Article
Multidisciplinary Sciences
Samit Ghosal, Debasis Datta, Binayak Sinha
Summary: GLP1-RA treatment shows significant improvement in liver function, weight reduction, decrease in liver fat content, better glycemic control, and reduction in hepatic inflammation for patients with both T2D and NAFLD.
SCIENTIFIC REPORTS
(2021)
Article
Polymer Science
Jian-Miao Yang, Lin-Jie Wu, Meng-Ting Lin, Yi-Ying Lu, Tian-Tian Wang, Min Han, Bin Zhang, Dong-Hang Xu
Summary: In this study, chitosan-based nanocarriers were developed to enhance the oral delivery of therapeutic peptides. The chitosan/alginate nanoparticles demonstrated efficient cellular uptake, controlled release, and protection against enzymatic degradation, leading to improved oral absorption and stability.
Article
Endocrinology & Metabolism
Linong Ji, Ying Du, Min Xu, Xiangjun Zhou, Zhaohui Mo, Jianhua Ma, Jiarui Li, Yufeng Li, Jingna Lin, Yanjun Wang, Jing Yang, Weihong Song, Hui Jin, Shuguang Pang, Hui Liu, Ping Li, Jie Liu, Minxiu Yao, Wenhui Li, Xiaohong Jiang, Feixia Shen, Houfa Geng, Haifeng Zhou, Jianmin Ran, Minxiang Lei, Yinghong Du, Shandong Ye, Qingbo Guan, Wenshan Lv, Huiwen Tan, Tao Chen, Jinkui Yang, Guijun Qin, Shiyun Li, Lei Chen
Summary: This study demonstrated that PB-119 doses were more effective in controlling blood sugar and well-tolerated compared to placebo over a 12-week period in treatment-naive Chinese patients with type 2 diabetes.
Review
Pharmacology & Pharmacy
Yan Tang, Lin Zhang, Yuping Zeng, Xia Wang, Mei Zhang
Summary: This systematic review and meta-analysis evaluated the clinical efficacy and safety of tirzepatide in patients with type 2 diabetes. The results showed that tirzepatide significantly reduced HbA1c, fasting serum glucose, and body weight, and improved blood pressure and fasting lipid profiles without increasing the risk of hypoglycemia.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, General & Internal
Rohit Vashisht, Ayan Patel, Lisa Dahm, Cora Han, Kathryn E. Medders, Robert Mowers, Carrie L. Byington, Suneil K. Koliwad, Atul J. Butte
Summary: This study assessed the relative effectiveness and safety of four treatment options added to metformin monotherapy in diabetes using electronic health record data. The results showed that SGLT2I, DPP4I, and GLP1RA were effective in glycemic control compared to sulfonylurea. Additionally, patients treated with SGLT2I and DPP4I had fewer cardiovascular events, while those treated with GLP1RA and SGLT2I had a lower risk of developing chronic kidney disease and hypertension. These findings highlight the value of clinical data analytics in guiding treatment choices in diabetes.
Article
Cardiac & Cardiovascular Systems
Chee Hae Kim, In-Chang Hwang, Hong-Mi Choi, Chang Ho Ahn, Yeonyee E. Yoon, Goo-Yeong Cho
Summary: SGLT2i demonstrated more benefits in heart failure and renal outcomes, whereas GLP1RA tended to have more favorable ischemic outcomes.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Tushar Issar, Natalie C. G. Kwai, Ann M. Poynten, Ria Arnold, Kerry-Lee Milner, Arun V. Krishnan
Summary: This study assessed the effect of exenatide, DPP-IV inhibitors, and SGLT-2 inhibitors on peripheral nerve excitability in patients with type 2 diabetes. Patients treated with exenatide showed improvements in nerve excitability, whereas those receiving DPP-IV or SGLT-2 inhibitors exhibited abnormalities in nerve function.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Mariam Alatrach, Christina Agyin, Carolina Solis-Herrera, Olga Lavryneko, John Adams, Amalia Gastaldelli, Curtis Triplitt, Ralph A. DeFronzo, Eugenio Cersosimo
Summary: This study found that SGLT2 inhibitors have an effect on the increase of endogenous glucose production (EGP) in patients with type 2 diabetes after oral glucose intake. Despite elevated plasma insulin and glucagon, the stimulation of EGP was observed, suggesting that additional factors may be involved.
