Low colonic absorption drugs: risks and opportunities in the development of oral extended release products

Oral delivery of macromolecular drugs: Where we are after almost 100 years of attempts

(2016) Elena Moroz et al.   ADVANCED DRUG DELIVERY REVIEWS

Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials

(2016) T.A.S. Aguirre et al.   ADVANCED DRUG DELIVERY REVIEWS

Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion

(2016) Isabel Lozoya-Agullo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Oral Absorption Promoters: Opportunities, Issues, and Challenges

(2015) Chetan Yewale et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

The biopharmaceutics of successful controlled release drug product: Segmental-dependent permeability of glipizide vs. metoprolol throughout the intestinal tract

(2015) Moran Zur et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Gamma scintigraphic study of the hydrodynamically balanced matrix tablets of Metformin HCl in rabbits

(2015) Mahboubeh Razavi et al.   Drug Design Development and Therapy

In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects

(2014) Erik Sjögren et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The Low/High BCS Permeability Class Boundary: Physicochemical Comparison of Metoprolol and Labetalol

(2014) Moran Zur et al.   MOLECULAR PHARMACEUTICS

Regional-Dependent Intestinal Permeability and BCS Classification: Elucidation of pH-Related Complexity in Rats Using Pseudoephedrine

(2013) Moran Fairstein et al.   AAPS Journal

Transport of gabapentin by LAT1 (SLC7A5)

(2013) David Dickens et al.   BIOCHEMICAL PHARMACOLOGY

Development of a gastric retentive system as a sustained-release formulation of pranlukast hydrate and its subsequent in vivo verification in human studies

(2013) Hikaru Sugihara et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

The complexity of intestinal permeability: Assigning the correct BCS classification through careful data interpretation

(2013) Moran Zur et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Active intestinal absorption of fluoroquinolone antibacterial agent ciprofloxacin by organic anion transporting polypeptide, Oatp1a5

(2012) Hiroshi Arakawa et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Mucoadhesion and the Gastrointestinal Tract

(2012) Felipe J. O. Varum et al.   CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS

Absorption Enhancers: Applications and Advances

(2011) Bruce J. Aungst   AAPS Journal

Recent advances in materials for extended-release antibiotic delivery system

(2011) Ping Gao et al.   JOURNAL OF ANTIBIOTICS

Clinical pharmacokinetic drug interaction studies of gabapentin enacarbil, a novel transported prodrug of gabapentin, with naproxen and cimetidine

(2010) Ritu Lal et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cytochrome P450-mediated metabolism in the human gut wall

(2010) Kirstin Thelen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

High-Permeability Criterion for BCS Classification: Segmental/pH Dependent Permeability Considerations

(2010) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

Physiological Parameters for Oral Delivery andin VitroTesting

(2010) Deanna M. Mudie et al.   MOLECULAR PHARMACEUTICS

Formulation and Evaluation of Swellable and Floating Gastroretentive Ciprofloxacin Hydrochloride Tablets

(2009) Ramji Anil Kumar Arza et al.   AAPS PHARMSCITECH

Small intestinal efflux mediated by MRP2 and BCRP shifts sulfasalazine intestinal permeability from high to low, enabling its colonic targeting

(2009) Arik Dahan et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

The assessment of human regional drug absorption of free acid and sodium salt forms of Acipimox, in healthy volunteers, to direct modified release formulation strategy

(2009) Rajeev Menon et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

Oral osmotically driven systems: 30 years of development and clinical use

(2009) Vincent Malaterre et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

An Oral Human Drug Absorption Study to Assess the Impact of Site of Delivery on the Bioavailability of Bevirimat

(2009) Alyson Connor et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Toward an Increased Understanding of the Barriers to Colonic Drug Absorption in Humans: Implications for Early Controlled Release Candidate Assessment

(2009) Christer Tannergren et al.   MOLECULAR PHARMACEUTICS

Once daily baclofen sustained release or gastro-retentive system are acceptable alternatives to thrice daily baclofen immediate release at same daily dosage in patients

(2009) ShravantiS Bhowmik et al.   NEUROLOGY INDIA

Mechanisms Underlying Saturable Intestinal Absorption of Metformin

(2008) W. R. Proctor et al.   DRUG METABOLISM AND DISPOSITION

The gastrointestinal microbiota as a site for the biotransformation of drugs

(2008) Tiago Sousa et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Clinical Pharmacokinetics of XP13512, a Novel Transported Prodrug of Gabapentin

(2008) Kenneth C. Cundy et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Transport of Angiotensin-Converting Enzyme Inhibitors by H+/Peptide Transporters Revisited

(2008) I. Knutter et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Applications of Physiologically Based Absorption Models in Drug Discovery and Development

(2008) Neil Parrott et al.   MOLECULAR PHARMACEUTICS

Selection of drug candidates for gastroretentive dosage forms: Pharmacokinetics following continuous intragastric mode of administration in a rat model

(2007) Leonid Kagan et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS