Article
Environmental Sciences
Li Cao, Jie Zhao, Jingru Xu, Lei Zhu, Sajid Ur Rahman, Shibin Feng, Yu Li, Jinjie Wu, Xichun Wang
Summary: The study demonstrates that N-acetylcysteine (NAC) can alleviate the damage of Sertoli cells induced by Zearalenone (ZEA) and Deoxynivalenol (DON) by reducing oxidative damage and apoptosis.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Jia Lin, Cuige Zuo, Tianzeng Liang, Yang Huang, Ping Kang, Kan Xiao, Yulan Liu
Summary: This study investigated the potential role of lycopene (LYC) in mitigating the combined effects of ZEN, DON, and AFB1 on the jejunum of mice. The results demonstrated that LYC alleviated jejunal injury by inhibiting oxidative stress-mediated ferroptosis and mitochondrial damage.
Article
Environmental Sciences
Xu Ji, Zhongqi Tang, Feng Zhang, Fen Zhou, Yijing Wu, Dong Wu
Summary: In this study, taurine supplementation was found to improve DON-induced liver injury in weaned piglets by reducing pathological and serum biochemical changes, attenuating oxidative stress and inflammation, and inhibiting hepatocyte apoptosis.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Xue Rong, Yuli Wang, Fangxin Ouyang, Weixuan Song, Songhua Li, Feng Li, Shancang Zhao, Dapeng Li
Summary: The co-exposure of zearalenone and deoxynivalenol had toxic effects on zebrafish embryos, leading to decreased movement and heartbeat, developmental toxicity, oxidative stress, hepatotoxicity, apoptosis, and inflammation.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Multidisciplinary Sciences
Eman H. H. Basha, Amira M. M. ElShamy, Hoda A. A. Ibrahim, Mohamed A. A. Safa, Nehal A. E. Heabah, Radwa Awad, Radwa Ismail, Rabab M. M. Amer, Ola M. M. Salem, Heba Faheem, Yasmeen M. M. El-Harty
Summary: The current study demonstrates the potential effect of Fucoidan in male rats with splenic dysfunction induced by Oxaliplatin. Fucoidan significantly reduced oxidative stress and inflammation induced by Oxaliplatin, as well as increased antioxidant capacity. This suggests that Fucoidan may have a significant role in the treatment of splenic dysfunction.
SCIENTIFIC REPORTS
(2022)
Article
Food Science & Technology
Rong Yan, Hanli Wang, Jiangning Zhu, Tiancheng Wang, Eugenie Nepovimova, Miao Long, Peng Li, Kamil Kuca, Wenda Wu
Summary: This study assessed the effects of procyanidins (PC) on cell apoptosis caused by zearalenone (ZEA) and validated the role of Nrf2 in this process. The findings demonstrated that PC could enhance the cell antioxidant capacity, mitigate ZEA-induced cell apoptosis, and promote the expression of Nrf2 and its downstream genes. This discovery contributes to the clinical application of PC in preventing reproductive toxicity caused by ZEA.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Food Science & Technology
Panagiotis D. Tassis, Nicole Reisinger, Veronika Nagl, Eleni Tzika, Dian Schatzmayr, Nikolaos Mittas, Athina Basioura, Ilias Michos, Ioannis A. Tsakmakidis
Summary: Deoxynivalenol (DON) and zearalenone (ZEN) have negative effects on boar fertility. Modified forms of DON and ZEN, such as de-epoxy-DON (DOM-1) and hydrolyzed ZEN (HZEN), have less impact on swine reproduction. In vitro experiments showed that DON negatively affected specific parameters of boar semen, while DOM-1 had no harmful effects. ZEN, on the other hand, affected almost all parameters and decreased viable spermatozoa while increasing abnormal spermatozoa.
Article
Food Science & Technology
Celine Peillod, Marie Laborde, Angelique Travel, Amandine Mika, Jean Denis Bailly, Didier Cleva, Cyril Boissieu, Jean Le Guennec, Olivier Albaric, Sophie Labrut, Pascal Froment, Didier Tardieu, Philippe Guerre
Summary: The study found that decreased performance may occur in ducks exposed to a combination of fumonisins B (FB), deoxynivalenol (DON) and zearalenone (ZEN), but did not reveal any other interactions between mycotoxins in other variables measured.
