Article
Health Care Sciences & Services
Layale Youssef, Jordan Granet, Vincent Marcangeli, Maude Dulac, Guy Hajj-Boutros, Olivier Reynaud, Fanny Buckinx, Pierrette Gaudreau, Jose A. Morais, Pascale Mauriege, Gilles Gouspillou, Philippe Noirez, Mylene Aubertin-Leheudre
Summary: This study compared the effects of HIIT and MICT on functional capacities, body composition, and muscle function in obese older adults. The results showed that HIIT had more beneficial effects on physical parameters, lean mass, and skeletal muscle markers related to mitochondrial content, fusion, and mitophagy compared to MICT.
Article
Endocrinology & Metabolism
Stella V. V. Philbois, Victor B. B. Ribeiro, Jens Tank, Rosana Maria dos Reis, Darius A. A. Gerlach, Hugo C. D. Souza
Summary: This study aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiovascular autonomic control in women with polycystic ovarian syndrome (PCOS). The results showed that both training protocols had similar effects on the evaluated parameters, suggesting that both HIIT and MICT can be recommended for the treatment of PCOS.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Peng Yu, Zicheng Zhu, Jiahui He, Bohua Gao, Qi Chen, Yifan Wu, Jing Zhou, Yixuan Cheng, Jitao Ling, Jing Zhang, Ao Shi, Huijing Huang, Runlu Sun, Yan Gao, Weiguang Li, Xiao Liu, Zhiwei Yan
Summary: This study aims to assess the impact of high-intensity interval training (HIIT), moderate-intensity continuous training (MICT), and guideline-based physical activity programs on the cardiovascular health, cognitive function, and motor function of elderly sedentary patients with type 2 diabetes mellitus (T2DM). The study will be a randomized, assessor-blind, three-arm controlled trial with a total of 330 participants. The results will evaluate the effects of 12 weeks of HIIT, MICT, and the guideline group on the patients.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Multidisciplinary Sciences
Haohan Yu, Xudong Zhao, Xiaoxia Wu, Jing Yang, Jun Wang, Lijuan Hou
Summary: This systematic review and meta-analysis compared the effects of high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on the quality of life (QOL) and mental health (MH) of patients with cardiovascular disease (CVDs). The study found that both HIIT and MICT had similar effects on QOL and MH in CVD patients. However, HIIT showed significant improvements in physical component summary (PCS) for coronary artery disease (CAD) patients and performed better in physical role, vitality, and social function compared to MICT.
SCIENTIFIC REPORTS
(2023)
Article
Health Care Sciences & Services
Bin Fang, Yonghwan Kim, Moonyoung Choi
Summary: The study compared the impact of short-term high intensity interval training (HIIT) and traditional moderate intensity continuous training (MICT) on adolescent soccer players, finding that HIIT effectively improved cardiorespiratory fitness and anaerobic power while MICT improved muscle endurance. Both training methods have their own benefits and could be considered in a time-efficient training strategy.
Article
Biochemistry & Molecular Biology
Layale Youssef, Melanie Bourgin, Sylvere Durand, Fanny Aprahamian, Deborah Lefevre, Maria Chiara Maiuri, Vincent Marcangeli, Maude Dulac, Guy Hajj-Boutros, Fanny Buckinx, Eva Peyrusque, Pierrette Gaudreau, Jose A. Morais, Gilles Gouspillou, Guido Kroemer, Mylene Aubertin-Leheudre, Philippe Noirez
Summary: Participating in HIIT and MICT can improve the quality of life for obese older individuals, with significant changes observed in serum metabolites related to muscle strength, glycemic parameters, and lipid profile parameters. Further research is needed to confirm the association between these metabolites and healthy aging.
Review
Medicine, General & Internal
Lei Li, Xuan Liu, Fei Shen, Naxin Xu, Yun Li, Kun Xu, Junping Li, Yong Liu
Summary: There is no significant difference between high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) in improving resting blood pressure in patients with essential hypertension. However, HIIT is more effective than MICT in reducing daytime systolic blood pressure and improving vasodilation.
