Article
Oncology
Qi Miao, Zhihao Wei, Chenchen Liu, Yuzhong Ye, Gong Cheng, Zhengshuai Song, Kailei Chen, Yunxuan Zhang, Jiawei Chen, Changjie Yue, Hailong Ruan, Xiaoping Zhang
Summary: Radical prostatectomy (RP) shows significant advantages over radiation therapy (RT) in improving overall survival (OS) and cancer-specific survival (CSS) for metastatic prostate cancer (mPCa).
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Oskar Bergengren, Marcus Westerberg, Lars Holmberg, Par Stattin, Anna Bill-Axelson, Hans Garmo
Summary: The study found that increased prostate-specific antigen testing and diagnostic activity are linked to a larger number of men being diagnosed with prostate cancer, mainly low- and intermediate-risk disease. The increased diagnostic activity was associated with a 2-fold increase in curative treatment and a modest decrease in mortality.
Article
Oncology
Frederik B. Thomsen, Hans Garmo, Klaus Brasso, Lars Egevad, Par Stattin
Summary: The study conducted in Sweden from 2000 to 2010 found that men diagnosed with clinically localized prostate cancer and treated with radical prostatectomy in 2007-2008 and 2009-2010 had a significantly lower risk of prostate cancer death compared to those diagnosed in 2000-2002. The reduced risk of prostate cancer death was only observed in men with intermediate-risk prostate cancer, showing a decrease in overall risk within the studied population.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Michelle S. Chen, Lauren E. Howard, Shannon Stock, Anna Dolgner, Stephen J. Freedland, William Aronson, Martha Terris, Zachary Klaassen, Christopher Kane, Christopher Amling, Matthew Cooperberg, Timothy J. Daskivich
Summary: The study aimed to validate the Prostate Cancer Comorbidity Index (PCCI) score in predicting other-cause mortality (OCM) and cancer outcomes in prostate cancer patients receiving hormone therapy. Through follow-up and assessment of 4857 patients, the study found that higher PCCI scores were associated with increased risk of OCM and worse cancer outcomes.
PROSTATE CANCER AND PROSTATIC DISEASES
(2022)
Article
Oncology
Philipp Mandel, Benedikt Hoeh, Felix Preisser, Mike Wenzel, Clara Humke, Maria-Noemi Welte, Inga Jerrentrup, Jens Koellermann, Peter Wild, Derya Tilki, Alexander Haese, Andreas Becker, Frederik C. Roos, Felix K. H. Chun, Luis A. Kluth
Summary: The study revealed a significant positive correlation between preoperative PSA and tumor weight in PCa patients undergoing RP, with an increase in PSA of almost 0.4 ng/ml per 1 g tumor weight. This finding could help estimate tumor burden before RP and in cases of biochemical recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas G. Wibmer, Ines Nikolovski, Joshua Chaim, Yulia Lakhman, Robert A. Lefkowitz, Evis Sala, Sigrid Carlsson, Samson W. Fine, Michael W. Kattan, Hedvig Hricak, Hebert Alberto Vargas
Summary: This study analyzed the relationship between staging discrepancies between MRI and histopathologic evaluation and recurrence and survival after radical prostatectomy. The findings showed that the local extent of prostate cancer at MRI is associated with oncologic outcomes after prostatectomy, independent of pathologic tumor stage. This could provide important insights into integrating MRI into clinical staging algorithms.
Article
Medicine, General & Internal
Michael Xiang, Ting Martin Ma, Ricky Savjani, Erqi L. Pollom, R. Jeffrey Karnes, Tristan Grogan, Jessica K. Wong, Giovanni Motterle, Jeffrey J. Tosoian, Bruce J. Trock, Eric A. Klein, Bradley J. Stish, Robert T. Dess, Daniel E. Spratt, Avinash Pilar, Chandana Reddy, Rebecca Levin-Epstein, Trude B. Wedde, Wolfgang A. Lilleby, Ryan Fiano, Gregory S. Merrick, Richard G. Stock, D. Jeffrey Demanes, Brian J. Moran, Hartwig Huland, Phuoc T. Tran, Santiago Martin, Rafael Martinez-Monge, Daniel J. Krauss, Eyad I. Abu-Isa, Ridwan Alam, Zeyad Schwen, Thomas M. Pisansky, C. Richard Choo, Daniel Y. Song, Stephen Greco, Curtiland Deville, Todd McNutt, Theodore L. DeWeese, Ashley E. Ross, Jay P. Ciezki, Paul C. Boutros, Nicholas G. Nickols, Prashant Bhat, David Shabsovich, Jesus E. Juarez, Natalie Chong, Patrick A. Kupelian, Matthew B. Rettig, Nicholas G. Zaorsky, Alejandro Berlin, Jonathan D. Tward, Brian J. Davis, Robert E. Reiter, Michael L. Steinberg, David Elashoff, Eric M. Horwitz, Rahul D. Tendulkar, Derya Tilki, Johannes Czernin, Andrei Gafita, Tahmineh Romero, Jeremie Calais, Amar U. Kishan
Summary: PSMA PET/CT can detect previously occult nonlocalized prostate cancer with important clinical implications. The upstaging probability on PSMA PET/CT is associated with long-term prognosis and shows superior risk discrimination compared with existing tools in high-risk patients.
