Article
Nutrition & Dietetics
Juan J. Lopez-Gomez, Jose L. Perez-Castrillon, Isabel Garcia de Santos, Maria Perez-Alonso, Olatz Izaola-Jauregui, David Primo-Martin, Daniel A. De Luis-Roman
Summary: This study examined the differences in bone metabolism between postmenopausal women with and without obesity, and compared the risk of fracture at five years between these groups.
Article
Endocrinology & Metabolism
Rikke Viggers, Zheer Al-Mashhadi, Jakob Starup-Linde, Peter Vestergaard
Summary: This study aimed to investigate the risk of major osteoporotic fractures in diabetes patients initiated with alendronate and denosumab. Results showed that the risk of incident major osteoporotic fractures among subjects with diabetes was similar between those initially treated with alendronate and denosumab, suggesting both treatments are equally effective in preventing osteoporotic fractures in subjects with diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
D. Ozaki, R. Kubota, T. Maeno, M. Abdelhakim, N. Hitosugi
Summary: The study found a significant association between the abundance of specific microbiota and fracture risk and vitamin K levels in postmenopausal Japanese women. Bacteroides genus may be related to vitamin K2 levels, while Rikenellaceae family may be associated with bone density and TRACP-5b levels. Further investigations on microbiota-related pathways in bone metabolism may help identify treatment strategies and prevent osteoporosis.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Medicine, General & Internal
Athanasios D. Anastasilakis, Elena Tsourdi, Gaia Tabacco, Anda Mihaela Naciu, Nicola Napoli, Fabio Vescini, Andrea Palermo
Summary: The study found that there is currently insufficient data to prove the significant impact of bone therapies on glucose metabolism in diabetic patients. It is uncertain whether antiosteoporotic drugs have different effects on fracture incidence between diabetic and nondiabetic patients. More research is needed to address these issues and provide stronger recommendations.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Endocrinology & Metabolism
Wacili Da, Lin Tao, Yue Zhu
Summary: In recent years, research on the mechanism underlying bone metabolic disorders based on energy metabolism has made significant progress, focusing on the impact of osteoclast energy metabolism disorder on bone homeostasis and proposing a compensatory recovery mechanism as a new approach for the treatment of osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Endocrinology & Metabolism
Gregory A. Kline, Suzanne N. Morin, Lisa M. Lix, Eugene McCloskey, Helena Johansson, Nicholas C. Harvey, John A. Kanis, William D. Leslie
Summary: This study found that medical comorbidity is associated with fracture risk and can increase the risk of fractures independently of FRAX. By using complex and simple measures of medical comorbidity, FRAX-based risk estimates can be modified to capture the increased fracture risk associated with multiple comorbid conditions in older patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jeongmin Lee, Kyungdo Han, Sang Hyun Park, Mee Kyoung Kim, Dong-Jun Lim, Kun-Ho Yoon, Moo-Il Kang, Seung-Hwan Lee
Summary: This study aimed to investigate the associations of body weight or glucose variability or their combination with the risk of hip fracture in people with diabetes. The results showed that high variability in body weight and glucose levels is associated with an increased incidence rate and risk of hip fracture in people with diabetes.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Biochemistry & Molecular Biology
Sara Dule, Ilaria Barchetta, Flavia Agata Cimini, Giulia Passarella, Arianna Dellanno, Tiziana Filardi, Vittorio Venditti, Enrico Bleve, Diego Bailetti, Elisabetta Romagnoli, Susanna Morano, Marco Giorgio Baroni, Maria Gisella Cavallo
Summary: Type 2 diabetes mellitus is associated with increased fracture risk. This study aimed to explore differences in bone alterations between women with type 2 diabetes and controls, and to identify clinical predictors of bone impairment in type 2 diabetes. The results showed that type 2 diabetes patients had a lower normal bone category and their bone status was correlated with high-density lipoprotein cholesterol and vitamin D levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Penghua Fang, Yuqing She, Long Han, Shiwei Wan, Wenbin Shang, Zhenwen Zhang, Wen Min
Summary: Type 2 diabetes mellitus is considered a risk factor for osteoporosis, but the bone abnormalities associated with these two conditions may differ. Neuropeptide galanin plays a significant role in the pathogenesis of both T2DM and osteoporosis.
MECHANISMS OF AGEING AND DEVELOPMENT
(2021)
Article
Endocrinology & Metabolism
Kaisa K. Ivaska, Fiona E. McGuigan, Linnea Malmgren, Paul Gerdhem, Helena Johansson, John A. Kanis, Kristina E. Akesson
Summary: This study found that CTX, urinary OC, and TRAcP5b are predictive for fracture risk within 1 to 3 years, but are less valuable in the long term or in individuals above the age of 80.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Qing Wu, Jongyun Jung
Summary: This study introduces a novel genome-wide polygenic score (GPS) to quantify inherited susceptibility to osteoporosis and osteoporotic fracture, providing new opportunities for clinical prevention and risk assessment.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Hui Cai, Huimei Zhang, Weiting He, Heng Zhang
Summary: Postmenopausal osteoporosis, known as the "invisible killer," is a degenerative disease. Estrogen is crucial for maintaining bone mineral content in women. Iron accumulation, with serum ferritin levels higher than normal but less than 1000 μg/L, has been found to occur simultaneously with osteoporosis after menopause. Recent studies have shown that iron accumulation plays a vital role in postmenopausal osteoporosis and is significantly correlated with fragility fractures.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2023)
Article
Endocrinology & Metabolism
Zheer Kejlberg Al-Mashhadi, Rikke Viggers, Jakob Starup-Linde, Peter Vestergaard, Soren Gregersen
Summary: This population-based cohort study using Danish national health registries found that in patients with T2D, SGLT2 inhibitors had no effect on the risk of major osteoporotic fractures compared to GLP-1 receptor agonists.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Miroslav Vujasinovic, Lorena Nezirevic Dobrijevic, Ebba Asplund, Wiktor Rutkowski, Ana Dugic, Mashroor Kahn, Ingrid Dahlman, Maria Saaf, Hannes Hagstrom, Johannes-Matthias Lohr
Summary: This study found that only 23% of patients with CP underwent DXA examination, with 53.4% of patients having low BMD. The fracture rate was significantly higher in patients with low BMD compared to those with normal BMD.
Article
Medicine, General & Internal
Yui Ogiso, Tatsunori Hanai, Kayoko Nishimura, Takao Miwa, Toshihide Maeda, Kenji Imai, Atsushi Suetsugu, Koji Takai, Masahito Shimizu
Summary: This cross-sectional study aimed to determine whether TBS can identify patients with liver cirrhosis that are at risk of vertebral fractures. The results showed a significant correlation between TBS and vertebral fractures, indicating that TBS can help identify patients at risk of vertebral fractures in liver cirrhosis.
JOURNAL OF CLINICAL MEDICINE
(2022)