Article
Biochemistry & Molecular Biology
Joana Silva, Joana Santiago, Barbara Matos, Magda C. Henriques, Daniela Patricio, Ana D. Martins, Jose A. Duarte, Rita Ferreira, Marco G. Alves, Paula Oliveira, Pedro F. Oliveira, Margarida Fardilha
Summary: This study examined the effects of age and lifelong moderate-intensity exercise on rat testis. The results showed that aging is associated with testicular atrophy and alterations in stress response and mitochondrial biogenesis and function. Exercise did not protect against age-induced testicular atrophy and led to deleterious effects on sperm morphology.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biology
Brandon G. Fico, Ryan S. Garten, Michael C. Zourdos, Michael Whitehurst, Peter J. Ferrandi, Katelyn M. Dodge, Gabriel S. Pena, Alexandra A. Rodriguez, Chun-Jung Huang
Summary: This study compared the acute effects of high-intensity interval exercise (HIIE) and continuous moderate-intensity exercise (CME) on vascular health indicators in individuals with obesity. The results showed that both exercise modalities led to improvements in vascular health, with HIIE being a time-effective strategy. Additionally, CME had a greater effect on improving endothelial function in obese participants.
Review
Medicine, General & Internal
Ping Lai, Jin-Hua Xue, Mu-Jin Xie, Jin-Hua Ye, Ning Yang, Yi-Ming Zhong, Yong-Ling Liao
Summary: This study aimed to compare the effects of high-intensity interval training (HIIT) and moderate-intensity interval training (MIIT) on patients with heart failure with preserved ejection fraction (HFpEF). The results showed that HIIT was beneficial for improving diastolic function in HFpEF patients, but did not significantly improve systolic function and CRF.
Article
Multidisciplinary Sciences
Morgane Pengam, Christelle Goanvec, Christine Moisan, Bernard Simon, Gaelle Albacete, Annie Feray, Anthony Guernec, Aline Amerand
Summary: This study aimed to compare the effects of moderate-intensity continuous training (MICT) and high-intensity interval training (HIIT) on metabolic processes in two different muscle types. The results showed that both training protocols led to specific muscular responses, with the genes involved being more significantly upregulated in the slow-twitch (soleus) muscle compared to the fast-twitch (extensor digitorum longus) muscle. HIIT showed better endurance performance and oxidative capacities in both muscles.
Review
Sport Sciences
Eric Tsz-Chun Poon, Waris Wongpipit, Robin Sze-Tak Ho, Stephen Heung-Sang Wong
Summary: This study demonstrated the effectiveness of interval training compared to moderate-intensity continuous training for improving cardiorespiratory fitness in middle-aged and older adults. High-intensity interval training (HIIT) and sprint interval training (SIT) were found to be more effective in increasing VO2max compared to MICT.
JOURNAL OF SPORTS SCIENCES
(2021)
Article
Sport Sciences
Songxin Tang, Weiwei Huang, Shen Wang, Yanying Wu, Lianmeng Guo, Junhao Huang, Min Hu
Summary: This study investigated the effects of aquatic high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) on cardiovascular parameters, endothelial function, and aerobic fitness in inactive adults. The results showed that aquatic HIIT reduced arterial stiffness, increased endothelial function and aerobic fitness, while aquatic MICT decreased arterial blood pressure, resting heart rate, and increased coronary blood flow reserve.
JOURNAL OF EXERCISE SCIENCE & FITNESS
(2022)
Article
Endocrinology & Metabolism
Neumir Sales de Lima, Ricardo Augusto Leoni De Sousa, Fabiano Trigueiro Amorim, Fernando Gripp, Caique Olegario Diniz e Magalhaes, Samuel Henrique Pinto, Marco Fabricio Dias Peixoto, Renato Sobral Monteiro-Junior, Kelsey Bourbeau, Ricardo Cardoso Cassilhas
Summary: The study showed that both 8 weeks of moderate intensity continuous training (MICT) and high intensity interval training (HIIT) can significantly improve cognitive function and BDNF levels in middle-aged overweight men, with no significant differences in cognitive function between MICT and HIIT.
