Review
Chemistry, Multidisciplinary
Susana Farinha, Joao Sa, Paulo Roque Lino, Marco Galesio, Joao Pires, Miguel Angelo Rodrigues, Joao Henriques
Summary: Biopharmaceuticals have become an integral part of the pharmaceutical pipeline, offering highly specific therapeutic options. However, challenges arise in the manufacturing, isolation, and delivery of these complex molecules, especially considering their short shelf-life. Inhalation administration is gaining attention as an alternative to intravenous administration, with dry powder inhalers (DPIs) being considered an appealing option due to improved stability. This review focuses on the application of spray freeze drying (SFD) to produce dry powders of biopharmaceuticals, particularly for inhalation delivery, and provides a comprehensive assessment of its current and future applications.
PHARMACEUTICAL RESEARCH
(2023)
Review
Food Science & Technology
Yuyan Xu, Mingsheng Dong, Hongmei Xiao, Siew Young Quek, Yukiharu Ogawa, Guangyuan Ma, Chuang Zhang
Summary: Probiotic powders produced by spray drying have advantages of high efficiency, cost-saving, and good powder properties. However, the harsh drying and digestion processes can reduce cell viability, limiting the effectiveness of live cells. Therefore, there is a need to develop targeted delivery systems using spray drying to protect bacteria and maintain their physiological functions. This review highlights recent studies on spray-dried targeted delivery vehicles for probiotics, focusing on strategies to protect bacteria, particle formation mechanism, and the targeted release and colonization of live cells. Further research is needed to improve the functional properties of microcapsules and understand the effects of spray drying on bacterial physiology for industrialization and commercialization.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Agriculture, Multidisciplinary
Yilun Weng, Supun Ranaweera, Da Zou, Anna Cameron, Xiaojing Chen, Hao Song, Chun-Xia Zhao
Summary: This study demonstrates a simple and effective method for enzyme immobilization via spray drying using alginate as a support material. The immobilized enzyme retains a high level of activity at high temperatures and can be promptly released in a simulated gastrointestinal tract.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Paraskevi Kyriaki Monou, Eleftherios G. Andriotis, Nikolaos Bouropoulos, Emmanuel Panteris, Melpomeni Akrivou, Ioannis S. Vizirianakis, Zeeshan Ahmad, Dimitrios G. Fatouros
Summary: In this study, a multi-component system for pulmonary delivery was developed, including engineered microparticles and investigation of two active pharmaceutical ingredients. All formulations exhibited satisfactory performance and drug release. Physicochemical properties evaluation showed appropriate morphology and aerodynamic performance of the microparticles, with release of the active ingredients monitored in simulated lung fluid.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Engineering, Chemical
Sagar Pardeshi, Mahesh More, Pritam Patil, Chandrakantsing Pardeshi, Prashant Deshmukh, Arun Mujumdar, Jitendra Naik
Summary: The article discusses the importance of pharmaceutical powder drying and the application of different particle engineering technologies, emphasizing the advancement and potential applications of drying in drug delivery systems. It provides information on commercial, regulatory, and scale-up strategies to help readers, researchers, and industrialists address key issues in drying operations.
Review
Pharmacology & Pharmacy
Shalvi Sinai Kunde, Ritushree Ghosh, Sarika Wairkar
Summary: In comparison with small molecular drugs, the use of biopharmaceuticals as therapeutics has gained popularity due to their higher specificity, selectivity and potency, as well as fewer side effects. The pulmonary route has been investigated as a potential noninvasive method for delivering biopharmaceuticals, offering higher drug concentrations and greater bioavailability than other noninvasive routes. This review focuses on the delivery of various biopharmaceuticals, including peptides, recombinant proteins, enzymes, monoclonal antibodies, and nucleic acids, via the pulmonary route, discussing their advantages and disadvantages.
DRUG DISCOVERY TODAY
(2022)
Article
Pharmacology & Pharmacy
Bence Sipos, Ildiko Csoka, Rita Ambrus, Zsuzsanna Schelz, Istvan Zupko, Gyorgy Tibor Balogh, Gabor Katona
Summary: This study aimed to develop a spray-dried powder containing indomethacin-loaded polymeric micelles for enhanced drug release and permeability. The resulting particles showed decreased size and monodisperse distribution, while the polymeric micelles exhibited nano size and monodisperse size distribution. The formulation achieved improved drug release in gastrointestinal conditions and demonstrated safety for oral application in cell line studies. Ex vivo studies on a porcine small intestine also showed increased drug flux and permeability. The solid formulation remained physically stable for 6 months.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Review
Engineering, Chemical
Nienke M. Eijkelboom, Anneloes P. van Boven, Isabel Siemons, Patrick F. C. Wilms, Remko M. Boom, Reinhard Kohlus, Maarten A. I. Schutyser
Summary: The ability to control the primary particle morphology and degree of agglomeration is crucial for achieving high-quality agglomerated powder products through spray drying. Single droplet drying approaches have been used to study the development of primary particle morphology and droplet collision behavior. This review discusses the potential and limitations of single droplet drying approaches in unraveling the evolution of particle morphology and agglomeration phenomena during spray drying.