Article
Endocrinology & Metabolism
Justin B. Echouffo-Tcheugui, Arnaud D. Kaze, Gregg C. Fonarow, Sam Dagogo-Jack
Summary: In individuals with type 2 diabetes, severe hypoglycemia is independently associated with a higher risk of incident heart failure.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Carlos Bendicho-Lavilla, Iria Seoane-Viano, Francisco J. Otero-Espinar, Asteria Luzardo-Alvarez
Summary: This article discusses the challenges of subcutaneous administration of peptide-based therapeutics in diabetes treatment and provides an overview of formulations available for different routes of administration with improved bioavailability and reduced frequency of administration.
ACTA PHARMACEUTICA SINICA B
(2022)
Article
Endocrinology & Metabolism
Lin Zhang, Yanjin Hu, Yu An, Qiu Wang, Jia Liu, Guang Wang
Summary: This study used a lipidomic approach to investigate lipid changes in response to treatment with exenatide in T2DM patients. The results showed that exenatide treatment can improve lipid metabolism, especially sphingomyelins, lysophosphatidylcholines, and lysophosphatidylethanolamines.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Multidisciplinary Sciences
Emilie H. Zobel, Rasmus S. Ripa, Bernt J. von Scholten, Viktor Rotbain Curovic, Andreas Kjaer, Tine W. Hansen, Peter Rossing, Joachim Storling
Summary: Liraglutide has been found to exert anti-inflammatory effects in the peripheral blood mononuclear cells of individuals with type 2 diabetes, with no significant presence of GLP-1 receptor expression. Further research is needed to clarify the indirect effects of liraglutide on PBMC gene expression and establish the anti-inflammatory potential of GLP-1 receptor agonists.
SCIENTIFIC REPORTS
(2021)
Article
Pharmacology & Pharmacy
Han Liu, Suohui Zhang, Zequan Zhou, Mengzhen Xing, Yunhua Gao
Summary: In this study, two-layer sustained-release microneedles (TS-MNs) were successfully fabricated for the sustained delivery of exenatide (EXT). The TS-MNs showed good mechanical strength and could penetrate the skin for drug release. Moreover, the TS-MNs retained high drug activity during storage and had high relative bioavailability.
Article
Endocrinology & Metabolism
R. Paul Wadwa, Lori M. Laffel, Denise R. Franco, Mary Anne Dellva, Alastair W. Knights, Robyn K. Pollom
Summary: In children and adolescents with type 1 diabetes, ultra-rapid lispro (URLi) showed good glycemic control and noninferiority to lispro in terms of HbA1c change both before and after meals. URLi before meals reduced 1-hour postprandial glucose levels and glucose excursions compared to lispro.
DIABETES OBESITY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Lee-Ling Lim, Eric S. H. Lau, Johnny T. K. Cheung, Siew Pheng Chan, Linong Ji, Soo Lim, Sirinart Sirinvaravong, A. G. Unnikrishnan, Andrea O. Y. Luk, Viviana Cortese, Alexandra Durocher, Juliana C. N. Chan
Summary: This study explored the usage patterns of oral glucose-lowering drugs (OGLDs), particularly sulphonylureas (SUs), in Asian patients with type 2 diabetes (T2D). The findings showed that SUs, often combined with metformin, are a popular class of OGLDs in Asia. They are associated with good glycemic control and safety profiles.