METABOLIC BRAIN DISEASE
(2022)
Article
Physiology
Molin Zheng, Chuanan Liu, Yuanyuan Lv, Jing Mi, Dan Qiu, Lingxiao He, Li Zhao
Summary: This study found that both high intensity interval training (HIIT) and continuous training (CT) can improve cardiac function in adolescent rats, with HIIT showing better results and less myocardial damage. Additionally, high and moderate intensities in HIIT have similar cardiac benefits. The study also suggests that myocardial damage induced by high intensity continuous training (HI-CT) may be associated with serum phospholipids.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Physiology
Ryosuke Takeda, Abigail S. L. Stickford, Stuart A. Best, Jeung-Ki Yoo, Yu-Lun Liu, Qi Fu
Summary: This study investigated the impact of salt loading versus salt reduction on hemodynamic and sympathetic neural responses during the cold pressor test in premenopausal women with a history of normal pregnancy. The results showed that salt loading increased sympathetic neural reactivity to the cold stimulus with similar pressor responses compared to salt reduction, possibly due to a blunted neurovascular transduction.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2021)
Review
Physiology
Masaki Mizuno, Norio Hotta, Rie Ishizawa, Han-Kyul Kim, Gary Iwamoto, Wanpen Vongpatanasin, Jere H. Mitchell, Scott A. Smith
Summary: Research suggests that high levels of insulin or blood glucose significantly impact neural regulatory pathways controlling circulation during exercise in diabetic patients.
EXERCISE AND SPORT SCIENCES REVIEWS
(2021)
Article
Peripheral Vascular Disease
Rie Ishizawa, Han-Kyul Kim, Norio Hotta, Gary A. Iwamoto, Jere H. Mitchell, Scott A. Smith, Wanpen Vongpatanasin, Masaki Mizuno
Summary: The cardiovascular response in type 2 diabetes patients is exaggerated and linked to TRPV1 activation, potentially due to sensitization of muscle afferents. This sensitization is associated with PKC-induced TRPV1 overactivity, leading to enhanced circulatory response to TRPV1 activation in hyperglycemic conditions.
Article
Cardiac & Cardiovascular Systems
Ahmad Sabbahi, Assem Ellythy, Chueh-Lung Hwang, Shane A. Phillips
Summary: Black Americans have earlier onset and higher rates of hypertension compared to whites, potentially due to microvasculature. A study found that vessels from self-identified black individuals showed greater susceptibility to microvascular dysfunction under high intraluminal pressure and depended more on H2O2 for flow-induced dilation compared to whites.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Editorial Material
Medicine, General & Internal
Mariann R. Piano, Chueh-Lung Hwang
ANNALS OF INTERNAL MEDICINE
(2021)
Article
Peripheral Vascular Disease
Sang Joon Ahn, Ibra S. Fancher, Sara T. Granados, Natalia F. Do Couto, Chueh-Lung Hwang, Shane A. Phillips, Irena Levitan
Summary: Studies have shown that endothelial Kir2.1 channels play a significant role in vasodilation, while high cholesterol levels inhibit this function. Through mouse models and human experiments, it was further confirmed that there is a negative correlation between high LDL cholesterol levels and FIV, and the regulatory mechanism of Kir2.1 in this process was explored.
