Drug target identification at the crossroad of neuronal apoptosis and survival

Identification of Inflammatory, Metabolic, and Cell Survival Pathways Contributing to Cerebral Small Vessel Disease by Postmortem Gene Expression Microarray

(2016) Marie-Françoise Ritz et al.   CURRENT NEUROVASCULAR RESEARCH

Targeting ceramide metabolic pathway induces apoptosis in human breast cancer cell lines

(2015) Helen Shiphrah Vethakanraj et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Involvement of NFκB signaling in mediating the effects of GRK5 on neural stem cells

(2015) Yun Zhang et al.   BRAIN RESEARCH

An Improved Nonradioactive Screening Method Identifies Genistein and Xanthohumol as Potent Inhibitors of Iodothyronine Deiodinases

(2015) Kostja Renko et al.   THYROID

Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax)

(2015) J D Leverson et al.   Cell Death & Disease

RNAi pathway participates in chromosome segregation in mammalian cells

(2015) Chuan Huang et al.   Cell Discovery

Programmed cell death during neuronal development: the sympathetic neuron model

(2014) M Kristiansen et al.   CELL DEATH AND DIFFERENTIATION

Featured Article: Transcriptome profiling of expression changes during neuronal death by RNA-Seq

(2014) Dharmendra Sharma et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Transcriptional Analysis of Apoptotic Cerebellar Granule Neurons Following Rescue by Gastric Inhibitory Polypeptide

(2014) Barbara Maino et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Identification of Palmitoyltransferase and Thioesterase Enzymes That Control the Subcellular Localization of Axon Survival Factor Nicotinamide Mononucleotide Adenylyltransferase 2 (NMNAT2)

(2014) Stefan Milde et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evaluation of the effect of apatinib (YN968D1) on cytochrome P450 enzymes with cocktail probe drugs in rats by UPLC–MS/MS

(2014) Yunfang Zhou et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Common mechanisms in neurodegeneration and neuroinflammation: a BrainNet Europe gene expression microarray study

(2014) Pascal F. Durrenberger et al.   JOURNAL OF NEURAL TRANSMISSION

Identification and Characterization of Amlexanox as a G Protein-Coupled Receptor Kinase 5 Inhibitor

(2014) Kristoff Homan et al.   MOLECULES

Ischemic insults induce necroptotic cell death in hippocampal neurons through the up-regulation of endogenous RIP3

(2014) M. Vieira et al.   NEUROBIOLOGY OF DISEASE

Necroptosis

(2014) Andreas Linkermann et al.   NEW ENGLAND JOURNAL OF MEDICINE

Targeting Arginine-Dependent Cancers with Arginine-Degrading Enzymes: Opportunities and Challenges

(2014) Melissa M. Phillips et al.   Cancer Research and Treatment

A sigma-1 receptor antagonist (NE-100) prevents tunicamycin-induced cell death via GRP78 induction in hippocampal cells

(2013) Yoko Ono et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The challenges of axon survival: Introduction to the special issue on axonal degeneration

(2013) Michael P. Coleman   EXPERIMENTAL NEUROLOGY

Chemokine CCL2 Induces Apoptosis in Cortex Following Traumatic Brain Injury

(2013) Su Liu et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Natriuretic peptide receptors regulate cytoprotective effects in a human ex vivo 3D/bioreactor model

(2013) Nicholas Peake et al.   ARTHRITIS RESEARCH & THERAPY

Viral modulation of programmed necrosis

(2013) William J Kaiser et al.   Current Opinion in Virology

Design, synthesis and SAR analysis of novel potent and selective small molecule antagonists of NPBWR1 (GPR7)

(2012) Mariangela Urbano et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

GADD45 Proteins: Central Players in Tumorigenesis

(2012) R. E. Tamura et al.   CURRENT MOLECULAR MEDICINE

p53 at the crossroads between cancer and neurodegeneration

(2012) Cristina Lanni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Desipramine Protects Neuronal Cell Death and Induces Heme Oxygenase-1 Expression in Mes23.5 Dopaminergic Neurons