DIABETES OBESITY & METABOLISM
(2023)
Article
Respiratory System
Olga Mediano, Nicolas Gonzalez Mangado, Josep M. Montserrat, M. Luz Alonso-Alvarez, Isaac Almendros, Alberto Alonso-Fernandez, Ferran Barbe, Eduardo Borsini, Candelaria Caballero-Eraso, Irene Cano-Pumarega, Felix de Carlos Villafranca, Carmen Carmona-Bernal, Jose Luis Carrillo Alduenda, Eusebi Chiner, Jose Aurelio Cordero Guevara, Luis de Manuel, Joaquin Duran-Cantolla, Ramon Farre, Carlos Franceschini, Carles Gaig, Pedro Garcia Ramos, Francisco Garcia-Rio, Onintza Garmendia, Teresa Gomez Garcia, Silvia Gonzalez Pondal, M. Blanca Hoyo Rodrigo, Albert Lecube, Juan Antonio Madrid, Lourdes Maniegas Lozano, Jose Luis Martinez Carrasco, Juan Fernando Masa, Maria Jose Masdeu Margalef, Merce Mayos Perez, Enrique Mirabet Lis, Carmen Monasterio, Nieves Navarro Soriano, Erika Olea de la Fuente, Guillermo Plaza, Francisco Javier Puertas Cuesta, Claudio Rabec, Pilar Resano, David Rigau, Alejandra Roncero, Concepcion Ruiz, Neus Salord, Adriana Saltijeral, Gabriel Sampol Rubio, M. Angeles Sanchez Quiroga, Oscar Sans Capdevila, Carlos Teixeira, Francisco Tinahones Madueno, Sonia Maria Togeiro, Maria Fernanda Troncoso Acevedo, Leslie Katherine Vargas Ramirez, Joao Winck, Nerea Zabala Urionaguena, Carlos Egea
Summary: The aim of this international consensus document is to provide guidelines for healthcare professionals in the care of adult patients with obstructive sleep apnea based on a critical analysis of the latest literature. The document was developed by an expert working group consisting of scientific societies, specialists, and a methodology expert, and includes systematic literature searches for each section. The document does not cover pediatric patients or the management of patients receiving chronic non-invasive mechanical ventilation.
ARCHIVOS DE BRONCONEUMOLOGIA
(2022)
Article
Biochemistry & Molecular Biology
Andrea G. Izquierdo, Hatim Boughanem, Angel Diaz-Lagares, Isabel Arranz-Salas, Manel Esteller, Francisco J. Tinahones, Felipe F. Casanueva, Manuel Macias-Gonzalez, Ana B. Crujeiras
Summary: The study identified specific epigenetic marks in visceral adipose tissue associated with colorectal cancer, potentially providing useful tools for prediction and personalized treatment of CRC.
Article
Urology & Nephrology
Hiddo J. L. Heerspink, David Cherney, Douwe Postmus, Bergur Stefansson, Glenn M. Chertow, Jamie P. Dwyer, Tom Greene, Mikhail Kosiborod, Anna Maria Langkilde, John J. McMurray, Ricardo Correa-Rotter, Peter Rossing, C. David Sjostrom, Robert D. Toto, David C. Wheeler
Summary: This analysis of DAPA-CKD found that dapagliflozin can reduce the risk of abrupt declines in kidney function in patients with CKD and substantial albuminuria.