JOURNAL OF FOOD ENGINEERING
(2023)
Article
Chemistry, Applied
Antonia Goncalves, Berta N. Estevinho, Fernando Rocha
Summary: Oil-in-water emulsions were utilized to produce RA-loaded biopolymer-based delivery systems using spray-drying technology, with different rheological properties and droplet size distributions. The use of a spray-dryer at an inlet air temperature of 130 degrees C significantly improved RA encapsulation efficiency in modified chitosan-based microparticles. The release time of RA from microparticles varied depending on the biopolymers used, with xanthan and arabic gums showing faster release (48 and 94 min, respectively) and alginic acid sodium prolonging the release time to almost 8 hours.
FOOD HYDROCOLLOIDS
(2022)
Article
Pharmacology & Pharmacy
Dariush Nikjoo, Ires van der Zwaan, Mikael Brulls, Ulrika Tehler, Goran Frenning
Summary: Hydrogels, particularly those made from hyaluronic acid (HA), show promise as a material for controlled pulmonary drug delivery. In this study, spray-dried microparticles were successfully prepared from crosslinked HA, with superior performance demonstrated by those crosslinked with glutaraldehyde (GA) in terms of aerosolization and swelling.
Article
Pharmacology & Pharmacy
Patricia Henriques, Ana Fortuna, Slavomira Doktorovova
Summary: Powders for nasal delivery have advantages over liquids and can be manufactured by spray drying. This review provides an overview of nasal powder formulation and processing, with a focus on the variables that impact on performance.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2022)
Article
Chemistry, Medicinal
Ashlee D. Brunaugh, Li Ding, Tian Wu, Michael Schneider, Ryan Khalaf, Hugh D. C. Smyth
Summary: Monoclonal antibody-based therapies have the potential to be a valuable treatment modality for acute and chronic lung diseases. Direct delivery to the lungs via inhalation can provide higher drug concentrations at the site of disease with reduced off-target effects. However, there is limited understanding of the impact of particle engineering processes on the stability and performance of dry powder inhaler formulations of monoclonal antibodies.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Engineering, Chemical
Lorena Pasero, Francesca Susa, Riccardo Chiavarino, Tania Limongi, Adamo Sulpizi, Tomaso Guidi, Roberto Pisano
Summary: Spray freeze-drying is a viable alternative to traditional spray drying for producing therapeutic dry microparticles, particularly suitable for pulmonary drug delivery. This study used ultrasonic spray freeze-drying to generate dry microparticles composed of mannitol or a combination of mannitol and salbutamol sulphate. The particle size, morphology, surface area, porosity, and crystallinity were influenced by solid concentration and feed flow rate. The aerodynamic properties for drug deposition were found to depend on solid concentration and feed flow rate.
Article
Pharmacology & Pharmacy
Si Nga Wong, Kam-Hung Low, Yi Lam Poon, Xinyue Zhang, Ho Wan Chan, Shing Fung Chow
Summary: This study successfully synthesized a cocrystal of remdesivir (RDV) with salicylic acid (SA) through liquid-assisted grinding and thermal annealing. The molecular structure of RDV-SA was resolved through powder X-ray analysis. RDV-SA was further developed as inhaled dry powders for potential COVID-19 therapy, displaying improved release in simulated lung fluid compared to raw RDV.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Pharmacology & Pharmacy
Mellissa Gomez, Joseph McCollum, Hui Wang, Mani Ordoubadi, Chester Jar, Nicholas B. Carrigy, David Barona, Isobel Tetreau, Michelle Archer, Alana Gerhardt, Chris Press, Christopher B. Fox, Ryan M. Kramer, Reinhard Vehring
Summary: This study aimed to develop a stable inhalable dry powder vaccine for respiratory infectious diseases like tuberculosis. Results showed that different additives in the formulations had varying effects on the stability and aerosol performance of the vaccine, providing important insights for vaccine preparation.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)