(2012) Hsiao-Yun Lin et al.   PLoS One

The Matrix Metalloproteinase Inhibitor Marimastat Promotes Neural Progenitor Cell Differentiation into Neurons by Gelatinase-Independent TIMP-2-Dependent Mechanisms

(2012) Maddalena Sinno et al.   STEM CELLS AND DEVELOPMENT

Microarrays, deep sequencing and the true measure of the transcriptome

(2011) John H Malone et al.   BMC BIOLOGY

Global analysis of gene expression in NGF-deprived sympathetic neurons identifies molecular pathways associated with cell death

(2011) Mark Kristiansen et al.   BMC GENOMICS

Regulation of CCL2/MCP-1 production in astrocytes by desipramine and atomoxetine: Involvement of α2 adrenergic receptors

(2011) Ara E. Hinojosa et al.   BRAIN RESEARCH BULLETIN

Design, synthesis and biological activity of pyrazolo[1,5-a]pyrimidin-7(4H)-ones as novel Kv7/KCNQ potassium channel activators

(2011) Jinlong Qi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

CREB-activity and nmnat2 transcription are down-regulated prior to neurodegeneration, while NMNAT2 over-expression is neuroprotective, in a mouse model of human tauopathy

(2011) M. Cecilia Ljungberg et al.   HUMAN MOLECULAR GENETICS

Evaluation of impact of Herba Erigerontis injection, a Chinese herbal prescription, on rat hepatic cytochrome P450 enzymes by cocktail probe drugs

(2011) Yong-Long Han et al.   JOURNAL OF ETHNOPHARMACOLOGY

Novel role of KCNQ2/3 channels in regulating neuronal cell viability

(2010) X Zhou et al.   CELL DEATH AND DIFFERENTIATION

p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival

(2010) Daniel R Croft et al.   CELL RESEARCH

The suitability of rat hepatoma cell line H4IIE for evaluating the potentials of compounds to induce CYP3A23 expression

(2010) Hisako Fujimura et al.   EXPERIMENTAL AND TOXICOLOGIC PATHOLOGY

Temporal transcriptomic profiling reveals cellular targets that govern survival in HOCl-mediated neuronal apoptosis

(2010) Yann Wan Yap et al.   LIFE SCIENCES

Antioxidant enzymatically modified isoquercitrin or melatonin supplementation reduces oxidative stress-mediated hepatocellular tumor promotion of oxfendazole in rats

(2009) Jihei Nishimura et al.   ARCHIVES OF TOXICOLOGY

Involvement of TRPC Channels in CCL2-Mediated Neuroprotection against Tat Toxicity

(2009) H. Yao et al.   JOURNAL OF NEUROSCIENCE

Activation of kinin receptor B1 limits encephalitogenic T lymphocyte recruitment to the central nervous system

(2009) Ulf Schulze-Topphoff et al.   NATURE MEDICINE

Effect of Psychotropic Drugs on the 21-Hydroxylation of Neurosteroids, Progesterone and Allopregnanolone, Catalyzed by Rat CYP2D4 and Human CYP2D6 in the Brain

(2008) Toshiro Niwa et al.   BIOLOGICAL & PHARMACEUTICAL BULLETIN

TIMP-3 and MMP-3 contribute to delayed inflammation and hippocampal neuronal death following global ischemia

(2008) Espen J. Walker et al.   EXPERIMENTAL NEUROLOGY

2-Bromopalmitate and 2-(2-hydroxy-5-nitro-benzylidene)-benzo[b]thiophen-3-one inhibit DHHC-mediated palmitoylation in vitro

(2008) Benjamin C. Jennings et al.   JOURNAL OF LIPID RESEARCH

Mitochondrial localization and function of a subset of 22q11 deletion syndrome candidate genes

(2008) T.M. Maynard et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Naturally occurring variants in the HTR3B gene significantly alter properties of human heteromeric 5-hydroxytryptamine-3A/B receptors

(2008) Jutta Walstab et al.   Pharmacogenetics and Genomics

Tempol-mediated activation of latent iron regulatory protein activity prevents symptoms of neurodegenerative disease in IRP2 knockout mice

(2008) M. C. Ghosh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA