez-Enriquez, Jazmin Cruz-Islas, Vilma Carolina Bekker-Mendez, Elva Jimenez-Hernandez, Aurora Medina-Sanson, Irma Olarte-Carrillo, Adolfo Martinez-Tovar, Janet Flores-Lujano, Julian Ramirez-Bello, Maria Luisa Perez-Saldivar, Jorge Alfonso Martin-Trejo, Hector Perez-Lorenzana, Raquel Amador-Sanchez, Felix Gustavo Mora-Rios, Jose Gabriel Penaloza-Gonzalez, David Aldebaran Duarte-Rodriguez, Jose Refugio Torres-Nava, Juan Eduardo Flores-Bautista, Rosa Martha Espinosa-Elizondo, Pedro Francisco Roman-Zepeda, Luz Victoria Flores-Villegas, Edna Liliana Tamez-Gomez, Victor Hugo Lopez-Garcia, Jose Ramon Lara-Ramos, Juana Esther Gonzalez-Ulivarri, Sofia Irene Martinez-Silva, Gilberto Espinoza-Anrubio, Carolina Almeida-Hernandez, Rosario Ramirez-Colorado, Luis Hernandez-Mora, Luis Ramiro Garcia-Lopez, Gabriela Adriana Cruz-Ojeda, Arturo Emilio Godoy-Esquivel, Iris Contreras-Hernandez, Abraham Medina-Hernandez, Maria Guadalupe Lopez-Caballero, Norma Angelica Hernandez-Pineda, Jorge Granados-Kraulles, Maria Adriana Rodriguez-Vazquez, Delfino Torres-Valle, Carlos Cortes-Reyes, Francisco Medrano-Lopez, Jessica Arleet Perez-Gomez, Annel Martinez-Rios, Antonio Aguilar-De-los-Santos, Berenice Serafin-Diaz, Maria de Lourdes Gutierrez-Rivera, Laura Elizabeth Merino-Pasaye, Gilberto Vargas-Alarcon, Minerva Mata-Rocha, Omar Alejandro Sepulveda-Robles, Haydee Rosas-Vargas, Alfredo Hidalgo-Miranda, Juan Manuel Mejia-Arangure
Summary: The study found that the SNP in the miR-499a gene (rs3746444) showed significant differences between ALL patients and the control group, with the GG genotype posing a higher risk for ALL, especially in males. There was also a gender-dependent association between SNPs in the miR-146a and miR-196a-2 genes and susceptibility to ALL in Mexican children.
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Shilin Xue, Wenya Shen, Jianning Cai, Jinhai Jia, Dan Zhao, Shan Zhang, Xiujun Zhao, Ning Ma, Wenjuan Wang, Bingshuang Wang, Xiaolin Zhang, Xuehui Liu
Summary: This meta-analysis aimed to examine the association between rs735482 polymorphism and cancer risk. The results showed that there is no significant association between rs735482 polymorphism and susceptibility to various cancers overall. However, stratified analysis by ethnicity indicated that rs735482 is associated with an increased risk of cancer in the Chinese population and a decreased risk in the Italian population.
Article
Medicine, General & Internal
Olfat G. Shaker, Omayma O. Abdelaleem, Nermeen A. Fouad, Naglaa A. Ahmed, Hoda A. Hussein, Enas G. Ibrahem, Abdelrahmaan A. Mohamed, Othman M. Ahmed, Doaa Y. Ali
Summary: This study found that miR-146a (rs2910164) and miR-155 (rs767649) gene polymorphisms are closely related to the development of BD in the Egyptian population and also influence disease severity.
ARCHIVES OF MEDICAL SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Chrysostomos Avgeros, Aikaterini Patsatsi, Dimitrios Dimitriadis, Andigoni Malousi, Triantafyllia Koletsa, Despoina Papathemeli, Antonia Syrnioti, Paraskevi Avgerou, Elizabeth Lazaridou, Georgios Tzimagiorgis, Elisavet Georgiou
Summary: This study evaluates the plasma levels of miR-146a and miR-155 in Mycosis Fungoides (MF) patients and investigates their association with SNPs of their genes. The results show that the plasma levels of miR-146a and miR-155 are significantly higher in MF patients compared to controls, especially in early and advanced stages. miR-155 levels are significantly higher in patients with skin tumors or erythroderma. The presence of specific SNPs is associated with the expression of miRs and potentially with disease susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Oncology
Maoquan Yang, Mingwei Zhang, Qiong Wang, Xiaojing Guo, Peizhen Geng, Jinhua Gu, Wansheng Ji, Li Zhang
Summary: In this meta-analysis, a significant association was found between H19 gene polymorphisms and cancer susceptibility. Specifically, the rs2107425 variation was related to decreased cancer risk among Caucasians, while the rs217727 polymorphism was associated with increased risk of lung cancer, hepatocellular carcinoma, and oral squamous cell carcinoma. Moreover, the rs2839698 polymorphism was linked to increased cancer risk among Asians and in different cancer types (such as gastric cancer and hepatocellular carcinoma) and larger study populations. Overall, H19 SNPs were found to be significantly correlated with cancer risk.
Review
Medicine, General & Internal
Qinxue Bao, Rui Li, Chengfeng Wang, Shan Wang, Minli Cheng, Chunhua Pu, Lei Zou, Chao Liu
Summary: This meta-analysis suggests that miR-146a rs2910164 may be associated with lower susceptibility to coronary heart disease. This association is particularly significant in the Chinese population.
Review
Medicine, General & Internal
Maoquan Yang, Wansheng Ji, Ning Xu, Chuanju Zong, Jinhua Gu, Xiaojing Guo, Li Zhang
Summary: In this meta-analysis, VDR gene polymorphisms including Cdx-2, Tru9I, FokI, BsmI, TaqI, and ApaI were found to be significantly associated with colorectal cancer (CRC) risk. Specifically, the BsmI variant was associated with a lower risk of CRC in Caucasian population, the FokI polymorphism was associated with colon cancer risk, and the Cdx-2 polymorphism was associated with decreased CRC risk among Africans.
Review
Oncology
Gaoming Li, Jingfu Ma, Ning Zhang, Xiaogang Li, Fangfang Li, Yuxing Jiang
Summary: This meta-analysis examined the associations between interleukin-17 (IL-17) polymorphisms and colorectal cancer susceptibility. The results showed that the IL-17A rs2275913 polymorphism was significantly associated with increased colorectal cancer susceptibility, while the IL-17F rs763780 polymorphism was not. These findings provide important evidence for the genetic risk of colorectal cancer and suggest potential targets for future research.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Jia-Kai Jiang, Han-Shen Chen, Wei-Feng Tang, Yu Chen, Jing Lin
Summary: This meta-analysis indicates that the rs3746444 locus in the miR-499 gene is associated with the occurrence of hepatocellular carcinoma (HCC), especially in Asian individuals.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Liwei Cheng, Fan Zhang, Ying Wang, Jing Chen, Xiaoping Yuan
Summary: This meta-analysis study found an association between IFNGR1 gene polymorphisms and tuberculosis susceptibility. The rs2234711 polymorphism was associated with increased tuberculosis susceptibility in Africans and decreased susceptibility in Asians. Additionally, the rs7749390 polymorphism was associated with decreased tuberculosis susceptibility in Africans.
FRONTIERS IN PUBLIC HEALTH
(2022)