KIDNEY INTERNATIONAL
(2022)
Letter
Medicine, General & Internal
Jose Antonio Lopez Medina, Victor Jose Simon Frapolli, Francisco Jose Tinahones Madueno
Letter
Medicine, General & Internal
Victor Jose Simon Frapolli, Jose Antonio Lopez Medina, Francisco Jose Tinahones Madueno
Article
Medicine, Research & Experimental
Cristina Ma Diaz-Perdigones, Araceli Munoz-Garach, Maria Dolores Alvarez-Bermudez, Isabel Moreno-Indias, Francisco J. Tinahones
Summary: This study found that patients with early intolerance to metformin had higher levels of Subdoligranulum in the gut microbiome, while Veillonella and Serratia were higher in the non-tolerant group. The tolerant group showed enrichment of Megamonas, Megamonas rupellensis, and Phascolarctobacterium spp, with lower levels of Ruminococcus gnavus in the longitudinal analysis.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Teresa Maria Linares-Pineda, Hatim Boughanem, Carolina Gutierrez-Repiso, Manuel Macias-Gonzalez, Eduardo Andres-Leon, Gemma Rojo-Martinez, Sergio Valdes, Francisco J. Tinahones, Sonsoles Morcillo
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2022)
Article
Food Science & Technology
Jiaqi Ni, Stephanie K. Nishi, Nancy Babio, Miguel A. Martinez-Gonzalez, Dolores Corella, Olga Castaner, J. Alfredo Martinez, Angel M. Alonso-Gomez, Enrique Gomez-Gracia, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Lapetra, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin-Sanchez, Xavier Pinto, Jose J. Gaforio, Ana Barabash Bustelo, Josep Vidal, Clotilde Vazquez, Lidia Daimiel, Emili Ros, Estefania Toledo, Oscar Coltell, Carlos Gomez-Martinez, Maria Dolores Zomeno, Carolina Donat-Vargas, Leire Goicolea-Guemez, Cristina Bouzas, Manoli Garcia-de-la-Hera, Alice Chaplin, Antonio Garcia-Rios, Rosa Casas, Isabel Cornejo-Pareja, Jose Manuel Santos-Lozano, Teresa Rognoni, Carmen Saiz, Indira Paz-Ganiel, Mireia Malcampo, Almudena Sanchez-Villegas, Itziar Salaverria-Lete, Ana Garcia-Arellano, Helmut Schroeder, Jordi Salas-Salvado
Summary: This study found that older adults with higher consumption of total milk and whole-fat milk are more likely to experience a decline in cognitive function, while consumption of low-fat milk, yogurt, cheese or fermented dairy had no significant impact.
MOLECULAR NUTRITION & FOOD RESEARCH
(2022)
Review
Endocrinology & Metabolism
Jose Ignacio Martinez-Montoro, Enrique Morales, Isabel Cornejo-Pareja, Francisco J. Tinahones, Jose Carlos Fernandez-Garcia
Summary: Obesity-related glomerulopathy (ORG) is a silent comorbidity associated with serious health consequences. Despite the pathogenic mechanisms not fully understood, factors such as glomerular hemodynamic changes and RAAS overactivation are believed to play a major role. Early diagnosis and intervention are crucial for improving the prognosis of ORG.
Article
Nutrition & Dietetics
Concepcion Santiago-Fernandez, Cristina Rodriguez-Diaz, Ailec Ho-Plagaro, Carolina Gutierrez-Repiso, Wilfredo Oliva-Olivera, Flores Martin-Reyes, Virginia Mela, Rocio Bautista, Monicas Tome, Josefa Gomez-Maldonado, Francisco J. Tinahones, Eduardo Garcia-Fuentes, Lourdes Garrido-Sanchez
Summary: This study found that extra virgin olive oil (EVOO) and sunflower oil (SO) have different effects on the miRNA composition of endothelial cell-derived extracellular vesicles (EVs). These EVs can regulate the transcriptomic profile of smooth muscle cells (SMCs), which plays a role in the development of atherosclerosis.
FRONTIERS IN NUTRITION
(2022)
Article
Nutrition & Dietetics
Almudena Carneiro-Barrera, Francisco J. Amaro-Gahete, Lucas Jurado-Fasoli, German Saez-Roca, Carlos Martin-Carrasco, Francisco J. Tinahones, Jonatan R. Ruiz
Summary: An eight-week interdisciplinary weight loss and lifestyle intervention resulted in significant improvements in dietary behavior, including adherence to the Mediterranean diet, in overweight/obese men with moderate-to-severe OSA.