Article
Toxicology
Karolina Kowalska, Marta Justyna Koziel, Dominika Ewa Habrowska-Gorczynska, Kinga Anna Urbanek, Kamila Dominska, Agnieszka Wanda Piastowska-Ciesielska
Summary: The PI3K/Akt signaling pathway is one of the most deregulated pathways in prostate cancer, and DON can affect apoptosis and autophagy in normal prostate epithelial cells by modulating this pathway. High concentrations of DON induce apoptosis, while low concentrations induce autophagy.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Food Science & Technology
Jing Wu, Jiayan Li, You Wu, Mengran Yang, Yunqin Chen, Naidong Wang, Ji Wang, Zhihang Yuan, Jine Yi, Chenglin Yang
Summary: This study first revealed the protective effect of betulinic acid (BA) on the hepatotoxicity of Zearalenone (ZEA), providing a new perspective for the development of ZEA antidote and the application of BA.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Article
Microbiology
Valentina Scarpino, Massimo Blandino
Summary: Enhancing FHB resistance in wheat is an effective method to reduce mycotoxin contamination. The study found that wheat genotypes with high deoxynivalenol tolerance can minimize sanitary risks, with the most FHB resistant genotypes showing the lowest contamination levels of various mycotoxins. An inverse relationship between deoxynivalenol amount and ratios of other mycotoxins was observed across all wheat cultivars and years.
Article
Food Science & Technology
Sirao Hai, Jiawen Chen, Li Ma, Chenlong Wang, Chuangjiang Chen, Sajid Ur Rahman, Chang Zhao, Shibin Feng, Jinjie Wu, Xichun Wang
Summary: This study investigated the regulatory mechanism of endoplasmic reticulum stress (ERS) on ZEA- combined with DON-induced mitochondrial pathway apoptosis in piglet Sertoli cells (SCs). The results showed that ZEA + DON damaged the cells, induced apoptosis, and affected mitochondrial function. Pretreatment with 4-phenylbutyric acid (4-PBA) alleviated the toxicity and improved cell survival. ERS plays an important role in the apoptosis of SCs co-infected with ZEA-DON, and intervention in this process can provide a new way to alleviate the reproductive toxicity.
Article
Fisheries
Xin Chen, Jun Ma, Hao Chen
Summary: This study found that deoxynivalenol (DON) can induce cytotoxicity, oxidative stress, and apoptosis in grass carp liver cells (L8824) through autophagy. Furthermore, oxidative stress inhibitor attenuates DON-induced autophagy, while autophagy inhibitor enhances ROS production.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Agriculture, Dairy & Animal Science
Xiaoya Li, Jiaxin Duan, Shiyou Wang, Jianyong Cheng, Huali Chen, Zelin Zhang, Li Yang, Rongmao Hua, Qingwang Li
Summary: This study found that isorhamnetin can protect oocytes from damage caused by ZEA through the PI3K/Akt signaling pathway, improving developmental capability and inhibiting early apoptosis, oxidative stress, and endoplasmic reticulum stress.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2023)
Article
Food Science & Technology
Johan S. Saenz, Alina Kurz, Ursula Ruczizka, Moritz Buenger, Maximiliane Dippel, Veronika Nagl, Bertrand Grenier, Andrea Ladinig, Jana Seifert, Evelyne Selberherr
Summary: Feeding animals with high concentrations of mycotoxins altered the gut microbiome composition, with an increase in Actinobacteria peptides and a decrease in Firmicutes peptides, as well as an increase in proteins associated with ribosomes and pentose-phosphate pathways, and a decrease in glycolysis and other carbohydrate metabolism pathways. Additionally, high levels of mycotoxins increased the abundance of the antioxidant enzyme thioredoxin-dependent peroxiredoxin, leading to disruption in the gut microbiome structure.