Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 45, Issue 3, Pages 127-135Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000111
Keywords
exercise physiology; exercise inflammation; exercise pharmacokinetics; CYP450 enzymes; personalized medicine; enzyme upregulation/downregulation; drug interactions
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Exercise frequently is prescribed therapeutically, either on its own or combined with drugs. A drug's absorption, distribution, metabolism, and excretion can be affected by the user's anatomy and physiology, which are both changed by the myriad of complex adaptations to acute and chronic exercise. This article reviews the research that suggests exercise may influence a drug's plasma concentration, and thus its efficacy and safety.
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