Article
Urology & Nephrology
Jochen Walz, Geraldine Pignot, Sami Fakhfakh, Jennifer Campagna, Mathilde Guerin, Cecile Vicier, Serge Brunelle, Naji Salem, Gwenaelle Gravis
Summary: The landscape of the management of metastatic prostate cancer is rapidly changing, with growing interest in local treatment of the primary tumor. While retrospective analysis and prospective randomized trials have shown no significant improvement in overall survival with local treatment, there may be a positive impact on failure-free survival in certain subgroups like patients with low volume disease or <5 metastases. Prospective non-randomized or retrospective studies have yielded inconclusive results due to major selection biases.
WORLD JOURNAL OF UROLOGY
(2021)
Review
Urology & Nephrology
Pawel Rajwa, Fabio Zattoni, Martina Maggi, Giancarlo Marra, Petra Kroyer, Shahrokh F. Shariat, Alberto Briganti, Francesco Montorsi, Isabel Heidegger, Giorgio Gandaglia
Summary: In this study, recent prospective studies on the survival and safety of cytoreductive radical prostatectomy (cRP) in patients with low-volume metastatic hormone-sensitive prostate cancer (mHSPC) were reviewed. The findings suggest that cRP is a feasible, safe, and potentially effective therapy for selected patients with mHSPC, providing favorable oncologic outcomes and beneficial effects on local disease control.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Andrology
Kan Wu, Yongquan Tang, Yanxiang Shao, Xiang Li
Summary: A novel nomogram and patient stratification method were developed to predict the risk of CSM in mPCa patients. The study found that RP was significantly correlated with a reduction in 5-year CSM risk in low- and intermediate-risk groups, but not in the high-risk group. Additional validation and improvement of these results are needed through ongoing prospective trials.
TRANSLATIONAL ANDROLOGY AND UROLOGY
(2021)
Review
Health Care Sciences & Services
Takafumi Yanagisawa, Pawel Rajwa, Fahad Quhal, Tatsushi Kawada, Kensuke Bekku, Ekaterina Laukhtina, Markus von Deimling, Marcin Chlosta, Pierre I. Karakiewicz, Takahiro Kimura, Shahrokh F. Shariat
Summary: This study reviewed several studies on the efficacy of adding androgen receptor signaling inhibitors (ARSIs) as a neoadjuvant treatment for patients with prostate cancer (PCa) undergoing radical prostatectomy (RP). The results suggest that neoadjuvant ARSI + ADT combination therapy improves pathologic response compared to ADT or ARSI alone.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Oncology
Johanna Classon, Margherita Zamboni, Camilla Engblom, Kanar Alkass, Giulia Mantovani, Christian Pou, Dieudonne Nkulikiyimfura, Petter Brodin, Henrik Druid, Jeff Mold, Jonas Frisen
Summary: The HLA-A * 02:01 and HLA-A * 11 alleles are independently associated with disease recurrence in prostate cancer patients. Patients with low-intermediate risk carrying the HLA-A * 02:01 gene and patients with high-risk carrying the HLA-A * 11 gene are more likely to experience disease recurrence. Furthermore, patients carrying HLA-A * 02:01 with detected anti-cytomegalovirus T-cell receptors are also at higher risk of recurrence.
MOLECULAR ONCOLOGY
(2022)
Article
Urology & Nephrology
Prasanna Sooriakumaran, Caroline Wilson, Ines Rombach, Neelam Hassanali, Jonathan Aning, Alastair D. Lamb, Paul Cathcart, Christopher Eden, Imran Ahmad, Prabhakar Rajan, Ashwin Sridhar, Richard J. Bryant, Oussama Elhage, Jonathan Cook, Hing Leung, Naeem Soomro, John Kelly, Senthil Nathan, Jenny L. Donovan, Freddie C. Hamdy
Summary: This study tested the feasibility of randomizing men with newly diagnosed oligo-metastatic prostate cancer to radical prostatectomy plus pelvic lymphadenectomy in addition to standard systemic therapy. The study found that surgery was safe and had a similar impact on functioning outcomes as surgery for standard indication. However, a larger randomized controlled trial is needed to examine the treatment effectiveness of this additional component.
