Inosine-5’-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016)

Nicotinamide Adenine Dinucleotide Based Therapeutics, Update

(2015) K.W. Pankiewicz et al.   CURRENT MEDICINAL CHEMISTRY

Synthesis, in Vitro Evaluation and Cocrystal Structure of 4-Oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase (CpIMPDH) Inhibitors

(2014) Zhuming Sun et al.   JOURNAL OF MEDICINAL CHEMISTRY

Repurposing Cryptosporidium Inosine 5′-Monophosphate Dehydrogenase Inhibitors as Potential Antibacterial Agents

(2014) Kavitha Mandapati et al.   ACS Medicinal Chemistry Letters

Validation of IMP Dehydrogenase Inhibitors in a Mouse Model of Cryptosporidiosis

(2013) Suresh Kumar Gorla et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

NAD-based inhibitors with anticancer potential

(2013) Krzysztof Felczak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Optimization of Benzoxazole-Based Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2013) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Novel Inhibitors of Inosine Monophosphate Dehydrogenase in Patent Literature of the Last Decade

(2013) Riccardo Petrelli et al.   Recent Patents on Anti-Cancer Drug Discovery

Structure–activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH

(2012) Sivapriya Kirubakaran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Phthalazinone inhibitors of inosine-5′-monophosphate dehydrogenase from Cryptosporidium parvum

(2012) Corey R. Johnson et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selective and Potent Urea Inhibitors of Cryptosporidium parvum Inosine 5′-Monophosphate Dehydrogenase

(2012) Suresh Kumar Gorla et al.   JOURNAL OF MEDICINAL CHEMISTRY

Cofactor-type inhibitors of inosine monophosphate dehydrogenase via modular approach: Targeting the pyrophosphate binding sub-domain

(2011) Krzysztof Felczak et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Taribavirin in the treatment of hepatitis C

(2011) Paulina Deming et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

The Structural Basis of Cryptosporidium-Specific IMP Dehydrogenase Inhibitor Selectivity

(2010) Iain S. MacPherson et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

IMP Dehydrogenase: Structure, Mechanism, and Inhibition

(2009) Lizbeth Hedstrom   CHEMICAL REVIEWS

Triazole Inhibitors ofCryptosporidium parvumInosine 5′-Monophosphate Dehydrogenase

(2009) Sushil K. Maurya et al.   JOURNAL OF MEDICINAL CHEMISTRY

Base-Functionalized Carbocyclic Nucleosides: Design, Synthesis, and Mechanism of Antiviral Activity

(2009) Vasu Nair et al.   NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS

Bis(sulfonamide) isosters of mycophenolic adenine dinucleotide analogues: Inhibition of inosine monophosphate dehydrogenase

(2008) Liqiang Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Targeting a Prokaryotic Protein in a Eukaryotic Pathogen: Identification of Lead Compounds against Cryptosporidiosis

(2008) Nwakaso N. Umejiego et al.   CHEMISTRY & BIOLOGY

A Phase I Dose-Ranging Study of the Pharmacokinetics, Pharmacodynamics, Safety, and Tolerability of AVN944, an IMPDH Inhibitor, in Healthy Male Volunteers

(2008) J. Michael Hamilton et al.   JOURNAL OF CLINICAL PHARMACOLOGY