Article
Neurosciences
Amane Hori, Norio Hotta, Ayumi Fukazawa, Juan A. Estrada, Kimiaki Katanosaka, Kazue Mizumura, Jun Sato, Rie Ishizawa, Han-Kyul Kim, Gary A. Iwamoto, Wanpen Vongpatanasin, Jere H. Mitchell, Scott A. Smith, Masaki Mizuno
Summary: This study demonstrates that insulin enhances the responsiveness of thin fibre muscle afferents to capsaicin, as well as the responsiveness of dorsal root ganglion neurons to capsaicin. Additionally, insulin augments the sympathetic nerve activity response to capsaicin. These findings highlight the importance of insulin in the regulation of sensory nerve activity.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Editorial Material
Public, Environmental & Occupational Health
Chueh-Lung Hwang, Shane A. Phillips, Min-Hsuan Tu, Mariann R. Piano
JOURNAL OF WOMENS HEALTH
(2022)
Article
Neurosciences
Maria Alejandra Gonzalez-Gonzalez, Kevin Romero, John Beitter, David Lloyd, Danny V. Lam, Ana Guadalupe Hernandez-Reynoso, Aswini Kanneganti, Han-Kyul Kim, Caroline K. Bjune, Scott Smith, Wanpen Vongpatanasin, Mario I. Romero-Ortega
Summary: Hypertension affects a large number of adults in the United States, and despite effective pharmacological treatments, a significant percentage of patients have uncontrolled blood pressure. This study investigated the use of deep peroneal nerve stimulation (DPNS) as a possible strategy to lower blood pressure in drug-resistant hypertension. The results suggest that DPNS consistently reduces blood pressure and alters renal sympathetic nerve activity. A novel wireless system was developed to test the acute effect of DPNS in awake animals, confirming its ability to lower blood pressure. These findings support the use of DPN neuromodulation as a potential approach to manage drug-resistant hypertension.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Peripheral Vascular Disease
Han-Kyul Kim, Rie Ishizawa, Ayumi Fukazawa, Zhongyun Wang, Ursa Bezan Petric, Ming Chang Hu, Scott A. Smith, Masaki Mizuno, Wanpen Vongpatanasin
Summary: This study found that SGLT2i can reduce blood pressure in hypertensive patients and attenuate renal sympathetic nerve activity and skeletal muscle reflex activity. Additionally, the study found that SGLT2i has no impact on glycemic control. These findings have important clinical implications for preventing hypertension and hypertensive heart disease in young prehypertensive individuals.
Article
Peripheral Vascular Disease
Mark B. Badrov, Jeung-Ki Yoo, Sarah L. Hissen, David B. Nelson, J. Kevin Shoemaker, Qi Fu
Summary: This study tested whether women who develop gestational hypertension (GH) display abnormal sympathetic action potential (AP) discharge patterns in late pregnancy (32-36 weeks), both at rest and during postural stress. The results showed that the burst frequency of muscle sympathetic nerve activity was elevated in GH compared to the control groups. Moreover, the content per integrated burst and the total AP firing frequency were also higher in the GH group. In conclusion, women who develop GH exhibit aberrant sympathetic AP firing patterns in both supine and upright postures.
Letter
Cardiac & Cardiovascular Systems
Andrew W. D'Souza, Jeung-Ki Yoo, Ryosuke Takeda, Mark B. Badrov, Elizabeth H. Anderson, Takuro Washio, Carol S. North, Alina Suris, Michael D. Nelson, J. Kevin Shoemaker, Qi Fu
Article
Geriatrics & Gerontology
Zhaoli Liu, Gabriela Whitener, Chueh-Lung Hwang
Summary: This study examined the knowledge, misconceptions, and predictors of palliative care among older adults using nationally representative data. Findings revealed that a significant proportion of older adults have limited knowledge about palliative care, and there are misconceptions associated with it. Furthermore, utilizing the internet for health information was found to be a significant predictor of palliative care knowledge among older adults.
Article
Physiology
Kanji Matsukawa, Gary A. Iwamoto, Jere H. Mitchell, Masaki Mizuno, Han-Kyul Kim, Jon W. Williamson, Scott A. Smith
Summary: Stimulation of the mesencephalic locomotor region results in exaggerated sympathetic nerve and pressor responses in hypertensive rats. The decerebrate animal model can evoke intermittent bouts of spontaneously occurring motor activity (SpMA) and associated cardiovascular responses. This study aimed to determine whether the responses in renal sympathetic nerve activity (RSNA) and mean arterial pressure (MAP) during SpMA are altered in hypertensive rats. The results showed that the increase in RSNA and MAP during SpMA was much greater in hypertensive rats compared to normotensive rats.
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY, INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2023)
Letter
Cardiac & Cardiovascular Systems
Mark B. Badrov, Jeung-Ki Yoo, Sarah L. Hissen, Andrew W. D'Souza, David B. Nelson, J. Kevin Shoemaker, Qi Fu