Article
Oncology
Daimantas Milonas, Tomas Ruzgas, Zilvinas Venclovas, Daniele Jonusaite, Aivaras Jonas Matijosaitis, Darius Trumbeckas, Edmundas Varpiotas, Stasys Auskalnis, Darijus Skaudickas, Ramunas Mickevicius, Kestutis Vaiciunas, Jonas Mickevicius, Mindaugas Jievaltas
Summary: This study aimed to identify clinical predictors and patient groups at increased risk of prostate cancer-related mortality. Factors such as Grade Group, pathological stage, age, and their combinations were analyzed to assess mortality rates. The study provides long-term mortality plots that can assist clinicians in identifying patients with aggressive prostate cancer who may benefit from more intensive or novel treatment strategies.
Article
Multidisciplinary Sciences
Jaehun Jung, Gi Hwan Bae, Jae Heon Kim, Jaehong Kim
Summary: This study aimed to evaluate the clinical impact of robot-assisted radical prostatectomy (RARP) on health outcomes in Korean patients with prostate cancer (PCa). The study found that RARP had a higher risk of overall mortality within 3 and 12 months compared to radical prostatectomy (RP). The RARP group in hospitals with the largest PCa surgery volume had higher mortality rates and more surgical complications than the total RARP patients. The study suggests that RARP may not be superior to RP, possibly due to increased robotic surgery in the elderly.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Carlo A. Bravi, Giorgio Gandaglia, Elio Mazzone, Nicola Fossati, Andrea Gallina, Armando Stabile, Simone Scuderi, Francesco Barletta, Luigi Nocera, Giuseppe Rosiello, Alberto Martini, Francesco Pellegrino, Vito Cucchiara, Federico Deho, Umberto Capitanio, Vincenzo Scattoni, Andrea Salonia, Alberto Briganti, Francesco Montorsi
Summary: This prospective randomized study aimed to investigate the effects of early ligation of the dorsal venous complex (DVC) on urinary continence (UC) recovery after robot-assisted radical prostatectomy (RARP) in patients with prostate cancer. The results showed that early DVC ligation did not improve UC recovery compared to the standard technique. This technique can be considered as an option for surgical dissection based on the surgeon's preference.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Urology & Nephrology
Francesco Pellegrino, Amy L. Tin, Alberto Martini, Emily A. Vertosick, Shaun P. Porwal, Armando Stabile, Giorgio Gandaglia, James A. Eastham, Alberto Briganti, Francesco Montorsi, Andrew J. Vickers
Summary: The commonly used prostate-specific antigen density (PSAd) cutoff of 0.15 ng/ml/cc is only justified for selecting patients with poor MRI quality, and a higher cutoff value (>= 0.20) should be used for patients with average MRI quality.
EUROPEAN UROLOGY FOCUS
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Giorgio Brembilla, Salvatore Lavalle, Tom Parry, Michele Cosenza, Tommaso Russo, Elio Mazzone, Francesco Pellegrino, Armando Stabile, Giorgio Gandaglia, Alberto Briganti, Francesco Montorsi, Antonio Esposito, Francesco De Cobelli
Summary: The impact of Prostate Imaging Quality (PI-QUAL) scores on the diagnostic performance of multiparametric MRI (mpMRI) in a targeted biopsy cohort was investigated. The results showed that scans of suboptimal quality (PI-QUAL < 4) were associated with lower positive predictive value (PPV) for clinically significant prostate cancer (csPCa) and lower detection rates in both PI-RADS 3 and PI-RADS 4-5.