Article
Nutrition & Dietetics
Isabel Cornejo-Pareja, Isabel M. Vegas-Aguilar, Henry Lukaski, Antonio Talluri, Diego Bellido-Guerrero, Francisco J. Tinahones, Jose Manuel Garcia-Almeida
Summary: This study found that hydration status is an important predictor of survival prognosis in COVID-19 patients, with higher hydration levels associated with higher mortality. Compared to traditional measurements, using a 50kHz phase-sensitive bioelectrical impedance measurement for hydration assessment can provide a more sensitive and specific prognostic test.
Article
Endocrinology & Metabolism
Yuan-Di Halvorsen, John Paul Lock, Juan P. Frias, Francisco Jose Tinahones, Dominik Dahl, Annie L. Conery, Mason W. Freeman
Summary: This study compared the effects of bexagliflozin tablets and glimepiride on the treatment of patients with type 2 diabetes. It was found that bexagliflozin tablets were noninferior to glimepiride in lowering HbA1c levels, and were superior in reducing body mass and systolic blood pressure. Additionally, bexagliflozin tablets were associated with fewer hypoglycemic events and had a favorable effect on estimated glomerular filtration rate (eGFR).
DIABETES OBESITY & METABOLISM
(2023)
Review
Nutrition & Dietetics
Hatim Boughanem, Pallavi Kompella, Francisco J. Tinahones, Manuel Macias-Gonzalez
Summary: Gene expression can be regulated by epigenomic modifications such as DNA methylation, histone modification, and chromosome remodeling. Vitamins, as natural bioactive compounds, have been found to modify epigenetic patterns and potentially impact the risk of cancer, including colorectal cancer (CRC). This review examines the relationship between vitamins and CRC risk through epidemiological and observational studies and discusses the potential of using vitamins as epigenetic modifiers for CRC treatment. Although more studies with better designs are needed, understanding the molecular mechanisms of vitamin-mediated epigenetic regulation can help identify effective therapeutic targets for CRC prevention and treatment.
Article
Psychology, Clinical
Sangeetha Shyam, Carlos Gomez-Martinez, Indira Paz-Graniel, Jose J. Gaforio, Miguel Angel Martinez-Gonzalez, Dolores Corella, Montserrat Fito, J. Alfredo Martinez, Angel M. Alonso-Gomez, Julia Warnberg, Jesus Vioque, Dora Romaguera, Jose Lopez-Miranda, Ramon Estruch, Francisco J. Tinahones, Jose Manuel Santos-Lozano, J. Luis Serra-Majem, Aurora Bueno-Cavanillas, Josep A. Tur, Vicente Martin Sanchez, Xavier Pinto, Maria Ramos, Josep Vidal, Maria Mar Alcarria, Lidia Daimiel, Emilio Ros, Fernando Fernandez-Aranda, Stephanie K. Nishi, Oscar Garcia Regata, Estefania Toledo, Jose V. Sorli, Olga Castaner, Antonio Garcia-Rios, Rafael Valls-Enguix, Napoleon Perez-Farinos, M. Angeles Zulet, Elena Rayo-Gago, Rosa Casas, Mario Rivera-Izquierdo, Lucas Tojal-Sierra, Miguel Damas-Fuentes, Pilar Buil-Cosiales, Rebeca Fernandez-Carrion, Albert Goday, Patricia J. Pena-Orihuela, Laura Compan-Gabucio, Javier Diez-Espino, Susanna Tello, Ana Gonzalez-Pinto, Victor de la O, Miguel Delgado-Rodriguez, Nancy Babio, Jordi Salas-Salvado
Summary: COVID-19 is associated with long-term depression risk in older adults, especially in women. Long-term evaluations of the impact of COVID-19 on mental health and preventive public health initiatives are necessary for older adults.
PSYCHOLOGICAL MEDICINE
(2023)