EUROPEAN JOURNAL OF RADIOLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Riccardo Leni, Armando Stabile, Giorgio Gandaglia, Vito Cucchiara, Giuseppe Rosiello, Elio Mazzone, Gabriele Sorce, Francesco Pellegrino, Simone Scuderi, Daniele Robesti, Donato Cannoletta, Mario De Angelis, Leonardo Quarta, Paolo Zaurito, Giorgio Brembilla, Francesco De Cobelli, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Francesco Pellegrino, Giorgio Gandaglia, Armando Stabile, Elio Mazzone, Giuseppe Rosiello, Gabriele Sorce, Luigi Nocera, Simone Scuderi, Francesco Barletta, Riccardo Leni, Mario De Angelis, Antony Pellegrino, Pietro Scilipoti, Paolo Zaurito, Emanuele Zaffuto, R. Jeffrey Karnes, Morgan Roupret, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Maria Monica Ratti, Giorgio Gandaglia, Elena Silvia Sisca, Alexandra Derevianko, Eugenia Alleva, Katharina Beyer, Charlotte Moss, Francesco Barletta, Simone Scuderi, Armando Stabile, Elio Mazzone, Muhammad Imran Omar, Steven Maclennan, Paula R. Williamson, Jihong Zong, Sara J. Maclennan, Nicolas Mottet, Philip Cornford, Olalekan Lee Aiyegbusi, Mieke Van Hemelrijck, James N'Dow, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Daniele Robesti, Elio Mazzone, Giorgio Gandaglia, Andrea Necchi, Daniele Raggi, Laura Marandino, Armando Stabile, Vito Cucchiara, Simone Scuderi, Francesco Barletta, Mario De Angelis, Giuseppe Ottone Cirulli, Andrea Farolfi, Stefano Fanti, Riccardo Schiavina, Lorenzo Bianchi, Eleonora Balestrazzi, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Simone Scuderi, Giorgio Gandaglia, Armando Stabile, Armando Stabile, Elio Mazzone, Francesco Barletta, Nicolai Huebner, Eugenio Brunocilla, Agostino Mattei, Luca Afferi, Shahrok Shariat, Giancarlo Marra, Junlong Zhuang, Hongqian Guo, Riccardo Schiavina, Lorenzo Bianchi, Fabio Zattoni, Giuseppe Reitano, Pawel Rajwa, Juan Gomez Rivas, Claudia Kesch, Enrico Checcucci, Francesco Porpiglia, Edoardo Cisero, Daniele Amparore, Maria Picchio, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Gabriele Sorce, Armando Stabile, Giorgio Gandaglia, Vito Cucchiara, Elio Mazzone, Marco Moschini, Nicola Fossati, Paolo Gontero, Andrea Minervini, Sergio Serni, Luca Afferi, Agostino Mattei, Junlong Zhuang, Hongqian Guo, Guillaume Ploussard, Razvan-George Rahota, Massimo Valerio, Arnas Rakauskas, Alessandro Marquis, Roderick van den Bergh, Timo Soeterik, Jean Baptiste Beavaul, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Armando Stabile, Giorgio Gandaglia, Francesco Pellegrino, Vito Cucchiara, Elio Mazzone, Nicola Fossati, Marco Moschini, Agostino Mattei, Luca Afferi, Sergio Serni, Andrea Minervini, Razvan-George Rahota, Guillaume Ploussard, Massimo Valerio, Jean Baptiste Beavaul, Alessandro Marquis, Arnas Rakauskas, Paolo Gontero, Hongqian Guo, Junlong Zhuang, Roderick Van den Bergh, Timo Soeterik, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Giorgio Gandaglia, Andrea Necchi, Daniele Raggi, Armando Stabile, Vito Cucchiara, Elio Mazzone, Gabriele Sorce, Francesco Pellegrino, Simone Scuderi, Francesco Barletta, Daniele Robesti, Antony Pellegrino, Leonardo Quarta, Paolo Zaurito, Emanuele Zaffuto, Maria Picchio, Ana Maria Samanes Gajate, Luigi Gianolli, Giancarlo Marra, Paolo Gontero, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Francesco Giganti, Armando Stabile, Riccardo Leni, Mark Emberton, Caroline M. Moore, Massimo Valerio, Veeru Kasivisvanathan
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Riccardo Leni, Armando Stabile, Giorgio Gandaglia, Vito Cucchiara, Marco Bandini, Elio Mazzone, Leonardo Quarta, Paolo Zaurito, Francesco De Cobelli, Giorgio Brembilla, Nicola Fossati, Emanuele Zaffuto, Marco Moschini, Giulio Avesani, Federico Deho, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Meeting Abstract
Urology & Nephrology
Elio Mazzone, Giorgio Gandaglia, Francesco Barletta, Andrea Necchi, Daniele Raggi, Laura Marandino, Armando Stabile, Vito Cucchiara, Giuseppe Rosiello, Gabriele Sorce, Francesco Pellegrino, Simone Scuderi, Daniele Robesti, Mattia Longoni, Mario De Angelis, Pietro Scilipoti, Giuseppe Ottone Cirulli, Nicola Fossati, Francesco Montorsi, Alberto Briganti
JOURNAL OF UROLOGY
(2023)
Article
Surgery
Carlo A. Bravi, Pietro Piazza, Elio Mazzone, Paolo Dell'Oglio, Giuseppe Rosiello, Alberto Martini, Armando Stabile, Marco Moschini, Marco Amato, Luca Sarchi, Maria Peraire, Rui Farinha, Simone Scarcella, Stefano Puliatti, Sophie Knipper, Camille Berquin, Dries Develtere, Celine Sinatti, Hannah Van Puyvelde, Ruben De Groote, Geert De Naeyer, Frederiek D'Hondt, Peter Schatteman, Alberto Briganti, Francesco Montorsi, Alexandre Mottrie
Summary: This study describes the long-term oncologic outcomes of patients receiving robotic radical cystectomy at a high-volume European institution. Acceptable rates of clinical recurrence and cancer-specific survival were observed in long-term follow-up. However, the cumulative incidence of death from causes other than bladder cancer should be taken into consideration.
JOURNAL OF ROBOTIC SURGERY
(2023)